| Interacting proteins: P60891 and Q14558 |
Pubmed |
SVM Score :0.0 |
| The deduced amino acid sequence of PAP 39 is remarkably similar to those of PRS 1 and PRS 2 . ^^^ |
|
| Interacting proteins: P60891 and Q14558 |
Pubmed |
SVM Score :0.0 |
| Excluding two regions ( about 45 residues in total ) , PAP 39 has a 48 % identity with PRS 1 . ^^^ Northern analysis detected a major 1 . 9 kilobase transcript in all 16 rat tissues examined , and the relative amounts of PAP 39 mRNA to PRS 1 mRNA varied with tissues . ^^^ |
|
| Interacting proteins: P60891 and Q14558 |
Pubmed |
SVM Score :0.0 |
| Human PRS exists as complex aggregates composed of the 34 kDa catalytic subunits ( PRS 1 and PRS 2 ) and other 39 kDa component designated PRPP synthetase associated protein ( PAP 39 ) . ^^^ |
|
| Interacting proteins: P60891 and Q14558 |
Pubmed |
SVM Score :0.0 |
| Rat liver phosphoribosylpyrophosphate synthetase is a complex aggregate of 34 kDa catalytic subunits ( PRS 1 and 2 ) and 39 and 41 kDa associated proteins ( PAP 39 and 41 ) . ^^^ |
|
| Interacting proteins: P60891 and Q14558 |
Pubmed |
SVM Score :0.0 |
| The enzyme complex was then partially reconstituted in situ by coexpression of PAP 39 with PRS 1 or PRS 2 in E . coli cells . ^^^ PAP 39 complexed with PRS 1 was more readily degraded by proteolysis than seen with PRS 2 , in vivo and in vitro . ^^^ |
|
| Interacting proteins: P60891 and Q14558 |
Pubmed |
SVM Score :0.0 |
| The deduced amino acid sequence exhibits the 98 . 9 % identity to rat PAP 41 and 72 . 2 , 50 . 6 , and 50 . 0 % identity with human PAP 39 , PRS 1 , and PRS 2 , respectively , but lacks the PRPP binding site . ^^^ |
|
| Interacting proteins: P60891 and Q14558 |
Pubmed |
SVM Score :0.0 |
| The rat liver enzyme is a complex aggregate of two highly homologous catalytic subunits ( PRS 1 and PRS 2 ) and two associated proteins ( PAP 39 and PAP 41 ) . ^^^ |
|
| Interacting proteins: P60891 and Q14558 |
Pubmed |
SVM Score :0.0 |
| PRPP synthetase from rat liver exists as large molecular weight aggregates composed of at least four different components , i . e . , two isoforms of 34 kDa catalytic subunits , PRSI and PRSII , and two associated proteins of 39 kDa and 41 kDa ( PAP 39 and PAP 41 ) . ^^^ |
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