| Rap 1 activated integrins by forming an integrin associated complex containing talin in combination with the Rap effector , RIAM . ^^^ CONCLUSIONS : We have , for the first time , ordered a pathway from agonist stimulation to integrin activation and established the Rap 1 induced formation of an `` integrin activation complex , ' ' containing RIAM and talin , that binds to and activates the integrin . . ^^^ |