| Interacting proteins: Q8WZA2 and P62834 |
Pubmed |
SVM Score :0.0 |
| Epac 1 ( cAMP GEFI ) and Epac 2 ( cAMP GEFII ) are closely related guanine nucleotide exchange factors ( GEFs ) for the small GTPase Rap 1 , which are directly regulated by cAMP . ^^^ |
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| Interacting proteins: Q8WZA2 and P62834 |
Pubmed |
SVM Score :0.0 |
| Liver specific cAMP GEFII also has GEF activity toward Rap 1 . ^^^ |
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| Interacting proteins: Q8WZA2 and P62834 |
Pubmed |
SVM Score :0.0 |
| However , cAMP also directly regulates Epac 1 and Epac 2 , guanine nucleotide exchange factors ( GEFs ) for the small GTPases Rap 1 and Rap 2 ( refs 2 , 3 ) . ^^^ |
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| Interacting proteins: Q8WZA2 and P62834 |
Pubmed |
SVM Score :0.0 |
| The lack of potent Rap 1 dominant negative mutants has limited our ability to decipher Rap 1 dependent pathways ; we have therefore developed a procedure to generate such mutants consisting in the oligonucleotide mediated mutagenesis of residues 14 19 , selection of mutants presenting an enhanced interaction with Epac 2 by yeast two hybrid screening and counter screening for mutants still interacting with Rap effectors . ^^^ |
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| Interacting proteins: Q8WZA2 and P62834 |
Pubmed |
SVM Score :0.0 |
| Elevation of the intracellular cAMP concentration ( [ cAMP ] 1 ) regulates metabolism , cell proliferation , and differentiation and plays roles in memory formation and neoplastic growth . cAMP mediates its effects mainly through activation of protein kinase A ( PKA ) as well as Epac 1 and Epac 2 , exchange factors activating the small GTPases Rap 1 and Rap 2 . ^^^ |
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| Interacting proteins: Q8WZA2 and P62834 |
Pubmed |
SVM Score :0.0 |
| The RAP 1 guanine nucleotide exchange factor Epac 2 couples cyclic AMP and Ras signals at the plasma membrane . ^^^ Thus , Epac 2 can respond to costimulation by agonists that jointly elevate Ras GTP and cyclic AMP levels , activating a specific pool of Rap 1 at the plasma membrane . ^^^ |
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| Interacting proteins: Q8WZA2 and P62834 |
Pubmed |
SVM Score :0.0 |
| PKA independent activation of Rap 1 by cAMP is mediated by direct binding of cAMP to Rap 1 guanine nucleotide exchange factors ( Rap 1 GEFs ) Epac 1 ( exchange protein directly activated by cAMP 1 ) and Epac 2 ( Epac 1 and Epac 2 are also called cAMP GEFI and GEFII ) . ^^^ |
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| Interacting proteins: Q8WZA2 and P62834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WZA2 and P62834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WZA2 and P62834 |
Pubmed |
SVM Score :0.0 |
| NA |
|