| Furthermore , mutation of the NAIP ATP binding pocket allowed full length protein to interact with caspase 9 . 0.79988867^^^ Thus , we conclude that NAIP binds to caspase 9 with a structural requirement for ATP and that in the absence of ATP the LRR domain negatively regulates the caspase 9 inhibiting activity of the BIR domains . 0.62762249^^^ |