A RING finger protein Praja 1 regulates Dlx 5 dependent transcription through its ubiquitin ligase activity for the Dlx / Msx interacting MAGE / Necdin family protein , Dlxin 1 . ^^^ Recently we have identified a novel protein , Dlxin 1 , that associates with these homeodomain proteins and regulates Dlx 5 dependent transcriptional function ( Masuda , Y . , Sasaki , A . , Shibuya , H . , Ueno , N . , Ikeda , K . , and Watanabe , K . ( 2001 ) J . ^^^ These results suggest that Praja 1 regulates the transcription function of the homeodomain protein Dlx 5 by controlling the stability of Dlxin 1 via an ubiquitin dependent degradation pathway . . ^^^ |