| Interacting proteins: O43150 and P62330 |
Pubmed |
SVM Score :0.72871357 |
| Here , we found that AMAP 2 , through its ArfGAP domain , binds to GTP Arf 6 but not to GDP Arf 6 or other Arfs irrespective of nucleotide status . 0.72871357^^^ |
|
| Interacting proteins: O43150 and P62330 |
Pubmed |
SVM Score :0.0 |
| We also examined possible interaction of PAG 3 with ARFs and showed evidence that at least one of them , ARF 6 , seems to be an intracellular substrate for GAP activity of PAG 3 . ^^^ |
|
| Interacting proteins: O43150 and P62330 |
Pubmed |
SVM Score :0.0 |
| Here we report that PAG 3 is enriched together with ARF 6 and F actin at phagocytic cups formed beneath immunoglobulin G opsonized beads in P388D1 macrophages , in which overexpression of ARF 6 , but not ARF 1 ( class 1 ) or ARF 5 ( class 2 ) , inhibits the phagocytosis . ^^^ Moreover , cooverexpression of ARF 6 , but not ARF 1 or ARF 5 , restored the phagocytic activity of PAG 3 overexpressing cells . ^^^ We propose that PAG 3 acts as a GAP for ARF 6 and is hence involved in FcgammaR mediated phagocytosis in mouse macrophages . . ^^^ |
|
| Interacting proteins: O43150 and P62330 |
Pubmed |
SVM Score :0.0 |
| In addition , in vitro recombinant Pap exhibits strong GTPase activating protein ( GAP ) activity towards the small GTPases Arf 1 and Arf 5 and weak activity towards Arf 6 . ^^^ |
|
| Interacting proteins: O43150 and P62330 |
Pubmed |
SVM Score :0.0 |
| Assays and properties of the ArfGAPs , AMAP 1 and AMAP 2 , in Arf 6 function . ^^^ We have found that two ArfGAPs , namely AMAP 1 and AMAP 2 , exhibit a novel biochemical property of directly and selectively binding to GTP Arf 6 without immediate GAPing activity , while they were previously shown to exhibit efficient catalytic GAPing activities to Arf isoforms except Arf 6 in vitro . ^^^ |
|
| Interacting proteins: O43150 and P62330 |
Pubmed |
SVM Score :0.0 |
| NA |
|