| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| We now report the cloning of a brain enriched gene , CalDAG GEFI , which has substrate specificity for Rap1A , dual binding domains for calcium ( Ca2+ ) and diacylglycerol ( DAG ) , and enriched expression in brain basal ganglia pathways and their axon terminal regions . ^^^ Expression of CalDAG GEFI activates Rap1A and inhibits Ras dependent activation of the Erk / MAP kinase cascade in 293T cells . ^^^ |
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| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| Three groups of Rap 1 specific guanine nucleotide exchange factors including C3G , CalDAG GEFI , and Epac / cAMP GEFI / II have been identified to date . ^^^ |
|
| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| CalDAG GEFI and Epac / cAMP GEFI , both of which are GEFs specific for Rap 1 , did not activate JNK or c Jun dependent transcription . ^^^ |
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| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| We characterized a novel guanine nucleotide exchange factor ( GEF ) for Ras family G proteins that is highly homologous to CalDAG GEFI , a GEF for Rap 1 and R Ras , and to RasGRP / CalDAG GEFII , a GEF for Ras and R Ras . ^^^ |
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| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| Guanine nucleotide exchange factors ( GEFs ) for Rap 1 , C3G , Epac ( or cyclic AMP [ cAMP ] GEF ) , CalDAG GEFI , PDZ GEF 1 , and GFR efficiently increased the level of GTP Rap 2 both in 293T cells and in vitro . ^^^ |
|
| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| RasGRP 2 also catalyzes nucleotide exchange on Rap 1 , but this RapGEF activity is less potent than that associated with CalDAG GEFI . ^^^ |
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| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| CalDAG GEFI and CalDAG GEFII ( identical to RasGRP ) are novel , brain enriched guanine nucleotide exchange factors ( GEFs ) that can be stimulated by calcium and diacylglycerol and that can activate small GTPases , including Ras and Rap 1 , molecules increasingly recognized as having signaling functions in neurons . ^^^ |
|
| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| On the other hand , retroviral expression of CalDAG GEFI , a Rap 1 exchange factor identified by megakaryocyte gene profiling as a candidate integrin regulator , enhanced agonist induced activation of Rap1b and fibrinogen binding to alphaIIbbeta 3 ( P < 0 . 01 ) . ^^^ |
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| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| Mouse platelets that lack CalDAG GEFI are severely compromised in integrin dependent aggregation as a consequence of their inability to signal through CalDAG GEFI to its target , the small GTPase Rap 1 . ^^^ |
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| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| Similarly to Rap1b stimulation , this process occurred downstream of PLC activation and was dramatically impaired in murine platelets lacking the Rap 1 exchange factor CalDAG GEFI . ^^^ |
|
| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| F actin dependent translocation of the Rap 1 GDP / GTP exchange factor RasGRP 2 . ^^^ The more divergent family member is RasGRP 2 , a Rap 1 specific exchange factor with low affinity toward diacylglycerol . ^^^ |
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| Interacting proteins: Q7LDG7 and P62834 |
Pubmed |
SVM Score :0.0 |
| NA |
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