| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Regulation of phosphoinositide metabolism , Akt phosphorylation , and glucose transport by PTEN ( phosphatase and tensin homolog deleted on chromosome 10 ) in 3T3 L 1 adipocytes . ^^^ To investigate the roles of PTEN ( phosphatase and tensin homolog deleted on chromosome 10 ) in the regulation of 3 position phosphorylated phosphoinositide metabolism as well as insulin induced Akt phosphorylation and glucose metabolism , wild type PTEN and its phosphatase dead mutant ( C124S ) with or without an N terminal myristoylation tag were overexpressed in Sf 9 cells and 3T3 L 1 adipocytes using baculovirus and adenovirus systems , respectively . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| TUNEL staining was used to analyze the cytotoxicity of TNFalpha treatment or TNFalpha combined with either the Akt activity inhibitor wortmannin , an adenovirus expressing dominant negative mutant ( AdAkt DN ) , or an adenovirus expressing phosphatase and tensin homolog deleted on chromosome 10 ( AdPTEN ) . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| A heterologous COS 7 cell system was used to examine the roles played by PI 3 kinase and the dual specificity phosphatase , phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) , in the signal transduction pathway leading to Fcgamma receptor IIA mediated phagocytosis and the activation of Rac . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| The PTEN / MMAC1 / TEP1 gene ( phosphatase and tensin homolog deleted on chromosome 10 / mutated in multiple advanced cancers / TGF beta regulated and epithelial cell enriched phosphatase 1 ) , which regulates the signaling pathways of Akt , is a novel tumor suppressor gene implicated in multiple cancers . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| In addition , mutations in the phosphatase and tensin homolog deleted on chromosome ten ( PTEN ) , one of the most frequently mutated tumor suppressor genes , results in elevated PKB activity . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| OBJECT : The phosphatase and tensin homolog deleted from chromosome 10 ( PTEN ) functions as a tumor suppressor by negatively regulating the growth / survival signals of the phosphatidylinositol 3 kinase ( PI 3 K ) / Akt pathway . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| In addition , ethanol exposure significantly reduced the levels of total phosphoinositol 3 kinase , Akt kinase , phospho BAD ( inactive ) , and glyceraldehyde 3 phosphate dehydrogenase and increased the levels of glycogen synthase kinase 3 activity , activated BAD , phosphatase and tensin homolog deleted in chromosome 10 ( PTEN ) protein , and PTEN phosphatase activity in cerebellar tissue . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| On the contrary , MDA 468 cells lack the phosphatase and tensin homolog ( PTEN ) , potentially setting Akt activity at a high threshold that is unresponsive to EGFR inhibition alone . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Several studies have suggested that the AKT mediated survival signaling pathway is an attractive target for cancer chemotherapy : ( 1 ) the AKT pathway is relatively inactive in resting cells ; ( 2 ) amplification of the AKT gene occurs in some tumors ; ( 3 ) loss of the tumor suppressor gene PTEN ( phosphatase and tensin homolog deleted on chromosome 10 ) is common in tumors and its loss constitutively activates AKT ; ( 4 ) AKT is activated at the cancer invasion front . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Studies of a parallel transduction pathway downstream from 5 HT1A receptor activation demonstrated a decrease in the activity of phosphatidylinositol 3 kinase and its downstream effector Akt , as well as an increase in PTEN ( phosphatase and tensin homolog deleted on chromosome 10 ) , the phosphatase that hydrolyzes phosphatidylinositol 3 , 4 , 5 triphosphate . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Furthermore , upregulation of the PI3K Akt pathway in mutant mice lacking phosphatase and tensin homolog , a lipid phosphatase counteracting PI3K , selectively enhanced chronic desensitization in a PI3K and MAPK dependent manner . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| These two growth factors stimulated a survival signaling pathway phosphatidylinositol 3 kinase ( PI3K ) , as identified by increased Akt phosphorylation and because blocking PI3K signalling by adenovirus mediated overexpression of wild type phosphatase and tensin homolog on chromosome 10 ( PTEN ) disrupted angiogenesis and decreased Bcl 2 expression by PlGF and PlGF / VEGF heterodimer , whereas a dominant negative PTEN mutant enhanced endothelial sprout formation and Bcl 2 expression . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : In advanced stages of prostate cancer , the phosphatidylinositol 3 ' kinase ( PI3K ) / Akt signaling cascade , one of the major survival pathways in the cell , is frequently constitutively activated due to mutation or loss of the tumor suppressor protein phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| In line with these results , 17 beta estradiol significantly increased Akt and cyclic AMP response element binding protein ( CREB ) with increased Bcl 2 protein in the ischemic area , whereas the elevated the phosphatase and tensin homolog deleted from chromosome 10 ( PTEN ) phosphorylation was significantly reduced with decreased Bax protein and cytochrome c release . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| This article reviews the control of Akt activation by the opposing actions of the oncogene phosphoinositide 3 kinase ( PI 3 K ) and the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide 3 kinase ( PI 3 kinase ) in the PI 3 kinase / Akt pathway . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| The ability of HGF / SF to activate NF kappaB signaling was dependent on c Akt > Pak 1 ( p 21 associated kinase 1 ) signaling ( with Pak 1 downstream of c Akt ) and was inhibited by the tumor suppressor PTEN ( phosphatase and tensin homolog ) . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| To ascertain whether the PTEN ( phosphatase and tensin homolog deleted on chromosome 10 ) / Akt signaling pathway is activated during ischemic brain injury , we investigated the expression and phosphorylation of PTEN and Akt by immunohistochemistry in the rat hippocampus after transient forebrain ischemia . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| PTEN ( phosphatase and tensin homolog deleted on chromosome 10 ) negatively regulates Akt activation . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| The clinical significance of phosphatase and tensin homolog deleted on chromosome ten ( PTEN ) protein expression and the correlation between the expression of PTEN and phosphorylation of protein kinase B ( PKB / AKT ) in human hepatocellular carcinoma ( HCC ) were investigated . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Here we present evidence that ceramide recruits the tumor suppressor PTEN ( phosphatase and tensin homolog deleted from chromosome 10 ) into membrane microdomains ( rafts ) , where it could act to reduce the levels of polyphosphoinositides necessary for the activation of Akt . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Overexpression of adenoviral constructs encoding dominant negative Akt kinase downstream of PI3K or wild type phosphatase and tensin homolog deleted on chromosome 10 , an important PI3K phosphatase , suppresses COX 2 mRNA expression induced by Zn2+ . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Papilloma cells overexpress the EGFR and have constitutively active extracellular signal regulated kinase ( ERK ) and enhanced phosphatidylinositol 3 kinase ( PI3K ) activity , but overexpression of the lipid phosphatase PTEN ( Phosphatase and Tensin Homolog ) reduces activation of Akt by PI3K . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Glioblastomas frequently carry genetic alterations resulting in an aberrant activation of the phosphoinositol 3 kinase ( Pi3k ) / protein kinase B ( Akt ) signalling pathway , including most notably phosphatase and tensin homolog ( PTEN ) mutation , epidermal growth factor receptor ( EGFR ) amplification and rearrangement , as well as carboxyl terminal modulator protein ( CTMP ) hypermethylation [ Knobbe et al . , ( 2004 ) Hypermethylation and transcriptional downregulation of the carboxyl terminal modulator protein gene in glioblastomas . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| PTEN ( phosphatase and tensin homolog deleted on chromosome 10 ) is a negative regulator of the oncogenic PI 3 K / Akt signaling pathway . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| A most notable finding is that tumorigenesis is accompanied by inactivation of phosphatase and tensin homolog deleted on chromosome 10 ( Pten ) , activation of AKT , fast proliferation and nuclear accumulation of cyclin D 1 . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Activation of the PI3K Akt pathway by loss of tumor suppressor PTEN ( phosphatase and tensin homolog deleted on chromosome 10 ) function , increased growth factor signaling , or oncogene expression renders cancer cells resistant to apoptotic signals and promotes tumor growth . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Akt is activated by growth factors via a phosphorylation dependent pathway involving the kinases phosphoinositide 3 ( PI 3 ) kinase and phosphoinositide dependent protein kinase 1 ( PDK 1 ) and is negatively regulated by phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Human cytomegalovirus inhibits Akt mediated eNOS activation through upregulating PTEN ( phosphatase and tensin homolog deleted on chromosome 10 ) . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Constitutively active mutants of Ras , PI3K , and Akt , or RNA interference ( RNAi ) knockdown of lipid phosphatase PTEN ( phosphatase and tensin homolog deleted on chromosome Ten ) , induced growth and elaboration of dendrites that was blocked by mTOR inhibitor rapamycin and / or by overexpression of eIF 4E binding protein 1 ( 4E BP 1 ) , which inhibits translation of 5 ' capped mRNAs . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) has been implicated in regulating cell survival signaling through the phosphoinositide 3 kinase ( PI3K ) / Akt pathway . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Given that Akt and Skp 2 proteins are highly activated in human cancers due to the loss of phosphatase and tensin homolog ( PTEN ) , deregulation of the FOXO 1 protein appears to be a promising target for future drug discovery and cancer therapy . . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Previous studies showed that MDM 2 is an oncoprotein that controls tumorigenesis through both p 53 dependent and p 53 independent mechanisms , and tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) , a dual specificity phosphatase that antagonizes phosphatidylinositol 3 kinase ( PI 3K ) / AKT signaling , is capable of blocking MDM 2 nuclear translocation and destabilizing the MDM 2 protein . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| We demonstrated that tyrosine phosphorylation of the phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) underlies the increased Akt Ser 473 phosphorylation by orthovanadate . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Both immortalized oligodendrocytes and SNB 19 glioblastoma cells were transfected with siRNA constructs for phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) or Akt / protein kinase B ( Akt ) . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| Apparent pKB and pA 2 analysis may prove useful for elucidating receptor mechanisms involved in the behavioral effects of BZs . . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| The lipid phosphatase activity of MMAC 1 results in decreased activation of the PIP 3 dependent , anti apoptotic kinase , AKT . ^^^ Lastly , we demonstrate that AKT 3 , an isoform of AKT highly expressed in the brain , is also a target for MMAC 1 repression . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| PTEN / MMAC 1 is a tumor suppressor that dephosphorylates phosphatidylinositol 3 , 4 , 5 triphosphate , an intermediate in the PI 3 K / Akt signaling pathway . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| By contrast , limiting the activation of Akt , either by inhibiting phosphatidylinositol 3 kinase or by ectopic expression of the phospholipid phosphatase MMAC 1 , results in a significant increase in the percentage of apoptotic cells after BCR cross linking . ^^^ |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60484 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|