| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.82520635 |
| IR induced activation of SAP kinase is associated with binding to the SH2 / SH3 containing adaptor protein Grb 2 . 0.82520635^^^ |
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| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb 2 and functions as a negative regulator of T cell activation . ^^^ METHODS : Using a protein interaction screening protocol based on phage display , T cell signaling components that associate with the adapter molecule , Grb 2 , the lymphoid specific tyrosine phosphatase Lyp was identified . ^^^ Grb 2 was co immunoprecipitated with Lyp in 293T cells overexpressing both proteins . ^^^ CONCLUSION : These data demonstrate a novel interaction between the phosphatase Lyp and the adaptor Grb 2 and are consistent with a negative regulatory role for Lyp in T cell signaling . . ^^^ |
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| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| Co expression of Lyp and Bcr Abl in Cos 7 cells resulted in decreased levels of Bcr Abl , Grb 2 , and Myc . ^^^ |
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| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| The results demonstrate that ara C also induces binding of SAP kinase to the SH2 / SH3 containing adapter protein Grb 2 . ^^^ SAP kinase binds to the SH 3 domains of Grb 2 , while interaction of the p 85 alpha subunit of phosphatidylinositol 3 kinase complex . ^^^ |
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| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| Prediction of binding sites of peptide recognition domains : an application on Grb 2 and SAP SH 2 domains . ^^^ We performed a proof of concept study on the SH 2 domains of SAP and Grb 2 proteins . ^^^ The binding motifs of the SAP and Grb 2 SH2 domains derived by the method agree well with those determined through experimental studies . ^^^ Using the derived binding motifs , we have predicted new possible interaction partners for the Grb 2 and SAP SH 2 domains as well as possible interaction sites for interaction partners already known . ^^^ |
|
| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60880 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|