| Interacting proteins: Q96CV9 and P61006 |
Pubmed |
SVM Score :0.0 |
| Optineurin also functions through its interactions with other proteins in cellular morphogenesis and membrane trafficking ( RAB 8 ) , vesicle trafficking ( Huntingtin ) , transcription activation ( TFIIIA ) , and assembly or activity of two unknown kinases . ^^^ |
|
| Interacting proteins: Q96CV9 and P61006 |
Pubmed |
SVM Score :0.0 |
| Two further binding partners for optineurin have been identified : huntingtin and Rab 8 . ^^^ |
|
| Interacting proteins: Q96CV9 and P61006 |
Pubmed |
SVM Score :0.0 |
| Optineurin increases cell survival and translocates to the nucleus in a Rab 8 dependent manner upon an apoptotic stimulus . ^^^ This translocation is dependent on the GTPase activity of Rab 8 , an interactor of optineurin . ^^^ |
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| Interacting proteins: Q96CV9 and P61006 |
Pubmed |
SVM Score :0.0 |
| The OPTN gene codes for a conserved 66 kilodalton protein of unknown function that has been implicated in the tumor necrosis factor alpha signaling pathway and that interacts with diverse proteins including Huntingtin , Ras associated protein RAB 8 , and transcription factor IIIA . ^^^ |
|
| Interacting proteins: Q96CV9 and P61006 |
Pubmed |
SVM Score :0.0 |
| FIP 2 , a coiled coil protein , links Huntingtin to Rab 8 and modulates cellular morphogenesis . ^^^ Here , we report that Huntingtin is linked to the Rab 8 protein through FIP 2 , a tumour necrosis factor alpha ( TNF alpha ) inducible coiled coil protein related to the NEMO protein [ 6 , 7 ] . ^^^ The activated form of Rab 8 interacted with the amino terminal region of FIP 2 , whereas dominant negative Rab 8 did not . ^^^ Coexpressed FIP 2 and Huntingtin enhanced the recruitment of Huntingtin to Rab 8 positive vesicular structures , and FIP 2 promoted cell polarisation in a similar way to Rab 8 . ^^^ We propose a model in which Huntingtin , together with FIP 2 and Rab 8 , are part of a protein network that regulates membrane trafficking and cellular morphogenesis . . ^^^ |
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| Interacting proteins: Q96CV9 and P61006 |
Pubmed |
SVM Score :0.0 |
| Extensive amino acid sequence similarity indicates that Ag 9C5 is likely the chicken homologue of a human protein , FIP 2 , which interacts with huntingtin and Rab 8 . ^^^ |
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