| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| In addition , the antioxidant N acetyl L cysteine ( NAC ) effectively blocks DA induced p 38 kinase activation , caspase 9 and caspase 3 cleavage and subsequent apoptosis , indicating that DA triggers apoptosis via a signaling pathway that is initiated by the generation of reactive oxygen species ( ROS ) . ^^^ |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| Furthermore , apoptosis could be completely blocked by Z VAD FMK ( a general caspase inhibitor ) or by IETD CHO ( a caspase 8 inhibitor ) , but was only partially blocked by Ac DEVD CMK ( a caspase 3 inhibitor ) , by N acetyl L cysteine ( NAC ) ( an antioxidant ) , by N acetyl leucyl leucyl norleucinal ( ALLN ) ( a calpain inhibitor 1 ) , or by Z LEHD FMK ( a caspase 9 inhibitor ) . ^^^ |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| Moreover , lectin 2 induced activation of caspase 9 and 3 like protease and cleavage of poly ( ADP ribose ) polymerase ( PARP ) were inhibited by pretreatment of cells with thiol antioxidants , GSH and NAC . ^^^ |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| The reduction in cell growth and enhancement in cell killing by the combination of GST MDA 7 and radiation were blocked by an ROS scavenger , N acetyl cysteine ( NAC ) , a JNK1 / 2 / 3 inhibitor SP 600125 , a pan caspase inhibitor ( zVAD ) and by an inhibitor of caspase 9 ( LEHD ) , but not by an inhibitor of caspase 8 ( IETD ) . ^^^ |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| Like the structurally related apoptotic protease activating factor 1 ( APAF 1 ) , which is responsible for the activation of caspase 9 , the NALP 1 protein forms a large , signal induced multiprotein complex , the inflammasome , resulting in the activation of pro inflammatory caspases . . ^^^ |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| NAC reduced Delta Psi ( m ) dissipation , caspase 9 activation , and apoptosis , indicating a role for PFOA induced ROS . ^^^ |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9C000 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|