| Interacting proteins: O15524 and P62993 |
Pubmed |
SVM Score :1.0824368 |
| We show that Grb 2 binds Socs 1 via its SH 3 domains to putative diproline determinants located in the N terminus of Socs 1 , and Socs 1 binds to the N terminal regulatory region of Vav . 1.0824368^^^ In order to define the mechanism by which Socs 1 mediated suppression of Kit dependent mitogenesis occurs , we demonstrate that Socs 1 binds to the signalling proteins Grb 2 and the Rho family guanine nucleotide exchange factors Vav . 0.66746727^^^ |
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| Interacting proteins: O15524 and P62993 |
Pubmed |
SVM Score :0.0 |
| To determine whether there were alterations of p 27 and the target proteins implicated in the ubiquitin degradation of p 27 and other cyclin dependent kinase inhibitors , we examined expression of SKP 2 , Grb 2 , and Jab 1 in the pituitaries of null mice . ^^^ |
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| Interacting proteins: O15524 and P62993 |
Pubmed |
SVM Score :0.0 |
| Our results further indicate that these tyrosine residues , via recruitment of the adaptor protein Grb 2 , are required for targeting the inhibitory protein suppressor of cytokine signaling 1 ( SOCS 1 ) to Jak 2 kinase . ^^^ |
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