| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.75201707 |
| In the presence of all three nuclear factors , cooperative interactions between recombinant PBX 1 and PREP 1 or PBX 1 and HOXB 1 result in binding of the heterodimers to FPB in vitro . 0.75201707^^^ |
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| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| Meis 1 and pKnox 1 bind DNA cooperatively with Pbx 1 utilizing an interaction surface disrupted in oncoprotein E2a Pbx 1 . ^^^ Here , we demonstrate that both Meis 1 and its relative , pKnox 1 , dimerize with Pbx 1 on the same TGATTGAC motif selected by dimers of Pbx proteins and unidentified partner ( s ) in nuclear extracts , including those from t ( 1 ; 19 ) pre B cells . ^^^ Outside their homeodomains , Meis 1 and pKnox 1 were highly conserved only in two motifs required for cooperativity with Pbx 1 . ^^^ Like the unidentified endogenous partner ( s ) , both Meis 1 and pKnox 1 failed to dimerize significantly with E2a Pbx 1 . ^^^ |
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| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| Recombinant Pbx 1 and Prep 1 proteins bind cooperatively to the UE A site , whereas neither protein can bind this site alone . ^^^ Transient transfection experiments reveal that both Pbx 1 and Prep 1 are required to generate a strong transcriptional activation from the UE A element when this element is inserted close to the TATA box . ^^^ In contrast , in the context of the intact somatostatin promoter or mini enhancer , Pbx 1 and Prep 1 alone have no effect , but they produce a drastic activation when the pancreatic homeodomain factor PDX 1 is also coexpressed . ^^^ |
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| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| The subcellular localization of PBX 1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP 1 and HTH . ^^^ |
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| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| Identification of homeodomain proteins , PBX 1 and PREP 1 , involved in the transcription of murine leukemia virus . ^^^ Mutations in the PCE completely inhibited viral transcription whereas overexpression of PBX 1 and a PBX 1 associated protein , PREP 1 , enhanced viral transcription . ^^^ Collectively , our results represent the first work demonstrating that the homeodomain proteins PBX 1 and PREP 1 are cellular factors involved in Moloney MLV transcription regulation . . ^^^ |
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| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| Previous studies investigating the anti viral mechanisms of several cyclin dependent kinase inhibitors showed that the homeoproteins , pre B cell leukemia transcription factor 1 ( PBX 1 ) and PBX regulating protein 1 ( PREP 1 ) , function as transcriptional activators of Moloney murine leukemia virus . ^^^ |
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| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| Activin regulation of the follicle stimulating hormone beta subunit gene involves Smads and the TALE homeodomain proteins Pbx 1 and Prep 1 . ^^^ Interestingly , the protein complex binding to the 134 site contains Smad 4 in association with the homeodomain proteins Pbx 1 and Prep 1 . ^^^ Using glutathione S transferase interaction assays , we demonstrate that Pbx 1 and Prep 1 interact with Smads 2 and 3 as well . ^^^ The two proximal activin response elements are well conserved across species , and Pbx 1 and Prep 1 proteins bind to the mouse gene in vivo . ^^^ Our studies provide a basis for understanding activin regulation of FSHbeta gene expression and identify Pbx 1 and Prep 1 as Smad partners and novel mediators of activin action . . ^^^ |
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| Interacting proteins: P55347 and P40424 |
Pubmed |
SVM Score :0.0 |
| Concomitantly , Prep 1 deficiency results in the overall decrease of protein levels of its related family member Meis 1 and its partners Pbx 1 and Pbx 2 . ^^^ |
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