| Stress associated endoplasmic reticulum ( ER ) protein 1 ( SERP 1 ) , also known as ribosome associated membrane protein 4 ( RAMP 4 ) , is a Sec 61 associated polypeptide that is induced by ER stress . ^^^ Experiments using pancreatic microsomes revealed aberrant association of ribosomes and the Sec 61 complex and enhanced ER stress in SERP 1 / pancreas . ^^^ In basal conditions , the Sec 61 complex in SERP 1 / microsomes was more cofractionated with ribosomes , compared with SERP1+ / + counterparts , in high salt conditions . ^^^ |