| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| In this report , we identified a novel TIR domain containing adapter protein designated as TIRP . ^^^ |
|
| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| TRAM interacts with TRIF , MyD 88 adaptor like protein ( Mal ) / TIRAP , and TLR 4 but not with TLR 3 . ^^^ |
|
| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| TIR domain containing adaptors , such as MyD 88 , TIRAP , TRIF , and TRAM , play pivotal roles in TLR signaling pathways . ^^^ |
|
| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the control of apoptosis by the TIR domain containing adapter proteins MyD 88 , TIR domain containing adapter protein ( TIRAP ) , TIR domain containing adapter inducing IFN beta ( TRIF ) , TRIF related adapter molecule ( TRAM ) , and sterile alpha motifs and beta catenin / armadillo repeats ( SARM ) . ^^^ |
|
| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| We designed a set of `` blocking peptides ' ' ( BPs ) comprised of the 14 aa that correspond to the sequences of the BB loops of the four known Toll IL 1 resistance ( TIR ) domain containing adapter proteins ( i . e . , MyD 88 , TIR domain containing adapter inducing IFN beta ( TRIF ) , TRIF related adapter molecule ( TRAM ) , and TIR domain containing adapter protein ( TIRAP ) ) linked to the cell penetrating segment of the antennapedia homeodomain . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| Three such adapter proteins have been discovered to date , and have been named MyD 88 , Mal [ MyD 88 adapter like ; also known as TIRAP ( TIR domain containing adapter protein ) ] and Trif ( TIR domain containing adapter inducing interferon beta ) . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| TIR domain containing adapter protein ( TIRAP ) / MyD88 adapter like , a second adapter harboring the TIR domain , is essential for MyD 88 dependent TLR 2 and TLR 4 signaling pathways , but not for MyD 88 independent pathways . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| After stimulation with LPS or LTA , a 1 . 5 4 . 2 fold up regulation of TLRs ( 2 , 3 , 4 , 6 , 7 ) and elements of the signaling cascade ( MyD 88 , TIR domain containing adapter protein [ TIRAP ] ) was observed . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| In its structural features , TICAM 2 resembled Mal / TIRAP , an adapter that links TLR2 / 4 and MyD 88 . ^^^ Hence , in LPS signaling TLR 4 recruits two types of adapters , TIRAP and TICAM 2 , to its cytoplasmic domain that are indirectly connected to two effective adapters , MyD 88 and TICAM 1 , respectively . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| TIRAP specifically participates in the MyD 88 dependent pathways shared by TLR 2 and TLR 4 , and TRAM is essential for the TLR 4 mediated MyD 88 independent pathway . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| A group of TIR domain containing adaptors ( MyD 88 , TIRAP , TRIF and TRAM ) , are differentially recruited to the Toll IL 1 receptors , contributing to the specificity of signaling . ^^^ LPS induced , TLR 4 mediated signaling employs multiple TIR domain containing adaptors , MyD88 / TIRAP to mediate NFkappaB activation , TRIF / TRAM for IRF 3 activation . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| Stimulation of TLR 5 and overexpression of MyD 88 , but not TRIF , TIRAP , or TRAM , result in p 27 degradation , which can be suppressed by dominant negative Akt and mutation of the p 27 C terminal Thr ( 187 ) site . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| Furthermore , TIR domain containing adaptors , such as MyD 88 , TRIF , TIRAP and TRAM , play essential roles in TLR signaling . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of many TLR related genes ( ICAM 1 , CD 14 , MyD 88 , LY 96 , TRIF , TICAM 2 , TIRAP , CD 83 , SOCS 1 , TNFAIP 3 , TOLLIP , IRAK 1 , IRAK 2 , IRAK 4 , and TRAF 6 ) was successfully detected in all of the tissues and cell lines . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| In TLR signaling pathways , Toll / IL 1 receptor ( TIR ) domain containing adaptors , such as MyD 88 , TIRAP , TRIF , and TRAM , have been shown to play pivotal roles . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| IL 21 weakly induced the expression Toll like receptor 4 ( TLR 4 ) and translation initiation region ( TIR ) domain containing adaptor protein ( TIRAP ) genes , whereas the expression of TIR domain containing adaptor inducing IFN beta ( TRIF ) , myeloid differentiation ( MyD 88 ) 88 factor , or TRIF related adaptor molecule ( TRAM ) genes remained unchanged . ^^^ |
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| Interacting proteins: P58753 and Q86XR7 |
Pubmed |
SVM Score :0.0 |
| The goal of this study was to clone and sequence the full length coding regions of bovine genes involved in TLR 4 signaling including CASP 8 , IRAK 1 , LY 96 ( MD 2 ) , TICAM 2 , TIRAP , TOLLIP and TRAF 6 and to position these genes , as well as MyD 88 and TICAM 1 , on the bovine genome using radiation hybrid mapping . ^^^ |
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