| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| TRAM interacts with TRIF , MyD 88 adaptor like protein ( Mal ) / TIRAP , and TLR 4 but not with TLR 3 . ^^^ |
|
| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| TIRAP specifically participates in the MyD 88 dependent pathways shared by TLR 2 and TLR 4 , and TRAM is essential for the TLR 4 mediated MyD 88 independent pathway . ^^^ |
|
| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| A group of TIR domain containing adaptors ( MyD 88 , TIRAP , TRIF and TRAM ) , are differentially recruited to the Toll IL 1 receptors , contributing to the specificity of signaling . ^^^ LPS induced , TLR 4 mediated signaling employs multiple TIR domain containing adaptors , MyD88 / TIRAP to mediate NFkappaB activation , TRIF / TRAM for IRF 3 activation . ^^^ |
|
| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| Stimulation of TLR 5 and overexpression of MyD 88 , but not TRIF , TIRAP , or TRAM , result in p 27 degradation , which can be suppressed by dominant negative Akt and mutation of the p 27 C terminal Thr ( 187 ) site . ^^^ |
|
| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the control of apoptosis by the TIR domain containing adapter proteins MyD 88 , TIR domain containing adapter protein ( TIRAP ) , TIR domain containing adapter inducing IFN beta ( TRIF ) , TRIF related adapter molecule ( TRAM ) , and sterile alpha motifs and beta catenin / armadillo repeats ( SARM ) . ^^^ |
|
| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| Furthermore , TIR domain containing adaptors , such as MyD 88 , TRIF , TIRAP and TRAM , play essential roles in TLR signaling . ^^^ |
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| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| We designed a set of `` blocking peptides ' ' ( BPs ) comprised of the 14 aa that correspond to the sequences of the BB loops of the four known Toll IL 1 resistance ( TIR ) domain containing adapter proteins ( i . e . , MyD 88 , TIR domain containing adapter inducing IFN beta ( TRIF ) , TRIF related adapter molecule ( TRAM ) , and TIR domain containing adapter protein ( TIRAP ) ) linked to the cell penetrating segment of the antennapedia homeodomain . ^^^ LPS ( TLR 4 ) mediated gene expression , as well as MAPK and transcription factor activation associated with both MyD 88 dependent and independent signaling pathways , were disrupted by all four BPs ( TRAM approximately MyD 88 > TRIF > TIRAP ) , but not by a control peptide . ^^^ |
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| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| In TLR signaling pathways , Toll / IL 1 receptor ( TIR ) domain containing adaptors , such as MyD 88 , TIRAP , TRIF , and TRAM , have been shown to play pivotal roles . ^^^ |
|
| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| TIR domain containing adaptors , such as MyD 88 , TIRAP , TRIF , and TRAM , play pivotal roles in TLR signaling pathways . ^^^ |
|
| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| IL 21 weakly induced the expression Toll like receptor 4 ( TLR 4 ) and translation initiation region ( TIR ) domain containing adaptor protein ( TIRAP ) genes , whereas the expression of TIR domain containing adaptor inducing IFN beta ( TRIF ) , myeloid differentiation ( MyD 88 ) 88 factor , or TRIF related adaptor molecule ( TRAM ) genes remained unchanged . ^^^ |
|
| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15629 and P58753 |
Pubmed |
SVM Score :0.0 |
| NA |
|