| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.80074099 |
| One putative receptor candidate is Sec 61 alpha , a multi spanning membrane protein that is associated with two additional membrane proteins ( Sec 61 beta and gamma ) to form the Sec61p complex . 0.80074099^^^ |
|
| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.0 |
| Membrane markers of rough endoplasmic reticulum ( TRAM and sec 61 beta ) , and for smooth endoplasmic reticulum ( cytochrome P 450 ) were not detected in the same fractions . ^^^ |
|
| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.0 |
| Yeast protein translocation complex : isolation of two genes SEB 1 and SEB 2 encoding proteins homologous to the Sec 61 beta subunit . ^^^ Seb1p shows 30 % identity to the mammalian Sec 61 beta subunit and 34 % identity to the Arabidopsis thaliana Sec 61 beta subunit . ^^^ |
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| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.0 |
| This approach identified chain length dependent cross linking products between nascent opsin and a 21 kDa ribosomal protein , followed by Sec61beta and finally with Sec61alpha . ^^^ |
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| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.0 |
| Using a cross linking approach to analyse the environment of a series of discrete Sec61alpha membrane integration intermediates , we find : ( 1 ) newly synthesized Sec61alpha is adjacent to known components of the ER membrane insertion site , namely Sec61alpha , Sec61beta and TRAM , and thus the integration of Sec61alpha appears to require a pre existing Sec 61 complex ; ( 2 ) a site specific cross linking analysis indicates that the first transmembrane domain of Sec61alpha remains adjacent to protein components of the ER insertion site ( specifically TRAM and Sec61beta ) during the insertion of at least three subsequent transmembrane domains ; and ( 3 ) the membrane integration of Sec61alpha requires ER targeting by the signal recognition particle . . ^^^ The complex consists of three subunits : Sec61alpha , Sec61beta and Sec61gamma , at least two of which ( alpha and beta ) are adjacent to nascent proteins during membrane insertion . ^^^ |
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| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.0 |
| With a reconstituted system , we show that a Sec 61 complex lacking Sec61beta is essentially inactive when elongation and membrane targeting of a nascent chain occur at the same time . ^^^ Using chemical cross linking we show that Sec61beta not only interacts with subunits of the Sec 61 complex but also with the 25 kD subunit of the signal peptidase complex ( SPC 25 ) , thus demonstrating for the first time a tight interaction between the SPC and the Sec 61 complex . ^^^ Interestingly , the cross links between Sec61beta and SPC 25 and between Sec61beta and Sec61alpha depend on the presence of membrane bound ribosomes , suggesting that these interactions are induced when translocation is initiated . ^^^ |
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| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence studies of endogenous Sec61beta and Sec 61 ( gamma ) showed that these proteins are also located in both the ER and the ERGIC . ^^^ |
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| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.0 |
| SERP1 / RAMP4 interacted with Sec61alpha and Sec61beta , which are subunits of translocon , and a molecular chaperon calnexin . ^^^ Furthermore , Sec61alpha and Sec61beta , but not SERP1 / RAMP4 , were found to associate with newly synthesized integral membrane proteins under stress . ^^^ |
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| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.0 |
| TM 2 is also found to be adjacent to Sec61alpha and Sec61beta during its membrane integration . ^^^ |
|
| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.0 |
| Sec61beta is a member of the Sec 61 heterotrimer , which is the main component of the endoplasmic reticulum translocon . ^^^ |
|
| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60468 and P61619 |
Pubmed |
SVM Score :0.0 |
| NA |
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