| SOX 6 binds CtBP 2 to repress transcription from the Fgf 3 promoter . ^^^ Mouse CtBP 2 cDNA clones were isolated and shown to bind SOX 6 in yeast and mammalian cells . ^^^ Furthermore , mutational analysis of SOX 6 showed that binding to CtBP 2 , and its responsiveness to this co repressor , were dependent on a short amino acid sequence motif PLNLSS . ^^^ Co expression studies in NIH3T3 cells showed that SOX 6 and CtBP 2 co operate to repress activity from the Fgf 3 promoter through the enhancer element PS4A . ^^^ These results show that SOX 6 can recruit CtBP 2 to repress transcription from the Fgf 3 promoter . . ^^^ |