| Interacting proteins: Q9Y2G2 and P55211 |
Pubmed |
SVM Score :0.0 |
| Overexpression of TUCAN in cells by stable or transient transfection inhibits apoptosis and caspase activation induced by Apaf1 / caspase 9 dependent stimuli , including Bax , VP 16 , and staurosporine , but not by Apaf1 / caspase 9 independent stimuli , Fas and granzyme B . ^^^ |
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| Interacting proteins: Q9Y2G2 and P55211 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to investigate the mechanism of caspase 9 inhibition , with a focus on a possible role of TUCAN as caspase 9 inhibitor and a determinant of chemosensitivity in NSCLC cells . ^^^ Proteins interaction assays , and RNA interference in combination with cell viability and apoptosis assays were used to investigate the involvement of TUCAN in inhibition of caspase 9 and chemosensitivity NSCLC . ^^^ The reported inhibitor of caspase 9 , TUCAN , was exclusively expressed in NSCLC cells . ^^^ Furthermore , RNA interference mediated down regulation of TUCAN did not restore cisplatin induced caspase 9 activation or affect cisplatin sensitivity in NSCLC cells . ^^^ |
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