| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| RAPL , a Rap 1 binding molecule that mediates Rap 1 induced adhesion through spatial regulation of LFA 1 . ^^^ Here , we identify the Rap 1 effector , RAPL , as an essential regulator in this activation . ^^^ RAPL was enriched in mouse lymphoid tissues and associated with Rap 1 after stimulation by the T cell receptor and with chemokine CXCL 12 . ^^^ Triggered by activated Rap 1 , RAPL associated with LFA 1 and rapidly relocated to the leading edge and accumulated at immunological synapses . ^^^ |
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| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| Signalling pathways involving ADAP , Vav 1 and SKAP 55 , as well as Rap 1 and RAPL , cause clustering of leukocyte function associated antigen 1 ( LFA 1 ; integrin alphaLbeta 2 ) . ^^^ |
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| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| Transfection of these cells with an expression plasmid encoding PLC gamma 1 restored Rap 1 activation by the TCR and the ability to adhere to ICAM 1 , accompanied by polarized LFA 1 surface clustering colocalized with regulator of adhesion and polarization enriched in lymphoid tissues ( RAPL ) . ^^^ |
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| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| Regulation of lymphocyte adhesion and migration by the small GTPase Rap 1 and its effector molecule , RAPL . ^^^ In the process of elucidating the molecular mechanisms of Rap 1 mediated integrin activation , we have identified a novel Rap 1 binding molecule , regulator of adhesion and cell polarization enriched in lymphoid tissues ( RAPL ) . ^^^ RAPL is predominantly expressed in immune cells , and mediates Rap 1 triggered integrin activation upon TCR engagement and chemokine stimulation . ^^^ |
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| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| Crucial functions of the Rap 1 effector molecule RAPL in lymphocyte and dendritic cell trafficking . ^^^ |
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| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| Local activation of Rap 1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL , a Rap 1 associating molecule , localizes . ^^^ We found that Rap 1 associating molecule , RAPL , which belongs to the Ras association domain family ( Rassf ) , localized on microtubules and that activated Rap 1 induced dissociation of RAPL from microtubules . ^^^ In addition , disconnection of Rap 1 and RAPL by expression of a RAPL mutant also perturbed wound healing . ^^^ Collectively , the locally activated Rap 1 and its association with RAPL controls the directional migration of vascular endothelial cells . . ^^^ |
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| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| In vitro , CXCL 13 activated the small guanosine triphosphatase ( GTPase ) Rap 1 in B cells , and corroborating this observation , a deficiency of RAPL , the Rap 1 effector molecule , caused a significant reduction in shear resistant B cell adhesion to intercellular adhesion molecule 1 ( ICAM 1 ) . ^^^ |
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| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| Regulator of adhesion and cell polarization enriched in lymphoid tissues ( RAPL ) is a novel Rap 1 effector molecule that mediates Rap 1 signalling to integrins . ^^^ The Rap 1 RAPL complex regulates the spatial distribution of the integrin lymphocyte function associated antigen 1 as well as cell polarization . ^^^ |
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| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WWW0 and P62834 |
Pubmed |
SVM Score :0.0 |
| NA |
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