Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.78194114
We have isolated cDNA sequences , INK4d , encoding a 19 kDa protein that is associated with CDK 6 in several hematopoietic cell lines . p 19 shares equal similarity and a common ancestor with other identified inhibitors of the p16 / INK4 family . p 19 interacts with and inhibits the activity of both CDK 4 and CDK 6 and exhibits no detectable interaction with the other known CDKs . p 19 protein is present in both cell nuclei and cytoplasm . 0.78194114^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
The crystal structure of the cyclin D dependent kinase Cdk 6 bound to the p 19 INK4d protein has been determined at 1 . 9 A resolution . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
The four members of the INK 4 gene family , p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) , are known to bind to and inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G1 / S transition in the cell division cycle . ^^^ A possible mode of binding between p 19 ( INK4d ) and CDK 4 and CDK 6 could therefore involve the loop segments of p 19 ( INK4d ) . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
BACKGROUND : The four members of the INK 4 gene family ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) and p 19 ( INK4d ) ) inhibit the closely related cyclin dependent kinases CDK 4 and CDK 6 as part of the regulation of the G 1 > S transition in the cell division cycle . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
The INK 4 family of cyclin dependent kinase ( CDK ) inhibitors includes four 15 to 19 kDa polypeptides ( p 16 ( INK4a ) , p 15 ( INK4b ) , p 18 ( INK4c ) , and p 19 ( INK4d ) ) that bind to CDK 4 and CDK 6 . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
Analysis of normal B cell precursors by Western blotting indicated that CDK 4 , CDK 6 , p 19 ( INK4d ) , and p 57 ( KIP 2 ) were expressed , whereas p 16 ( INK4a ) was not detected . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
The kinase activation was found to result from Tax induced expression of genes for cell cycle regulatory molecules including cyclin D 2 , cyclin E , E2F1 , CDK 2 , CDK 4 and CDK 6 , and Tax induced reduction of CDK inhibitors p 19 ( INK4d ) and p 27 ( Kip 1 ) . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
P 19 ( INK4d ) is a tumor suppressing protein and belongs to a family of cyclin D dependent kinase inhibitors of CDK 4 and CDK 6 , which play a key role in human cell cycle control . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
The first group , including p16Ink4a , p15Ink4b , p18Ink4c and p19Ink4d , is specific for the G 1 CDKs , CDK 4 and CDK 6 , inhibiting the kinase activity of cyclin D / CDK4 CDK 6 complexes on pRb . p16Ink4a , down regulated by pRb , inhibits G 1 CDKs by competition with cyclin D ; p15Ink4b , the synthesis of which is induced by TGF beta , seems to be a mediator of TGF beta mediated cell cycle arrest . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
In murine C2C12 myoblast cells , G 1 CDK enzymes ( CDK 2 , CDK 4 , and CDK 6 ) associate with four CDK inhibitors : p18INK4c , p19INK4d , p 21 , and p27Kip1 . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
NMR structural characterization of the CDK inhibitor p19INK4d . p19INK4d is a 165 amino acid protein that belongs to the INK 4 family of CDK 4 and CDK 6 inhibitors . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
We derived 32D cells in which the expression of p19INK4d , a specific polypeptide inhibitor of CDK 4 and CDK 6 , is regulated by the heavy metal inducible sheep metallothionein promoter . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
In situ hybridization of mouse embryo sections demonstrated expression of mRNAs encoding two polypeptide inhibitors ( p18INK4c and p19INK4d ) of cyclin D dependent kinase ( CDK ) 4 and CDK 6 in the central nervous system . ^^^ The p19INK4d and p18INK4c proteins formed complexes with either CDK 4 or CDK 6 in a temporal pattern consistent with the results of in situ hybridization . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
The 50 70 kDa complex was made up of two moieties , a 66 kDa complex containing cdk 6 bound to p19INK4d and monomeric cdk 6 . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
The structures of Cdk 6 bound to p16INK4a and to the related p19INK4d reveal that the INK 4 inhibitors bind next to the ATP binding site of the catalytic cleft , opposite where the activating cyclin subunit binds . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
Expression of p19INK4d , CDK 4 , CDK 6 in glioblastoma multiforme . ^^^ No gene rearrangement or deletion was observed in the p19INK4d gene in these cell lines ; however , expression of CDK 4 and CDK 6 was elevated relative to matched normal brain tissue in eight of 18 GBM tumours ( 44 % ) . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
We also review our recent structural studies on intracellular signalling complexes , focusing on phosducin transducin GPry , CK 2 protein kinase and its complexes , and the cyclin D dependent kinase , Cdk 6 , bound to the cell cycle inhibitor p19INK4d . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
While members of the INK 4 family ( p16INK4A , p15INK4B , p18INK4C , p19INK4D ) interact specifically with CDK 4 and CDK 6 , the CIP / KIP inhibitors p21CIP1 / WAF1 , p27KIP1 and p57KIP2 inhibit a broader spectrum of CDK . ^^^
Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
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Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
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Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
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Interacting proteins: P55273 and Q00534	Pubmed	SVM Score :0.0
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