| Interacting proteins: P48742 and P61371 |
Pubmed |
SVM Score :0.0 |
| A recent study in chick shows that the combinatorial expression of Islet 1 , Lim 1 , and two other LIM homeobox genes , Islet 2 and Lim 3 , defines subclasses of motor neurons in the spinal cord , supporting a model where combinatorial repertoires of transcription factors may act to generate diverse cell types . . ^^^ |
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| Interacting proteins: P48742 and P61371 |
Pubmed |
SVM Score :0.0 |
| Comparatively in vertebrates , Lim 1 ( Lhx 1 ) along with Lim 3 ( Lhx 3 ) , Gsh 4 ( Lhx 4 ) , Isl 1 and Isl 2 are expressed in developing motorneurons along the spinal column , where their overlapping expression suggests a role for these genes in the establishment of specific motorneuron subtypes . dLim 1 is absent from all cells expressing Isl , Lim 3 , and Apterous , indicating that these proteins function independently within the Drosophila embryo . ^^^ |
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| Interacting proteins: P48742 and P61371 |
Pubmed |
SVM Score :0.0 |
| The members of the LIM homeobox genes family which have recently been identified include lin 11 , mec 3 , apterous ( ap ) , isl 1 , LH 2 , Rlim , lim 1 , lmx 1 , Xlim 1 and Xlim 3 . ^^^ |
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| Interacting proteins: P48742 and P61371 |
Pubmed |
SVM Score :0.0 |
| Unlike their embryonic counterparts , however , adult progenitors could not generate specific neurons that expressed markers appropriate for spinal motoneurons or interneurons , including Islet 1 , Lim 1 , Lim 3 , and HB 9 . ^^^ |
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| Interacting proteins: P48742 and P61371 |
Pubmed |
SVM Score :0.0 |
| The combinatorial expression of the LIM homeodomain proteins Isl 1 , Isl 2 , Lhx 1 , and Lhx 3 in subsets of developing motor neurons correlates with the future organization of these neurons into motor columns with distinct innervation targets , implying a functional role for LIM homeodomain protein combinations in the specification of neuronal identity . ^^^ |
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| Interacting proteins: P48742 and P61371 |
Pubmed |
SVM Score :0.0 |
| We have defined a set of regulatory genes , which include five LIM homeodomain transcription factors ( Isl 1 , Lhx 1 , Lhx 2 , Lhx 5 , and Lhx 9 ) and three other genes ( Gbx 2 , Ngn 2 , and Pax 6 ) , that are differentially expressed in dTh and vTh of early postnatal mice in distinct but overlapping patterns that mark nuclei or subsets of nuclei . ^^^ |
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| Interacting proteins: P48742 and P61371 |
Pubmed |
SVM Score :0.0 |
| We have cloned a family of LIM homeobox genes in chick and show here that the combinatorial expression of four of these genes , Islet 1 , Islet 2 , Lim 1 , and Lim 3 , defines subclasses of motor neurons that segregate into columns in the spinal cord and select distinct axonal pathways . ^^^ |
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| Interacting proteins: P48742 and P61371 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48742 and P61371 |
Pubmed |
SVM Score :0.0 |
| NA |
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