| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.53621472 |
| Substitution of the N terminal domain of CtBP 1 with the corresponding CtBP 2 domain confers a dominant nuclear localization pattern to CtBP 1 . 0.53621472^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| Scatchard analysis of L 3 , 5 , 3 ' triodo thyronine binding showed a high affinity site with Kd on the order of 10 ( 10 ) M for CTBP 2 and Kd values of about 10 ( 9 ) M for CTBP 1 and 4 and of about 10 ( 8 ) M for CTBP 3 . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| Two peptides , corresponding to the amino acid sequences from residues 57 to 69 ( CTBP 1 ) and 47 to 60 ( CTBP 2 ) of the cholera toxin B subunit , were synthesized by the solid phase method . ^^^ Synthesized peptides were coupled to carrier proteins through additional cysteine residues at the carboxyl ( CTBP 1 ) or amino terminal ends ( CTBP 2 ) . ^^^ On the other hand , anti peptide sera failed to react with CT and LTh in GM 1 ( ganglioside ) ELISA , thereby suggesting the possible involvement of CTBP 1 and CTBP 2 peptide regions of the toxin molecule in GM 1 receptor binding . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| We conclude that CTBP 1 and CTBP 2 are polymeric forms of CTBP IV . . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| A novel C terminal binding protein ( CTBP 2 ) is closely related to CTBP 1 , an adenovirus E1A binding protein , and maps to human chromosome 21q21 . 3 . ^^^ Here we report the identification and sequence of a novel gene in human ( CTBP 2 ) and mouse ( Ctbp 2 ) , both highly related to CTBP 1 and thus also likely to bind to the E1A protein . ^^^ We mapped CTBP 1 and CTBP 2 to human chromosomes 4p16 and 21q21 . 3 , respectively . . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| BARS shares high homology with two known proteins , C terminal binding protein 1 ( CtBP 1 ) and CtBP 2 . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| Identification of CtBP 1 and CtBP 2 as corepressors of zinc finger homeodomain factor deltaEF 1 . deltaEF 1 , a representative of the zinc finger homeodomain protein family , is a transcriptional repressor which binds E 2 box ( CACCTG ) and related sequences and counteracts the activators through transrepression mechanisms . ^^^ Here we demonstrate that deltaEF 1 has a second mechanism of transrepression recruiting CtBP 1 or CtBP 2 as its corepressor . ^^^ CtBP 1 is the mouse orthologue of human CtBP , known as the C terminal binding protein of adenovirus E1A , while CtBP 2 is the second homologue . ^^^ Fusion of mouse CtBP 1 or CtBP 2 to Gal4DBD ( Gal 4 DNA binding domain ) made them Gal 4 binding site dependent transcriptional repressors in transfected 10T1 / 2 cells , indicating their involvement in a transcriptional repression mechanism . ^^^ In the mouse , CtBP 1 is expressed from embryo to adult , but CtBP 2 is mainly expressed during embryogenesis . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| Kheper interacted with the transcriptional corepressors CtBP 1 and CtBP 2 . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| Overlapping and unique roles for C terminal binding protein 1 ( CtBP 1 ) and CtBP 2 during mouse development . ^^^ We generated mice harboring mutations in both Ctbp 1 and Ctbp 2 to address the in vivo function of CtBPs during vertebrate development . ^^^ Ctbp 1 mutant mice are small but viable and fertile , whereas Ctbp 2 null mice show defects in axial patterning and die by E10 . 5 due to aberrant extraembryonic development . ^^^ Mice harboring various combinations of Ctbp 1 and Ctbp 2 mutant alleles exhibit dosage sensitive defects in a wide range of developmental processes . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| Studies with mutant mouse suggest that the two mouse genes , Ctbp 1 and Ctbp 2 , play unique and redundant gene regulatory roles during development . 1 Ctbp 1 deficient mice are viable , but are small and die early , while Ctbp 2 deficiency leads to embryonic lethality . ^^^ The Ctbp 2 mutant phenotype is more severe in the absence of Ctbp 1 . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| CtBP 2 , a close homolog of CtBP 1 , lacked the SUMOylation site and was not modified by SUMO 1 . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| We have defined the interaction of both CtBP 1 and CtBP 2 with RIP 140 and delineated two motifs ( PIDLS and PINLS ) differentially required for in vitro interaction . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| Expression of avian C terminal binding proteins ( Ctbp 1 and Ctbp 2 ) during embryonic development . ^^^ We have cloned the avian orthologues of Ctbp 1 and Ctbp 2 and examined their expression pattern by whole mount in situ hybridization between Hamburger and Hamilton ( HH ) stages 3 and 24 . ^^^ In most places , Ctbp 1 and Ctbp 2 are expressed in overlapping domains . ^^^ For instance , Ctbp 1 is predominantly expressed in the epiblast , whereas Ctbp 2 is in the primitive streak at HH stage 3 . ^^^ Similarly , although both genes display similar expression patterns in early somitogenesis , in mature somites , Ctbp 1 transcripts are located in myotomal cells , whereas Ctbp 2 transcripts are observed in dermomyotomal cells . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| There are two highly homologous genes , CtBP 1 and CtBP 2 that encode CtBP . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| The antiapoptotic transcriptional corepressor C terminal binding protein 2 ( CtBP 2 ) was identified , and ARF interactions with both CtBP 1 and CtBP 2 were confirmed in vitro and in vivo . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| Here , we show that HIC 1 interacts with both CtBP 1 and CtBP 2 and that this interaction is stimulated by agents increasing NADH levels . ^^^ Conversely , in perfect agreement with the structural data and the universal conservation of this residue in all C terminal binding protein interacting motifs , mutation of the central leucine residue ( leucine 225 in HIC 1 ) abolishes the interaction between HIC 1 and CtBP 1 or CtBP 2 . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| The C terminal binding protein ( CtBP ) family includes four proteins ( CtBP 1 [ CtBP 1 L ] , CtBP3 / BARS [ CtBP 1 S ] , CtBP 2 , and RIBEYE ) which are implicated both in transcriptional repression and in intracellular trafficking . ^^^ Moreover , CtBP 2 can heterodimerize with CtBP 1 L and CtBP 1 S and direct them to the nucleus . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| In co immunoprecipitation studies , calsenilin also interacted with CtBP 1 , a CtBP 2 homolog . ^^^ |
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| Interacting proteins: Q13363 and P56545 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : CtBP 1 and CtBP 2 are transcriptional co repressors that modulate the activity of a large number of transcriptional repressors via the recruitment of chromatin modifiers . ^^^ CtBP 1 and CtBP 2 are highly similar proteins , although evidence is emerging that their activity can be differentially regulated , particularly through the control of their subcellular localisation . ^^^ Finally , CtBP 1 and CtBP 2 can form heterodimers , and we show that the interaction with CtBP 2 is one mechanism whereby CtBP 1 can be recruited to the nucleus . ^^^ |
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