| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| We have cloned a family of LIM homeobox genes in chick and show here that the combinatorial expression of four of these genes , Islet 1 , Islet 2 , Lim 1 , and Lim 3 , defines subclasses of motor neurons that segregate into columns in the spinal cord and select distinct axonal pathways . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| A recent study in chick shows that the combinatorial expression of Islet 1 , Lim 1 , and two other LIM homeobox genes , Islet 2 and Lim 3 , defines subclasses of motor neurons in the spinal cord , supporting a model where combinatorial repertoires of transcription factors may act to generate diverse cell types . . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| Whereas Islet 1 is expressed by motor neurons of all cranial nerves , Islet 2 is expressed only in nuclei that contain somatic motor neurons and transiently in a specialized population of contralateral vestibuloacoustic efferent neurons . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| We have isolated the Drosophila homolog of the vertebrate islet 1 and islet 2 genes , two members of the LIM homeodomain family implicated in the transcriptional control of motor neuronal differentiation . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| To discover whether the identity of these motor neuron subtypes was changed in the mutant , we examined expression of LIM homeobox genes , Islet 1 , Islet 2 and Lim 3 . ^^^ In the Pax 6 mutant hindbrain , Islet 2 expression was specifically missing , which resulted in the loss of the cells harboring the postotic hindbrain SM type LIM code ( Islet 1 + Islet 2 + Lim 3 ) . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| In wild type control embryos , all brachial and lumbar MNs appear to express the GDNF receptors c ret and GFRalpha 1 and the MN markers ChAT , islet 1 , and islet 2 , whereas only a small subset express GFRalpha 2 . ^^^ GDNF dependent MNs that are lost in GDNF deficient animals express ret / GFRalpha1 / islet 1 , whereas many surviving GDNF independent MNs express ret / GFRalpha1 / GFRalpha2 and islet 1 / islet 2 . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| Islet 1 and Islet 2 are members of a family of homeodomain containing transcription factors , and Islet 1 has been shown to be involved in differentiation of several cell types . ^^^ The expression pattern of Islet 1 and Islet 2 was examined in the presumptive limb buds of early chick embryos by using specific monoclonal antibodies . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| We find that activated RARbeta up regulates islet 1 expression , whereas activation of RARalpha can either act in combination with RARbeta signalling to maintain islet 1 expression or induce islet 2 expression in the absence of activated RARbeta . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| Islet 1 and Islet 2 have equivalent abilities to promote motoneuron formation and to specify motoneuron subtype identity . ^^^ The expression of LIM homeobox genes islet 1 and islet 2 is tightly regulated during development of zebrafish primary motoneurons . ^^^ By the time primary motoneurons undergo axogenesis , specific subtypes express islet 1 , whereas other subtypes express islet 2 , suggesting that these two genes have different functions . ^^^ We also provide evidence that Islet 2 can substitute for Islet 1 during primary motoneuron formation . ^^^ Surprisingly , our results demonstrate that despite the motoneuron subtype specific expression patterns of Islet 1 and Islet 2 , the differences between the Islet 1 and Islet 2 proteins are not important for specification of the different primary motoneuron subtypes . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| Nucleotide sequence analysis of reverse transcriptase polymerase chain reaction amplified products reveal that the isl gene family contains two members ( a and b ) each of both isl 1 and isl 2 genes , and one member of isl 3 gene in the two tetraploid salmonid species , chinook salmon and rainbow trout , and only one member each of isl 1 , isl 2 , and isl 3 genes in the diploid zebrafish . ^^^ The level of isl 1 mRNA is generally higher than those of isl 2 and isl 3 mRNAs . ^^^ In the retina , isl 1 mRNA could be found in both the ganglion and inner nuclear layers while isl 2 and isl 3 mRNAs could only be detected in the ganglion layer . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| We have recently isolated several clones from a chinook salmon pituitary cDNA library that encode two novel LIM homeodomain proteins , Isl 2 and Isl 3 , which are structurally related to rat Isl 1 . ^^^ In contrast to a previous observation that the LIM domains of rat Isl 1 have an inhibitory role in DNA binding , full length salmon Isl 2 containing both the LIM domains and a homeodomain can bind to a TAAT target sequence . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| The combinatorial expression of the LIM homeodomain proteins Isl 1 , Isl 2 , Lhx 1 , and Lhx 3 in subsets of developing motor neurons correlates with the future organization of these neurons into motor columns with distinct innervation targets , implying a functional role for LIM homeodomain protein combinations in the specification of neuronal identity . ^^^ Although the interaction between most LIM homeodomain proteins is dependent on NLI , a direct interaction between the LIM domains of Lhx 3 and the homeodomains of Isl 1 and Isl 2 was also observed . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| Comparatively in vertebrates , Lim 1 ( Lhx 1 ) along with Lim 3 ( Lhx 3 ) , Gsh 4 ( Lhx 4 ) , Isl 1 and Isl 2 are expressed in developing motorneurons along the spinal column , where their overlapping expression suggests a role for these genes in the establishment of specific motorneuron subtypes . dLim 1 is absent from all cells expressing Isl , Lim 3 , and Apterous , indicating that these proteins function independently within the Drosophila embryo . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that loss of Math 5 function severely reduced the RGC expression of the transcription factors Brn 3b , Gfi 1 , Isl 1 , Isl 2 , Nscl 1 , Nscl 2 , and RPF 1 , suggesting that Math 5 expression is required to activate a comprehensive transcription network of RGC differentiation . . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| All spinal motor neuron subtypes initially express both Isl 1 and Isl 2 , but Isl 2 is rapidly downregulated by visceral motor neurons . ^^^ Additional genetic mutations that reduce or eliminate both Isl 1 and Isl 2 activity result in more pronounced defects in visceral motor neuron generation and erode somatic motor neuron character . ^^^ |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96A47 and P61371 |
Pubmed |
SVM Score :0.0 |
| NA |
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