| Interacting proteins: P06748 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06748 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06748 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06748 and P62993 |
Pubmed |
SVM Score :0.0 |
| Treatment with 17 AAG decreased NPM ALK expression and phosphorylation , thus impairing its association with phospholipase C gamma , Src homology 2 domain containing protein ( Shc ) , growth factor receptor bound protein 2 ( Grb 2 ) , and insulin receptor substrate 1 ( IRS 1 ) . ^^^ |
|
| Interacting proteins: P06748 and P62993 |
Pubmed |
SVM Score :0.0 |
| In addition , in common with NPM ALK , the TFG ALK proteins formed stable complexes with the signaling proteins Grb 2 , Shc , and PLC gamma . ^^^ |
|
| Interacting proteins: P06748 and P62993 |
Pubmed |
SVM Score :0.0 |
| Both of the effects were dependent on ALK kinase activity and on the adaptor protein growth factor receptor bound protein 2 ( Grb 2 ) , since no binding or phosphorylation was found with the kinase dead mutant NPM ALK ( K210R ) or in the presence of a Grb 2 dominant negative protein . ^^^ |
|