| Interacting proteins: O75581 and P56704 |
Pubmed |
SVM Score :0.0 |
| In the absence of exogenous Wnt 3a , full length ( FL ) LRP 6 , but not LRP 5 , increased TCF / LEF 1 transcriptional activity , however both significantly potentiated Wnt 3a induced TCF / LEF 1 activation . ^^^ In contrast to the findings with the FL constructs , the intracellular domains ( membrane anchored and cytosolic ) of both LRP 5 and LRP 6 significantly increased TCF / LEF 1 activation in the absence of Wnt 3a , and potentiated the Wnt 3a induced decrease in beta catenin phosphorylation , increase in free beta catenin levels and the increase in TCF / LEF 1 activity . ^^^ These findings demonstrate that : ( 1 ) LRP 5 and LRP 6 differentially modulate TCF / LEF 1 activation in the absence of Wnt 3a and ( 2 ) the intracellular C terminal domains of LRP5 / 6 potentiate Wnt 3a induced TCF / LEF 1 activation whether or not they are membrane anchored . ^^^ |
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| Interacting proteins: O75581 and P56704 |
Pubmed |
SVM Score :0.0 |
| Whereas Wnt3a regulates CKIepsilon kinase activity , LRP 6 does not , placing CKIepsilon upstream of LRP 6 . ^^^ |
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| Interacting proteins: O75581 and P56704 |
Pubmed |
SVM Score :0.0 |
| Caveolin is necessary for Wnt 3a dependent internalization of LRP 6 and accumulation of beta catenin . beta catenin mediated Wnt signaling is critical in animal development and tumor progression . ^^^ Here , we present evidence that LRP 6 is internalized with caveolin and that the components of this endocytic pathway are required not only for Wnt 3a induced internalization of LRP 6 but also for accumulation of beta catenin . ^^^ Overall , our data suggest that Wnt 3a triggers the interaction of LRP 6 with caveolin and promotes recruitment of Axin to LRP 6 phosphorylated by glycogen synthase kinase 3beta and that caveolin thereby inhibits the binding of beta catenin to Axin . ^^^ |
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| Interacting proteins: O75581 and P56704 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75581 and P56704 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75581 and P56704 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75581 and P56704 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75581 and P56704 |
Pubmed |
SVM Score :0.0 |
| NA |
|