| DCoHm ( dimerization cofactor of hepatocyte nuclear factor 1alpha ( HNF1alpha ) from muscle ) , a novel gene of the DCoH family with 78 % amino acid identity to DCoH , was identified as a Mirk binding protein by yeast two hybrid analysis and cloned . ^^^ The Mirk binding protein DCoH has been shown to be selectively expressed in colon carcinomas but not in normal tissue . ^^^ Mirk may function as an HNF1alpha transcriptional activator in response to an MKK 3 mediated stress signal , and the selective expression of DCoH could restrict the Mirk response to carcinoma cells . . ^^^ |