| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.93346229 |
| Krit 1 interacted strongly with Krev 1 but only weakly with Ras , suggesting it might specifically regulate Krev 1 activities . 0.93346229^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.51306342 |
| These findings , coupled with evidence of interaction of KRIT 1 with Krev 1 and integrin cytoplasmic domain associated protein 1 alpha ( ICAP 1 alpha ) , suggest that KRIT 1 may help determine endothelial cell shape and function in response to cell cell and cell matrix interactions by guiding cytoskeletal structure . 0.51306342^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| Our studies suggest that : ( 1 ) the increase in cAMP , induced to differentiate MSCs , activates the classical PKA pathway and not through the exchange protein directly activated by cAMP ( EPAC ) , a guanine nucleotide exchange factor for the small GTPase Rap 1 and Rap 2 ; ( 2 ) MEK ERK signaling could contribute to neural commitment and differentiation ; ( 3 ) CaM KII activity seems dispensable for neuron differentiation . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| Here we report a physical and transcriptional map of this interval and that CCM 1 , a gene whose protein product , KRIT 1 , interacts with RAP1A ( also known as KREV 1 ; ref . 9 ) , a member of the RAS family of GTPases , is mutated in CCM 1 families . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| The first mutations were identified in the CCM 1 gene ( located on 7q21 22 ) , which encodes KRIT 1 protein ( KREV 1 interaction trapped 1 ) , presumably a membrane bound protein with signalling activity . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| Mutations in KRIT 1 , a protein initially identified based on a yeast two hybrid interaction with the RAS family GTPase RAP1A , are responsible for the development of the inherited vascular disorder cerebral cavernous malformations ( CCM 1 ) . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| Three CCM loci were previously mapped on 7q ( CCM 1 ) , 7p ( CCM 2 ) and 3q ( CCM 3 ) and CCM 1 gene was identified as coding Krit 1 , a protein of unknown function , which was shown initially to interact in yeast two hybrid assays with Rap1A , a small ras GTPase and more recently to Icap1alpha , a modulator of beta 1 integrin signal transduction . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| Neither the CCM 1 pathogenetic mechanisms nor the function of the Krit 1 protein are understood so far , although several hypotheses have been inferred from the predicted consequences of Krit 1 mutations as well as from the identification of Krit 1 as a binding partner of Rap1A , ICAP1A and microtubules . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| Examination of the CCM 1 locus established KRIT 1 ( Krev 1 Interaction Trapped genre 1 ) as the CCM 1 gene . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| Using the selective interactions of Ras and Krev 1 ( Rap1A ) with Raf , RalGDS , and Krit 1 as a model , we systematically compared LexA and cI fused baits and reporters . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| The third has homology , with transcriptional or processing variations , to a human genomic sequence , a positional candidate for a tumour suppressor gene , encoding the Krit 1 protein which interacts with the Ras family GTPase Krev 1 . . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| The mutation in exon 19 causes a premature stop codon ( Q698X ) predicted to produce a truncated Krev 1 interaction trapped 1 ( KRIT 1 ) protein . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| To gain a better understanding of the role of KRIT 1 during morphogenesis , the main goal of this study was to provide a detailed description of the spatio temporal expression pattern of Krit 1 and its interaction partner Rap1A during mouse embryogenesis . ^^^ At early embryonic stages , Krit 1 and , to a lesser extent , Rap1A are expressed in the developing nervous system . ^^^ These findings provide evidence of differential Krit 1 and Rap1A expression during mouse ontogenesis and suggest a more widespread functional significance of Krit 1 , not restricted to vascular endothelial cells . . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| The newly identified mutation creates a premature termination codon and is predicted to produce a truncated Krev 1 interaction trapped 1 protein , KRIT 1 . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| By yeast two hybrid and GST trapping assays we identified KRIT 1 ( krev 1 interaction trapped 1 ) as a new specific interaction partner of the FC unit of SNX 17 . ^^^ |
|
| Interacting proteins: O00522 and P62834 |
Pubmed |
SVM Score :0.0 |
| NA |
|