| Interacting proteins: P61371 and P03372 |
Pubmed |
SVM Score :0.99500202 |
| The relationship between ER and ISL 1 was further analyzed at the molecular level and we could show that 1 ) ISL 1 directly interacts in vivo and in vitro with the rat ER , as well as with various other nuclear receptors ; 2 ) ISL 1 ER interaction is mediated , at least in part , by the ligand binding domain of ER and is significantly strengthened by estradiol ; 3 ) as a consequence , ISL 1 prevents ER dimerization in solution , thus leading to a strong and specific inhibition of ER DNA binding activity ; 4 ) ISL 1 , via its N terminal LIM domains , specifically inhibits the ER driven transcriptional activation in some promoter contexts , while ER can serve as a coactivator for ISL 1 in other promoter contexts . 0.99500202^^^ |
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| Interacting proteins: P61371 and P03372 |
Pubmed |
SVM Score :0.0 |
| Islet 1 ( Isl 1 ) is a LIM homeodomain containing transcription factor that has been implicated in neuronal differentiation , is located in the hypothalamus , and can alter ER function in vitro . ^^^ Differential colocalization of Islet 1 and estrogen receptor alpha in the murine preoptic area and hypothalamus during development . ^^^ |
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| Interacting proteins: P61371 and P03372 |
Pubmed |
SVM Score :0.0 |
| Islet 1 expression and its correlations to ER in the developing pituitary gland are unknown . ^^^ We therefore determined the pituitary cell specific expression of Islet 1 and its colocalization with ER alpha ( ERalpha ) in sheep foetus by immunohistochemistry . ^^^ All of the ERalpha ir cells were colocalized with Islet 1 at day 60 of gestation , although a few ERalpha ir cells were negative for Islet 1 in the later stage of gestation . ^^^ These data suggest that the development and functional establishment of pituitary gonadotrophs , thyrotrophs and lactotrophs might be regulated by the expressions of Islet 1 and ERalpha and by their interactions , although any mechanisms need to be elucidated further . . ^^^ |
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| Interacting proteins: P61371 and P03372 |
Pubmed |
SVM Score :0.0 |
| Computational analysis of the region containing the M box that includes the MITF CATGTG binding motif demonstrated that this sequence overlaps with the estrogen receptor alpha ( ER alpha ) , USF 1 , TFE 3 , Isl 1 and AP 1 binding elements . ^^^ |
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| Interacting proteins: P61371 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
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