| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| TRAM interacts with TRIF , MyD 88 adaptor like protein ( Mal ) / TIRAP , and TLR 4 but not with TLR 3 . ^^^ |
|
| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| TIR domain containing adaptors , such as MyD 88 , TIRAP , TRIF , and TRAM , play pivotal roles in TLR signaling pathways . ^^^ |
|
| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| Three such adapter proteins have been discovered to date , and have been named MyD 88 , Mal [ MyD 88 adapter like ; also known as TIRAP ( TIR domain containing adapter protein ) ] and Trif ( TIR domain containing adapter inducing interferon beta ) . ^^^ |
|
| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| TLR 3 is associated with a TIR domain containing adapter protein TRIF , which activates distinct downstream pathways leading to activation of NF kappaB and ISRE sites in the promoters of type 1 IFNs . ^^^ |
|
| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the control of apoptosis by the TIR domain containing adapter proteins MyD 88 , TIR domain containing adapter protein ( TIRAP ) , TIR domain containing adapter inducing IFN beta ( TRIF ) , TRIF related adapter molecule ( TRAM ) , and sterile alpha motifs and beta catenin / armadillo repeats ( SARM ) . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| We designed a set of `` blocking peptides ' ' ( BPs ) comprised of the 14 aa that correspond to the sequences of the BB loops of the four known Toll IL 1 resistance ( TIR ) domain containing adapter proteins ( i . e . , MyD 88 , TIR domain containing adapter inducing IFN beta ( TRIF ) , TRIF related adapter molecule ( TRAM ) , and TIR domain containing adapter protein ( TIRAP ) ) linked to the cell penetrating segment of the antennapedia homeodomain . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| The resulting predictions show the presence of one or more counterparts for the human TLR 1 , TLR 2 , TLR 3 , TLR 4 , TLR 5 , TLR 7 , TLR 8 , TLR 9 , IL 1R and IL 18R genes and one copy of the adaptor genes MyD 88 , MAL , TRIF and SARM . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| In this study we show that SV induces IFN alphabeta gene expression normally in cells from mice with targeted deletions of the Toll IL 1 resistance domain containing adapters MyD 88 , Mal , Toll / IL 1R domain containing adaptor inducing IFN beta ( TRIF ) , and TRIF related adaptor molecule TLR 3 , or the E 3 ubiquitin ligase , TNFR associated factor 6 . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| As is the case in MyD 88 and TIRAP , overexpression of TRIF activated the NF kappaB dependent promoter . ^^^ Furthermore , TRIF , but neither MyD 88 nor TIRAP , activated the IFN beta promoter . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| All of the TLRs use the adaptor MyD 88 to transduce a signal ; however , two newly identified signaling molecules , TIRAP and TRIF , interact with a subset of the TLRs , suggesting a signaling specificity that may be relevant to the type of infection . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| Hence , in LPS signaling TLR 4 recruits two types of adapters , TIRAP and TICAM 2 , to its cytoplasmic domain that are indirectly connected to two effective adapters , MyD 88 and TICAM 1 , respectively . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| Recognition of pathogens by Toll like receptors ( TLRs ) triggers innate immune responses through signaling pathways mediated by Toll interleukin 1 receptor ( TIR ) domain containing adaptors such as MyD 88 , TIRAP and TRIF . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| Recent accumulating evidence has demonstrated that TIR domain containing adaptors , such as MyD 88 , TIRAP , and TRIF , modulate TLR signaling pathways . ^^^ TIRAP is specifically involved in the MyD 88 dependent pathway via TLR 2 and TLR 4 , whereas TRIF is implicated in the TLR 3 and TLR 4 mediated MyD 88 independent pathway . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| Recognition of pathogens by Toll like receptors ( TLRs ) triggers innate immune responses via signaling pathways mediated by several Toll / IL 1R ( TIR ) domain containing adaptors such as MyD 88 , TIRAP , and TRIF . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| A group of TIR domain containing adaptors ( MyD 88 , TIRAP , TRIF and TRAM ) , are differentially recruited to the Toll IL 1 receptors , contributing to the specificity of signaling . ^^^ LPS induced , TLR 4 mediated signaling employs multiple TIR domain containing adaptors , MyD88 / TIRAP to mediate NFkappaB activation , TRIF / TRAM for IRF 3 activation . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| Stimulation of TLR 5 and overexpression of MyD 88 , but not TRIF , TIRAP , or TRAM , result in p 27 degradation , which can be suppressed by dominant negative Akt and mutation of the p 27 C terminal Thr ( 187 ) site . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| Mycobacterial heat shock protein 65 induced NF kappaB activation was MyD 88 , TIRAP , TRIF , and TRAM dependent and required the presence of MD 2 . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| Furthermore , TIR domain containing adaptors , such as MyD 88 , TRIF , TIRAP and TRAM , play essential roles in TLR signaling . ^^^ |
|
| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of many TLR related genes ( ICAM 1 , CD 14 , MyD 88 , LY 96 , TRIF , TICAM 2 , TIRAP , CD 83 , SOCS 1 , TNFAIP 3 , TOLLIP , IRAK 1 , IRAK 2 , IRAK 4 , and TRAF 6 ) was successfully detected in all of the tissues and cell lines . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| In TLR signaling pathways , Toll / IL 1 receptor ( TIR ) domain containing adaptors , such as MyD 88 , TIRAP , TRIF , and TRAM , have been shown to play pivotal roles . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| IL 21 weakly induced the expression Toll like receptor 4 ( TLR 4 ) and translation initiation region ( TIR ) domain containing adaptor protein ( TIRAP ) genes , whereas the expression of TIR domain containing adaptor inducing IFN beta ( TRIF ) , myeloid differentiation ( MyD 88 ) 88 factor , or TRIF related adaptor molecule ( TRAM ) genes remained unchanged . ^^^ |
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| Interacting proteins: P58753 and Q8IUC6 |
Pubmed |
SVM Score :0.0 |
| The goal of this study was to clone and sequence the full length coding regions of bovine genes involved in TLR 4 signaling including CASP 8 , IRAK 1 , LY 96 ( MD 2 ) , TICAM 2 , TIRAP , TOLLIP and TRAF 6 and to position these genes , as well as MyD 88 and TICAM 1 , on the bovine genome using radiation hybrid mapping . ^^^ |
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