| Interacting proteins: Q9NR09 and P55211 |
Pubmed |
SVM Score :0.0 |
| Apollon ubiquitinates SMAC and caspase 9 , and has an essential cytoprotection function . ^^^ Here we report that Apollon binds to , ubiquitinates and facilitates proteasomal degradation of SMAC and caspase 9 , which both contain IAP binding motifs . ^^^ |
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| Interacting proteins: Q9NR09 and P55211 |
Pubmed |
SVM Score :0.0 |
| Apollon binds and ubiquitylates SMAC / DIABLO and caspase 9 , and regulates apoptosis by facilitating proteasomal degradation of these proteins . ^^^ |
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| Interacting proteins: Q9NR09 and P55211 |
Pubmed |
SVM Score :0.0 |
| The membrane associated inhibitor of apoptosis protein , BRUCE / Apollon , antagonizes both the precursor and mature forms of Smac and caspase 9 . ^^^ Through these associations , BRUCE promotes the degradation of Smac and inhibits the activity of caspase 9 but not the effector caspase , caspase 3 . ^^^ These results suggest that the ability of BRUCE to antagonize both the precursor and mature forms of Smac and caspase 9 is an important mechanism for the prevention of apoptosis under normal conditions . . ^^^ |
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| Interacting proteins: Q9NR09 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
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