Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The pharmacological properties of mSSTR 3 and its ability to couple with adenylylcyclase distinguish SSTR 3 from the other cloned somatostatin receptors and indicates that it mediates biological functions different from SSTR 1 or SSTR 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We previously reported the cloning of two distinct somatostatin receptor ( SSTR ) subtypes , SSTR 1 and SSTR 2 . ^^^ Although both SSTR 1 and SSTR 2 bound somatostatin specifically and with high affinity , neither was coupled to adenylyl cyclase , a major cellular effector of somatostatin ' s actions . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Stably transfected Chinese hamster ovary cells expressing SSTR 1 or SSTR 2 exhibit specific somatostatin binding , with an apparently higher affinity for somatostatin 14 than somatostatin 28 , and NH 2 terminally extended form of somatostatin 14 . ^^^ A SSTR 1 probe hybridized to multiple DNA fragments in EcoRI digests of human and mouse DNA , indicating that SSTR 1 and SSTR 2 are members of a larger family of somatostatin receptors . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Previous studies have shown that at least two subtypes of somatostatin ( SRIF ) receptors ( SRIF 1 and SRIF 2 ) are expressed in mammalian cells . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The amino acid sequence of rSSTR 4 is 60 % and 48 % identical to that of somatostatin receptors SSTR 1 and SSTR 2 , respectively , two recently cloned subtypes . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The genes encoding two different somatostatin receptors ( SSTRs ) have been isolated and characterized , and RNA blotting studies have shown that both SSTR 1 and SSTR 2 are expressed in the brain . ^^^ In order to gain a better understanding of the functions of somatostatin in the CNS , the distribution of SSTR 1 and SSTR 2 mRNAs was determined using the technique of in situ hybridization . ^^^ Several regions of the brain reported to contain dense somatostatin like immunoreactive terminal fields and receptor binding sites were devoid of both SSTR 1 and SSTR 2 mRNA , suggesting the existence of additional SSTR subtypes . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The effect of various sulfhydryl binding reagents on the release of somatostatin immunoreactivity ( SRIF 1 ) from secretion granules of the islets of Langerhans was studied . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Identification of a critical aspartate residue in transmembrane domain three necessary for the binding of somatostatin to the somatostatin receptor SSTR 2 . ^^^ To determine which residues within the rat somatostatin receptor subtype SSTR 2 may be interacting with the lys 9 of somatostatin 14 ( S 14 ) , mutant SSTR 2 receptors were created by mutating asp 89 or asp 122 . [ 125I Tyr 11 ] S 14 binding to D89A and D89E mutants suggests that asp 89 is not directly involved in S 14 binding . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Immunological detection of isoforms of the somatostatin receptor subtype , SSTR 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
These results suggest that the somatostatin receptors in the external granule cell layer are type 2 receptors ( sstr 2 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
With the aim of elucidating the role of individual somatostatin receptors in the central control of growth hormone secretion , we have examined the distribution of sstr 1 and sstr 2 mRNAs in the hypothalamus of the adult rat by in situ hybridization using 35S labelled antisense riboprobes . ^^^ Within the arcuate nucleus , the distribution of cells expressing sstr 1 and sstr 2 was comparable to that of neurons which bind somatostatin 14 selectively , one third of which have been documented to contain growth hormone releasing hormone . ^^^ Within the periventricular nucleus , the distribution of cells expressing sstr 1 and , to a lesser extent , sstr 2 was reminiscent of that of both [ 125I ] somatostatin labelled and somatostatin immunoreactive cells . ^^^ Taken together , these results imply a role for both sstr 1 and sstr 2 receptors in the central regulation of growth hormone releasing hormone and somatostatin secretion , and hence of growth hormone release , by somatostatin . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
To determine the molecular mechanisms of action of somatostatin , we have investigated the interaction of the different cloned receptors with G proteins and cellular effector systems . sstr 2 , sstr 3 and sstr 5 associate with pertussis toxin sensitive G proteins and are able to mediate the inhibition of adenylyl cyclase activity by somatostatin . ^^^ The truncated sstr2B mediated the inhibition of cAMP formation by somatostatin , indicating that the C terminus is not needed for coupling sstr 2 to adenylyl cyclase . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
RESULTS : Polymerase chain reaction performed with templates from an ECL cell complementary DNA library and primers specific to each of the five known somatostatin receptor subtypes showed that the somatostatin receptor type 2 was significantly enriched in ECL complementary DNA . ^^^ Single cell videoimaging of highly purified ECL cells in culture showed that only the somatostatin receptor type 2 selective agonist , DC 32 87 , inhibited the gastrin induced calcium signal at 10 ( 11 ) mol / L . ^^^ The somatostatin receptor type 2 analogue also inhibited gastrin stimulated histamine release with a 50 % inhibitory concentration ( IC 50 ) value of 2 10 10 ( 12 ) mol / L , whereas somatostatin 14 and the type 3 and 4 analogues showed IC 50 values of 1 to 5 10 10 ( 9 ) mol / L . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Morphine cross reacts with somatostatin receptor SSTR 2 in the T47D human breast cancer cell line and decreases cell growth . ^^^ The latter was confirmed by reverse transcription PCR , which revealed the existence of the somatostatin receptor subtypes 2 and 3 ( SSTR 2 and SSTR 3 ) , with a relative mRNA concentration of 85 and 15 % , respectively . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In rat GH 3 pituitary tumour cells exposed to 1 microM somatostatin for up to 48 h , sstr 1 , 3 , 4 and 5 mRNA increased dramatically while sstr 2 mRNA exhibited a biphasic response . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
This effect of octreotide , which appears to be mediated by the SSTR 2 and SSTR 5 subtypes of somatostatin receptors , was paralleled by its ability to inhibit TPA stimulated GH 3 cell proliferation . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin ( SRIF ) binding was also adapted to the SPA format in a GH4C1 cell line transfected with the SRIF receptor subtype 2 ( SSTR 2 ) and in HEK 293 cells transfected with the SRIF receptor subtype 5 ( SSTR 5 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin ( SSTR 2 ) receptors mediate phospholipase C independent Ca2+ mobilization in rat AR42J pancreas cells . ^^^ Rat AR42J pancreas cells , which express somatostatin SSTR 2 type receptors , responded to SSTR 2 selective somatostatin ( SRIF ) agonist ligands with a dose dependent increase in intracellular Ca2+ . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We purified somatostatin receptors by immunoaffinity from pancreatic membranes that strongly expressed the type 2 somatostatin receptor sstr 2 . ^^^ We then expressed sstr2A in monkey kidney COS 7 cells and mouse NIH / 3T3 fibroblasts and demonstrated that somatostatin analogues ( RC 160 , octreotide and BIM 23014 ) which exhibited high affinity for sstr 2 stimulated a PTP activity and inhibited cell proliferation in proportion to their affinities for sstr 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin analogues selective for sstr 2 , sstr 3 and sstr 5 have been identified which will facilitate in vivo studies of the functions of these somatostatin receptors . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The sstr 2 receptor is apparently the predominant subtype expressed in somatostatin receptor positive tumours . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Using a cDNA probe , genomic clones were obtained for the 5 ' flanking promoter sequence of the human somatostatin receptor 2 encoding gene ( SSTR 2 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Infusion of SSTR 2 agonist into the isolated perfused human pancreas resulted in a significant inhibition of insulin and C peptide secretion ( insulin = 1468 + / 480 pM , P < 0 . 05 , and C peptide = 2328 + / 437 pM , P < 0 . 05 ) but not islet amyloid polypeptide or somatostatin . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Finally , we studied the expression of the somatostatin receptor gene by both ribonuclease ( RNase ) protection and nuclear run on assays using cDNA encoding for two subtypes of the somatostatin receptor gene ( i . e . , SSTR 1 and SSTR 2 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The relative affinities of various selective somatostatin analogs and the ability of GTP to inhibit radioligand binding suggested that the receptor expressed in the tumor cells belonged to the SSTR 2 subtype . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Patterns of expression of SSTR 1 and SSTR 2 somatostatin receptor subtypes in the hypothalamus of the adult rat : relationship to neuroendocrine function . ^^^ Taken together , these distributional patterns conform to those of somatostatin binding sites as visualized by in vitro autoradiography , suggesting that an important proportion of SSTR 1 and SSTR 2 receptors in the hypothalamus are associated with the perikarya and dendrites of intrinsic neurons . ^^^ Within the arcuate nucleus , the distribution of SSTR 1 and SSTR 2 messenger RNA expressing cells was comparable to that of neurons previously found to selectively bind somatostatin 14 within this area . ^^^ Taken together , the present results suggest that SSTR 1 and SSTR 2 somatostatin receptor messenger RNAs are heavily expressed in those neurons containing somatostatin and / or growth hormone releasing factor and thereby imply a role for both SSTR 1 and SSTR 2 somatostatin receptor subtypes in neuroendocrine regulation of growth hormone secretion in both sexes of this species . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Characterization and distribution of somatostatin SS 1 and SRIF 1 binding sites in rat brain : identity with SSTR 2 receptors . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Mediation by SRIF 1 receptors of the contractile action of somatostatin in rat isolated distal colon ; studies using some novel SRIF analogues . 1 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The somatostatin receptor agonists included peptides with relative specificity for SSTR 1 5 ( somatostatin 14 ; 10 nmol . kg 1 . h 1 ) ; SSTR 2 , SSTR 3 , and SSTR 5 [ SMS ( 201 995 ) ; 10 nmol . kg 1 . h 1 ] ; SSTR 2 ( 1 1 , 000 nmol . kg 1 . h 1 ) ; SSTR 3 ( 10 1 , 000 nmol . kg 1 . h 1 ) ; and SSTR 5 ( 10 1 , 000 nmol . kg 1 . h 1 ) . ^^^ At 10 nmol . kg 1 . h 1 , the SSTR 2 agonist inhibited acid secretion ( 40 + / 7 % of maximum ) similarly to somatostatin ( 37 + / 4 % of maximum ) and SMS ( 201 995 ) ( 31 + / 4 % of maximum ) . ^^^ These results indicate that somatostatin regulates gastric acid secretion by activation of SSTR 2 receptors . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
To determine whether cloned somatostatin receptors could mediate coupling to phosphotyrosine phosphotyrosine phosphatase activity , we examined phosphatase activity after somatotostatin activation of the rat somatostatin receptors SSTR 1 and SSTR 2 after their stable expression in heterologous Chinese Hamster Ovary ( CHO K 1 ) cells . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Detection of somatostatin receptor subtype 2 ( SSTR 2 ) in established tumors and tumor cell lines : evidence for SSTR 2 heterogeneity . ^^^ The somatostatin receptor subtype 2 ( SSTR 2 ) was detected in a wide range of human and rat tumors using in vitro receptor binding ( [ 125I ] MK 678 ) , receptor gene expression analysis , and immunoblotting techniques . ^^^ Somatostatin ( SRIF ) peptides with high SSTR 2 affinity and antiproliferative properties were potent inhibitors of [ 125I ] MK 678 binding to several tumor types , suggesting that they may exert antitumor effects via the SSTR 2 receptor . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Two amino acids , located in transmembrane domains 6 and 7 , determine the selectivity of the peptide agonist SMS 201 995 for the SSTR 2 somatostatin receptor . ^^^ To understand the molecular nature of selective peptide agonist binding to somatostatin receptors we have now , by site directed mutagenesis , identified amino acids mediating SMS 201 995 specificity for SSTR 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Two classes of somatostatin receptors , SRIF 1 and SRIF 2 , have been distinguished biochemically and pharmacologically . ^^^ The pharmacological characteristics of receptors expressing these cDNAs resemble those of the SRIF 2 and SRIF 1 classes of somatostatin receptors , respectively . ^^^ The somatostatin receptors SSTR 1 and SSTR 2 are coupled to inhibition of adenylyl cyclase in Chinese hamster ovary cells via pertussis toxin sensitive pathways . ^^^ Two cDNAs have been recently isolated that encode somatostatin receptors 1 and 2 ( SSTR 1 and SSTR 2 , respectively ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues : mediation by human somatostatin receptor subtypes SSTR 1 and SSTR 2 . ^^^ The effects of somatostatin analogues RC 160 and SMS 201 995 on tyrosine phosphatase and cell proliferation were investigated in COS 7 and NIH 3T3 cells expressing human somatostatin receptor subtype 1 or 2 ( SSTR 1 or SSTR 2 ) . ^^^ The somatostatin analogues RC 160 and SMS 201 995 exhibited low affinity for SSTR 1 ( IC 50 of 0 . 43 and 1 . 5 microM , respectively ) and high affinity for SSTR 2 ( IC 50 of 0 . 27 and 0 . 19 nM ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Transfected human somatostatin receptor type 2 , SSTR 2 , not only inhibits adenylate cyclase but also stimulates phospholipase C and Ca2+ mobilization . ^^^ COS 7 cells were transfected with human somatostatin ( SRIF ) receptor type 1 and 2 ( human SSTR 1 and SSTR 2 , respectively ) cDNAs . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
T lymphocytes isolated from the hepatic granulomas of schistosome infected mice express somatostatin receptor subtype 2 ( SSTR 2 ) messenger RNA . ^^^ It is probable that the lymphocyte SSTR 2 receptor mediates somatostatin induced modulation of IFN gamma secretion . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Inhibition of cell proliferation by the somatostatin analogue RC 160 is mediated by somatostatin receptor subtypes SSTR 2 and SSTR 5 through different mechanisms . ^^^ Binding experiments were performed on crude membranes by using [ 125I labeled Tyr 11 ] somatostatin 14 ; RC 160 exhibited moderate to high affinities for SSTR 2 , 3 , and 5 ( IC 50 , 0 . 17 , 0 . 1 and 21 nM , respectively ) and low affinity for SSTR 1 and 4 ( IC 50 , 200 and 620 nM , respectively ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The rat SSTR 2 somatostatin receptor subtype is coupled to inhibition of cyclic AMP accumulation . ^^^ The rat somatostatin receptor SSTR 2 subtype has been cloned and expressed in Chinese Hamster Ovary ( CHO ) cells . ^^^ Four different radioligands were used to determine the pharmacological properties of this somatostatin receptor subtype . [ 125ITyr11 ] S 14 , [ 125ITyr25 ] S 28 , and cyclo ( D Trp Lys Abu Phe MeAla [ 125ITyr ] ) displayed comparable affinities for the SSTR 2 subtype ( approximately 100 pM ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Human somatostatin receptor , SSTR 2 , is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein . ^^^ Among these subtypes SSTR 2 is present in many endocrine tumors as well as normal tissues and may mediate the effects of somatostatin analog , SMS 201 995 . ^^^ Somatostatin 14 does not affect the forskolin stimulated cAMP formation when human SSTR 2 is expressed in CHO cells , which lack internal Gi alpha 1 protein . ^^^ However , somatostatin 14 inhibits the adenylyl cyclase in a dose dependent and pertussis toxin sensitive manner when human SSTR 2 is co expressed with Gi alpha 1 in CHO cells . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Gene expression of somatostatin receptor subtypes , SSTR 1 and SSTR 2 , in human lung cancer cell lines . ^^^ In the present study , we investigated the expression of somatostatin receptor ( SSTR ) subtype ( SSTR 1 and SSTR 2 ) mRNA in various human lung cancer cell lines by the sensitive reverse transcription PCR method and Southern blotting . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Several different somatostatin receptor subtypes can be expressed by these tumors , the SSTR 2 subtype being the most frequently and abundantly expressed . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin receptor subtype SSTR 2 mediates the inhibition of high voltage activated calcium channels by somatostatin and its analogue SMS 201 995 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
It was found that NC 8 12 and DC 25 100 , which have high affinity for SSTR 2 and much less affinity for the type 5 receptor , were by far the most potent inhibitors of glucagon secretion with EC50s of 48 and 18 nmole , respectively , relative to somatostatin itself ( EC 50 131 nmole ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Expression and localization of somatostatin receptor SSTR 1 , SSTR 2 , and SSTR 3 messenger RNAs in primary human tumors using in situ hybridization . ^^^ Somatostatin receptor gene expression of SSTR 1 , SSTR 2 , and SSTR 3 subtypes was evaluated by in situ hybridization in 55 human primary tumors shown to contain a high density of somatostatin receptors in binding assays . ^^^ Of 55 somatostatin receptor positive tumors , 46 had SSTR 2 mRNA ; all 46 were characterized as having receptors with a high affinity for the synthetic analogue octreotide . ^^^ Whereas meningiomas , neuroblastomas , pituitary adenomas , small cell lung carcinomas , lymphomas , and breast tumors expressed primarily a high abundance of SSTR 2 , carcinoids , islet cell carcinomas , medullary thyroid carcinomas , and ovarian tumors had a mixed distribution of the somatostatin receptor subtypes . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Gi alpha 3 and G ( o ) alpha selectively associate with the cloned somatostatin receptor subtype SSTR 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In the present study , we have investigated the affinities of a battery of SRIF analogues to bind to SRIF receptor subtypes SSTR 1 ( cloned somatostatin complex ) , SSTR 2 , and SSTR 3 , as well as their abilities to inhibit the release of growth hormone from anterior pituitary cells in vitro . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
To investigate Na+ regulation of agonist binding to somatostatin receptors , Na+ was tested for its effect on the binding of agonists to cloned somatostatin receptor type 1 ( SSTR 1 ) and somatostatin receptor type 2 ( SSTR 2 ) stably expressed in Chinese hamster ovary cells . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The expression of two somatostatin receptor subtypes , SSTR 1 and SSTR 2 , was studied in 27 pituitary tumors and 1 chronic lymphocytic leukemia pituitary infiltrate . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Subtype specific signaling mechanisms of somatostatin receptors SSTR 1 and SSTR 2 . ^^^ We expressed two somatostatin receptor subtypes , SSTR 1 and SSTR 2 , stably in mouse fibroblast Ltk cells and transiently in human embryonic kidney HEK 293 cells to investigate subtype specific pharmacological and functional properties . ^^^ The effects of GTP gamma S and pertussis toxin on [ 125I Tyr 11 ] somatostatin 14 binding indicated that SSTR 2 may couple exclusively to pertussis toxin sensitive G proteins , whereas SSTR 1 may couple to both pertussis sensitive and insensitive G proteins . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We found that somatostatin inhibited cAMP accumulation in human embryonic kidney 293 cells only when cells were transfected with either SSTR 1 or SSTR 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Localization of somatostatin ( SRIF ) SSTR 1 , SSTR 2 and SSTR 3 receptor mRNA in rat brain by in situ hybridization . ^^^ In situ hybridization histochemistry was performed to analyse the distribution of the messenger RNA ( mRNA ) of three putative somatostatin ( SRIF ) receptors in rat brain , using oligonucleotide probes derived from the cDNA coding for SSTR 1 , SSTR 2 , and SSTR 3 receptors . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Differential expression of messenger RNAs for somatostatin receptor subtypes SSTR 1 , SSTR 2 and SSTR 3 in adult rat brain : analysis by RNA blotting and in situ hybridization histochemistry . ^^^ The messenger RNAs encoding three somatostatin receptor subtypes , SSTR 1 , SSTR 2 and SSTR 3 , were detected in rat by RNA blotting and in situ hybridization histochemistry to identify the sites of synthesis and expression of these somatostatin receptor subtypes . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The tissue distribution of mRNA encoding five somatostatin receptor subtypes , SSTR 1 , SSTR 2 , SSTR 3 , SSTR 4 , and SSTR 5 , was determined in adult rat tissues by solution hybridization / nuclease protection analysis using sequence specific cRNA probes . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
They exhibited specific and high affinity binding of somatostatin 14 , somatostatin 28 and octreotide , suggesting a preferential expression of the SSTR 2 receptor subtype . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Multiple gene transcripts of the somatostatin receptor SSTR 2 : tissue selective distribution and cAMP regulation . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The genes encoding three different human somatostatin receptor subtypes , designated SSTR 1 , SSTR 2 , and SSTR 3 , were mapped to chromosomes 14 , 17 , and 22 , respectively , by analyzing their segregation in a panel of reduced human hamster somatic cell hybrids . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In this study , we investigated whether thyroid hormones modulate GH secretion through their effects on the gene expression of GRF , somatostatin ( SS ) , GRF receptor , and receptor subtype 2 for SS ( SSTR 2 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
By using a selective agonist of type 2 somatostatin receptors ( SSTR 2 ) NC 8 12 , we identified this receptor as the subtype coupling to calcium channels in RINm5F cells . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
To increase further the reliability and prognostic value of sstr identification , we investigated the presence of mRNA for the subtypes sstr 1 and sstr 2 by in situ hybridization on tumor specimen from 25 carcinoid patients ( 22 midgut , 2 foregut , and 1 hindgut ) , all receiving somatostatin analogue treatment ( 12 lanreotide , 8 octreotide , and 5 octastatin ) and compared this to the therapeutic response evaluated as inhibition of hormone secretion . ^^^ Expression of sstr 2 mRNA could be detected in 15 patients , all responding to somatostatin analogue treatment and showing pathological tracer uptake in tumor lesions at sstr scintigraphy . ^^^ In the remaining 10 patients , no sstr 2 mRNA could be detected , and none of the patients responded to somatostatin analogue treatment . ^^^ In patients with pathological tracer accumulation without expression of somatostatin sstr 2 mRNA , other sstr may be present that can bind the somatostatin analogue but not inhibit hormone secretion . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin receptor subtypes SSTR 2 and SSTR 5 couple negatively to an L type Ca2+ current in the pituitary cell line AtT 20 . ^^^ The somatostatin receptor subtypes SSTR 2 and SSTR 5 mediate distinct endocrine and exocrine functions of somatostatin and may also be involved in mediating the neuromodulatory actions of somatostatin in the brain . ^^^ These studies reveal that two different somatostatin receptor subtypes , SSTR 2 and SSTR 5 , can mediate the inhibition of an L type Ca2+ channel in AtT 20 cells by somatostatin . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
CONCLUSIONS : SSTR 2 receptors expressed by colonocytes mediate somatostatin ' s antisecretory actions in rat colon . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The somatostatin ( SRIF ) receptors ( SSTRs ) 1 and 2 bind SRIF and SRIF 28 with high affinity , although a number of synthetic hexapeptide and octapeptide analogs of SRIF bind selectively to SSTR 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The effects of octreotide , a long acting somatostatin agonist selective of the sstr2 / sstr3 / sstr5 receptor subtypes , on ectopic GH secretion and tumor growth were investigated in Wistar Furth female rats implanted with GH secreting ( GC ) cells which express mostly somatostatin receptors of the sstr 1 and sstr 2 subtypes . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In order to investigate the gonadal regulation of pituitary somatostatin receptors ( SSTRs ) gene expression , we studied the existence of sexual dimorphism on SSTR 1 , SSTR 2 , and SSTR 3 mRNA levels in the rat anterior pituitary . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
These results demonstrate that chick sympathetic neurons possess SRIF 1 type somatostatin receptors which control transmitter release . ^^^ Since alpha 2 adrenergic agonists share all of these actions and occlude the effects of somatostatin , alpha 2 adrenoceptors and SRIF 1 receptors seem to regulate sympathetic transmitter release via common signalling mechanisms . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The messenger RNA ( mRNA ) expression of somatostatin ( SRIF ) receptors SSTR 1 , SSTR 2 , SSTR 3 , SSTR 4 and SSTR 5 ( called sst 1 5 , now ) was studied in rat brain between embryonic day 17 ( E 17 ) and post natal day 5 ( P 5 ) by in situ hybridization histochemistry and compared to that of adult rats . sst 1 receptor mRNA expression was very low and restricted at E 17 , spread out at E 18 , to reach very high levels comparable to that of adult at P 5 ( e . g . in temia tecta , posteromedial cortical amygdaloid nucleus , subiculum ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Expression of somatostatin receptor ( SSTR ) subtypes in pituitary adenomas : quantitative analysis of SSTR 2 mRNA by reverse transcription polymerase chain reaction . ^^^ The expression of somatostatin receptor ( SSTR ) subtypes and relative abundance of SSTR 2 mRNA were examined in 18 pituitary adenomas using the reverse transcription polymerase chain reaction ( RT PCR ) method . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Efficacy of SMS 201 995 , a clinically available somatostatin analog , against endocrine tumors seems to be correlated with expression of SSTR 2 which has a high affinity for SMS 201 995 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Pharmacological characterisation of human cerebral cortex somatostatin SRIF 1 and SRIF 2 receptors . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Autoradiographic analysis of somatostatin SRIF 1 and SRIF 2 receptors in the human brain and pituitary . ^^^ The distribution of somatostatin ( SRIF ) receptor sites was studied by in vitro receptor autoradiography in the human brain and pituitary using the SRIF 1 ( sst 2 ) receptor selective [ 125I ] Tyr 3 octreotide , the non subtype selective [ 125I ] LTT SRIF 28 ( [ Leu 8 , D Trp 22 , 125I Tyr 25 ] SRIF 28 ) and the SRIF 2 receptor selective [ 125I ] CGP 23996 ( c [ Asu Lys Asn Phe Phe Trp Lys Thr Tyr Thr Ser ] ) in buffer containing 120 mM Na+ . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The pharmacological profile of [ 125I ] 204 090 sites in cerebellar membranes was established using a range of ligands known to interact with SSTR 2 ( now called sst 2 ) and other somatostatin ( SRIF ) receptors . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Genomic DNA coding for somatostatin receptor ( SSTR 2 ) from each adenoma was PCR amplified and sequenced . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The somatostatin analogue , octreotide , binds with high affinity to the SSTR 2 and SSTR 5 subtype and with a low affinity to the SSTR 3 subtype . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In group ( 3 ) , muscarinic cholinoceptors , alpha 2 and beta adrenoceptors , P 2 purinoceptors , and receptors for the neuropeptides NPY , somatostatin ( SRIF 1 ) and LHRH , as well as opioid ( delta and kappa ) receptors can be found . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Peptide agonists with relatively high specificity for SSTR 1 5 ( somatostatin 14 ) , SSTR 2 ( MK 678 ) , SSTR 3 ( L 362823 ) , and SSTR 5 ( L 362855 ) were infused i . v . after nutrient stimulated gastric acid secretion and gastrin release with intraduodenal perfusions of 8 % peptone and after secretagogue stimulated acid secretion with gastrin ( 75 pmol kg 1 h 1 ) or histamine ( 20 micrograms kg 1 h 1 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The potent SRIF 1 receptor selective ligand , BIM 23027 , was able to displace completely the specific binding of radioiodinated somatostatin , [ 125I ] Tyr 11 SRIF 14 , with a pIC 50 of 10 . 3 , suggesting that Neuro2A cells contain predominantly receptors of the SRIF 1 receptor group . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
These results show that presynaptic somatostatin receptors of the SRIF 1 family inhibit glutamate release at hippocampal synapses . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin ( SRIF ) receptor subtypes ( sst ) were characterized in hypothalamic neurons and astrocytes by quantitative reverse transcription polymerase chain reaction and radioreceptor assays using [ 125I Tyr 0 , D Trp 8 ] SRIF 14 as a ligand in ionic conditions discriminating between SRIF 1 ( sst 2 , 3 , and 5 receptors ) and SRIF 2 ( sst 1 and 4 receptors ) binding sites . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Treatment of membranes from sstr 2 , sstr 3 , or sstr 4 expressing cells with somatostatin 14 plus guanyl 5 ' yl imidodiphosphate ( GMPPNP ) increased PTPase activity , and this stimulation was pertussis toxin sensitive . ^^^ Somatostatin plus GMPPNP stimulated PTPase activity in vitro when sstr 2 was coexpressed with wild type PTP1B or a Cys to Ser ( C / S ) , catalytically inactive PTP1B or with wild type SH 2 domain containing PTPase SHP 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
This is consistent with their affinities to SSTR 2 , the receptor which is believed to be linked to the inhibition of growth hormone release by somatostatin and its analogs . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin is a potent inhibitor of gastrin stimulated acid secretion by activation of somatostatin receptor type 2 ( sst 2 ) in vivo , probably in part by blocking gastrin stimulated histamine release from enterochromaffin like cells expressing sst 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Although this is unlikely to have diagnostic or prognostic significance , SSTR 2 specific somatostatin analogues may have therapeutic potential in breast cancer . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The transcript of the somatostatin receptor gene ( SSTR 2 ) was detected at all ages studied with no seasonal variations in its expression , indicating separate regulatory mechanisms . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Previously , we have shown somatostatin receptor ( SSTR ) subtype specific regulation of growth hormone ( GH ) , thyroid stimulating hormone , and prolactin ( PRL ) secretion in human fetal pituitary cultures , where GH and thyroid stimulating hormone are mediated by both SSTR 2 and SSTR 5 , whereas SSTR 2 preferentially mediates PRL secretion . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
S 49 cells expressed type 2 somatostatin receptors ( sstr 2 ) by immunoblotting . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In the two cholangiocyte subpopulations , we also studied basal somatostatin receptor ( SSTR 2 ) gene expression as well as the effects of somatostatin on 1 ) SR gene expression and secretin induced cAMP synthesis and 2 ) [ 3H ] thymidine incorporation and H 3 histone gene expression . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Among the three cases with a true positive study , SSTR 2 , the SSTR subtype that preferentially binds to the somatostatin analogue octreotide , was detected in two , SSTR 5 was demonstrated in the three , and SSTR 3 was detected in one . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Imaging of somatostatin receptors by indium 111 pentetreotide correlates with quantitative determination of somatostatin receptor type 2 gene expression in neuroblastoma tumors . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Quantitation of somatostatin receptor type 2 gene expression in neuroblastoma cell lines and primary tumors using competitive reverse transcription polymerase chain reaction . ^^^ Given that the adrenal gland and its relative embryonal and adult tumors express an abundance of mRNA for somatostatin receptor type 2 ( sst 2 ) mRNA , we studied the quantitative expression of sst 2 in 6 NB cell lines and 15 primary tumors using competitive reverse transcription ( RT ) PCR . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Both overlapping and distinct signaling pathways for somatostatin receptor subtypes SSTR 1 and SSTR 2 in pituitary cells . ^^^ To elucidate the signaling events mediated by specific somatostatin receptor ( SSTR ) subtypes , we expressed SSTR 1 and SSTR 2 individually in rat pituitary GH12C1 and F4C1 cells , which lack endogenous somatostatin receptors . ^^^ In transfected F4C1 cells , both SSTR 1 and SSTR 2 mediated somatostatin induced inhibition of adenylyl cyclase via a PTx sensitive pathway . ^^^ Thus , by expressing individual somatostatin receptor subtypes in pituitary cells , we have identified both overlapping and distinct signaling pathways for SSTR 1 and SSTR 2 , and have shown that sequences other than simply the intracellular domains are required for SSTR 2 to couple to the PLC signaling pathway . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Activation of human somatostatin receptor type 2 causes inhibition of cell growth in transfected HEK 293 but not in transfected CHO cells . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Participation of somatostatin in the control of FRTL 5 cell proliferation is in agreement with the detection of specific somatostatin receptor type 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The rat somatostatin receptor subtype 2 ( SSTR 2 ) is rapidly internalized and phosphorylated in the presence of somatostatin 14 ( SST 14 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
A microplate binding assay for the somatostatin type 2 receptor ( SSTR 2 ) . ^^^ The clinical importance of somatostatin type 2 receptors ( SSTR 2 ) and the study of novel analogues of somatostatin such as OctreoScan or [ Tyr 3 ] octreotide containing DOTA ( 1 , 4 , 7 , 10 tetraazacyclododecane 1 , 4 , 7 , 10 tetraacetic acid ) as metal chelator led us to develop a methodology to monitor the expression of SSTR 2 on tumours of pancreatic origin ( e . g . rat AR 4 2J cancer cells ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin receptor type 2 expression in the mammalian brain displays a spatially and temporally very restricted pattern . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Human gliomas , especially of low grade type , have been shown to express high affinity somatostatin receptor type 2 ( J C . ^^^ DOTATOC competes specifically with somatostatin binding to somatostatin receptor type 2 in the low nanomolar range as shown by a displacement curve of 125I [ Tyr 3 ] octreotide in tumor tissue sections . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We report here an interaction between the C terminus of the rat somatostatin receptor subtype 2 ( SSTR 2 ) and a protein that has recently been identified as cortactin binding protein 1 ( CortBP 1 ) . ^^^ This process is largely increased when the receptor is stimulated by somatostatin ; as CortBP 1 interacts with the C terminus of SSTR 2 , our data suggest that the binding of agonist to the receptor increase the accessibility of the receptor C terminus to the PDZ domain of CortBP 1 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
This holds true for the following heteroreceptors : adenosine A 1 , cannabinoid CB 1 , dopamine D2 / D3 , histamine H 3 , 5 hydroxytryptamine ( serotonin ) 5 HT ( 1B ) , imidazoline , muscarine M 2 , delta opioid , kappa opioid , mu opioid , orphan opioid ( ORL 1 ) , prostaglandin EP 3 , and somatostatin SRIF 1 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Identification of a functional 3 ' , 5 ' cyclic adenosine monophosphate response element within the second promoter of the mouse somatostatin receptor type 2 gene . ^^^ Important physiological actions of somatostatin are mediated by the somatostatin receptor type 2 . ^^^ It is known that the mRNA of the somatostatin receptor type 2 gene is induced by cAMP , but little is known about the mechanisms underlying this regulation . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We investigated the distribution of SSTR subtype 2 ( SSTR 2 ) in relation to gastrin and somatostatin containing cells and the effect of ammonia solution ( 0 . 01 % 0 . 1 % ) administered orally for 2 to 4 weeks on these cells in rat antral mucosa by immunohistochemistry . ^^^ Double staining experiments revealed that SSTR 2 peptide [ 31 41 ] positive cells are co localized in 85 . 0 + / 2 . 2 % of the gastrin containing cells and in 34 . 4 + / 4 . 8 % of the somatostatin containing cells . ^^^ Ammonia solution significantly decreased the number of somatostatin containing cells and increased the proportion of SSTR 2 peptide [ 31 41 ] labeling in the somatostatin containing cells in a duration dependent manner . ^^^ These findings suggest that SSTR 2 are localized in antral endocrine cells and that ammonia solution mainly decreases somatostatin containing cells without SSTR 2 expression , resulting in an increase in gastrin secretion into the portal vein . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Identification of distinct signalling pathways for somatostatin receptors SSTR 1 and SSTR 2 as revealed by microphysiometry . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Differential regulation of somatostatin receptor type 2 ( sst 2 ) expression in AR 4 2J tumor cells implanted into mice during octreotide treatment . ^^^ Its efficacy in tumors depends mainly on the expression of the somatostatin receptor type 2 ( sst 2 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Regulation of mouse somatostatin receptor type 2 gene expression by glucocorticoids . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The purpose of the second aspect of the study was to determine the biodistribution of 64Cu 1 , 4 , 8 , 11 tetraazacyclotetradecane 1 , 4 , 8 , 11 tetraacetic acid ( TETA ) octreotide in a human ovarian cancer model induced to express human somatostatin receptor subtype 2 ( SSTr 2 ) using gene transfer techniques as a prelude to future therapy studies . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma , but does not involve mutations in the somatostatin receptor 2 ( SSTR 2 ) gene at 17q24 . ^^^ Expression of the somatostatin receptor 2 ( SSTR 2 ) , localized in chromosome region 17q24 , has in previous studies been shown to be positively related to survival in neuroblastoma . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Genomic structure and transcriptional regulation of the human somatostatin receptor type 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomas . ^^^ Somatostatin receptor type 2 A ( sst2A ) and Gi 2 are proposed to mediate selectively the inhibition of GH release in the somatotroph . ^^^ CONCLUSION : Mutations of the somatostatin receptor type 2 A and the gip oncogene are unlikely to be involved in the pathogenesis of acromegaly . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Recently , studies using somatostatin ( SRIF ) analogs preferential for either the SRIF receptor 2 ( SSTR 2 ) or the SSTR 5 subtype demonstrated a variable suppression of GH and PRL release from GH secreting human adenomas . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Less sequence identity exists with the mammalian opioid / nociceptin orphanin FQ receptors ( 26 % identity with the rat micro opioid receptor ) , and mammalian somatostatin receptors ( 25 % identity with the rat somatostatin receptor type 2 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Correlative immunohistochemical and reverse transcriptase polymerase chain reaction analysis of somatostatin receptor type 2 in neuroendocrine tumors of the lung . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In the present study we investigated the presence of CCK A and CCK B , as well as somatostatin 2 ( SSTR 2 ) receptors by RT PCR , and studied the actions of EGF , CCK and octreotide on DNA synthesis in the human pancreatic adenocarcinoma cell line Capan 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In anaesthetised rats , administration of seglitide ( MK 678 ) , a somatostatin analogue with selectivity for the SRIF 1 receptor ( comprising somatostatin sst 2 , sst 3 and sst 5 subtypes ) significantly increased extracellular levels of dopamine in the ipsilateral nucleus accumbens shell . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
CONCLUSIONS : These findings show that SSTR 2 is the primary SSTR that is upregulated after injury and likely mediates the effects of somatostatin analogs on intimal hyperplasia . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In animal models the somatostatin analog angiopeptin inhibits intimal hyperplasia by acting primarily through somatostatin receptor 2 ( SSTR 2 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Octreotide , which acts preferentially via somatostatin receptor subtype 2 ( SSTR 2 ) , was very effective in inhibiting TK activity in the rat pituitary tumor , but it is a rather weak inhibitor of TK activity in murine colonic cancer . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Tumor tissue expressed both somatostatin receptor type 2 and dopamine receptor type 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We previously found a great variability in the expression of somatostatin receptor type 2 ( sst 2 ) in several human NB cell lines and primary tumors . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
These granulomas produce somatostatin 1 14 and express somatostatin receptor subtype number 2 ( SSTR 2 ) , which is the exclusive somatostatin receptor present in this inflammation . ^^^ Somatostatin can suppress IFN gamma secretion from T cells via interaction with the SSTR 2 receptor expressed on these cells . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Gene structure and regulation of the somatostatin receptor type 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Simultaneous traditional chemical synthesis yielded an additional series of somatostatin subtype 2 receptor ( SSTR 2 ) selective agonists . ^^^ In vitro experiments demonstrated the role of the SSTR 2 in inhibition of glucagon release from mouse pancreatic alpha cells and the somatostatin subtype 5 receptor ( SSTR 5 ) as a mediator of insulin secretion from pancreatic beta cells . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Adenovirus vectors encoding the genes for a variety of antigens / receptors ( carcinoembryonic antigen , gastrin releasing peptide receptor , somatostatin receptor subtype 2 ( SSTr 2 ) ) have all shown that their expression is increased on cancer cells both in vitro and in vivo following adenovirus infection . ^^^ Various radioisotopes have been attached to somatostatin analogues for imaging and therapy of SSTr 2 positive tumors both clinically and in animal models . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The antiproliferative effects of somatostatin and its analogs on human pancreatic cancers were studied : ( 1 ) by evaluating the gene expression of somatostatin receptor ( sstr ) subtypes in human pancreatic cancer cell lines and cancer tissue specimens , ( 2 ) by evaluating the antiproliferative effects of somatostatin analogs , and ( 3 ) by evaluating the effect of sstr 2 cDNA transduction . ^^^ Based on these findings , it is concluded that somatostatin analogs with their antiproliferative effects mediated by sstr 2 could be potentially useful in the treatment of pancreatic cancers . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Although both somatostatin receptor subtype 2 ( SSTR 2 ) and SSTR 5 messenger ribonucleic acid ( mRNA ) are consistently expressed in GH secreting adenomas , SSTR 2 has been believed to be the key modulator of somatostatin mediated inhibition of GH release . ^^^ The somatostatin agonists currently in clinical use , octreotide and lanreotide , are directed mainly to SSTR 2 ( IC ( 50 ) 12 to 18 fold higher than for SSTR 5 ) . ^^^ In the present study we quantified SSTR 2 and SSTR 5 mRNA expression and the GH suppressive effects of somatostatin 14 ; octreotide ; a SSTR 2 preferential compound , BIM 23197 ; a SSTR 5 preferential compound , BIM 23268 ; and a new SSTR 2 and SSTR 5 bispecific compound , BIM 23244 , in GH secreting tumors classified as either full responders to octreotide ( n = 5 ) or partially sensitive to octreotide ( n = 5 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The role of somatostatin receptor subtypes 2 and 5 ( SSTR 2 and SSTR 5 ) in determining the secretory and proliferative phenotype as well as the sensitivity to somatostatin analogue treatment is not clearly established . ^^^ PCR products of SSTR 2 and SSTR 5 DNA from tumours resistant to somatostatin analogues were directly sequenced . ^^^ No significant correlation between the levels of SSTR 2 and SSTR 5 expression and the in vivo responsiveness to somatostatin analogues was observed , although a tendency to a low SSTR 2 expression in resistant tumours was found . ^^^ No mutations in the coding or bordering regions of either SSTR 2 or SSTR 5 adenomatous DNA from patients totally or partially resistant to somatostatin analogues were found . ^^^ The study shows that the different expression of SSTR 2 and SSTR 5 in GH secreting adenomas is not significantly correlated with the secretory and proliferative phenotype , although the large , hypersecretory tumours and those with a poor sensitivity to somatostatin analogues seem to express low levels of SSTR 2 mRNA . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
METHODS : Using both techniques , reverse transcriptase polymerase chain reaction and immunohistochemistry , we analysed mRNA of different subtypes of somatostatin receptors in 15 medulloblastomas and the localisation of the subtype SSTR 2 receptor at the cellular level in 13 medulloblastomas . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
However , in clinical practice only somatostatin analogs selective for SSTR 2 ( octreotide and lanreotide ) are available . ^^^ In this study , we investigated the inhibitory effect of two new SRIH analogs with high selectivity for SSTR 2 ( NC 4 28B ) and SSTR 5 ( BIM 23268 ) and compared it to that of native somatostatin ( SRIH 14 ) on a large number of GH secreting adenomas obtained by transphenoidal neurosurgery . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Real time polymerase chain reaction was performed to quantify the expression of SSTR mRNAs and functionality of the SSTRs was assessed in cell culture studies with various concentrations of native somatostatin ( SRIF 14 ) and of analogues preferential for SSTR 2 or SSTR 5 . ^^^ DISCUSSION : In this plurihormonal secreting adenoma , the high efficacy of somatostatin analogues to inhibit PRL , LH and alpha subunit secretion in vivo may be explained by the unusually high level of expression and by the functionality of both SSTR 2 and SSTR 5 receptor subtypes . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin receptor type 2 gene expression in neuroblastoma , measured by competitive RT PCR , is related to patient survival and to somatostatin receptor imaging by indium 111 pentetreotide . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Radioimmunoassay for somatostatin receptor type 2 . ^^^ OBJECTIVE : To develop radioimmunoassay for somatostatin receptor type 2 ( SSTR 2 ) and search for its presence in certain rat tissues . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Association analysis of somatostatin receptor ( SSTR 1 and SSTR 2 ) polymorphisms in breast cancer and solar keratosis . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin and somatostatin analogs specific for SSTR 2 and / or SSTR 3 enhanced adhesion of T cells to fibronectin ( FN ) , and to a certain extent , also to collagen type 4 ( CIV ) and laminin ( LAM ) . ^^^ T lymphocytes express multiple SSTR and somatostatin may therefore regulate lymphocyte functions via distinct receptor subtypes as shown here for adhesion to extracellular matrix components ( ECM ) via SSTR 2 and SSTR 3 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In addition , the viruses contain the human somatostatin receptor subtype 2 gene ( SSTR 2 ) , the expression of which can be noninvasively imaged . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin receptor type 2 ( sstr2A ) mediates antiproliferative actions of somatostatin and has the strongest affinity to the therapeutically used somatostatin analog octreotide . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Several reporter genes , such as the herpes simplex virus type 1 thymidine kinase , the dopamine type 2 receptor , and the somatostatin receptor type 2 , are currently being successfully used with gamma camera , single photon emission computed tomography , and positron emission tomography imaging . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Although density of SSTR 2 and intensity of expression of somatostatin genes have no prognostic significance in medulloblastoma . their presence may bring along important information on oncogenesis and relate medulloblastoma to cPNETs . ^^^ Unfortunately , radiolabeled octreotide scintigraphy is not useful in the differential diagnosis of gliomas , because the results are altered by the disruption of the blood brain barrier ( BBB ) ; in addition , radionuclide labeled somatostatin analogues are not useful in the therapy of low grade gliomas , because the intact BBB prevents them from reaching the target SSTR 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The objectives of this study were to 1 ) induce somatostatin receptor ( SSTr 2 ) expression in tumor cells using an adenovirus encoding the SSTr 2 gene ( AdSSTr 2 ) , 2 ) demonstrate tumor localization of [ ( 111 ) In ] DTPA D Phe ( 1 ) octreotide in AdSSTr 2 injected tumors , and 3 ) show therapeutic efficacy with [ ( 90 ) Y ] DOTA D Phe ( 1 ) Tyr ( 3 ) octreotide ( [ ( 90 ) Y ] SMT 487 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Noninvasive monitoring of somatostatin receptor type 2 chimeric gene transfer . ^^^ Most gene transfer imaging systems do not directly detect the gene of interest , and most do not exploit radiopharmaceuticals that have Food and Drug Administration approval for total body use . ( 111 ) In Octreotide is used clinically to locate tumors overexpressing primarily somatostatin receptor type 2 ( SSTR 2 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : To study the mechanisms underlying the antiproliferative responses of myeloblasts to somatostatin , clones of the IL 3 dependent murine cell line 32D that stably express SSTR 2 and G CSF receptors were generated . ^^^ CONCLUSION : Based on these data and previous results , we propose a model in which recruitment and activation of the tyrosine phosphatase SHP 1 by SSTR 2 is involved in the selective negative action of somatostatin on G CSF R signaling . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Surprisingly , we found that , compared to ( 111 ) In or ( 90 ) Y , labeling with ( 67 ) Ga considerably improved the biologic performance of the tested somatostatin analogs with respect to SSTR 2 affinity and tissue distribution . ( 67 ) Ga labeled DOTA somatostatin analogs were rapidly excreted from nontarget tissues , leading to excellent tumor to nontarget tissue uptake ratios . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Tc 99m depreotide is a new radiolabeled somatostatin analogue that shows high affinity for SSTR 2 , SSTR 3 , and SSTR 5 subtypes . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
It is useful for the coupling to the N terminus of peptides on solid phase and in solution ; it was coupled to [ Tyr 3 ] octreotide ( TOC ) on solid phase , and the resulting peptide , NODAGA Tyr 3 octreotide ( NODAGATOC ) , was labeled with the radiometals 111In and 67Ga in high yields and good specific activities . [ 67Ga ] and [ 111In ] NODAGA Tyr 3 octreotide appear to be useful to visualize primary tumors and metastases which express somatostatin receptors subtype 2 ( sstr 2 ) , such as neuroendocrine tumors , because of their high affinity to this receptor subtype with IC ( 50 ) = 3 . 5 + / 1 . 6 nM and 1 . 7 + / 0 . 2 nM , respectively . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
SSTR 2 mediates the somatostatin induced increase in intracellular Ca ( 2+ ) concentration and insulin secretion in the presence of arginine vasopressin in clonal beta cell HIT T 15 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
IMR 32 cells , which over express somatostatin receptor type 2 ( SSTR 2 ) and contain the n myc oncogene , were treated with these PNA SSA conjugates . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr 2 knockout / lacZ knockin mice . ^^^ The actions of somatostatin are mediated by a family of G protein coupled receptors that compose five subtypes ( SSTR 1 5 ) , each of which is encoded by a separate gene . lacZ `` knockin ' ' mice , in which the reporter gene lacZ was engineered into the genomic locus of Sstr 2 by gene targeting , were used to examine the expression pattern of Sstr 2 and identify potential targets for neurally released and hormonal somatostatin in the gastrointestinal tract . ^^^ The presence of SSTR 2 on both parietal and ECL cells suggests that somatostatin acting on SSTR 2 may reduce acid secretion by both acting directly on parietal cells and by reducing histamine release from ECL cells . ^^^ Thus , somatostatin acting at SSTR 2 receptors on NOS neurons might modulate descending relaxation . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
A T ( s , p ) 5 motif within intracellular domain 2 and a QQ ( r ) motif within intracellular domain 3 are shared by the somatostatin receptor subtypes SSTR 1 , 3 , and 4 , which couple to the inhibition of NHE 1 , but not by SSTR 2 and 5 , which do not signal to NHE 1 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
To elucidate whether prostatic epithelial cells express mRNA for somatostatin receptor ( SSTR ) subtype 2 and 4 , we have investigated the localization of SSTR 2 and SSTR 4 transcripts in prostatic tissues by in situ hybridization . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Expression of somatostatin receptor type 2 ( sst2A ) in immature porcine Leydig cells and a possible role in the local control of testosterone secretion . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
CONCLUSIONS : ( 1 ) This first comparison between somatostatin receptor status in vivo and ex vivo in MTC shows a marked positive octreoscan despite absent SSTR 2 expression , and ( 2 ) this is the first report of a discrepancy between immunostaining and gene transcription for POMC and CRH . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR 2 on cholangiocytes . ^^^ With an in vitro model using enclosed intrahepatic bile duct units ( IBDUs ) isolated from wild type and somatostatin receptor ( SSTR ) subtype 2 knockout mice , we tested the effects of somatostatin , secretin , and a selective SSTR 2 agonist ( L 779976 ) on fluid movement across the bile duct epithelial cell layer . ^^^ No significant decrease of luminal area by either somatostatin or L 779976 was observed in IBDUs from SSTR 2 knockout mice . ^^^ The inhibitory effect of both somatostatin and L 779976 on secretin induced IBDU secretion was absent in IBDUs of SSTR 2 knockout mice . ^^^ Somatostatin induced an increase of intracellular cGMP and inhibited secretin stimulated cAMP synthesis in cholangiocytes ; depletion of SSTR 2 blocked these effects of somatostatin . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
A differential expression of somatostatin receptor SSTR 2 , not known to be a cocaine responsive gene , as well as the clock gene Per 2 , were found by microarrays and confirmed by RNase protection assay . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin receptor type 2 mediates bombesin induced inhibition of gastric acid secretion in mice . ^^^ We characterized the effects of exogenous bombesin on gastric acid secretion in mice and determined the involvement of somatostatin and somatostatin receptor type 2 ( SSTR 2 ) by using somatostatin immunoneutralization , the SSTR 2 antagonist , PRL 2903 , and SSTR 2 knockout mice . ^^^ Somatostatin antibody and PRL 2903 increased basal secretion in wild type mice but not in SSTR 2 knockout animals . ^^^ In wild type mice pretreated with somatostatin antibody or PRL 2903 and in SSTR 2 knockout mice , bombesin and somatostatin 14 I . ^^^ These results indicate that , in mice , bombesin inhibits gastric acid secretion through the release of somatostatin and the activation of SSTR 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Human GH is regulated through ligand binding to both SSTR 2 and SSTR 5 , but octreotide and lanreotide , the two clinically available somatostatin analogs , bind to human SSTR 2 much better than to SSTR 5 . ^^^ A new SSTR2+5 bispecific analog with high affinity and selectivity for both SSTR 2 and SSTR 5 , and a somatostatin analog with a unique broad receptor ( SSTR 1 , 2 , 3 , and 5 ) binding profile , are both able to inhibit in vitro GH release in GH cell adenomas partially sensitive to octreotide . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
BACKGROUND : The aim of this study was to investigate the importance of somatostatin receptor subtype 2 ( SSTR 2 ) expression for 111In labelled diethylenetriamine pentaacetic acid ( DTPA ) D Phe 1 octreotide binding and uptake of 111In in neuroendocrine tumours . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Both analogs have a high affinity mainly to a somatostatin receptor subtype 2 ( SSTR 2 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
METHODS : Twenty five patients who have positive expression of vascular endothelial growth factor ( VEGF ) and somatostatin receptor 2 ( SSTR 2 ) were selected by gastroscopic biopsy and immunohistochemical staining before surgical operation . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We have demonstrated previously that somatostatin inhibits the growth of pancreatic cancers expressing somatostatin receptor subtype 2 ( SSTR 2 ) , but not receptor negative cancers . ^^^ We hypothesized that SSTR 2 gene transfer would restore the growth inhibitory response of human pancreatic cancer to somatostatin . ^^^ CONCLUSIONS : Expression of SSTR 2 by human pancreatic cancer causes significant slowing of tumor growth by a mechanism independent of exogenous somatostatin . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Furthermore , even during the immunoneutralization of endogenous intrapancreatic somatostatin , the SSTR 2 agonist was able to reverse the effect of somatostatin immunoneutralization by suppressing insulin secretion . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The aim of the study was to determine the inhibitory effects of somatostatin analogues with relative specificity to somatostatin receptor subtype 2 ( SSTR 2 ) ( BIM 23197 ) , subtype 5 ( SSTR 5 ) ( BIM 23268 ) , and their combination on GH and PRL secretion in acromegalic adenomas in vitro . ^^^ In conclusion the somatostatin analogue BIM 23268 had an additive effect on suppression of GH secretion in a subset of adenomas , where both SSTR 2 and SSTR 5 were involved . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin acts as a neuromodulator via a family of five 7 transmembrane G protein coupled receptors , SSTR 1 5 , one of which , SSTR 2 , is known to be functional in the striatum . ^^^ Microdialysis in the striatum showed Sstr 2 null mice were selectively refractory to somatostatin induced dopamine and glutamate release . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In order to determine the mechanism by which these hypothalamic hormones modulate chicken TSH release , we examined the cellular localization of TRH receptors ( TRH R ) , CRH receptors type 1 ( CRH R 1 ) and somatostatin subtype 2 receptors ( SSTR 2 ) in the chicken pars distalis by in situ hybridization ( ISH ) , combined with immunological staining of thyrotropes . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
BACKGROUND : Previous studies showed that the subtype 2 of somatostatin receptors ( sstr 2 ) is generally expressed by soft tissue sarcomas . ^^^ RESULTS : Somatostatin receptors were identified in 84 % of the tumors analyzed by RT PCR analysis . sstr 1 and sstr 2 were the receptors most frequently detected . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
InIII DOTA NOC exhibited the following IC 50 values ( nM ) when studied in competition with [ 125I ] [ Leu 8 , d Trp 22 , Tyr 25 ] somatostatin 28 ( values for YIII DOTA NOC are shown in parentheses ) : sstr 2 , 2 . 9 + / 0 . 1 ( 3 . 3 + / 0 . 2 ) ; sstr 3 , 8 + / 2 ( 26 + / 1 . 9 ) ; sstr 5 , 11 . 2 + / 3 . 5 ( 10 . 4 + / 1 . 6 ) . ^^^ InIII DOTA NOC is superior to all somatostatin based radiopeptides having this particular type of binding profile , including DOTA lanreotide , and has three to four times higher binding affinity to sstr 2 than InIII , YIII DOTA Tyr 3 octreotide ( InIII , YIII DOTA TOC ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Investigating three somatostatin receptor ( SSTR ) positive ( + ) human breast cancer cell lines , Xu et al . found a time and dose dependent up or down regulation of SSTR 2 mRNA expression by 17beta oestradiol ( E ( 2 ) ) or the anti oestrogen tamoxifen , respectively , in the two oestrogen receptor positive ( ER+ ) cell lines but not in the oestrogen receptor negative ( ER ) cell line . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Like octreotide long acting repeatable ( LAR ) , it has high binding affinity for the somatostatin receptor subtype SSTR 2 and less binding affinity for SSTR 5 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Among the five different G protein coupled somatostatin receptors ( SSTRs ) , SSTR 1 is expressed in human kidney collecting ducts and SSTR 2 is expressed in rat and human collecting ducts and glomeruli . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Here , we evaluated somatostatin receptor type 2 ( sst ( 2 ) ) expression using an antibody in an array of CNS tumors of childhood . ^^^ RESULTS : Abundant expression of somatostatin receptor type 2 in stPNET , a ME , and ependymomas warranted in vivo imaging of 7 stPNET , 1 rhabdomyosarcoma , 3 ependymomas , 1 ME , and 1 glioblastoma . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
OBJECTIVES : To observe the expression of somatostatin receptor subtype 2 ( SSTR 2 ) mRNA , and investigate the relationship between the expression of SSTR 2 mRNA and the expressions of estrogen and progesterone receptors ( ERs and PRs ) in benign and malignant breast tissues . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
AIM : To investigate the anti angiogenic effect of somatostatin receptor subtype 2 ( SSTR 2 ) gene transfer into pancreatic cancer cell line PC 3 , and the mechanisms involved in this effect . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We characterized the effects of exogenous PACAP on gastric acid secretion in urethane anesthetized mice implanted with a gastric cannula and in conscious 2 h pylorus ligated mice , and determined the involvement of somatostatin and somatostatin receptor type 2 ( SSTR 2 ) by using somatostatin immunoneutralization , the SSTR 2 antagonist , PRL 2903 , and SSTR 2 knockout mice . 3 . ^^^ Somatostatin antibody and PRL 2903 increased basal secretion in wild type mice but not in SSTR 2 knockout animals . 4 . ^^^ In wild type urethane anesthetized mice pretreated with somatostatin antibody or PRL 2903 and in SSTR 2 knockout mice , peripheral infusion of PACAP 38 or somatostatin 14 did not inhibit the increased basal gastric acid secretion . 6 . ^^^ These results indicate that , in mice , peripheral PACAP inhibits gastric acid secretion through the release of somatostatin and the activation of SSTR 2 receptors . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Radioligand targeting of somatostatin receptor subtype 2 ( sstr 2 ) positive tumors with synthetic somatostatin analogues such as octreotide is subject to improvement in tumor to nontumor biodistribution , in part because internalization of such somatostatin analogues is limited by sstr 2 recycling to the cell surface . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
CONCLUSION : The effect exerted by somatostatin and its analogues on HSCs may mainly depend on the expression of SSTR 2 , SSTR 3 and SSTR 5 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The role of somatostatin in galanin induced inhibition of gastric acid secretion in urethane anesthetized mice was investigated by using immunoneutralization of endogenous somatostatin and somatostatin receptor type 2 ( SSTR 2 ) knockout mice . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Two CPT SSA conjugates , JF 10 71 and JF 10 81 , containing a chemically adjustable release rate carbamate linker , have been reported previously by us to potently inhibit growth of human neuroblastoma IMR 32 cells overexpressing somatostatin receptor type 2 ( SSTR 2 ) but are stable under buffer incubation conditions or in rat plasma . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
These results demonstrate somatostatin and octreotide mediated attenuation of both IGF 1R signal transduction and VEGF mRNA accumulation via somatostatin receptor type 2 ( sst 2 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin ( SRIF ) analogs interacting with SRIF receptor ( SSTR ) subtypes SSTR 2 and SSTR 5 reduce hormone secretion of pituitary adenomas , but their antiproliferative effects are still controversial . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Role of somatostatin receptors on gastric acid secretion in wild type and somatostatin receptor type 2 knockout mice . ^^^ Somatostatin , probably acting through somatostatin type 2 receptors ( SSTR 2 ) , is the main inhibitor of gastric acid secretion . ^^^ We characterized gastric acid secretion in SSTR 2 knockout mice , and used preferential somatostatin receptor agonists to assess the relative role of SSTR 1 , 2 , 3 , 4 , and 5 on gastric acid secretion . ^^^ However , under urethane anesthesia , which releases endogenous somatostatin , SSTR 2 knockout mice had a basal secretion 11 15 fold higher than wild type animals ( micromol / 10 min : 1 . 40+ / 0 . 09 vs . 0 . 10+ / 0 . 01 , p < 0 . 05 ) . ^^^ In wild type mice , somatostatin 14 , SMS 201 995 , and the SSTR 2 preferential agonist , DC 32 87 , inhibited gastrin stimulated acid secretion with an order of potency SMS 201 995 > DC 32 87 > somatostatin 14 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin receptor 2 ( SSTR 2 ) mediates neuromodulatory signals of somatostatin and cortistatin in the cerebral cortex . ^^^ SSTR 2 internalization was associated with a transient depletion of somatostatin from axonal terminals and increased expression of SSTR 2 mRNA . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the antitumor effect of somatostatin receptor subtype 2 ( SSTR 2 ) gene transfection into pancreatic cancer cell line PC 3 , and the mechanisms involved in this effect . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
To facilitate imaging , a 10 expressing the human somatostatin receptor type 2 ( SSTR 2 ) was created . ^^^ Oncolytic vaccinia virus expressing the human somatostatin receptor SSTR 2 : molecular imaging after systemic delivery using 111In pentetreotide . ^^^ Cells infected with the SSTR 2 expressing 10 or controls were incubated with the somatostatin analog 111In pentetreotide with or without an excess of nonradiolabeled pentetreotide . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The effects of somatostatin were insensitive to tetrodotoxin , reduced by Ba2+ , occluded or abolished by the presence of nonhydrolysable GTP or GDP analogues , respectively , and blocked or mimicked by a somatostatin receptor type 2 antagonist ( BIM 23627 ) or somatostatin receptor type 2 agonist ( L 779 , 976 ) , respectively , while somatostatin receptor type 1 , 3 and 4 agonists were ineffective ( L 797 , 591 , L 796 , 778 , L 803 , 087 ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
STUDY DESIGN : Three single nucleotide polymorphisms ( a 83 g , c 57 g , and t80c ) of SSTR 2 and three ( t 461c , c325t , and c1004t ) of SSTR 5 were analyzed in 66 acromegalic patients with different responsiveness to somatostatin analogs and 66 healthy controls . ^^^ No correlation between SSTR 2 and SSTR 5 genotypes , responsiveness to somatostatin therapy , and mRNA expression in the removed adenomas ( n = 10 ) was found . ^^^ CONCLUSIONS : These data suggest a role for SSTR 5 t 461c and c1004t alleles in influencing GH and IGF 1 levels in patients with acromegaly , whereas SSTR 2 and SSTR 5 variants seem to have a minor role in determining the responsiveness to somatostatin analogs . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin inhibits insulin release via SSTR 2 in hamster clonal beta cells and pancreatic islets . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We have previously shown that the somatostatin receptors SSTR 2 and SSTR 3 are present on the parasite egg and worms . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The respective products of all 5 subtypes of somatostatin receptors were found in human LECs and somatostatin receptor type 2 in bovine LECs . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The SSTR was detected using a radioligand binding assay ( RBA ) with 125I somatostatin 14 , and the SSTR 2 mRNA of the pancreas was analyzed using in situ hybridization . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Gene transfer of somatostatin receptor type 2 by intratumoral injection inhibits established pancreatic carcinoma xenografts . ^^^ AIM : To investigate the therapeutic effect of somatostatin receptor type 2 ( SSTR 2 ) gene transfection on pancreatic carcinoma xenografts in vivo in experimental cancers . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin , acting via ssTR 2 receptors , exerts a tonic paracrine inhibitory influence on the secretion of gastrin , histamine , and acid secretion . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Five human somatostatin receptors ( hsstr 1 hsstr5 ) are known to be overexpressed to some degree on various tumors , sstr 2 being the most important one . ^^^ Clinically used somatostatin based radiopeptides target exclusively sstr 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
METHODS : The expression of somatostatin receptor 2 ( SSTR 2 ) messenger RNA ( mRNA ) in human HCC cell line HepG ( 2 ) was examined by reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
OBJECTIVE : This study compared the potency of a somatostatin receptor ( sstr ) 2 sstr 5 analog , BIM 23244 , of an sstr 2 dopamine D 2 receptor ( sstr 2 DAD2 ) molecule , BIM 23A387 and of new somatostatin dopamine chimeric molecules with differing , enhanced affinities for sstr 2 , sstr 5 and DAD 2 , BIM 23A758 , BIM 23A760 and BIM 23A761 , to suppress GH and prolactin ( PRL ) from 18 human GH adenomas that are partially responsive to octreotide or lanreotide . ^^^ CONCLUSIONS : Novel dopamine somatostatin chimeric molecules with differing , enhanced activity at sstr 2 , sstr 5 and DAD 2 , consistently produced significatly greater suppression of GH and PRL than either octreotide or single receptor interacting ligands in tumors from patients classified as only partially responsive to octreotide therapy . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Medications targeting the somatostatin type 2 receptor ( SSTR 2 ) have been employed for pancreatic inflammations and cancers , possibly via the regulation of the transcription factor nuclear factor kappaB ( NFkappaB ) . ^^^ Although c Jun N terminal kinase and p 38 mitogen activated protein kinase ( MAPK ) were also stimulated by SSTR 2 , suppression of these two MAPKs was ineffective in altering the somatostatin mediated responses . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Transfection of SSTR 1 and SSTR 2 inhibits Panc 1 cell proliferation and renders Panc 1 cells responsive to somatostatin analogue . ^^^ Cell growth rate in Panc 1 cells transfected with SSTR 1 and SSTR 2 was inhibited about 41 % , and the cell proliferation of Panc 1 expressing SSTR 1 and SSTR 2 was further reduced about 12 % on treatment with somatostatin analogue as compared with the control group . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin receptor type 2 undergoes plastic changes in the human epileptic dentate gyrus . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin receptor subtype 2 ( SSTR 2 ) has been used as a reporter probe for gamma camera imaging of gene transfer in animal models . ^^^ The somatostatin analog Demotate 1 ( Tyr ( 3 ) octreotate conjugated to the 1 , 4 , 8 , 11 tetraazaundecane chelator ) was used for chelation of the positron emitter ( 94m ) Tc ( half life , 52 min ) and targeting to SSTR 2 . ^^^ CONCLUSION : These studies show that the positron emitting somatostatin analog ( 94m ) Tc Demotate 1 could be used to determine SSTR 2 gene transfer by microPET imaging , a result that will improve the sensitivity of the SSTR 2 reporter gene system . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
GIBLO displaced [ 125I ] TOC from somatostatin receptor subtype 2 ( SSTR 2 ) positive AR42J rat pancreatic tumor cell membranes with an IC 50 of 0 . 46 + / 0 . 05 nM suggesting that GIBLO retained affinity to SSTR 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Somatostatin receptor scintigraphy ( SRS ) has become a routine imaging method for the diagnostics of neuroendocrine tumours ( NET ) . ( 99m ) Tc EDDA / HYNIC octreotate ( Polatom , Poland ) is a new radiotracer with high affinity for SSTR 2 and similar physiological biodistribution to ( 111 ) In Octreoscan . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Immunohistochemical analysis in tissue specimens showed a strong membrane immunoreactivity for somatostatin receptors type 2 ( SSTR 2 ) in both the primary nodule and the metastases . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We report the comparative efficacy of a somatostatin receptor 1 and 5 subtypes ( SSTR 2 and SSTR 5 ) , and dopamine D 2 ( DAD 2 ) compound , BIM 23A760 , in suppressing GH secretion , in cell culture from human GH secreting tumors , from patients partially responsive to long term treatments with octreotide or lanreotide . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In vitro studies using human pituitary adenoma cells demonstrate a more profound inhibition of GH , PRL and ACTH secretion by somatostatin analogs targeting both SSTR2s and SSTR5s , compared with SSTR 2 preferential somatostatin analogs . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Resistance to currently available somatostatin analogs in some patients may be due to reduced density of SSTR 2 on the tumors of these patients . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Moreover , new molecules with selective activity on the somatostatin receptor type 2 , or 5 , or 1 have been reported in vitro to strongly suppress GH secretion . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Tumors and metastases bearing the somatostatin receptor subtypes 2 ( SSTR 2 ) or SSTR 5 can be visualized in vivo after injection of radiolabeled octapeptide somatostatin analogs like 111In pentetreotide . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We used a real time PCR set up to quantify whole pituitary mRNA expression of the beta subunit of thyrotrophin ( TSH beta ) , type 1 thyrotrophin releasing hormone receptor ( TRH R 1 ) , corticotrophin releasing hormone receptors ( CRH R 1 and CRH R 2 ) and somatostatin subtype receptor 2 ( SSTR 2 ) on every day of the last week of embryonic development , including the day of hatch and the first day of posthatch life . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The inhibition of metastatic progression of Somatostatin receptor type 2 ( SSTR 2 ) gene transfection mediated by adenovirus in human pancreatic carcinoma cells and the mechanisms involved in this effect were studied . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Tumor DNA was employed to evaluate two quantitative PCR methods : the HER2 / neu DNA Quantification Kit ( Roche Diagnostics GmbH , Germany ) , which uses the gastrin chromosome 17 reference gene , and our recently developed Oncolab qPCR assay , where both a chromosome 17 gene ( somatostatin receptor type 2 ( SSTR 2 ) ) and a non chromosome 17 reference gene ( glyceraldehyde 3 phosphate deshydrogenase ( GAPDH ) ) were used to detect an increase in HER 2 gene copy number and to evaluate the aneusomy of chromosome 17 , respectively . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The development of specific somatostatin subtypes analogs , mainly for SSTR 5 , of a SSTR 2 SSTR5 bispecific compound , and of a `` universal ' ' analog with high affinity to SSTR 1 , 2 , 3 , and 5 showed preliminary , albeit promising results for the treatment of resistant somatotropic adenomas . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We sought to test this by functionally expressing two medically important mammalian GPCRs , somatostatin receptor 2 ( Sstr 2 ) and chemokine receptor 5 ( CCR 5 ) in the gustatory neurons of C . elegans . ^^^ RESULTS : Expression of Sstr 2 and CCR 5 in gustatory neurons allow C . elegans to specifically detect and respond to somatostatin and MIP 1alpha respectively in a robust avoidance assay . ^^^ In structure function studies using a panel of somatostatin 14 analogues , we identified key residues involved in the interaction of somatostatin 14 with Sstr 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
This implies that SST analogs like SMS 201 995 , known to interact with SSTR2A , but not with SSTR 1 , act on pituitary tumors mainly via the SSTR 2 subtype . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
SSTR 2 gives rise to spliced variants , SSTR2A and 2B . hSSTR 1 4 display weak selectivity for SST 14 binding whereas hSSTR 5 is SST 28 selective . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
SSTR 2 SSTR5 , but not SSTR 1 coupled efficiently to the activation of GIRK currents when stimulated by SST 14 or SST 28 . ^^^ A comparison of the dose response curves and of the maximum currents obtained indicates that SSTR 2 couples most efficiently to this effector , supporting the notion that SSTR 2 is involved in activation of potassium conductances by SST in vivo . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Specific high affinity receptors for SST were found on Dunning R 3327 AT 1 tumor membranes by radioligand binding assay and were identified by reverse transcription PCR as SSTR 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In vitro data also demonstrated absence of SSTR 2 expression , suggesting pancreatic cancer not to be a potential target for treatment with SST analogues . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Five distinct membrane receptors ( SSTR 1 5 ) for SST are known , and at least two ( SSTR 2 and SSTR 5 ) have been proposed to regulate pancreatic endocrine function . ^^^ In conclusion , our data demonstrate that SST inhibition of glucagon release in mouse islets is primarily mediated via SSTR 2 , whereas insulin secretion is regulated primarily via SSTR5 . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The expression of messenger ribonucleic acid ( mRNA ) for SST receptor subtype 1 ( SSTR 1 ) , subtype 2 ( SSTR 2 ) , and subtype 5 ( SSTR 5 ) was also investigated in 22 samples by RT PCR . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In the present study , we have assessed the role of a series of SST analogs , three of which were selective for SSTR 1 , SSTR 2 or SSTR 5 , in these cellular events . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We have recently demonstrated that hematopoietic precursors express SSTR 2 and that SST is a chemoattractant for these cells . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Despite the presence of SSTR 4 , bone marrow cells from SSTR 2 deficient mice failed to migrate toward SST gradients , suggesting that SSTR 2 and SSTR 4 are functionally different in this respect . ^^^ SST activated phosphatidylinositol 3 kinase and the MAP kinases Erk1 / 2 and p 38 in 32D [ SSTR 2 ] cells . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The evidence of the expression of SSTRs , mainly of SSTR 2 , in this series of specimens we analyzed altogether with in vitro antiproliferative effects of SST may open interesting perspectives for the diagnosis and the therapy of meningiomas . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
SST inhibited NO production stimulated by bFGF through SST receptor 1 ( SSTR 1 ) , SSTR 2 , and SSTR 3 and by CCK through SSTR 2 and SSTR 3 . ^^^ SSTR 2 and 3 on CCK activity were related to the inhibition of intracellular Ca++ mobilization , whereas the lack of effects on insulin was paralleled by the absence of SST activity on Akt phosphorylation . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
RESULTS : Without TNF alpha treatment , HCAECs showed mRNA expression of SST , SSTR 1 , SSTR 2 , and SSTR 5 . ^^^ After treatment with TNF alpha , the mRNA levels of SST , SSTR 1 , SSTR 2 , and SSTR 5 were significantly reduced in a dose dependent fashion . ^^^ TNF alpha ( 1 ng / ml ) reduced SST , SSTR 1 , SSTR 2 , and SSTR 5 by 93 , 51 , 85 , and 99 % , respectively , compared to controls ( P < 0 . 001 , t test ) . ^^^ CONCLUSIONS : HCAECs express SST , SSTR 1 , SSTR 2 , and SSTR 5 , which are all decreased by TNF alpha treatment . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
Characterization of somatostatinergic ( sst ) neuronal activity through the application of nonpeptidyl agonists L 779 , 976 and L 817 , 818 which are highly specific for the sst receptors ( sstr ) sstr ( 2 ) and sstr ( 5 ) , respectively , shows for the first time that sstr 2 , 5 like subtypes are the two major sstr subtypes operating in the brain of the teleost sea wrasse , Coris julis . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
SST and SSTR 2 polymorphisms showed weak but statistically significant associations with breast cancer risk . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
We investigated single nucleotide polymorphisms ( SNPs ) in the GHRH , GHRHR , GHRL , GHSR , SST and SSTR 2 gene regions in a Polish and a German cohort of 798 breast cancer cases and 1011 controls . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
In rodents , SST inhibits the release of glucagon , but not that of insulin , via SSTR 2 . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
The activation of SHP 1 , which is attributed to the SSTR 2 receptor and negatively regulates the EGF receptor , corresponds with the ability of cCD 2 to inhibit the EGF induced MAPK activation in COS 7 cells . ( 7 ) Our results show that in SH SY5Y cells cCD 2 inhibits cell growth via the SSTR 1 receptor signalling pathway but may , in other cells , also use other SSTR subtypes and their signalling mechanisms . ( 8 ) cCD 2 represents a novel type of opioid derived antiproliferative SST receptor agonist , which possesses low mu receptor affinity but may induce mu receptor sensitization and is structurally different from the hitherto known SST receptor agonists . . ^^^
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
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Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA
Interacting proteins: P61278 and P30874	Pubmed	SVM Score :0.0
NA