| Interacting proteins: P61371 and Q9UBR4 |
Pubmed |
SVM Score :0.0 |
| The combinatorial expression of the LIM homeodomain proteins Isl 1 , Isl 2 , Lhx 1 , and Lhx 3 in subsets of developing motor neurons correlates with the future organization of these neurons into motor columns with distinct innervation targets , implying a functional role for LIM homeodomain protein combinations in the specification of neuronal identity . ^^^ Although the interaction between most LIM homeodomain proteins is dependent on NLI , a direct interaction between the LIM domains of Lhx 3 and the homeodomains of Isl 1 and Isl 2 was also observed . ^^^ |
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| Interacting proteins: P61371 and Q9UBR4 |
Pubmed |
SVM Score :0.0 |
| Here we study two members of this gene family in Drosophila , namely lim 3 , the homologue of the vertebrate Lhx 3 and Lhx 4 genes , and islet , the homologue of the vertebrate Isl 1 and Is 12 genes . ^^^ |
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| Interacting proteins: P61371 and Q9UBR4 |
Pubmed |
SVM Score :0.0 |
| Comparatively in vertebrates , Lim 1 ( Lhx 1 ) along with Lim 3 ( Lhx 3 ) , Gsh 4 ( Lhx 4 ) , Isl 1 and Isl 2 are expressed in developing motorneurons along the spinal column , where their overlapping expression suggests a role for these genes in the establishment of specific motorneuron subtypes . dLim 1 is absent from all cells expressing Isl , Lim 3 , and Apterous , indicating that these proteins function independently within the Drosophila embryo . ^^^ |
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| Interacting proteins: P61371 and Q9UBR4 |
Pubmed |
SVM Score :0.0 |
| In motor neurons , however , Isl 1 is available to compete for binding to NLI , displacing Lhx 3 to a high affinity binding site on the C terminal region of Isl 1 and thereby transforming Lhx 3 from an interneuron promoting factor to a motor neuron promoting factor . ^^^ |
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| Interacting proteins: P61371 and Q9UBR4 |
Pubmed |
SVM Score :0.0 |
| To address this , we examined how bHLH proteins Ngn 2 and NeuroM controlling neurogenesis functionally converge with LIM homeodomain ( LIM HD ) factors Isl 1 and Lhx 3 involved in motor neuron subtype specification . ^^^ We found that Ngn 2 and NeuroM transcriptionally synergize with Isl 1 and Lhx 3 to specify motor neurons in the embryonic spinal cord and in P 19 stem cells . ^^^ |
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| Interacting proteins: P61371 and Q9UBR4 |
Pubmed |
SVM Score :0.0 |
| A more complex molecular language consisting of a hexamer complex involving NLI and 2 LIM homeodomain proteins , Lhx 3 and Isl 1 determines ventral motor neuron formation . ^^^ |
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| Interacting proteins: P61371 and Q9UBR4 |
Pubmed |
SVM Score :0.0 |
| The LIM homeodomain proteins Isl 1 and Lhx 3 act with steroidogenic factor 1 to enhance gonadotrope specific activity of the gonadotropin releasing hormone receptor gene promoter . ^^^ Here , using transient transfections combined with DNA / protein interaction assays , we have delineated cis acting elements within the rat GnRH R gene promoter that represent targets for the LIM homeodomain ( LIM HD ) proteins , Isl 1 and Lhx 3 . ^^^ In heterologous cells , the expression of Isl 1 and Lhx 3 , together with steroidogenic factor 1 ( SF 1 ) , culminates in the activation of both the rat as well as human GnRH R promoter , suggesting that this combination is evolutionarily conserved among mammals . ^^^ Finally , using a transgenic model that allows monitoring of in vivo promoter activity , we show that the overlapping expression of Isl 1 and Lhx 3 in the developing pituitary correlates with promoter activity . ^^^ |
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| Interacting proteins: P61371 and Q9UBR4 |
Pubmed |
SVM Score :0.0 |
| Molecular analyses of the genes of the transcriptional factors POU1F1 , PROP 1 , LHX 3 , LHX 4 , ISL 1 and HESX 1 detected no mutations in APA patients . ^^^ |
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