| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| Activation of C3G guanine nucleotide exchange factor for Rap 1 by phosphorylation of tyrosine 504 . ^^^ C3G is a guanine nucleotide exchange factor for Rap 1 and is activated by the expression of Crk adaptor proteins . ^^^ |
|
| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| Characterization of GFR , a novel guanine nucleotide exchange factor for Rap 1 . ^^^ In the present study , we report a new Rap 1 guanine nucleotide exchange factor which we have named GFR ( guanine nucleotide exchange factor for Rap 1 ) . ^^^ |
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| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| The CrkL adaptor protein is involved in signaling from the receptor for erythropoietin ( Epo ) as well as interleukin ( IL ) 3 and activates beta ( 1 ) integrin mediated hematopoietic cell adhesion through its interaction with C3G , a guanine nucleotide exchange factor for Rap 1 . ^^^ |
|
| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| RA GEF 1 , a guanine nucleotide exchange factor for Rap 1 , is activated by translocation induced by association with Rap1 * GTP and enhances Rap 1 dependent B Raf activation . ^^^ |
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| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| Here we show that the CDC 25 homology domain of PLCepsilon functions as a guanine nucleotide exchange factor for Rap 1 but not for any other Ras family GTPases examined including Rap 2 and Ha Ras . ^^^ |
|
| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| To investigate the molecular basis for Rap 1 activation , we examined complexes containing C3G , a guanine nucleotide exchange factor for Rap 1 , and CrkL , an adapter protein known to influence Rap 1 signaling . ^^^ |
|
| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| Drosophila PDZ GEF , a guanine nucleotide exchange factor for Rap 1 GTPase , reveals a novel upstream regulatory mechanism in the mitogen activated protein kinase signaling pathway . ^^^ PDZ GEF is a novel guanine nucleotide exchange factor for Rap 1 GTPase . ^^^ |
|
| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| To study its role in signaling pathways we used the Hck SH 3 domain in protein interaction cloning and identified C3G , the guanine nucleotide exchange factor for Rap 1 and R Ras , as a protein that associated with Hck . ^^^ |
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| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| Epac 1 is a guanine nucleotide exchange factor for Rap 1 that is activated by direct binding of cAMP . ^^^ |
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| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| Although the decreased permeability and the increased VE cadherin mediated adhesion by prostacyclin and forskolin were insensitive to a specific inhibitor for cAMP dependent protein kinase , these effects were mimicked by 8 ( 4 chlorophenylthio ) 2 ' O methyladenosine 3 ' , 5 ' cyclic monophosphate , a specific activator for Epac , which is a novel cAMP dependent guanine nucleotide exchange factor for Rap 1 . ^^^ |
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| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| We found that MAGI 1 localized to cell cell contacts presumably by associating with beta catenin and that MAGI 1 bound to a guanine nucleotide exchange factor for Rap 1 , PDZ GEF 1 . ^^^ |
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| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| C3G , a Crk SH 3 domain binding guanine nucleotide releasing factor functions as a guanine nucleotide exchange factor for Rap 1 . ^^^ |
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| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the inhibition of STAT phosphorylation and SOCS 3 induction did not require cAMP dependent protein kinase activity but could be recapitulated upon selective activation of the alternative cAMP sensor Epac , a guanine nucleotide exchange factor for Rap 1 . ^^^ |
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| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| Two of these GEFs , MR GEF ( M Ras regulated GEF , KIAA 0277 ) and PDZ GEF ( KIAA 0313 ) bound specifically to nucleotide free Rap 1 and Rap1 / Rap2 , respectively . ^^^ By searching for in vitro interaction with Ras GTP proteins , PDZ GEF specifically bound to Rap1A and Rap2B GTP , whereas MR GEF bound to M Ras GTP . ^^^ In addition , a constitutively active M Ras ( 71L ) mutant inhibited the ability of MR GEF to promote Rap1A activation in a dose dependent manner . ^^^ |
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| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| We have cloned both rat and mouse GEF genes and shown that they are orthologs of the human gene , MR GEF , which encodes a GEF that specifically activates the small GTPase , Rap 1 . ^^^ |
|
| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| A third member of the family , Repac ( GFR ) , which lacks the cAMP dependent regulatory sequences , is a constitutive activator of both Rap 1 and Rap 2 . ^^^ |
|
| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| Guanine nucleotide exchange factors ( GEFs ) for Rap 1 , C3G , Epac ( or cyclic AMP [ cAMP ] GEF ) , CalDAG GEFI , PDZ GEF 1 , and GFR efficiently increased the level of GTP Rap 2 both in 293T cells and in vitro . ^^^ |
|
| Interacting proteins: Q92565 and P62834 |
Pubmed |
SVM Score :0.0 |
| NA |
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