| Interacting proteins: O00401 and P62993 |
Pubmed |
SVM Score :0.0 |
| GRB 2 links signaling to actin assembly by enhancing interaction of neural Wiskott Aldrich syndrome protein ( N WASp ) with actin related protein ( ARP2 / 3 ) complex . ^^^ |
|
| Interacting proteins: O00401 and P62993 |
Pubmed |
SVM Score :0.0 |
| Here we show that the actin polymerization is dependent upon activation of the Arp2 / 3 complex by neural Wiskott Aldrich Syndrome protein ( N WASP ) via Grb 2 and Nck 2 . ^^^ |
|
| Interacting proteins: O00401 and P62993 |
Pubmed |
SVM Score :0.0 |
| Phosphatidylinositol 4 , 5 biphosphate ( PIP 2 ) induced vesicle movement depends on N WASP and involves Nck , WIP , and Grb 2 . ^^^ |
|
| Interacting proteins: O00401 and P62993 |
Pubmed |
SVM Score :0.0 |
| These tyrosines differentially contribute to actin polymerization in a fashion reminiscent of actin ' tail ' formation mediated by the vaccinia virus envelope protein A36R , which utilizes two similarly spaced phosphotyrosines to recruit the adaptors Nck and Grb 2 , respectively , in order to stimulate N WASP . ^^^ Neither phosphorylated Y 454 nor Y 474 directly bind Grb 2 , but Tir derivatives harbouring these residues ultimately recruit N WASP and Arp2 / 3 independently of Nck , suggesting that EPEC exploits additional phosphotyrosine binding adaptors capable of initiating actin assembly . . ^^^ |
|
| Interacting proteins: O00401 and P62993 |
Pubmed |
SVM Score :0.0 |
| The epithelial podosome like structures specifically contain Arp2 / 3 complex , cortactin , dynamin , gelsolin , N WASP , VASP , Grb 2 and src like kinase ( s ) . ^^^ |
|
| Interacting proteins: O00401 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00401 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
|