| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.64523753 |
| Mal associates with TLR 4 . 0.64523753^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.63238201 |
| Another adaptor , TIRAP ( also known as Mal ) , has been cloned as a molecule that specifically associates with TLR 4 and thus may be responsible for the MyD 88 independent response . 0.63238201^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| In the case of TLR 2 and TLR 4 , another adaptor related to MyD 88 called Mal also participates in signalling . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| TIRAP : how Toll receptors fraternize . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| TRAM interacts with TRIF , MyD 88 adaptor like protein ( Mal ) / TIRAP , and TLR 4 but not with TLR 3 . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| Toll IL 1R domain containing adaptor protein ( TIRAP ) is a key molecule in the TLR 4 and 2 signaling . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| Furthermore , co immunoprecipitation experiments revealed that Btk can also interact with key proteins involved in TLR 4 signal transduction , namely , MyD 88 , Mal ( MyD 88 adapter like protein ) , and interleukin 1 receptor associated kinase 1 , but not TRAF 6 . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| The Toll interleukin 1 receptor domain containing adapter Mal ( MyD 88 adapter like protein ) is involved in Toll like receptor ( TLR ) 2 and TLR 4 signal transduction . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| TIR domain containing adapter protein ( TIRAP ) / MyD88 adapter like , a second adapter harboring the TIR domain , is essential for MyD 88 dependent TLR 2 and TLR 4 signaling pathways , but not for MyD 88 independent pathways . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| TLR 4 induced IFN beta mRNA was MyD 88 and PKR ( double stranded RNA dependent protein kinase ) independent , but TIRAP ( Toll interleukin 1 receptor domain containing adapter protein ) dependent . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| These differences may be because of different signalling adapters , with MyD 88 being used by several TLRs , and the adapter MyD 88 adapter like ( Mal ) being recruited specifically by TLR 4 . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| Differences between signals generated by TLRs are emerging , with both TLR 4 and TLR 2 signalling requiring an additional adapter termed MyD 88 adapter like ( Mal ; also known as TIRAP ) . ^^^ In addition , structural models reveal marked differences in surface charges which , when taken with surface charge differences between TLR 2 and TLR 4 TIR domains , may indicate that TLR 4 but not TLR 2 recruits Mal directly . ^^^ |
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| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| To identify structural features that may contribute to the formation of signaling complexes , we produced models of the TIR domains from human Toll like receptor 4 ( TLR 4 ) , Mal , and MyD 88 . ^^^ Neither theoretical nor experimental data suggest a direct role for the conserved proline in the BB loop in the association of TLR 4 , Mal , and MyD 88 . ^^^ Structural complementarity of Toll / interleukin 1 receptor domains in Toll like receptors and the adaptors Mal and MyD 88 . ^^^ Finally we show a sequence relationship between the Drosophila protein Tube and Mal that may indicate a functional equivalence of these two adaptors in the Drosophila and vertebrate Toll pathways . . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| The resulting predictions show the presence of one or more counterparts for the human TLR 1 , TLR 2 , TLR 3 , TLR 4 , TLR 5 , TLR 7 , TLR 8 , TLR 9 , IL 1R and IL 18R genes and one copy of the adaptor genes MyD 88 , MAL , TRIF and SARM . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| We show here that the membrane bound form of ST 2 negatively regulated type 1 interleukin 1 receptor ( IL 1RI ) and Toll like receptor 4 ( TLR 4 ) but not TLR 3 signaling by sequestrating the adaptors MyD 88 and Mal . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| We have recently demonstrated that the membrane bound form of ST 2 ( ST2L ) negatively regulated IL 1RI and TLR 4 but not TLR 3 signaling by sequestrating the adaptors MyD 88 and Mal . ^^^ Thus , ST 2 suppresses IL 1R and TLR 4 signaling via MyD 88 and Mal dependent pathways and modulates innate immunity . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| The adaptor protein Mal is specifically involved in signaling via TLR 2 and TLR 4 . ^^^ We demonstrate here that after TLR 2 and TLR 4 stimulation Mal becomes phosphorylated by Bruton ' s tyrosine kinase ( Btk ) and then interacts with SOCS 1 , which results in Mal polyubiquitination and subsequent degradation . ^^^ |
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| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| MyD 88 adapter like ( Mal ) is phosphorylated by Bruton ' s tyrosine kinase during TLR 2 and TLR 4 signal transduction . ^^^ MyD 88 adapter like ( Mal ) is one such adapter that specifically is involved in TLR 2 and TLR 4 signaling . ^^^ Activation of THP 1 monocytic cells with the TLR 4 agonist LPS and the TLR 2 agonist macrophage activating lipopeptide 2 induced phosphorylation of Mal on tyrosine residues . ^^^ Our study therefore provides the first demonstration of the key role of Mal phosphorylation on tyrosine during signaling by TLR 2 and TLR 4 and identifies a novel function for Btk as the kinase involved . . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| We have identified and characterized a Toll interleukin 1 receptor ( TIR ) domain containing adapter protein ( TIRAP ) and have shown that it controls activation of MyD 88 independent signaling pathways downstream of TLR 4 . ^^^ TIRAP : an adapter molecule in the Toll signaling pathway . ^^^ |
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| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| TLR 4 , but not TLR 2 , agonists can induce IFN beta expression via a mechanism that requires the adapter protein Toll IL 1R domain containing adapter protein ( TIRAP ) / myeloid differentiation protein 88 ( MyD 88 ) adapter like ( Mal ) , but not the adapter protein MyD 88 . ^^^ TLR 4 dependent induction of IL 6 expression did require Toll IL 1R domain containing adapter protein ( TIRAP ) / MyD88 adapter like ( Mal ) , but unlike iNOS and IP 10 , it did not require the expression of IFN beta . ^^^ Toll like receptor 4 and Toll IL 1 receptor domain containing adapter protein ( TIRAP ) / myeloid differentiation protein 88 adapter like ( Mal ) contribute to maximal IL 6 expression in macrophages . ^^^ |
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| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| TIRAP , an adaptor protein in the TLR signalling pathway , has been identified and shown to function downstream of TLR 4 ( refs 4 , 5 ) . ^^^ TIRAP deficient mice respond normally to the TLR 5 , TLR 7 and TLR 9 ligands , as well as to IL 1 and IL 18 , but have defects in cytokine production and in activation of the nuclear factor NF kappaB and mitogen activated protein kinases in response to lipopolysaccharide , a ligand for TLR 4 . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| The adaptor proteins MyD 88 and TIRAP contribute to the activation of several and possibly all pathways via direct interactions with TLR 4 ' s Toll / interleukin 1 receptor ( IL 1R ) ( TIR ) domain . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| TLR 4 induced IFN beta mRNA was found to be MyD 88 and PKR ( double stranded RNA dependent protein kinase ) independent , but TIRAP ( Toll / interleukin 1 receptor domain containing adapter protein ) / Mal ( MyD 88 adapter like ) dependent . ^^^ In the present paper , we outline the recent controversy over the role of TIRAP / Mal in TLR 2 and TLR 4 signalling in the context of the current molecular tools used for such studies . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| Although MyD 88 and Mal / TIRAP adapters functions downstream of TLR 4 , DC maturation and IFN beta induction are independent of MyD 88 and Mal / TIRAP . ^^^ Hence , in LPS signaling TLR 4 recruits two types of adapters , TIRAP and TICAM 2 , to its cytoplasmic domain that are indirectly connected to two effective adapters , MyD 88 and TICAM 1 , respectively . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| TIRAP is specifically involved in the MyD 88 dependent pathway via TLR 2 and TLR 4 , whereas TRIF is implicated in the TLR 3 and TLR 4 mediated MyD 88 independent pathway . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| Recently , Toll IL 1R domain containing adapter protein ( TIRAP ) has been identified as an adapter molecule that mediates responses to TLR 2 and TLR 4 ligands , and TIRAP was suggested to provide signaling specificity for different TLRs . ^^^ Together these results underscore the importance of Rac 1 and TIRAP in TLR 4 activation of HIV replication and help delineate the signaling pathways induced by TLRs to mediate microbial Ag induced HIV replication and HIV pathogenesis . . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| TIRAP specifically participates in the MyD 88 dependent pathways shared by TLR 2 and TLR 4 , and TRAM is essential for the TLR 4 mediated MyD 88 independent pathway . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| A group of TIR domain containing adaptors ( MyD 88 , TIRAP , TRIF and TRAM ) , are differentially recruited to the Toll IL 1 receptors , contributing to the specificity of signaling . ^^^ |
|
| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| LPS ( TLR 4 ) mediated gene expression , as well as MAPK and transcription factor activation associated with both MyD 88 dependent and independent signaling pathways , were disrupted by all four BPs ( TRAM approximately MyD 88 > TRIF > TIRAP ) , but not by a control peptide . ^^^ |
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| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| IL 21 weakly induced the expression Toll like receptor 4 ( TLR 4 ) and translation initiation region ( TIR ) domain containing adaptor protein ( TIRAP ) genes , whereas the expression of TIR domain containing adaptor inducing IFN beta ( TRIF ) , myeloid differentiation ( MyD 88 ) 88 factor , or TRIF related adaptor molecule ( TRAM ) genes remained unchanged . ^^^ |
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| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| The goal of this study was to clone and sequence the full length coding regions of bovine genes involved in TLR 4 signaling including CASP 8 , IRAK 1 , LY 96 ( MD 2 ) , TICAM 2 , TIRAP , TOLLIP and TRAF 6 and to position these genes , as well as MyD 88 and TICAM 1 , on the bovine genome using radiation hybrid mapping . ^^^ |
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| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that TIRAP and MyD 88 have distinct functions and describe a mechanism of recruitment of TIRAP and MyD 88 to TLR 4 . ^^^ TIRAP then functions to facilitate MyD 88 delivery to activated TLR 4 to initiate signal transduction . ^^^ |
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| Interacting proteins: P58753 and O00206 |
Pubmed |
SVM Score :0.0 |
| TIRAP ( Toll / IL 1R domain containing adaptor protein ) is an adaptor in TLR 1 , TLR 2 , TLR 4 , and TLR 6 signaling , whereas MyD 88 is an adaptor for all TLRs . ^^^ |
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