| The results demonstrated that 1 ) zinc fingers 1 and 6 of FOG 2 are each capable of interacting with evolutionarily conserved motifs within the N terminal zinc finger of mammalian GATA proteins , 2 ) a nuclear localization signal ( RKRRK ) ( amino acids 736 740 ) is required to program nuclear targeting of FOG 2 , and 3 ) FOG 2 can interact with the transcriptional co repressor , C terminal binding protein 2 via a conserved sequence motif in FOG 2 ( PIDLS ) . ^^^ Surprisingly , however , this interaction with C terminal binding protein 2 is not required for FOG 2 mediated repression of GATA 4 dependent transcription . ^^^ |