| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.82273618 |
| The existence of regulatory interactions between Wnt 1 , Wnt 3a , and engrailed genes was also examined in this study . 0.82273618^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Wnt 1 and a related gene , Wnt 3a , are coexpressed from early somite stages in dorsal aspects of the myelencephalon and spinal cord . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| After neural tube closure , when the embryonic subdivisions of the neural tube became apparent , Wnt 1 , Wnt 3a and Wnt 4 are all broadly expressed in partially overlapping domains in the mesencephalon and caudal diencephalon , as well as in the rhombencephalon and spinal cord . ^^^ The mesencephalic expression patterns are subsequently modified such that Wnt 1 and Wnt 4 are expressed in a characteristic ring just rostral to the isthmus , at the mesencephalic / metencephalic junction ; and Wnt 1 and Wnt 3a expression become restricted to the dorsal midline . ^^^ Wnt 1 , Wnt 3a , Wnt 4 , Wnt 5a and Wnt 8b are expressed in one or two caudal subdivisions of the developing diencephalon , the synencephalon and posterior parencephalon , but do not extend ventral to the zona limitans interparencephalica . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that juxtaposition of the non neural and neural ectoderm is sufficient to induce the expression of dorsal markers , Wnt 1 , Wnt 3a and Slug , as well as the formation of neural crest cells . ^^^ In addition , the competence of neural plate to express Wnt 1 and Wnt 3a appears to be stage dependent , occurring only when neural tissue is taken from stage 8 10 embryos but not from stage 4 embryos , regardless of the age of the non neural ectoderm . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Wnt 1 , Wnt 3A , and Wnt 7A were highly transforming and induced colonies which formed and shed balls of cells . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Antisense attenuation of Wnt 1 and Wnt 3a expression in whole embryo culture reveals roles for these genes in craniofacial , spinal cord , and cardiac morphogenesis . ^^^ Wnt 1 and Wnt 3a proto oncogenes have been implicated in the development of midbrain and hindbrain structures . ^^^ Antisense knockout of Wnt 3a , a gene structurally related to Wnt 1 , targeted the forebrain and midbrain region , which were hypoplastic and failed to expand , and the spinal cord , which exhibited lateral outpocketings at the level of the forelimb buds . ^^^ Dual antisense knockouts of Wnt 1 and Wnt 3a targeted all brain regions leading to incomplete closure of the cranial neural folds , and an increase in the number and severity of outpocketings along the spinal cord , suggesting that these genes complement one another to produce normal patterning of the spinal cord . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| In the spinal cord , Wnt 1 , Wnt 3 , and Wnt 3a are expressed dorsally , Wnt 5a , Wnt 7a , and Wnt 7b more ventrally , and Wnt 4 both dorsally and in the floor plate . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the expression of Zic genes in Pax 3 , Wnt 1 , and Wnt 3a mutant embryos suggested that Zic genes are not primarily regulated by the three genes which were expressed in dorsal areas similar to Zic genes . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| The genes Wnt 1 and Wnt 3a , which encode members of the Wnt family of cysteine rich secreted signals , are coexpressed at the dorsal midline of the developing neural tube , coincident with dorsal patterning . ^^^ Each signal is essential for embryonic development , Wnt 1 for midbrain patterning , and Wnt 3a for formation of the paraxial mesoderm , but the absence of a dorsal neural tube phenotype in each mutant suggests that Wnt signalling may be redundant . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| The documented expression of Wnt 1 and Wnt3a in the dorsal neural tube and of Wnt 4 and Wnt 6 in the surface ectoderm at the time of dermomyotome specification prompted us to investigate the involvement of WNT proteins in patterning the dermomyotome . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Here , we used Wnt 11 as a molecular marker for the medial compartment of dermomyotome ( the ' medial lip ' ) to demonstrate that BMP in the dorsal neural tube indirectly induces formation of the medial lip by up regulating Wnt 1 and Wnt 3a ( but not Wnt 4 ) expression in the neural tube . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Regulation of dorsal fate in the neuraxis by Wnt 1 and Wnt 3a . ^^^ We show that Wnt 1 and Wnt 3a , both of which are expressed in the dorsal portion of the neural tube , could synergize with the neural inducers noggin and chordin in Xenopus animal explants to generate the most dorsal neural structure , the neural crest , as determined by the expression of Krox 20 , AP 2 , and slug . ^^^ Overexpression of Wnt 1 or Wnt 3a in the neuroectoderm of whole embryos led to a dramatic increase of slug and Krox 20 expressing cells , but the hindbrain expression of Krox 20 remained unaffected . ^^^ We suggest that Wnt 1 and Wnt 3a have a role in patterning the neural tube along its dorsoventral axis and function in the differentiation of the neural crest . . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Wnt 1 , Wnt 2 , Wnt 3 , and Wnt3a induced strong transformation and an elongated refractile cell morphology . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| The Wnt 4 signal can be replaced by other members of the Wnt gene family including Wnt 1 , Wnt 3a , Wnt 7a and Wnt 7b . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Wnt 1 and Wnt 3a , which encode members of the Wnt family of cystein rich secreted signaling molecules , are coexpressed at the dorsal midline of the developing neural tube , an area adjacent to the dorsomedial portion of the somite . ^^^ Several lines of evidence indicate that Wnt 1 and Wnt 3a have the ability to induce the development of the medial and dorsal portion of somites , as well as to induce myogenesis . ^^^ To address whether these Wnt signalings are really essential for the development of somites during normal embryogenesis , we investigated the development of somites in mouse embryos lacking both Wnt 1 and Wnt 3a . ^^^ These results indicate that Wnt 1 and Wnt 3a signalings actually regulate the formation of the medial compartment of the dermomyotome and the early part of myogenesis . . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Wnt 1 and Wnt 3a are candidate genes for influencing neural crest fate , as they are expressed next to medial , but not lateral , crest cells . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| The neural crest phenotype of alyron mutants resembles that observed in mouse mutants that lack Pax 3 or both Wnt 1 and Wnt 3a function , and expression of the zebrafish homologues of these genes is greatly reduced in the dorsal neural keels of alyron mutants . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| In order to gain a better understanding of the potential roles of Frzb 1 in chick development , we utilized the polymerase chain reaction to isolate a partial cDNA of the chick orthologue of frzb 1 , cfrzb 1 , and compared its expression pattern to that of Wnt 1 , Wnt 3a , Wnt 5a , Wnt 7a , and Wnt 8c . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| We further show that SFRP 2 expressing cells can reduce the dermomyotome inducing activity of WNT 1 and WNT 4 , but not that of WNT3a . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| METHODS : For this study we used in vitro cell culture techniques , in vivo mouse chick chimeras , BrdU cell proliferation labeling , TUNEL labeling to visualize apoptosis and the molecular markers AP 2 , Wnt 1 and Wnt 3a to characterize NCC morphogenesis in vivo . ^^^ Further expression analysis revealed that Wnt 1 , but not Wnt 3a , is expressed at decreased levels within Sp ( 2H ) and that the cardiac NCC fail to undergo normal NC stem cell proliferative expansion prior to migration while still in the neural folds . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Mice deficient for both Wnt 1 and Wnt3a have a marked deficiency in trunk neural crest derivatives including NC Ms . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Wnt 1 and Wnt3a are signaling factors known to play a role in the induction of myogenesis in the myotome of the differentiating somite . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that absence of Wnt 1 and Wnt3a , normally expressed in the roof plate , leads to diminished development of D 1 and D 2 neurons and a compensatory increase in D 3 neuron populations . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Wnts expressed at the dorsal midline of the spinal cord , Wnt 1 and Wnt3a , have mitogenic activity while more broadly expressed Wnts do not . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Inhibition by Wnt 1 or Wnt 3a of nerve growth factor induced differentiation of PC 12 cells is reversed by bisindolylmaleimide 1 but not by several other PKC inhibitors . ^^^ Wnt 1 and Wnt 3a exhibit redundancy in neural crest development . ^^^ However , both Wnt 1 or Wnt 3a inhibit nerve growth factor ( NGF ) induced neurite outgrowth . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Among 19 WNT genes , WNT 3 and WNT14B genes are clustered in human chromosome 17q21 , WNT3A and WNT 14 in human chromosome 1q42 , WNT10A and WNT 6 in human chromosome 2q35 , and WNT10B and WNT 1 in human chromosome 12q13 . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| However , wnt 1 and wnt10b are not required for the maintenance of fgf 8 , en 3 , wnt8b , or wnt3a expression . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Differential regulation of midbrain dopaminergic neuron development by Wnt 1 , Wnt 3a , and Wnt 5a . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| In addition , Wnt 11 mediated inhibition of canonical signaling in NIH3T3 cells is ligand specific ; Wnt 11 could effectively repress canonical signaling activated by Wnt 1 , Wnt 3 , or Wnt3a but not by Wnt7a or Wnt7b . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| The expression pattern of wnt3a appears to be evolutionarily conserved between zebrafish and mouse , and MO knockdown shows that Wnt3a , while not uniquely required for MHB development , is required in the absence of Wnt 1 and Wnt10b for the formation of the MHB constriction . ^^^ In zebrafish embryos lacking Wnt3a , Wnt 1 and Wnt10b , the expression of engrailed orthologs , pax2a and fgf 8 is not maintained after mid somitogenesis . ^^^ In contrast to acerebellar and no isthmus mutants , in which midbrain and hindbrain cells acquire new fates but cell number is not significantly affected until late in embryogenesis , zebrafish embryos lacking Wnt3a , Wnt 1 and Wnt10b undergo extensive apoptosis in the midbrain and cerebellum anlagen beginning in mid somitogenesis , which results in the absence of a significant portion of the midbrain and cerebellum . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Several wnt genes ( wnt 1 , wnt3a , wnt8b , and wnt10b ) show elevated expression at rhombomere boundaries , whereas several delta genes ( dlA , dlB , and dlD ) are expressed in transverse stripes flanking rhombomere boundaries . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Transgenic mice expressing Ryk siRNA exhibit defects in axon guidance , and Ryk is required for neurite outgrowth induced by Wnt 3a and in the activation of T cell factor ( TCF ) induced by Wnt 1 . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| This study demonstrates that mouse embryos lacking both Wnt 1 and Wnt 3a are indeed defective in determination of dorsal interneurons . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| WNT 1 , WNT 2 , WNT2B ( WNT 13 ) , WNT 3 , WNT3A , WNT 4 , WNT5A , WNT5B , WNT 6 , WNT7A , WNT7B , WNT8A , WNT8B , WNT9A ( WNT 14 ) , WNT9B ( WNT14B ) . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| WNT 1 , WNT 2 , WNT2B , WNT 3 , WNT3A , WNT8A , WNT8B , WNT10A and WNT10B are canonical WNTs to activate WNT beta catenin pathway . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Using the TaqMan panel , we have compared the gene expression profiles induced by Wnt 1 , Wnt 2 , and Wnt3a in C3H10T1 / 2 cells , and also by two different GSK 3beta inhibitors : LiCl and SB 216773 . ^^^ Our data show that Wnt 1 and Wnt3a act in a similar manner , distinct from Wnt 2 . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| We also identified expression patterns for the Wnt 1 , Wnt3a , Wnt 6 , Wnt7b , Wnt9a , Wnt10b , and Sfrp 1 genes at the blastocyst stage . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| WNT 1 and WNT3a promote expansion of melanocytes through distinct modes of action . ^^^ Summary WNT 1 and WNT3a have been described as having redundant roles in promoting the development of neural crest derived melanocytes ( NC Ms ) . ^^^ RCAS infection of DCT TVA+ cells demonstrated that overexpression of canonical WNT signaling genes ( betaCAT , WNT3a or WNT 1 ) can increase NC M numbers in an endothelin dependent manner . ^^^ However , WNT 1 and WNT3a have different modes of action with respect to melanoblast fate . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Each mutant receptor was able to reach the cell surface , albeit at differing amounts , and transduce exogenously supplied Wnt 1 and Wnt3a signal . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Simultaneous knockdown of Lmx1b . 1 and Lmx1b . 2 using morpholino antisense oligos results in a loss of wnt 1 , wnt3a , wnt10b , pax 8 and fgf 8 expression at the IsO , leading ultimately to programmed cell death and the loss of the isthmic constriction and cerebellum . ^^^ We propose that Lmx1b . 1 and Lmx1b . 2 mediated regulation of wnt 1 , wnt3a , wnt10b , pax 8 and fgf 8 maintains cell survival in the isthmocerebellar region . . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| We further show that the source of Wnt impacting on dorsal otic development emanates from the dorsal hindbrain , and identify Wnt 1 and Wnt3a as the specific ligands required for this function . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| Serum withdrawal induced apoptosis was prevented by the canonical Wnts ( Wnt3a and Wnt 1 ) and the noncanonical Wnt5a in all cell types . ^^^ Beta catenin mediated transcription was permissive for the anti apoptotic actions of Wnt 1 and Wnt3a but was dispensable for the anti apoptotic action of Wnt5a . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| In the developing chick neural tube , sfrp 1 , 2 , and 3 transcripts are expressed in and adjacent to the dorsal neural tube , where Wnt 1 and Wnt 3a are expressed . ^^^ |
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| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| We show that Wnt 1 and Wnt3a signaling from the neural tube inhibit Wnt 6 expression in the medial surface ectoderm via dermomyotomal Wnt 11 . ^^^ |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56704 and P04628 |
Pubmed |
SVM Score :0.0 |
| NA |
|