| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.56647519 |
| CD 16 mediated p21ras activation is associated with Shc and p 36 tyrosine phosphorylation and their binding with Grb 2 in human natural killer cells . 0.56647519^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :1.2579206 |
| Whereas Grb 2 connects activated receptor tyrosine kinases with Sos and activates p21ras , recent evidence suggests that this may not be the major mechanism by which Crk and Nck signal to downstream effectors . 1.2579206^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| The Shc Grb 2 complex has been implicated in coupling these receptors to p21ras . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated Shc binds to Grb 2 which forms a complex with Sos guanine nucleotide exchange factor for p21ras . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| We found that the MAPK pathway protein set consisting of the following gene products was present : FRS 2 alpha , GRB 2 , GAB 1 , SOS 1 , Ha ras , Raf1 / RafB , MEK 1 , 2 , 5 , MAPK / ERK1 , 2 , MAPK / ERK5 , and RSK 1 , 2 , 3 ( see abbreviations ) . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| EGF induced association of Shc with the adapter protein Grb 2 may have implications for activation of the p21ras signaling pathway in the intestine . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| It was asked whether Shc p46 / p52 , a protein containing a src homology region 2 ( SH 2 ) domain , and known to function upstream from p21ras , might form specific complexes with p210bcr abl and thus , possibly alter p21ras activity by coupling to the guanine nucleotide exchange factor ( Sos / CDC25 ) through the Grb 2 protein Sos complex . ^^^ Thus , p210bcr abl appears to function in a hematopoietic p21ras activation pathway to allow growth factor independent coupling between Grb 2 , which exists in a complex with the guanine nucleotide exchange factor ( Sos ) , and p21ras . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Two substrates for TCR regulated protein tyrosine kinases ( PTKs ) have been implicated in p21ras activation in T cells : p95vav and a 36 kD protein that associates with a complex of Grb 2 and the Ras exchange protein Sos . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Growth factor receptor binding protein 2 ( GRB 2 ) couples growth factor receptor activation to the p21ras nucleotide exchange factor son of sevenless ( SOS ) . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| However , immunoblotting of anti Son of sevenless ( Sos ) 1 and 2 immunoprecipitates with anti Grb 2 antisera revealed that p21ras desensitization in response to insulin and PDGF , but not EGF , is associated with a marked decrease in cellular complexes containing Sos and Grb 2 proteins . ^^^ PDGF action triggers both mechanisms of Grb 2 disassembly , which probably operate in concert with GAP to attenuate p21ras signaling . . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Activation of p21ras by receptor tyrosine kinases is thought to result from recruitment of guanine nucleotide exchange factors such as Son of sevenless ( Sos ) to plasma membrane receptor substrates via adaptor proteins such as Grb 2 . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| T cell antigen CD 28 binds to the GRB 2 / SOS complex , regulators of p21ras . ^^^ Finally , immunoblotting shows that CD 28 also associates with the gene product of the human homolog of the Drosophila Son of sevenless gene ( SOS ) , a GRB 2 complexed guanine nucleotide exchange factor responsible for converting p21ras to a GTP bound active state . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| A mutant insulin receptor induces formation of a Shc growth factor receptor bound protein 2 ( Grb 2 ) complex and p21ras GTP without detectable interaction of insulin receptor substrate 1 ( IRS 1 ) with Grb 2 . ^^^ The activation of p21ras by receptor tyrosine kinases involves the translocation of the growth factor receptor bound protein 2 mammalian son of sevenless protein ( Grb 2 SOS ) complex to the plasma membrane where p21ras is localized . ^^^ Insulin receptors induce p21ras GTP formation by two possible mechanisms : tyrosine phosphorylation of insulin receptor substrate 1 ( IRS 1 ) and its subsequent association with Grb 2 , or Shc phosphorylation and its subsequent association with Grb 2 . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Disassembly of Son of sevenless proteins from Grb 2 during p21ras desensitization by insulin . ^^^ Insulin receptor signaling acutely stimulates GTP loading of p21ras , apparently by mobilizing complexes of Grb 2 and the guanine nucleotide exchangers Son of sevenless ( Sos ) 1 and 2 to associate with tyrosine phosphorylated proteins in the plasma membrane . ^^^ The disassembly of Grb 2 from Sos proteins slightly precedes the time course of p21ras deactivation in response to insulin . ^^^ These data are consistent with the hypothesis that the dissociation of Grb 2 from Sos proteins caused by insulin in 3T3 L 1 cells mediates p21ras deactivation and desensitization . . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylated IRS 1 binds the 85K subunit of phosphatidylinositol 3 kinase which may be involved in the translocation of glucose transporters and the abundant src homology protein ( ASH ) / Grb2 which may be involved in activation of p21ras and MAP kinase cascade . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| B cell antigen receptor cross linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS 1 as well as assembly of complexes containing SHC , GRB 2 , mSOS 1 , and a 145 kDa tyrosine phosphorylated protein . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Grb 2 , Sos , Ras Gap , p21ras , Raf , MEK and MAPK , genetic studies have suggested that two novel proteins , the protein tyrosine phosphatase ( PTPase ) Csw and the transmembrane protein Rho , are involved in RPTK signalling . . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Shc , grb 2 , and Son of sevenless ( mSos 1 ) proteins are potential upstream regulators of p21ras . ^^^ Together , these data suggest that the current model for regulation of p21ras , which proposes a stable association of Shc grb 2 Sos1 complexes at the plasma membrane , may be an oversimplification . . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| From these results , we conclude that after insulin and EGF treatment , Shc associates with both Grb 2 and mSOS and therefore may mediate , at least in part , insulin and EGF induced activation of p21ras . ^^^ These results indicate that the association of Grb 2 nSOS with Shc may be an important event in insulin induced , mSOS mediated activation of p21ras . . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| GRB 2 is a small SH 2 and SH 3 domain containing adapter protein that associates with the mammalian SOS homolog to regulate p21ras during growth factor signaling . ^^^ The Shc GRB 2 complex formed during insulin stimulation is a possible mediator of p21ras and MAP kinase activation in IRS 1 deficient 32 D cells . ^^^ Our results suggest that the Shc GRB 2 complex and the activation of p21ras dependent signaling pathways , including MAP kinase , are insufficient for insulin stimulated mitogenesis and that the essential function ( s ) of IRS 1 in proliferative signaling is largely unrelated to IRS 1 GRB 2 complex formation . . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Epidermal growth factor regulates p21ras through the formation of a complex of receptor , Grb 2 adapter protein , and Sos nucleotide exchange factor . ^^^ These results suggest that EGF induced activation of nucleotide exchange on p21ras proceeds through the recruitment of cytosolic Sos to a complex with EGF receptor and Grb 2 at the plasma membrane . . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Both GRB 2 and sem 5 have been implicated in a highly conserved mechanism that regulates p21ras signalling by receptor tyrosine kinases . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| In these cells , activated HERRet induces tyrosine phosphorylation of Shc , complex formation of Shc with Grb 2 and Sos and activation of p21ras . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Therefore , we investigated the effects of IL 6 on some recently identified signaling intermediates , Shc ( Src homology and collagen ) and Grb 2 ( growth factor receptor bound protein 2 ) , known to activate p21ras . ^^^ This led to the complex formulation of Shc with Grb 2 , an adaptor protein known to relocate a p21ras GDP exchange factor . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| The activation pathway does not directly involve phorbol ester sensitive protein kinase C types , but does require ( 1 ) pertussis toxin sensitive G protein beta gamma subunits , ( 2 ) a staurosporine and genistein sensitive protein kinase , ( 3 ) phosphoinositide 3 ' kinase activity , ( 4 ) activation of Sos in a multimolecular complex that contains p46Shc , and p52Shc , and Grb 2 , ( 5 ) the GTPase p21Ras , and ( 6 ) the protein kinase p74Raf 1 . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| It has been suggested that a key event in growth factor induced p21Ras activation by the guanine nucleotide exchange factor Sos , is the recruitment of Sos to the plasma membrane by its interaction with the adaptor protein Grb 2 . ^^^ However , other evidence argues that the sub cellular localisation of Sos is independent of Grb 2 , and that the Sos / Grb2 interaction can be dispensed with for p21Ras activation . ^^^ This shows that the Grb2 / Sos interaction is required to mediate growth factor dependent activation of p21Ras , and requires the presence of intact SH 2 and SH 3 domains of Grb 2 . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| The first peak of activation of p21ras , at 2 5 min , is mediated by immediate association of phosphorylated Shc with the guanosine exchange factor Sos 1 via the adaptor protein Grb 2 . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Arachidonic acid mediates angiotensin 2 effects on p21ras in renal proximal tubular cells via the tyrosine kinase Shc Grb 2 Sos pathway . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| While injection of GRB 2 or H ras proteins alone into quiescent rat fibroblasts did not have mitogenic effect , microinjection of GRB 2 together with H ras protein stimulated DNA synthesis . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| On the other hand , expression of Grb 2 and Sos proteins was substantially increased in all human bladder cancer cell lines examined in comparison with cultured normal urothelial cells , whether codon 12 of H ras was mutated or not . ^^^ |
|
| Interacting proteins: P01112 and P62993 |
Pubmed |
SVM Score :0.0 |
| Proteins studied included cell surface receptors ( Ephrins and Eph receptors , CD 44 ) , kinases ( EGFR cytoplasmic domain , CDK 2 and 4 ) , proteases ( MMP 1 , CASP 2 ) , signal transduction proteins ( GRB 2 , RAF 1 , HRAS ) and transcription factors ( GATA 2 , Fli 1 , Trp 53 , Mdm 2 , JUN , FOS , MAD , MAX ) . ^^^ |
|