| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analyses showed that bone marrow precursors express appreciable levels of caspase 3 and caspase 9 but no or very low levels of c fms ( M CSF receptor ) and the apoptosis regulators 10 linked inhibitor of apoptosis protein ( XIAP ) , c IAP 1 , Bcl 2 and Bax . ^^^ |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| The overexpression of either caspase 9 mutant forms or recombinant c IAP 1 in AT5BIVA cells inhibited the IR induced activation of caspases 3 and 9 and reduced the apoptotic index of the irradiated cells . ^^^ |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| In H 460 cells , the overexpressed XIAP , but not c IAP 1 , bound to the processed form of caspase 9 and suppressed the activation of downstream effector caspases . ^^^ |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| For the pathway of etodolac induced apoptosis , reduction of anti apoptotic bcl 2 mRNA and Bcl 2 protein , activation of Caspase 9 and 3 , down regulation of caspase inhibitors , c IAP 1 and Survivin were involved . ^^^ |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| Thus , activation of the Fas system is critical , which is in line with the finding that in sensitive cells , caspase 8 along with caspase 9 and 3 were activated by cDDP . cDDP provoked the activation of stress activated protein kinase / c Jun N terminal kinase ( SAPK / JNK ) and p 38 kinase dose dependently , with significantly lower levels in ACR cells than in the sensitive parental line . cDDP induces c Jun and AP 1 activity , as measured by a reporter gene assay , which was again attenuated in ACR cells . ^^^ |
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| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that membrane presented CD 40 ligand ( CD 154 ) ( mCD40L ) , but not soluble agonists , triggers cell death in malignant human urothelial cells via a direct mechanism involving rapid upregulation of TNFR associated factor ( TRAF ) 3 protein , without concomitant upregulation of TRAF 3 mRNA , followed by activation of the c Jun N terminal kinase ( JNK ) / activator protein 1 ( AP 1 ) pathway and induction of the caspase 9 / caspase 3 associated intrinsic apoptotic machinery . ^^^ |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| SN 50 induced apoptosis in MM cell lines and patient cells ; down regulated expression of Bcl 2 , A 1 , 10 chromosome linked inhibitor of apoptosis protein ( XIAP ) , cellular inhibitor of apoptosis protein 1 ( cIAP 1 ) , cIAP 2 , and survivin ; up regulated Bax ; increased mitochondrial cytochrome c release into the cytoplasm ; and activated caspase 9 and caspase 3 , but not caspase 8 . ^^^ |
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| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| Finally , exogenous glutathione protected T cells from thimerosal induced apoptosis by upregulation of XIAP and cIAP 1 and by inhibiting activation of both caspase 9 and caspase 3 . ^^^ |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| Screening potential mediators of DN IkappaB and TNF induced apoptosis shows that caspase 3 , caspase 9 , poly ( ADP ribose ) polymerase , and Bax are activated , whereas levels of Bcl XL , cIAP 1 , and TRAF 6 were reduced . ^^^ |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| Apoptosis inducing concentrations of dideoxypetrosynol A induced caspase 3 and caspase 9 activation accompanied by proteolytic degradation of poly ( ADP ribose ) polymerase and selective down regulation of cIAP 1 . ^^^ |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| Etodolac induced down regulation of Bcl 2 protein and mRNA , activation of Caspase 9 , 7 and 3 , cIAP 1 and Survivin , and loss of mitochondrial membrane potential in a dose dependent manner . ^^^ |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| We also observed activation of caspase 9 and caspase 3 , DNA ladder formation , proteolytic degradation of poly ( ADP ribose ) polymerase ( PARP ) , and selective down regulation of cIAP 1 . ^^^ |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|