Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.52809442
Cytochrome c associates with Apaf 1 and caspase 9 to form the apoptosome . 0.52809442^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.6399442
Furthermore , caspase 9 activated by released cytochrome c was not significantly activated after 9 HPbD photosensitization . 0.6399442^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , cytochrome c is translocated to the cytosol of Casp 9 / ES cells upon UV stimulation , suggesting that Casp 9 acts downstream of cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
A regulator of apoptosis , Apaf 1 , binds to and activates pro casp 9 in the presence of cytochrome c and dATP , a requirement that is bypassed by deletion of the WD 40 repeats located in the C terminal half of Apaf 1 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the presence of cytochrome c ( Cyt c ) released from mitochondria , Apaf 1 binds to Casp 9 and causes its activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Previous studies have shown that Apaf 1 and caspase 9 in the presence of cytochrome c and dATP can form an initiating complex for an apoptotic protease cascade . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In cell extracted cytosols , Zn2+ ions inhibited the cleavage of the 32 kDa precursor by caspase 9 ( Aapf 3 ) that was activated by addition of cytochrome c and dATP . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Recent studies have demonstrated that Apaf 1 is the adaptor molecule which in the presence of cytosolic cytochrome c ( cyt c ) and dATP interacts with procaspase 9 , resulting in the sequential cleavage and activity of caspase 9 and caspase 3 , followed by apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Here , we show that this activation requires a previously identified apoptosis promoting complex consisting of caspase 9 , APAF 1 , and cytochrome c . ^^^ Oncogenes , such as E1A , appear to facilitate caspase 9 activation by several mechanisms , including the control of cytochrome c release from the mitochondria . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Ordering the cytochrome c initiated caspase cascade : hierarchical activation of caspases 2 , 3 , 6 , 7 , 8 , and 10 in a caspase 9 dependent manner . ^^^ In the cytosol , cytochrome c binds to the CED 4 homologue , Apaf 1 , thereby triggering Apaf 1 mediated activation of caspase 9 . ^^^ Depletion of caspase 9 from cell extracts abrogated cytochrome c inducible activation of caspases 2 , 3 , 6 , 7 , 8 , and 10 , suggesting that caspase 9 is required for all of these downstream caspase activation events . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
It induces purified mitochondria to release the apoptogenic proteins cytochrome c and caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These results suggest that the execution phase of chemical induced apoptosis in THP . 1 cells may be initiated following mitochondrial damage resulting in release of cytochrome c leading to activation of caspase 9 and then activation of effector caspases 3 and 7 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The recombinant form of the proapoptotic caspase 9 purified following expression in Escherichia coli is processed at Asp 315 , but largely inactive ; however , when added to cytosolic extracts of human 293 cells it is activated 2000 fold in the presence of cytochrome c and dATP . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NO donor glycerol trinitrate ( at the concentration , which induces apoptotic cell death ) caused ( 1 ) a significant decrease in the concentration of cardiolipin , a major mitochondrial lipid ; ( 2 ) a downregulation in respiratory chain complex activities ; ( 3 ) a release of the mitochondrial protein cytochrome c into the cytosol ; and ( 4 ) an activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the cytosol , cytochrome c combines with APAF 1 in the presence of ATP to activate caspase 9 that , in turn , activates effectors caspases such as caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the early process of apoptosis , cytochrome c , which usually is involved in the respiratory chain , is released from mitochondria into the cytosol , then bind to Apaf 1 , a homologue of CED 4 of nematoda , to process pro caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Pathways to caspase 3 activation have been identified that are either dependent on or independent of mitochondrial cytochrome c release and caspase 9 function . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Functional assays with cytoplasmic preparations from Fas DNP treated cells also indicated that there was no major contribution by cytochrome c or caspase 9 to the activation of effector caspases . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These results suggested that the ATP dependent step ( s ) of Fas mediated apoptotic signal transduction in type 1 cells are only located downstream of caspase 3 activation , whereas the activation of caspase 9 by released cytochrome c is the most upstream ATP dependent step in type 2 cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 9 is critical for cytochrome c ( cyto c ) dependent apoptosis and normal brain development . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These observations indicate that cytochrome c and dATP are required for oligomerization of Apaf 1 and suggest that the WD 40 domain plays an important role in oligomerization of full length Apaf 1 and the release of mature caspase 9 from the Apaf 1 oligomeric complex . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Role of cytochrome c and dATP / ATP hydrolysis in Apaf 1 mediated caspase 9 activation and apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Because the activation of procaspase 3 by caspase 9 requires the release of cytochrome c into the cytoplasm , we determined the level of cytoplasmic cytochrome c in each cell line in response to cisplatin treatment . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptotic protease activating factor 1 ( Apaf 1 ) has been identified as a proximal activator of caspase 9 in cell death pathways that trigger mitochondrial damage and cytochrome c release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In mammals , apoptotic protease activating factor 1 ( Apaf 1 ) , cytochrome c , and dATP activate caspase 9 , which initiates the postmitochondrial mediated caspase cascade by proteolytic cleavage / activation of effector caspases to form active approximately 60 kDa heterotetramers . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Human platelets contained caspase 9 , caspase 3 , and the caspase activators APAF 1 and cytochrome c as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis and Western blotting . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Two main mechanisms for caspase 7 activation have been proposed : ( 1 ) caspase 8 recruitment to death receptors ( Fas or tumour necrosis factor ) ; and ( 2 ) changes in mitochondrial membrane permeability and cytochrome c release , which activate caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the presence of cytochrome c and ATP , caspase 9 and 3 were activated , which initiated chromatin condensation and DNA cleavage in rat pheochromocytoma ( PC 12 ) nuclei . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We conclude that HSP 27 inhibits etoposide induced apoptosis by preventing cytochrome c and dATP triggered activity of caspase 9 , downstream of cytochrome c release . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , ELL 12 triggered release of cytochrome c from mitochondria to the cytoplasm before caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
However , unlike staurosporine induced apoptosis , cytochrome c , which activates caspase 9 , was not detected in the cytosol of RA / BMP 4 treated cells . ^^^ RA and BMP 4 may activate caspase 9 through an apoptotic pathway other than the Apaf 1 / cytochrome c pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These results suggest the possibility that cytochrome c released to the cytosol can activate caspases ( caspase 9 , 3 , and 2 ) during C 2 ceramide induced apoptosis of SK N MC cells . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Thus , BCR mediated apoptosis is initiated by the caspase independent induction of mitochondrial PT resulting in release of cytochrome c and subsequent activation of caspase 9 , downstream caspases and apoptosis . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , the release of cytochrome c from the mitochondria and its subsequent activation of caspase 9 and caspase 3 play a key role in cocaine induced apoptosis . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the cytosol , cytochrome c forms part of a proteinaceous complex that directly activates caspase 9 , one of the apical enzymes responsible for the dismantling of the cell . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
After 3 h of NH2Cl treatment , when the apoptosis was beginning to increase , the cells showed cytochrome c release from mitochondria , proteolytic activation of caspase 9 , and poly ( ADP ribose ) polymerase cleavage , regardless of Fas stimulation . ^^^ By contrast , Fas stimulation alone resulted in neither cytochrome c release nor caspase 9 activation at 3 h , and the increase in the DEVD cleavage activity and apoptosis became evident at later time points . ^^^ These results suggested that NH2Cl enhanced Fas induced apoptosis through the cytochrome c release and caspase 9 activation at the early stage of apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Together , these data support the notion that these three teratogens induce changes in embryonic mitochondria resulting in the release of cytochrome c and the subsequent activation of caspase 9 , the upstream activator of caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
When K 562 cells ( derived from a patient with blast crisis CML ) were treated with AG 957 , dose and time dependent p210bc / abl down regulation was followed by mitochondrial release of cytochrome c , activation of caspase 9 and caspase 3 , and apoptotic morphological changes . ^^^ These observations not only demonstrate that AG 957 induced p210bcr / abl down regulation is followed by activation of the cytochrome c / Apaf 1 / caspase 9 pathway but also indicate that this class of kinase inhibitor exhibits selectivity worthy of further evaluation . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , direct cleavage of caspase 9 by calpain blocks dATP and cytochrome c induced caspase 3 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase 9 and caspase 3 in leukaemia HL 60 cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Oligomerization of Apaf 1 , in the presence of dATP and cytochrome c , is required for the activation of caspase 9 and produces a caspase activating apoptosome complex . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Exogenous sphingosine , as well as cell permeable C ( 2 ) ceramide , induced cytochrome c release from mitochondria in a caspase independent fashion leading to activation of caspase 9 and executioner caspases and , surprisingly , activation of the initiator caspase 8 and processing of its substrate Bid . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In this report , we demonstrate that in HL 60 / Apaf 1 cells , the activity of caspase 9 and 3 induced by Apaf 1 overexpression was associated with a significant increase ( 5 fold ) in the cytosolic accumulation of cytochrome c ( cyt c ) , loss of mitochondrial membrane potential ( deltapsim ) , and an increase in the reactive oxygen species . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
However , the onconase induced activation of the caspase 9 / caspase 3 cascade correlated with atypically little release of cytochrome c from mitochondria . ^^^ This suggests the possibility of involvement of a different , potentially Bax and cytochrome c independent mechanism of caspase 9 activation in onconase treated cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Previous reports have suggested at least two distinct mechanisms : Bcl 2 and Bcl xL may inhibit either the formation of the cytochrome c / Apaf 1 / caspase 9 apoptosome complex ( by preventing cytochrome c release from mitochondria ) or the function of this apoptosome ( through a direct interaction of Bcl 2 or Bcl xL with Apaf 1 ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c release was induced by TNF alpha treatment in both cell lines , but caspase 9 was not activated . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The release of cytochrome c from the mitochondria and its subsequent activation of caspase 9 and caspase 3 may play a key role in cocaine induced apoptosis . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In this study , we demonstrate that two of the early events after Fas ligation are the release of cytochrome c from the mitochondria and activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In contrast , the reduction of the mitochondrial membrane potential is enhanced by hyperthermia both in the absence and presence of CHX , and enhanced cytochrome c release is not associated with significantly enhanced caspase 9 processing . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We also show that c Myc induced apoptosis involves loss of mitochondrial transmembrane potential , release of cytochrome c from mitochondria into the cytosol and subsequent processing of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Overexpression of ASK1DeltaN , a constitutively active mutant of ASK 1 , induced cytochrome c release from mitochondria and activation of caspase 9 and caspase 3 but not of caspase 8 like proteases . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Whereas A 1 is able to inhibit mitochondrial depolarization , loss of cytochrome c , cleavage of caspase 9 , BID , and poly ( ADP ribose ) polymerase , it does not block caspase 8 or caspase 3 cleavage . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
RESULTS : By 24 h , zinc treatment resulted in the translocation of cytochrome c from the mitochondria to the cytosol , the activation of caspase 9 and caspase 3 , and eventually , the cleavage of nuclear poly ( ADP ) ribose polymerase ( PARP ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
BAD translocation induces the release of cytochrome C from the mitochondria into the cytoplasm , which results in activation of caspase 9 and DNA fragmentation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Inactive caspase 9 zymogen is known to be localized within the mitochondrial intermembrane space where it is involved in monitoring mitochondrial damage associated cytochrome c release and subsequent activation of procaspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The apoptotic pathway that was activated involved the release of cytochrome c from the intermitochondrial space and activation of caspase 9 . ^^^ These results show that the differential susceptibility of glial cell types to menadione induced oxidative stress and apoptosis appears to correlate with increased oxidative mtDNA damage and support the hypothesis that mtDNA damage could participate in the initiation of apoptosis through the enhanced release of cytochrome c and the activation of caspase 9 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 9 deficiency also arrested NGF deprived sympathetic neurons after release of cytochrome c , and permitted these neurons to be rescued with NGF readdition . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
As a corollary , the cytosolic levels of cytochrome c were significantly higher in AS versus C cells , which correlated with approximately 2 and approximately 3 fold higher activation of caspase 9 and 3 , respectively , in AS versus C cells in response to camptothecin . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We report here the identification of a novel protein , Smac , which promotes caspase activation in the cytochrome c / Apaf 1 / caspase 9 pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c promotes caspase 9 activation by inducing nucleotide binding to Apaf 1 . ^^^ These data indicate that the key event in Apaf 1 mediated caspase 9 activation is cytochrome c induced dATP binding to Apaf 1 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These results suggest that cytoskeletal disruption in the apoptotic cells promotes damage of the mitochondrial membrane , resulting in the enhanced release of cytochrome c necessary for the activation of caspase 9 that initiates the caspase cascade . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The release of cytochrome c from mitochondria results in the formation of an Apaf 1 caspase 9 apoptosome and induces the apoptotic protease cascade by activation of procaspase 3 . ^^^ Immunodepletion of Hsp 90 depletes Apaf 1 and thereby inhibits cytochrome c mediated activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Rather , TNF alpha induced a tBid dependent conformational change in Bax that allowed an interaction between E1B 19K and conformationally altered Bax , which caused inhibition of cytochrome c release and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 9 is autoprocessed by the Apaf 1 / cytochrome c pathway and acts at an early point in this cascade , whereas Bcl xL , an antiapoptotic member of the Bcl 2 family , prevents activation of caspases in vitro . ^^^ Furthermore , we demonstrate that Bcl xL blocks cytochrome c release from mitochondria , causing activation of caspase 9 in anterior horn cells and dorsal root ganglia neurons in mouse embryos at embryonic day 11 . 5 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 8 and caspase 3 were activated in MMC treated cells whereas caspase 1 was not activated , and cytochrome c was released from mitochondrial membrane to cytosol suggesting that caspase 9 was activated during the MMC induced apoptotic process . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the second one , activated caspase 8 will trigger the cleavage of the bcl ( 2 ) family member Bid , which will act on mitochondria , resulting in cytochrome c release , caspase 9 activation and finally , activation of all executioner caspases . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptosis in THP 1 cells induced by Z LLL CHO involved a cytochrome c dependent pathway , which included the release of mitochondrial cytochrome c , activation of caspase 9 and 3 , and cleavage of Bcl 2 into a shortened 22 kDa fragment . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The upregulation of Bax was accompanied by the translocation of mitochondrial cytochrome c to the cytoplasm , and activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Protein kinase C inhibitor and irradiation induced apoptosis : relevance of the cytochrome c mediated caspase 9 death pathway . ^^^ We report the importance of the cytochrome c mediated caspase 9 death pathway for radiosensitization by the protein kinase C ( PKC ) inhibitors staurosporine ( STP ) and PKC 412 . ^^^ In our genetically defined tumor cells , treatment with low doses of STP or the conventional PKC specific inhibitor PKC 412 in combination with irradiation ( 5 Gy ) potently reduced viability , enhanced mitochondrial cytochrome c release into the cytosol , and specifically stimulated the initiator caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , MT 21 induced the release of cytochrome c from the mitochondria that is necessary to activate caspase 9 , and this release occurred before a change in membrane potential . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Here we show that GD 3 induces dissipation of DeltaPsim and swelling of isolated mitochondria , which results in the mitochondrial release of cytochrome c , apoptosis inducing factor , and caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In cell extracts , cytochrome c addition led to the activation of caspase 9 , 3 and 7 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the apoptosis pathway in mammals , cytochrome c and dATP are critical cofactors in the activation of caspase 9 by Apaf 1 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Etoposide induced increased formation of ceramide from sphingomyelin and release of mitochondrial cytochrome c followed by activation of caspase 9 and caspase 3 , but not caspase 1 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These results suggest that cytochrome c and caspase 9 initiate the activation of executor caspase 3 in H2O2 treated PC 12 cells , and that Bcl 2 inhibits H2O2 induced release of cytochrome c from mitochondria and then proteolytic processing of procaspase 9 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase activation occurs during the early hours of reperfusion following mitochondrial release of caspase 9 and cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Once released into the cytosol , cytochrome c binds to its adaptor molecule , Apaf 1 , which oligomerizes and then activates pro caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , IFN gamma sensitized MCF 7 and MDA MB 231 cells to CD 95 mediated activation of caspase 8 , induction of cytochrome c release from mitochondria , and processing of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Overall , the data indicate that O6MeG induces apoptosis via secondary lesions that trigger Bcl 2 decline , cytochrome c release , and caspase 9 and caspase 3 activation independently of Fas / Fas ligand and p 53 , for which the cells are mutated . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Addition of cytochrome c and dATP to lysates from cells expressing active Akt do not activate caspase 9 or 3 and immunoprecipitated Akt added to control lysates blocks cytochrome c induced activation of the caspase cascade . ^^^ Taken together , these data suggest that Akt inhibits activation of caspase 9 and 3 by posttranslational modification of a cytosolic factor downstream of cytochrome c and before activation of caspase 9 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Collectively , these data indicate that the release of cytochrome c from the mitochondria and the subsequent activation of caspase 9 and caspase 3 play a key role in cocaine induced apoptosis in these cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apo 2L induced apoptosis was associated with the processing of caspase 8 , Bid , and the cytosolic accumulation of cytochrome c as well as the processing of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The pathway is characterized by cytochrome c release into the cytoplasm , and activation of caspase 9 and caspase 3 , 4 6h after treatment ; cleavage products of caspase 8 and caspase 2 were not detectable in the cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c is released into the cytosol in E4orf4 expressing cells , but caspase 9 is not required for induction of apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Wnt 1 signaling inhibited the cytochrome c release and the subsequent caspase 9 activation induced by chemotherapeutic drugs , including both vincristine and vinblastine . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The involvement of mitochondria in tumor induced apoptosis of T cells was demonstrated by changes in mitochondrial permeability transition as assessed by 3 , 3 ' dihexiloxadicarbocyanine staining , by cleavage of cytosolic BID and its translocation to the mitochondria , by release of cytochrome c to the cytosol , and by the presence of active subunits of caspase 9 in Jurkat T cells cocultured with tumor cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These results suggest that the mechanism of enhanced apoptosis by this combination involves p 53 dependent increase of death receptors by CD 437 , activation of these receptors by TRAIL , enhanced Bid cleavage , release of cytochrome c , and activation of caspase 3 , caspase 7 , caspase 8 , and caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Unlike Bcl 2 , MIHA functioned after release of cytochrome c and DIABLO from the mitochondria and was able to bind to both processed caspase 9 and processed caspase 3 to prevent feedback activation of their zymogen forms . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Activated caspase 8 is known to propagate the apoptotic signal either by directly cleaving and activating downstream caspases or by cleaving the BH 3 Bcl2 interacting protein , which leads to the release of cytochrome c from mitochondria , triggering activation of caspase 9 in a complex with dATP and Apaf 1 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Here we show that metastatic melanomas often lose Apaf 1 , a cell death effector that acts with cytochrome c and caspase 9 to mediate p 53 dependent apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This is demonstrated by the absence of early cytochrome c release from mitochondria into the cytosol , the lack of mitochondrial membrane depolarization at early times , and the minor role of caspase 9 in DTT induced apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Moreover , Bax translocation , cytochrome c release , and caspase 9 activation were blocked by the broad spectrum caspase inhibitor , Z VAD fmk and the caspase 8 preferential inhibitor , Ac IETD CHO , suggesting that the mitochondria might participate in apoptosis by amplifying the upstream death signals . ^^^ In conclusion , our results indicated that activation of caspase 8 or other caspase ( s ) by p 53 triggered the membrane translocation of Bax and cytosolic release of cytochrome c , which might amplify the apoptotic signal by activating caspase 9 and its downstream caspases . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Induction of apoptosis by the oolong tea polyphenol theasinensin A through cytochrome c release and activation of caspase 9 and caspase 3 in human U 937 cells . ^^^ Furthermore , it was found that theasinensin A induced loss of mitochondrial transmembrane potential , elevation of ROS production , release of mitochondrial cytochrome c into the cytosol , and subsequent induction of caspase 9 activity . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We also showed that the both apoptosis by AIP were associated with the release of cytochrome c from mitochondria and activation of caspase 9 , and overexpressed Bcl 2 could inhibit both of the AIP induced apoptosis . ^^^ These results indicate that AIP induces apoptosis in cells by two distinct mechanisms ; one rapid and mediated by H2O2 , the other delayed and mediated by deprivation of L lysine , both of which utilize caspase 9 / cytochrome c system . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The results show that BMP 2 uses a Smad independent , PKC dependent pathway to promote apoptosis via a Bax / Bcl 2 and cytochrome c caspase 9 caspase 3 , 6 , 7 cascade in human osteoblasts . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In response to oncogene activation , p 53 mediates apoptosis through a linear pathway involving bax transactivation , Bax translocation from the cytosol to membranes , cytochrome c release from mitochondria , and caspase 9 activation , followed by the activation of caspase 3 , 6 , and 7 . p 53 mediated apoptosis can be blocked at multiple death checkpoints , by inhibiting p 53 activity directly , by Bcl 2 family members regulating mitochondrial function , by E1B 19K blocking caspase 9 activation , and by caspase inhibitors . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These observations indicate that DA induces apoptosis primarily by generating ROS , p 38 kinase activation , cytochrome c release followed by caspase 9 and caspase 3 activation . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The present study demonstrates that ( 1 ) the interaction of cell associated gp 120 with CXCR 4 expressing target cells triggers a rapid dissipation of the mitochondrial transmembrane potential resulting in the cytosolic release of cytochrome c from the mitochondria to cytosol , concurrent with activation of caspase 9 and 3 ; ( 2 ) this apoptotic process is independent of Fas signaling ; and ( 3 ) cooperation with a CD 4 signal is not required . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We further demonstrated that freezing triggers one of the caspase cascade involved in apoptosis : release of cytochrome c from mitochondria to cytosol , followed by activation of caspase 9 and degradation of PARP . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Moreover , cytochrome c release and activation of caspase 9 and 3 increased from 1 to 4 weeks of pacing . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Biochemical analysis of TNF treated cell lines expressing mouse DAPK beta suggests that the cytoprotective effect of DAPK is mediated through both intrinsic and extrinsic apoptotic signaling pathways and results in the inhibition of cytochrome c release from the mitochondria as well as inhibition of caspase 3 and caspase 9 activity . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Decreased phosphatidylinositol 3 kinase and Akt activities occurred in association with cytochrome c release and caspase 9 activation when cells were placed in defined medium . ^^^ C5b 9 inhibited the mitochondrial pathway of apoptosis in oligodendrocytes , as shown by decreased cytochrome c release and inhibition of caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In vivo intracerebroventricular z IETD fluoromethyl ketone administration significantly reduced seizure induced activities of caspases 8 , 9 , and 3 as well as reducing Bid and caspase 9 cleavage , cytochrome c release , DNA fragmentation , and neuronal death . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In this system , changes in mitochondrial membrane potential and cytochrome c release are shown to be dependent on caspase activation , and to occur concurrently with the release of caspase 9 from mitochondria , genomic DNA fragmentation and apoptotic body formation . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Moreover , the release of cytochrome c from mitochondria and the activation of caspase 3 and caspase 9 were also observed . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In contrast , mitochondrial cytochrome c release and activation of caspase 9 were significantly delayed in hsp 72 antisense cells stimulated either with TNF or monochloramine . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
VHL negative cells displayed a significant ( greater than 5 fold ) activation of caspase 9 and release of cytochrome c into the cytosol following chemical hypoxia . ^^^ In contrast , VHL positive cells showed minimal caspase 9 activation , and absence of cytochrome c release under the same conditions . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Pre treatment with the cell permeable caspase inhibitor , benzyloxycarbonyl Val Ala Asp ( OMe ) fluoromethyl ketone ( Z VAD . fmk ) , did not prevent the release of cytochrome c or partial processing of caspase 9 but prevented activation of effector caspases and the induction of apoptosis . ^^^ These results suggest that the release of cytochrome c is caspase independent and that caspase 9 is the initiator caspase in proteasome inhibitor induced apoptosis of B CLL cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Decreased psi ( m ) was associated with a cyclosporin A sensitive loss of cytochrome c but not with activation of caspase 3 or caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c release into the cytosol was noted by 4 h of FC loading , and activation of caspase 9 and effector caspases was observed at 6 h . ^^^ Thus , FC loading , perhaps via increased levels of Bax and / or cholesterol overloading of mitochondria , triggers cytochrome c release and activation of caspase 9 and the effector caspases , leading to macrophage apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c and dATP / ATP induce oligomerization of Apaf 1 into two distinct apoptosome complexes : an approximately 700 kDa complex , which recruits and activates caspases 9 , 3 and 7 , and an approximately 1 . 4 MDa complex , which recruits and processes caspase 9 , but does not efficiently activate effector caspases . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Investigations of apoptosis revealed that cytosolic cytochrome c is associated with a complex of apoptotic protease activating factor 1 ( Apaf 1 ) , an adapter molecule , and caspase 9 to activate caspase 3 . ^^^ The accumulation of cytosolic cytochrome c , an activator of caspase 9 , and the induction of the mitochondrial membrane associated voltage dependent anion channel were also reduced in cisplatin resistant cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
RESULTS : The cells did not show any decrease of MMP level up to 2 . 5 h after 1 mM adenosine exposure , whereas cytochrome c release , caspase 9 and caspase 3 activity , and DNA fragmentation were already activated , suggesting that mitochondrial depolarization is not a prerequisite of other apoptosis related mitochondrial events . ^^^ Moreover , we found that most of the apoptotic parameters in adenosine induced cellular changes , such as translocation of Bax , the release of cytochrome c , and the consequent activation of caspase 9 and caspase 3 , were attenuated by thymidine supplement , thus indicating that the sensing of a nucleoside or nucleotide balance might be an upstream event of cytochrome c release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Bax complex formation is associated with the release of cytochrome c , which propagates death signaling by acting as a cofactor for caspase 9 activation . ^^^ The adenovirus Bcl 2 homologue E1B 19K blocks TNF alpha mediated apoptosis by preventing cytochrome c release , caspase 9 activation , and apoptosis of virus infected cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We found that treatment of MDA MB 453 human breast cancer cells with adriamycin ( also known as doxorubicin , a DNA topoisomerase IIalpha inhibitor ) induced a series of time dependent events , including the mitochondrial release of cytochrome c and apoptosis inducing factor , mitochondrial membrane depolarization , activation of a set of caspases ( caspase 9 , 3 , 7 , 2 , and 8 ) , cleavage of poly ( ADP ribose ) polymerase ( PARP ) , and up regulation of expression of the Fas ligand . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The mechanism of GT1b activation of caspase 9 involved inhibition of beta ( 1 ) integrin serine / threonine phosphorylation and decreased phosphorylation of both integrin linked kinase and protein kinase B / Akt at its Ser 473 site , leading to cytochrome c release from mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptosis induction by T 2 toxin : activation of caspase 9 , caspase 3 , and DFF 40 / CAD through cytosolic release of cytochrome c in HL 60 cells . ^^^ These data indicate that T 2 induced apoptosis involves activation of caspase 3 and DFF 40 / CAD through cytosolic accumulation of cytochrome c along with caspase 9 activation . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
CONCLUSION : Cytochrome c release and caspase 9 activation are required for the activation of executor caspase 3 in TNF alpha induced hepatocyte apoptosis , but caspases 8 and 2 play , if any , a minimal role . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Upon treatment with staurosporine , generation of effector caspase activity , processing of caspase 3 and caspase 9 and cytochrome c redistribution were all profoundly inhibited in cells infected with C . pneumoniae . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the absence of extracellular glucose , hypoxia caused cytochrome c release , caspase 3 and poly ( ADP ribose ) polymerase cleavage , and DNA fragmentation ; this apoptotic response was blocked by the caspase 9 inhibitor z LEHD FMK . ^^^ The presence of extracellular glucose during hypoxia prevented cytochrome c release and activation of caspase 9 but did not prevent apoptosis in Jurkat cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c release is upstream to activation of caspase 9 , caspase 8 , and caspase 3 in the enhanced apoptosis of anaplastic thyroid cancer cells induced by manumycin and paclitaxel . ^^^ The drug combination enhanced the activation of caspase 9 , caspase 8 , and caspase 3 and cytochrome c release into the cytosol . ^^^ Cytochrome c release was not affected by the inhibitors of caspase 9 , caspase 8 and caspase 3 . ^^^ We concluded that the cytochrome c release was upstream of the activation of caspase 9 , caspase 8 , and caspase 3 in the enhanced apoptosis of anaplastic thyroid cancer cells treated with manumycin plus paclitaxel , and that the interaction between manumycin and paclitaxel occurred at or upstream of cytochrome c in the apoptosis regulatory pathway in anaplastic thyroid cancer cells . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Death receptors , eg , CD 95 ( APO 1 / Fas ) , trigger caspase 8 , and mitochondria release apoptogenic factors ( cytochrome c , Apaf 1 , AIF ) , leading to the activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Although mitochondrial cytochrome c release and caspase 9 cleavage were detectable by immunoblotting , assays of cytosol and nuclei prepared from the apoptotic cells failed to demonstrate the presence of activity that cleaved the synthetic caspase substrates LEHD 7 amino 4 trifluoromethylcoumarin ( LEHD AFC ) , DEVD AFC , and VEID AFC . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The antiapoptotic effect of vitamin C was associated with reduced cytochrome C release from mitochondria and the inhibition of caspase 9 activity . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We found loss of mitochondrial transmembrane potential , release of cytochrome C from mitochondria and subsequent activation of Caspase 9 in SNB 19 AS uPAR cells compared to parental and vector controls . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Taken together , the results suggest that apicidin might induce apoptosis through selective induction of Fas / Fas ligand , resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase 9 and caspase 3 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We show that in human breast tumor MCF 7 cells , TRAIL induced a mitochondrial pathway of apoptosis that involved cytochrome c release from mitochondria and activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Released cytochrome c allows the formation of a high molecular weight complex , the apoptosome , which consists of the adapter protein Apaf 1 and caspase 9 , which is activated following recruitment into the apoptosome . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Mitochondrial cytochrome c release and activation of caspase 9 accompanied DN HNF 1 alpha induced apoptosis , suggesting the involvement of the mitochondrial apoptosis pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Comparison of cell lines genetically matched at the bax , cytochrome c , apaf , caspase 9 and caspase 3 loci indicated that except for bax , all of these genes were essential for hypoxia induced apoptosis both in cell culture and in transplanted tumours . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Time sequence analysis of the induction of apoptosis by 4HPR revealed that an initial caspase 8 activation was followed by late mitochondrial cytochrome c release and minor caspase 9 activation , which suggested that caspase 8 activation is the primary upstream regulatory point . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
MPTP was found to elicit not only the activation of the effector caspase 3 but also the initiators caspase 8 and caspase 9 , mitochondrial cytochrome c release , and Bid cleavage in the SN of wild type mice . ^^^ MPTP associated toxicity in culture was found temporally to involve cytochrome c release , activation of caspase 9 , caspase 3 , and caspase 8 , and Bid cleavage . ^^^ Caspase 9 inhibition prevented the activation of both caspase 3 and caspase 8 and also inhibited Bid cleavage , but not cytochrome c release . ^^^ These data demonstrate that MPTP mediated activation of caspase 9 via cytochrome c release results in the activation of caspase 8 and Bid cleavage , which we speculate may be involved in the amplification of caspase mediated dopaminergic cell death . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The death observed during oxygen deprivation involves a decrease in the mitochondrial membrane potential , followed by the release of cytochrome c and the activation of caspase 9 . ^^^ Bcl 10 ( L ) prevented oxygen deprivation induced cell death by inhibiting the release of cytochrome c and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Our investigation of apoptosis in Hep G 2 cells showed a sequence of associated intracellular events that included ( a ) increased cytosolic free Ca ( 2+ ) ; ( b ) increased translocation of cytochrome c ( Cyto c ) from mitochondria to cytosol ; ( c ) activation of caspase 3 , caspase 8 , and caspase 9 ; and ( d ) downregulation of bcl 2 protein . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Moreover , treatment of HL 60 cells with Cd resulted in the appearance of Cytochrome c ( Cyt c ) , a potent activator of caspase 9 , in the cytosol at 3 h , which closely paralleled the activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the present study , we found that mature erythrocytes contain considerable amounts of caspase 3 and 8 , whereas essential components of the mitochondrial apoptotic cascade such as caspase 9 , Apaf 1 and cytochrome c were missing . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Formation of the Apaf 1 / cytochrome c complex precedes activation of caspase 9 during seizure induced neuronal death . ^^^ In this study we examine the in vivo formation of the Apaf 1 / cytochrome c complex and activation of caspase 9 following limbic seizures in the rat . ^^^ These data suggest seizures induce formation of the Apaf 1 / cytochrome c complex prior to caspase 9 activation and caspase 9 may be a potential therapeutic target in the treatment of brain injury associated with seizures . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Overexpression of MEKK 1 , however , failed to release cytochrome c from the mitochondria or activate caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Mitochondria are known to be involved in the early stage of apoptosis by releasing cytochrome c , caspase 9 , and the second mitochondria derived activator of caspases ( Smac ) . ^^^ In the Wt animals , early superoxide production , mitochondrial release of cytochrome c , Smac , and cleaved caspase 9 were observed after ischemia . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the U 937 cells treated with DZA , cytochrome c release from mitochondria and subsequent activation of caspase 9 , 8 and 3 were observed before the induction of apoptosis . zDEVD Fmk , a specific inhibitor of caspase 3 , and zLEHD Fmk , a specific inhibitor of caspase 9 , prevented the activation of caspase 8 but neither caspase 3 nor caspase 9 , indicating that caspase 8 is downstream of both caspase 3 and caspase 9 , which are activated by independent pathways . zVAD Fmk , a universal inhibitor of caspases , kept the caspase 3 from being activated but not caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Infection of tumor cells with pAd T34A resulted in cytochrome c release from mitochondria , cleavage of approximately 46 kDa upstream caspase 9 , processing of caspase 3 to the active subunits of approximately 17 and 19 kDa , and increased caspase 3 catalytic activity . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
RESULTS : In terminally failing hearts , there was a significant accumulation of cytochrome c in the cytosol , which was associated with activation of caspase 9 and downregulation of its inhibitor , caspase 9S . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In mammalian cells , nonreceptor mediated apoptosis occurs predominantly via assembly of a cytochrome c dependent apoptosome complex containing caspase 9 and apoptotic protease activating factor 1 ( Apaf 1 ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c was released from mitochondria , and caspase 9 was activated in Bax or Bak deficient cells in response to TNF alpha but not in cells deficient in both . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Interestingly , the release of cytochrome c did not activate caspase 9 and 3 , the main caspases involved in apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptotic signaling by p 53 induced a Bid independent conformational change in Bax , a Bax Bak interaction , release of cytochrome c and Smac / DIABLO from mitochondria , caspase 9 and 3 activation , cleavage of known caspase substrates , and apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
HCCS 1 transfected HeLa cells were shown to release cytochrome c from mitochondria , which activates caspase 9 and 3 and finally results in cleavage of poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Nitric oxide administered during hypoxia induced the release of cytochrome c , caspase 9 activation , and the loss of mitochondrial membrane potential followed by DNA fragmentation and lactate dehydrogenase release ( markers of cell death ) . ^^^ Bcl 10 ( L ) protected cells from nitric oxide induced apoptosis during hypoxia by preventing the release of cytochrome c , caspase 9 activation , and by maintaining a mitochondrial membrane potential . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Rat1a cells exposed to hyperoxia underwent apoptosis characterized by the release of cytochrome c , activation of caspase 9 , and nuclear fragmentation that was prevented by the overexpression of Bcl 10 ( L . ) Murine embryonic fibroblasts from bax ( / ) bak ( / ) mice were resistant to hyperoxia induced cell death . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
However , cytochrome c translocation to the cytosol and activation of caspase 9 and caspase 3 were markedly reduced in Hsp 70 overexpressing cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We show here that the lung epithelial cell line A 549 releases cytochrome c and activates caspase 9 followed by DNA fragmentation and plasma membrane breakage in response to anoxia . ^^^ The antiapoptotic protein Bcl 10 ( L ) prevented the anoxia induced cell death by inhibiting the release of cytochrome c and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In pheochromocytoma cells , MMT exposure resulted in rapid increase in generation of reactive oxygen species ( ROS ) within 5 15 min , followed by release of mitochondrial cytochrome C into cytoplasm and subsequent activation of cysteine proteases , caspase 9 ( twofold to threefold ) and caspase 3 ( 15 to 25 fold ) , but not caspase 8 , in a time and dose dependent manner . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the apoptosome , cytochrome c and Apaf 1 activate caspase 9 which subsequently leads to the activation of caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
However , other proteins analyzed [ namely , Apaf 1 , Bax , Bid , caspase 3 , caspase 8 , caspase 9 , 10 linked inhibitor of apoptosis protein ( XIAP ) , cellular inhibitor of apoptosis protein ( cIAP ) 1 , cIAP 2 , cytochrome c , Fas , Fas ligand , FLIP , p 53 , and poly ( ADP ribose ) polymerase ] were not affected by either rituximab or cisplatin . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The release of cytochrome c from mitochondria is necessary for the formation of the Apaf 1 apoptosome and subsequent activation of caspase 9 in mammalian cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cer , in turn , induced mitochondrial translocation of PKCdelta and stimulated the activity of this kinase , promoting cytochrome c release and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Because caspase 9 activation requires the release of mitochondorial cytochrome c ( Cyt c ) into the cytoplasm , we determined the level of cytoplasmic Cyt c in response to cisplatin treatment . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Nitric oxide inhibits apoptosis downstream of cytochrome C release by nitrosylating caspase 9 . ^^^ In conclusion , NO inhibits apoptosis downstream of cytochrome c release by directly blocking caspase 9 activation . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The sequence of events may be summarized as follows : activation of Bax induces mitochondrial permeability transition , leading to release of cytochrome c , activation of caspase 9 , and entry into the execution phase of apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , Bax translocation , cytochrome C release , and caspase 9 activation were blocked by Z VAD . fmk and Z IETD CHO . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c is released from mitochondria , while caspase 9 and caspase 3 , but not caspase 8 , are activated upon inhibition of the TRX 2 transgene . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
IFN gamma promoted TRAIL mediated activation of caspase 8 , Bcl 2 interacting domain death agonist ( Bid ) degradation , Bcl 2 associated 10 protein ( Bax ) translocation to mitochondria , cytochrome c release to the cytosol and activation of caspase 9 in these cell lines . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We show here that declopramide at doses above 250 microM in the mouse 70Z / 3 pre B cell line or in the human promyeolocytic cancer cell line HL 60 induced cytochrome c release into the cytosol and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c then facilitates the activation of a caspase cascade involving caspase 9 and 3 . ^^^ Work from my laboratory in the last 5 years has shown that teratogens , such as hyperthermia , 4 hydroperoxycyclophosphamide , and staurosporine , induce cell death in day 9 mouse embryos by activating the mitochondrial apoptotic pathway , i . e . , mitochondrial release of cytochrome c , activation of caspase 9 and 3 , inactivation of poly ( ADP ribose ) polymerase ( PARP ) , and systematic degradation of DNA . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The temporal profile of caspase 9 activation coincided with that of cytochrome c release and caspase 3 activation , but preceded CA 1 neuronal death . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
SN 50 induced apoptosis in MM cell lines and patient cells ; down regulated expression of Bcl 2 , A 1 , 10 chromosome linked inhibitor of apoptosis protein ( XIAP ) , cellular inhibitor of apoptosis protein 1 ( cIAP 1 ) , cIAP 2 , and survivin ; up regulated Bax ; increased mitochondrial cytochrome c release into the cytoplasm ; and activated caspase 9 and caspase 3 , but not caspase 8 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , these results indicate that release of mitochondrial cytochrome c into the cytoplasm within 2 3 h post PDT is a secondary event following the activation of initiator caspase 8 preceding Apaf 1 , caspase 9 and caspase 3 activation , cleavage of PARP and DNA fragmentation . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 9 activation occurred without the release of cytochrome c from mitochondria and was not dependent on the presence of Apaf 1 or reactive oxygen intermediates . ^^^ Our results therefore suggest an alternative mechanism for caspase 9 activation in virally infected cells beside the well characterized pathways via death receptors or mitochondrial cytochrome c release . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Highly cisplatin resistant cells ( MeWo ( Cis 1 ) ) , however , demonstrated a reduced caspase 9 activity and cytochrome c release but the extent of effector caspase activation as well as DNA fragmentation was comparable to that of sensitive MeWo cells at equitoxic concentrations . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Decylubiquinone , a mitochondrial permeability transition pore inhibitor , does not suppress the activation of caspase 8 but suppresses release of cytochrome c , activation of caspase 9 , and induction of apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This inhibitor induced death response is associated with the release of cytochrome c from mitochondria and the activation of apical caspase 9 and is blocked by overexpression of Bcl 2 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptotic protease activating factor 1 ( Apaf 1 ) and cytochrome c are cofactors critical for inducing caspase 9 activation following stress induced apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Activation of caspase 9 , 8 , 7 , and 3 and the expression of Bcl 2 family proteins , inhibitors of apoptosis ( IAPs ) , cytochrome c , as well as Smac proteins were evaluated with immunoblotting . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This fact is preceded by the induction of several mitochondrial events , including increase in Bax / Bcl 2 ratio followed by cytochrome c release and consequent activation of caspase 9 and 3 , reduction of ATP levels , depolarization of membrane potential ( DeltaPsi ) and rupture of the outer membrane . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
TRAIL induced translocation of Bax from cytosol to mitochondria , release of cytochrome c from mitochondria and activation of caspase 9 were all inhibited by PKC activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , E 6 ( AS ) induced loss of mitochondrial transmembrane potential , release of mitochondrial cytochrome c into the cytoplasm , and subsequent activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome C and caspase 9 expression in Huntington ' s disease . ^^^ One important event in the apoptotic cascade is the release of cytochrome c by mitochondria into the cytoplasm , activating caspase 9 , leading to the subsequent activation of downstream executioner caspases . ^^^ In the present study , we examined the distribution of cytochrome c and caspase 9 in Huntington ' s disease ( HD ) patients and in a transgenic model of HD ( R6 / 2 line ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We observed that apoptosis was induced through the mitochondrial pathway as we observed changes in the cytochrome c content accompanied by caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c independent activation of caspase 9 by caspase 12 . ^^^ Although cytochrome c released from mitochondria has been believed to be required for caspase 9 activation during apoptosis ( Zou , H . , Henzel , W . ^^^ S . , and Wang , 10 . ( 1997 ) Cell 91 , 479 489 ) , caspase 9 as well as caspase 12 and 3 are activated in cytochrome c free cytosols in murine myoblast cells under ER stress . ^^^ These results suggest that caspase 12 can activate caspase 9 without involvement of cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In contrast , p 75 mediated neuronal death was associated with mitochondrial loss of cytochrome c and required Apaf 1 and caspase 9 , 6 , and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In mitochondrion dependent apoptosis , release of cytochrome C into the cytosol results in the formation of apoptosome containing cytochrome C , Apaf 1 and caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Further investigations revealed that while caspase 8 activity is detected concomitant to caspase 3 , caspase 9 activation , following mitochondrial cytochrome c release , is detectable later on . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Treatment of NCI H 82 cells with etoposide induces a series of time dependent events , including the release of cytochrome c from the mitochondria to the cytosol , activation of caspase 9 and caspase 3 , and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptosis was associated with depolarization of mitochondrial membrane , release of cytochrome c and apoptosis inducing factor ( AIF ) from the mitochondria , and activation of caspase 9 and caspase 3 , but not of caspase 8 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The increased mitochondrial localization of Bim coincided with a marked cytochrome c release and preceded the peak of caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In parent HeLa cells , activation of caspase 9 and release of cytochrome c were observed after 8h treatment with 0 . 5ng / ml pierisin 1 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Released cytochrome c interacts with apoptotic protease activating factor 1 and caspase 9 , both of which play important roles in the cytochrome c dependent mitochondrial pathway of apoptosis by activating caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These protective effects were accompanied by significant inhibition of cytochrome c release from mitochondria and caspase 9 activation , therefore localizing N SMase activation upstream of mitochondrial dysfunction . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , satratoxin G caused a release of cytochrome c from mitochondria into the cytosol and increased the activity of caspase 9 against LEHD AMC . ^^^ These findings indicate that satratoxin G induced apoptosis involves activation of caspase 3 and DFF 40 / CAD through both activation of caspase 8 and cytosolic accumulation of cytochrome c along with activation of caspase 9 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
It also enhanced activation of caspase 9 but it did not increase cytochrome c in the cytosol . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Hepatocyte apoptosis induced by glycodeoxycholate ( GCDC ) was associated with mitochondrial depolarization , activation of caspases , the release of cytochrome c from the mitochondria , and translocation of BAX from the cytosol to the mitochondria . cAMP inhibited GCDC induced apoptosis , caspase 3 and caspase 9 activation , and cytochrome c release in a PI3K dependent manner . cAMP activated PI3K in p 85 immunoprecipitates and resulted in PI3K dependent activation of the survival kinase Akt . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This initiates the activation of the mitochondrial apoptotic pathway leading to release of cytochrome c and activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptosis that occurred in cells may be related to the dysfunction of mitochondria , the release of cytochrome c into cytosol , and the activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Further studies showed that the cytochrome c / caspase 9 pathway was responsible for imperatorin induced apoptosis ; i . e . , mitochondrial membrane was depolarized , Bcl 2 was down regulated , cytochrome c was released from mitochondria , caspase 9 and caspase 3 were activated , and poly ( ADP ribose ) polymerase was cleaved . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These inhibitors also induced cytochrome c release , caspase 9 activation , as well as downstream caspase 3 , caspase 7 activation , and PARP cleavage . ^^^ In conclusion , blockade of both 5 LOX and 12 LOX pathways induces apoptosis in breast cancer cells through the cytochrome c release and caspase 9 activation , with changes in the levels of Bcl 2 family proteins . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Further , in Bax deficient cells , neither sulindac sulfide nor SC ' 236 in combination with Apo2L / TRAIL effectively promotes the release of cytochrome c from mitochondria into cytosol and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The apoptosis triggered by H 6 was accompanied by up regulation of Bcl 10 ( S ) , accumulation of cytosolic cytochrome c and activation of caspase cascade ( caspase 9 and 3 ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We have previously shown that the mitochondrial dependent programmed cell death ( PCD ) pathway , including the redistribution of Bax , the cytosolic release of cytochrome c , and the activation of caspase 9 , is recruited during neurodegeneration in spinal cords of transgenic mutant SOD 1 mice . ^^^ We also found that the expression of a dominant negative mutant of caspase 1 attenuates Bid cleavage as well as the mitochondrial release of cytochrome c , and the ensuing activation of caspase 9 and 3 in spinal cords of transgenic mutant SOD 1 mice . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The role of mitochondria , cytochrome c and caspase 9 in embryonic lens fibre cell denucleation . ^^^ At the same time , caspase 9 co localizes with cytochrome c in the cytosol . ^^^ Apaf 1 , another cytosolic protein of the apoptotic cascade , also migrates to the permeabilized mitochondria and also co localizes with caspase 9 and cytochrome c in the cytosol or mitochondria of denucleating cells , thus providing evidence for the formation of an ' apoptosome ' in these cells , as in apoptotic cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We report that cytosolic cytochrome c induced apoptosis in competent sympathetic neurons is completely dependent on caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c was released into the cytosol at very early stages of apoptosis induction , long before detectable production of reactive oxygen species and activation of caspase 9 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Results of experiments utilizing this cell line suggest that the alteration responsible for resistance of CA CD437R cells to CD 437 induced event maps after the activation of p 38 and TR 3 expression , prior to mitochondrial depolarization , subsequent release of cytochrome c and activation of caspase 9 and caspase 3 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Early steps in these death promoting events are the release of cytochrome c from the mitochondria and activation of caspase 9 . ^^^ Inhibition of caspase 9 , the apical caspase in cytochrome c dependent apoptosis , is an effective intervention to attenuate neurological injury after focal ischemia . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
BCR ligation activated mitochondrial apoptotic pathways including down regulation of Bcl 10 ( L ) , dissipation of mitochondrial transmembrane potential , release of cytochrome c , and activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Superoxide production , mitochondrial release of cytochrome c , and activation of caspase 9 were examined , and apoptotic DNA injury was also characterized . ^^^ In the wild type animals , increased superoxide production , mitochondrial release of cytochrome c , and cleaved caspase 9 were observed exclusively in VMN after SCI . ^^^ Transgenic animals showed less superoxide production , mitochondrial cytochrome c release , and caspase 9 activation , resulting in death of only 45 % of the VMN . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptotic signaling during oxygen deprivation occurs through the release of cytochrome c and apaf 1 mediated caspase 9 activation . ^^^ Pro apoptotic Bcl 2 family members such as bax or bak are clearly required to initiate cytochrome c / apaf 1 / caspase 9 mediated cell death during oxygen deprivation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Here we show that upon PKR expression , caspase 9 is processed and activated , correlating with the translocation of cytochrome c to the cytoplasm and breakdown of mitochondrial potential upon Bax insertion . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptosis initiated by Bcl 2 regulated caspase activation independently of the cytochrome c / Apaf 1 / caspase 9 apoptosome . ^^^ Because Apaf 1 requires cytochrome c to activate caspase 9 , and Bcl 2 prevents mitochondrial cytochrome c release , Bcl 2 is widely believed to inhibit apoptosis by safeguarding mitochondrial membrane integrity . ^^^ Caspase activity was still discernible in cells lacking Apaf 1 or caspase 9 , and a potent caspase antagonist both inhibited apoptosis and retarded cytochrome c release . ^^^ We conclude that Bcl 2 regulates a caspase activation programme independently of the cytochrome c / Apaf 1 / caspase 9 ' apoptosome ' , which seems to amplify rather than initiate the caspase cascade . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Taken together , these results are consistent with a model in which Smac / DIABLO mediated inhibition of IAPs , rather than cytochrome c mediated activation of caspase 9 , is the key event responsible for mitochondrial augmentation of reovirus induced apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Accordingly , Mphi death induced by inoculation with Mtb had the characteristics of apoptosis and necrosis and correlated with moderate increase of mitochondrial permeability transition ( MPT ) , mitochondrial cytochrome c release , and caspase 9 and 3 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Further studies on these pathways showed that PS 341 decreases the levels of several antiapoptotic proteins and triggers a dual apoptotic pathway of mitochondrial cytochrome c release and caspase 9 activation , as well as activation of Jun kinase and a Fas / caspase 8 dependent apoptotic pathway [ which is inhibited by a dominant negative ( decoy ) Fas construct ] . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 9 is positioned at the apex of the pro apoptotic signaling cascade induced by cytochrome c release from mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 9 , 8 , and 3 activation and cytochrome c release can be detected 1 to 2 hours after DEX treatment . ^^^ Caspase 9 inhibition does not counter cytochrome c release , caspase 8 and caspase 3 activation , and apoptosis . ^^^ Caspase 8 inhibition counters cytochrome c release , caspase 9 and caspase 3 activation , and apoptosis , thus suggesting that caspase 8 inhibitor can directly inhibit caspase 9 and / or that DEX induced caspase 8 activation is upstream to mitochondria and can regulate caspase 3 directly or through cytochrome c release and the consequent caspase 9 / caspase 3 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The present data demonstrate that almost 50 % of erythroid progenitor cells derived from patients with MDS exhibit spontaneous release of cytochrome c from mitochondria with ensuing activation of caspase 9 , whereas normal erythroid progenitors display neither of these features . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In contrast to our previous findings in non neuronal cell lines , reovirus induced neuronal apoptosis is not accompanied by significant release of cytochrome c from the mitochondria or with caspase 9 activation following infection . ^^^ This suggests that in neuronal cells , unlike their non neuronal counterparts , the mitochondria mediated apoptotic pathway associated with cytochrome c release and caspase 9 activation does not play a significant role in augmenting reovirus induced apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
To investigate the regulation of cell cycle modulators during drug treatment , we analyzed release of the apoptosis initiator cytochrome c and activation of the downstream effectors caspase 9 , caspase 3 and poly ( ADP ribose ) polymerase 16 hr after GCV sensitization , followed by transient escalation of tumor suppressor p 53 and cell cycle modulators cyclin A and B ( 1 ) before committing to programmed cell death . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This cell death was associated with cleavage of nuclear chromatin , mitochondrial depolarization , cytochrome c extrusion , activation of caspase 9 , and expression of phosphatidylserine on the outer cell membrane . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Toxin A also induced changes in mitochondrial membrane potential and cytochrome c release at 18 24 h , a time course similar to caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In contrast to the MOLT 4 wild type cells , Ara G resistant cells displayed no increase in caspase 3 or caspase 9 activity , DNA fragmentation , cytochrome c release or a drop in the mitochondrial membrane potential ( DeltaPsi ( mito ) ) upon Ara G treatment . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Naphthazarin induced cytotoxicity was evidenced by the ordered development of lysosomal acridine orange relocation , decrease in mitochondrial potential , cytochrome c release , and caspase 9 activation , and was inhibited by guanabenz , rilmenidine , and AGN 192403 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
At the end of hypoxia homogenous cytosolic immunoreactivity of cytochrome c increased approximately fourfold , cytochrome c intensity in western blot analyses increased more than fivefold , and whole cell and cytosolic cleaved caspase 9 underwent 50 % and 100 % increases , respectively . ^^^ Immunostaining of sections taken 1 . 5 h after hypoxia showed : ( 1 ) more than a threefold increase in cleaved caspase 9 ; ( 2 ) localization of cleaved caspase 9 to the interior and peripheral exterior of nuclei ; and ( 3 ) homogeneously distributed cytochrome c in the cytosol . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Moreover , cytochrome c release and activation of caspase 9 was also observed in apoptotic cells and a specific inhibitor of caspase 9 ( zLEHD Fmk ) prevented both DNA fragmentation and activation of caspase 3 , but not relative cell survival , implying the upstream mitochondrial event of caspase 3 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The pan caspase inhibitor Boc fmk and the caspase 8 inhibitor lETD fmk opposed CGP74514A induced caspase 9 activation and PARP degradation , but not cytochrome c or Smac / DIABLO release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This was followed temporally by activation and mitochondrial translocation of Bax , induction of mitochondrial permeability transition , release of cytochrome c into the cytosol , activation of caspase 9 , and entry into the execution phase of apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The caspase cascade is activated by the release of cytochrome c , which is initiated by the formation of apoptosomes consisting of procaspase 9 , Apaf 1 and cytochrome c in the presence of dATP , and results in the activation of caspase 9 and caspase 3 , thereby leading to apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Moreover , the membrane potential ( deltapsi ( m ) ) was affected , and translocation of cytochrome c to the cytosol , overexpression of apoptotic protease activating factor 1 and a significant increase of caspase 9 activity were demonstrated , indicating that the apoptosome is formed . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In this pathway , cytochrome c released from mitochondria facilitates the formation of an Apaf 1 apoptosome that recruits and activates caspase 9 . ^^^ Recent data indicate that in some cells caspase 9 may not be the initiator caspase in stress mediated apoptosis because caspase 2 is required upstream of mitochondria for the release of cytochrome c and other apoptogenic factors . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These effects were mediated through activation of caspase 9 and 3 , mitochondrial release of cytochrome c and subsequent PARP cleavage . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This was associated with translocation of cytochrome c from the mitochondria to the cytosol , resulting in activation of the caspase cascade via caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Poliovirus infection activates the apoptotic pathway , involving mitochondrial damage , cytochrome c efflux , and consecutive activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c and caspase 9 function downstream of p 53 in mediating the drug triggered apoptosis in SH SY5Y cells . ^^^ In drug treated cells , cytochrome c is released , and caspase 9 becomes activated . ^^^ Inactivation of p 53 blocks cytochrome c release and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
RESULTS : Incubation of gastric epithelial cells with H . pylori caused a time and concentration dependent induction of DNA fragmentation ( 3 fold increase ) , cleavage of BID , release of cytochrome c and a concomittant sequential activation of caspase 9 ( 4 fold ) , caspase 8 ( 2 fold ) , caspase 6 ( 2 fold ) , and caspase 3 ( 6 fold ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Prodigiosin induces caspase 9 and caspase 8 activation and cytochrome C release in Jurkat T cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In fact , unlike GD 3 , 9 O acetyl GD 3 is completely ineffective in inducing cytochrome c release and caspase 9 activation on isolated mitochondria and fails to induce the collapse of mitochondrial transmembrane potential and cellular apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
TxA caused a more rapid decrease in ATP , release of cytochrome c , and activation of caspase 9 in C2AS cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Once released into the cytosol , cytochrome c binds to its adaptor molecule , apoptotic protease activating factor 1 , which oligomerizes and then activates pro caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We detected a decrease in the expression of bcl 2 and bcl 10 ( L ) , two antiapoptotic proteins that decrease mitochondrial membrane permeability , an increase in cytochrome c immunoreactivity in the cytosolic fraction , and an activation of caspase 9 in brain regions which show apoptotic neurodegeneration following percussion brain trauma in 7 day old rats . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The apoptosome is a multiprotein complex comprising Apaf 1 , cytochrome c , and caspase 9 that functions to activate caspase 3 downstream of mitochondria in response to apoptotic signals . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
As well as inhibiting the Akt NFkappaB pathway , InsP ( 6 ) itself caused mitochondrial permeabilization , followed by cytochrome c release , which later caused activation of the apoptotic machinery , caspase 9 , caspase 3 and poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In accordance with the changes in ARC expression observed , calorie restriction attenuated the increases in cytosolic cytochrome c and caspase 2 activity with age and suppressed the age associated rise in cleaved caspase 9 and cleaved caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
CH 11 increased cytochrome c release and consequent activation of caspase 9 , independent of caspase 8 and increased p 38 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In these cell lines , apoptosis was accompanied by activation of caspase 9 and caspase 3 and by release of cytochrome c to the cytosol . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 protected CH 27 cells against magnolol triggered apoptosis . 4 Magnolol treatment resulted in accumulation of cytosolic cytochrome c and activation of caspase 9 and downstream caspases ( caspase 3 and 6 ) . ^^^ The responsiveness of JNK and ERK to magnolol suggests the involvement of these kinases in the initiation of the apoptosis process . 6 These results indicate that regulation of the Bcl 2 family , accumulation of cytosolic cytochrome c , and activation of caspase 9 and caspase 3 may be the effector mechanisms of magnolol induced apoptosis . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The initiator caspase 9 was also activated by both K 5 and STS , as well as cytochrome c release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Data show that NF kappaB was constitutively activated in neurons , and demonstrate for the first time that drug dependent NF kappaB inhibition induced rapid mitochondrial release of cytochrome c , caspase 9 and 3 activation , poly ( ADP ribose ) polymerase 1 cleavage , membrane blebbing and nuclear fragmentation , without evidence of procaspase 8 and Bid processing . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We show that treatment of CLL cells with rolipram , a prototypic PDE 4 inhibitor , and forskolin , an adenylate cyclase activator , induces mitochondrial depolarization , release of cytochrome c into the cytosol , caspase 9 and 3 activation , and cleavage of poly ( adenosine diphosphate [ ADP ] ribose ) polymerase . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Asbestos induced deltapsi ( m ) was associated with the release of cytochrome c from the mitochondria to the cytoplasm as well as activation of caspase 9 , a mitochondrial activated caspase . ^^^ We conclude that asbestos induced AEC apoptosis results from mitochondrial dysfunction , in part due to iron derived ROS , which is followed by the release of cytochrome c and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We demonstrate that NaSal mediates ROS production followed by a decrease in mitochondrial membrane potential ( deltapsi ( m ) ) , release of cytochrome c , and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Phytosphingosine also induced activation of caspase 9 and 3 , loss of mitochondrial membrane potential , and the cytochrome c release from mitochondria . ^^^ Moreover , caspase 8 inhibitor z IETD fmk did not affect phytosphingosine induced cytochrome c release and caspase 9 activation , suggesting that phytosphingosine induced cytochrome c release is caused by caspase 8 independent manner . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , activation of mitochondria via Bid is associated with release of cytochrome c and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
ER stress induces caspase 8 activation , stimulating cytochrome c release and caspase 9 activation . ^^^ Excess ER stress induces caspase 12 activation and / or cytochrome c release , causing caspase 9 activation . ^^^ We examined the relationship between ER stress mediated cytochrome c / caspase 9 and caspase 12 activation by using caspase 9 and caspase 8 deficient mouse embryonic fibroblasts and a P 19 EC cell clone [ P 19 36 / 12 ( ) cells ] lacking expression of caspase 12 . ^^^ P 19 36 / 12 ( ) cells underwent apoptosis upon ER stress , with cytochrome c release and caspase 8 and caspase 9 activation . ^^^ The dominant negative form of FADD and z VAD fmk inhibited caspase 8 , caspase 9 , Bid processing , cytochrome c release , and DNA fragmentation induced by ER stress , suggesting that caspase 8 and caspase 9 are the main caspases involved in ER stress mediated apoptosis of P 19 36 / 12 ( ) cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , the exclusion from the platelet progeny of caspase 9 present in the progenitor accounts for failure of mitochondrial release of cytochrome c to activate caspase 3 during platelet death . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Hyperoxia induced cell death is associated with cytochrome c release , subsequent caspase 9 and 3 activation , and poly ( ADP ribosyl ) polymerase cleavage , which can all be suppressed by DPI and PD 98059 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Selective structural mitochondrial swelling , alteration of mitochondrial membrane potential , and cytochrome c and caspase 9 release from the mitochondria occurred 18 24 h later . alpha Tocopherol inhibited the alteration of both mitochondrial permeability and the leakage of procaspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Theoretically , procaspase 9 might be activated in the mitochondria in a cytochrome c / Apaf 1 dependent manner , or activated caspase 9 and 3 may translocate to the mitochondria , or the mitochondrially localized procaspases may be activated by the translocated active caspases . ^^^ Both the early release of proteins like cytochrome c and Hsp 60 from the mitochondria as well as the later translocation of the active caspase 9 / 3 are partially inhibited by cyclosporin A , an inhibitor of mitochondrial membrane permeabilization . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apaf 1 , Bcl xL , cytochrome c , and caspase 9 form the critical elements for cerebral vascular protection by erythropoietin . ^^^ Consistent with the modulation of Apaf 1 and the release of cytochrome c , EPO also inhibits the activation of caspase 9 and caspase 3 like activities . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Also , 17 AAG induced the mitochondrial release and cytosolic accumulation of cytochrome c ( cyt c ) and second mitochondria derived activator of caspases ( Smac ) / DIABLO , resulting in the activation of caspase 9 and caspase 3 and apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These apoptotic events involve the mitochondria because we found cytochrome c depletion and caspase 9 and caspase 3 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Similar to apoptosis in animal system , mitochondrial membrane potential was decreased , cytochrome c released from mitochondria to cytosol , and caspase 9 and caspase 3 like proteolytic activities detected in the cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
CONCLUSIONS : Our results suggest that the release of cytochrome c from mitochondria and its subsequent activation of caspase 9 and caspase 3 in testes play a key role in cocaine induced germ cell apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Once released , cytochrome c cooperates with apoptotic protease activating factor 1 and deoxyadenosine triphosphate in caspase 9 activation and initiation of the apoptotic protease cascade . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Mitochondrial involvement is evident due to the loss of mitochondrial transmembrane potential , release of cytochrome c into the cytosol and activation of caspase 9 in dexamethasone treated thymocytes . ^^^ The addition of spermine inhibited the release of cytochrome c from the mitochondria into the cytosol , and also the activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Tocopheryl quinone induces apoptosis in cancer cells via caspase 9 activation and cytochrome c release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Further investigation demonstrated that leptin activated caspase 3 and caspase 9 , but not caspase 8 , and increased the cleavage of poly ( ADP ribose ) polymerase and cytochrome c release into cytosol . ^^^ These data indicated that leptin induced hBMSC apoptosis via ERK / cPLA2 / cytochrome c pathway with activation of caspase 9 and caspase 3 , and cleavage of poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The release of cytochrome c was correlated with caspase 9 activity . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cortical neurons treated with MK 801 / CNQX triggered activation of caspase 9 , release of cytochrome c from mitochondria , and translocation of Bax into mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
LPA reduced cytochrome c release from mitochondria and prevented activation of caspase 9 . ^^^ These data indicate that LPA protects IEC 6 cells from camptothecin induced apoptosis through G ( 1 ) coupled inhibition of caspase 3 activation mediated by the attenuation of caspase 9 activation due to diminished cytochrome c release , involving upregulation of Bcl 2 protein expression and prevention of Bax translocation . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The prevention of proteolysis was also confirmed by both the following results : one is the inhibition of in vitro caspase 3 / 7 and 9 activation in cell lysates exposed to UVB in the presence of cytochrome c and dATP , which was caused by the production of ROS , and the other is the inhibition of in vitro caspase 3 / 7 activation in the presence of active caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Exogenous ROS and caspase 3 induced deltapsi ( m ) drop and cytochrome c release from mitochondria , which could be prevented by molecular ( dominant negative caspase 9 ) and pharmacologic ( zVAD fmk ) caspase inhibitors and overexpression of Bcl 2 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Induction of mitochondrial alterations , i . e . , mitochondrial depolarization and release of cytochrome c , as well as cleavage of caspase 9 , 7 , and 1 occurred only at later time points . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Although these data suggested that caspase 8 mediated cleavage of Bid with release of cytochrome c from mitochondria and activation of caspase 9 were responsible for the apoptosis , preincubation of HeLa cells with a specific inhibitor of caspase 9 did not protect against apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Western blot analysis showed that I / R induced expressions of platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) and Fas and Fas ligand ( FasL ) proteins , cleaved Bid , and enhanced the release of cytochrome c from mitochondria to activate caspase 9 . ^^^ The activated PAF increased the mucosal IL 6 and PECAM 1 , enhanced the expression of FasL but not Fas , and led to the cleavage of Bid and the release of cytochrome c from mitochondria to activate caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 3 and caspase 9 activities and cytochrome c release were significantly inhibited in Tg mice compared with those in WT mice . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c binds to Apaf 1 and dATP and recruits and cleaves pro caspase 9 in the apoptosome . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Vpr ' s attack on the mitochondria results in release of cytochrome c resulting in activation of the caspase 9 pathway culminating in the activation of caspase 3 and the downstream events of apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Here , we report that 2 methoxy estradiol ( 2 Me ) , a natural estrogen metabolite , induced a caspase dependent apoptosis of Ewing sarcoma derived cells independently of their p 53 status . 2 Me induced apoptosis occurred through the mitochondrial death pathway as evidenced by reduction of the mitochondrial transmembrane potential , cytochrome c release and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
TG also promoted the release of cytochrome c into cytosol and caspase 9 activation in Bax proficient cells but not in Bax deficient cells . ^^^ Although both agents in combination also induced cytochrome c release into cytosol and caspase 9 activation in Bax proficient cells , these events were abrogated in Bax deficient cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These experiments show that targeting the OGG repair enzyme to mitochondria reduces the release of cytochrome c from the intermitochondrial space and the activation of caspase 9 in oligodendrocytes after exposure to menadione . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This was accompanied by inhibition of mitochondrial depolarization , cytochrome c release , and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Serotonin prevents cytochrome c release and caspase 9 and 3 activation after serum deprivation via cross talks between phosphatidylinositol 3 kinase / Akt and extracellular signal regulated kinase ( ERK ) 1 / 2 signaling pathways . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Moreover , alterations of some apoptotic factors such as caspase 9 , Bax , and cytochrome c in the tissues demonstrated participation of mitochondrial disturbance in one of the apoptotic mechanisms . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
After exposure to either chemical alone , there was a discrepancy between the findings on tumor necrosis factor alpha and caspase 8 , on one hand , and on cytochrome c and caspase 9 , on the other hand . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Data show that VES induced apoptosis involves : ( a ) translocation of Bax from the cytosol to the mitochondria and cytochrome c release from the mitochondria to the cytosol as determined by Western immunoblot analyses of mitochondrial and cytosolic enriched cellular fractions ; ( b ) increased permeabilization of mitochondrial membranes as determined by confocal and fluorescence activated cell sorting analyses of loss of a mitochondrial selective fluorescent dye ; ( c ) processing of caspase 9 and 3 but not caspase 8 to active forms and cleavage of poly ( ADP ribose ) polymerase ( PARP ) as determined by Western immunoblot analyses using antibodies capable of detecting both proenzyme and processed enzyme forms or the intact or cleaved forms of PARP . ^^^ Taken together , these data suggest that the activation of JNK , translocation of Bax to the mitochondria , increased mitochondrial membrane permeability with release of cytochrome c , and activation of caspase 9 and 3 are critical events in VES induced apoptosis of human MDA MB 435 breast cancer cells . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Analysis of the caspase proteolytic cascade reveals that ARMER inhibits proteolysis of the caspase 9 specific fluorogenic substrate LEHD AFC as well as endogenous substrates downstream of caspase 9 ; however , it does not inhibit cytochrome c release or cleavage of caspase 9 itself . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Following JNK phosphorylation , cytochrome c is released into the cytosol , leading to the activation of caspase 9 and eventually caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
To definitively rule out a role for the caspase 9 / cytochrome c dependent mitochondrial pathway of cell death , neither adenosine analog had any effect on mitochondrial membrane potential , which was instead markedly reduced by other apoptotic stimuli ( e . g . , deoxyribose , NaCN , and betulinic acid ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
However , with both 150 and 500 J / m ( 2 ) UVB irradiation , cytochrome c , an activator of caspase 9 via the formation of apoptosome , was released from mitochondria to the cytosol at the same extent . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytosolic cytochrome c levels , caspase 9 activity , mitochondrial membrane depolarization , and dependence of apoptosis on caspase 9 in treated cells were studied to determine the role of the mitochondria in mediating apoptosis induced by this drug combination . ^^^ The essential role of mitochondria in mediating cell death was indicated by robust translocation of cytochrome c from the mitochondria into the cytosol , 2 . 5 to 5 fold activation of caspase 9 , severe disruption of mitochondrial inner membrane potential , and complete inhibition of apoptosis by the selective caspase 9 inhibitor . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c appeared not to play a major role in sensitization of melanoma to TRAIL in that caspase 9 activation was not detected in most of the cell lines . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
TUDCA significantly inhibited the release of cytochrome C from mitochondria into cytosol , and the activity of caspase 9 , 3 ( t > or = 13 . 00 , P < 0 . 01 ) , especially at 12 h , caspase 3 activity decreased by 54 . 9 % ( t = 16 . 88 , P < 0 . 01 ) and 52 . 5 % , however it had no obvious effect on the activity of caspase 8 ( t = 1 . 94 , P > 0 . 05 ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cellular location of activated caspase 9 and cytochrome c in dying SG neurons were examined for analysis of cell death pathway . ^^^ In dying SG neurons , expression of activated caspase 9 and translocation of cytochrome c from mitochondria to cytoplasm were observed , indicating the mitochondrial pathway of apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Elevated caspase 3 activity in cerebellum than cortex correlating with cytochrome c , caspase 9 , active caspase 3 ( p 17 ) , poly ( ADP ribose ) polymerase 1 and PKC delta data , suggests a mechanism by which ethanol might be exerting pro apoptotic events in brain and how selective brain regions such as cerebellum are vulnerable to ethanol neurotoxicity in terms of cell death . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the TNF alpha treated MCF 7 cells that expressed Bid targeted ribozymes , the release of cytochrome c and the activation of caspase 9 , but not of caspase 8 , was delayed . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
During 4 h of such exposure , cytochrome c was released from the mitochondria into the cytoplasm and the number of cells demonstrating cleaved caspase 9 activity increased . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Here we show that the relocation of Bax is accompanied by cytosolic translocation of cytochrome c and is associated with activation of the initiator caspase 9 and the executioner caspases 3 , 6 , and 7 and cleavage of poly ( ADP ) ribose polymerase . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Fenretinide induces cytochrome c release , caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 9 activation was mediated through the mitochondrial pathway of apoptosis , as evidenced by loss of transmembrane potential and cytoplasmic release of cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , irradiation mediated mitochondrial damage resulted in perturbation of mitochondrial membrane potential , caspase 9 activation and cytochrome c release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The results indicate that POX induces apoptosis in EL 4 cells through a direct effect on mitochondria by disrupting its transmembrane potential , causing the release of cytochrome c into the cytosol and subsequent activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Exposure of PC 12 cells to dieldrin ( 100 300 microM ) results in the rapid release of cytochrome C , followed by the activation of caspase 9 and caspase 3 in a time and dose dependent manner . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Specifically , we examined the activation status of caspase 9 , 8 , 7 , 3 , and 2 and determined the caspase requirements for cytochrome c release , DNA fragmentation , and apoptosis associated proteolysis of specific caspase substrates . ^^^ Experiments performed using a cell free system indicate that cytochrome c dependent proteolysis and activation of caspase 9 can be restored in a neonatal cell free system . ^^^ However , we found that cytochrome c dependent proteolysis and activation of caspase 9 could not be restored in an adult cell free system because of an age related decrease in the expression of Apaf 1 in the normal developing mouse retina . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , the mitochondrial membrane potential of apoptotic SW 480 cells after 12 h treatment with Vat C was significantly lost , and concurrently the cytochrome c release and activation of caspase 9 were also detected by western blot analysis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Taken together , these results suggest that Korean mistletoe lectin 2 is a strong inducer of pro oxidant generation such as H2O2 , which mediates the JNK / SAPK activation , cytochrome c release , activation of caspase 9 and caspase 3 like protease , and PARP cleavage in human myeloleukemic U 937 cells . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
An interesting observation was that caspase 9 activation preceded the release of cytochrome C from mitochondria during apoptosis in WERI cells , contrary to the general notion that caspase 9 is activated by cytochrome C . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In Bax positive cells , Nbk induced a conformational switch in the Bax N terminus coinciding with cytochrome c release , mitochondrial permeability transition and caspase 9 processing . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The cell death pathway initiated by survivin targeting was mapped with respect to cytochrome c release , changes in mitochondrial transmembrane potential , and apoptosome requirements using mouse embryonic fibroblasts deficient in Apaf 1 or caspase 9 . ^^^ Cell death induced by survivin targeting exhibited the hallmarks of mitochondrial dependent apoptosis with release of cytochrome c and loss of mitochondrial transmembrane potential and was suppressed in Apaf 1 or caspase 9 knockout mouse embryonic fibroblasts . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Dose dependent loss of mitochondrial trans membrane potential in SNB 19 cells occurred with treatment , along with release of cytochrome c , processing of caspase 9 , and 3 and specific cleavage of poly ADP ribose polymerase ( PARP ) , a substrate of caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
SP 600125 , a specific inhibitor of JNK activation , prevented cytochrome c release from mitochondria , JNK activation , DNA fragmentation , and caspase 9 activation in response to TNF alpha / CHX . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
TPCK may act by reducing caspase 9 activation by cytochrome c . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Our investigations have focused on cell populations that expressed apoptotic effectors in the enzymatic death pathway including cytochrome c , caspase 9 and caspase 3 . ^^^ In addition , immunodetection demonstrated that cytochrome c and activated caspase 9 and caspase 3 were expressed not only in the neurones , the primarily affected cells , but also within the astrocytes , which constituted a dense network delineating the infarct . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c release , caspase 9 , and caspase 3 activation were not implicated , excluding a direct involvement of the intrinsic mitochondrial pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This increase in sensitivity was a direct result of a significant increase in caspase 8 activation and caspase 8 dependent acidification in the absence of caspase 9 activity or cytochrome c release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This was accompanied by increase in ( a ) protein expression of cytochrome c and apoptotic protease activating factor 1 and ( b ) activity and protein expression of caspase 3 , caspase 7 , caspase 8 , and caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Expression of Bbc3 / PUMA correlated with a Bcl xL sensitive release of cytochrome c and the activation of caspase 9 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Mitochondria are known to play a fundamental role in apoptosis by releasing apoptogenic molecules such as cytochrome c into the cytoplasm , thereby sequentially activating initiator caspase 9 . ^^^ However , the mechanisms of cytochrome c release or caspase 9 activation in response to hypoxia are unclear . ^^^ In this report , we show that caspase 9 is activated by reactive oxygen species ( ROS ) without involvement of cytochrome c release in hypoxic injury . ^^^ In addition , activated caspase 9 induces permeability transition ( PT ) independent cytochrome c release , suggesting that caspase 9 may disrupt mitochondrial diffusion limit of cytochrome c and serve to amplify further release of cytochrome c . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Results showed that 3NP induced death of striatal neurons was preceded by cytochrome c redistribution , transient caspase 9 processing , and activation of calpain , whereas levels of the active / processed form of caspase 3 remained low and were even reduced as compared with control animals . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Afferent regulation of cytochrome c and active caspase 9 in the avian cochlear nucleus . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Myocardial cells did not express apoptotic protease activating factor 1 ( Apaf 1 ) , the allosteric activator of caspase 9 acting downstream of cytochrome c release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 9 is activated in a cytochrome c independent manner early during TNFalpha induced apoptosis in murine cells . ^^^ Bcl 10 ( L ) expression delays , but does not totally block , the release of mitochondrial cytochrome c ( cyt c ) in these cells in response to TNFalpha induced apoptosis and caspase 9 is processed prior to mitochondrial cyt c release under these circumstances . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Such relocation of Bax is further accompanied by sequestration of mitochondria and endoplasmic reticulum ( ER ) into paranuclear areas , cytosolic translocation of cytochrome c and is associated with activation of the initiator caspase 9 and the executioner caspases 3 , 6 , and 7 , and cleavage of PARP . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Inhibition of UV induced activation of Akt increased release of mitochondrial cytochrome c 3 . 5 fold , and caused appearance of active forms of caspase 9 , caspase 8 , and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
UV induced apoptosis is mediated independent of caspase 9 in MCF 7 cells : a model for cytochrome c resistance . ^^^ Following DNA damage cytochrome c and other pro apoptotic factors are released from the mitochondria , allowing for formation of the apoptosome and subsequent cleavage and activation of caspase 9 . ^^^ Because caspase 8 was activated with UV treatment alone , we believe that UV induced apoptosis in MCF 7 cells occurs independently of cytochrome c and caspase 9 , supporting the existence of a cytoplasmic inhibitor of cytochrome c in MCF 7 cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , caspase 9 activation , which is dependent on the release of mitochondrial cytochrome c , was not required for ceramide accumulation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Reactive oxygen species was positively correlated with cytochrome c ( r= . 43 ; P < . 03 ) , caspase 9 ( r= . 56 ; P < . 001 ) , and caspase 3 ( r= . 65 ; P < . 01 ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , expression of myristoylated Akt 1 not only prevented cell injury through the prevention of membrane phosphatidylserine exposure and genomic DNA fragmentation but also inhibited microglial activation and proliferation that required the inhibition of caspase 9 , caspase 3 , and caspase 1 like activities linked to cytochrome c release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
MPP+ exposure in rat dopaminergic neuronal cells resulted in time dependent increases in reactive oxygen species generation , cytochrome c release , and caspase 9 and caspase 3 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Treatment of SH SY5Y cells with DADS resulted in arrest of cell cycle in G ( 2 ) / M phase and commitment to apoptosis through the activation of the mitochondrial pathway ( Bcl 2 down regulation , cytochrome c release into the cytosol , and activation of caspase 9 and caspase 3 ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
On the other hand , treatment with SB 203580 , a p 38 MAPK specific inhibitor , or expression of a dominant negative form of p 38 MAPK suppressed phytosphingosine induced translocation of the proapoptotic protein , Bax , from the cytosol to mitochondria , cytochrome c release , and subsequent caspase 9 activation but did not affect caspase 8 activation , indicating that activation of p 38 MAPK is involved in the mitochondrial activation mediated cell death pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The release of mitochondrial apoptogenic proteins , such as cytochrome c , into the cytoplasm leading to Apaf 1 dependent activation of caspase 9 is a key event in this pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
However , blood neutrophils containing extremely low amounts of cytochrome c displayed strong caspase 9 activation during apoptosis , which was also observed in apoptotic neutrophil derived cytoplasts lacking any detectable cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Similar to other chemotherapeutic drugs , these retinoid analogs have been suggested to induce apoptosis through the intrinsic pathway , which requires the release of cytochrome c from the mitochondria for the effective activation of caspase 9 . ^^^ Whereas the RRMs could induce the release of cytochrome c in the absence of caspase 9 activity , the later is necessary for the effective release of Smac / Diablo from the mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Maybe it is activated by caspase 9 , which is triggered by cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We further demonstrated that TGF beta 1 also activates the mitochondrial pathway showing Bid mediated loss of mitochondrial membrane potential and subsequent cytochrome c release associated with the activations of caspase 9 and the effector caspases . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Exposure to DETA NO resulted in a decrease in Psim and concomitant release of cytochrome c and caspase 9 activation , which were enhanced by hypoxia . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
When the extract was activated by cytochrome c , caspase 3 recruitment to the apoptosome was not observed , although apoptotic protease activating factor 1 ( Apaf 1 ) , caspase 9 , and 10 linked inhibitor of apoptosis protein ( XIAP ) existed in the apoptosome . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The combination treatment resulted in the formation of truncated Bid , cytosolic accumulation of cytochrome c and second mitochondria derived activator of caspase / direct inhibitor of apoptosis binding protein with low PI , activation of caspase 9 , caspase 7 , caspase 3 , and cleavage of poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
AFP was unable to regulate activity of caspase 3 in cell extracts depleted of cytochrome c or caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
When Jurkat T cells were treated with thialysine ( 0 . 32 2 . 5 mM ) , apoptotic cell death along with several biochemical events such as mitochondrial cytochrome c release , caspase 9 activation , caspase 3 activation , degradation of poly ( ADP ribose ) polymerase , and DNA fragmentation was induced in a dose and time dependent manner . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
A strong cytoplasmic accumulation of cytochrome C detected by immunoblotting 6h post treatment was accompanied by an activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The present study was initiated to determine whether AMPA receptor induced DCD in PNs is associated with Bax translocation to the mitochondria , cytochrome C release from the mitochondria , changes in mitochondrial potential , and activation of representative initiator and executor caspases that include caspase 9 , caspase 3 , and caspase 7 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These cells were resistant to both receptor mediated apoptosis ( induced by anti Fas IgM and tumor necrosis factor related apoptosis inducing ligand ) and chemical induced apoptosis ( induced by pyrrolidine dithiocarbamate , etoposide , and staurosporine ) , as evidenced by the presence of hypodiploid DNA positive cells , activation of caspase 3 and caspase 9 , disruption of mitochondrial transmembrane potential ( DeltaPsim ) and inhibition of cytochrome c release in tax positive JPX 9 cells compared with tax negative JPX 9 cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Of the four nonclear cell RCC that could be included , both oncocytomas gave no response to cytochrome c ( in one case , no Apaf 1 was detected ) , one chromophobe RCC lacked caspase 9 and failed to activate caspase 3 in response to cytochrome c , and one papillary RCC showed good caspase activation despite the lack of caspase 7 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Exposure of cells to adaphostin concentrations > or =0 . 75 microM for intervals > or =6 h resulted in a pronounced release of cytochrome c and AIF , activation of caspase 9 , 8 , and 3 , and apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cell death proceeds via activation of mitochondrial permeability transition , cytochrome c release and activation of caspase 9 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Consequently , Bax was proposed to play a central role in bridging the active caspase 2 with mitochondria by affecting mitochondrial permeability , cytochrome c release into the cytosol and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Silibinin also induced the cytochrome c release , activation of caspase 3 and caspase 9 and cleavage of PARP . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Indeed , cytochrome c was not released to the cytosol ; Bax and caspase 9 and 3 were not involved ; overexpressed Bcl xL did not block the death ; and the mitochondrial ultrastructure was not changed . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
After treatment of RA synovial fibroblasts with anti Fas monoclonal antibody , the expression levels of activated caspase 9 and 3 , Bid cleavage , cytochrome c release and phosphorylation of p 53 at Ser 15 were assessed using immunoblot analysis . ^^^ RESULTS : Fas ligation induced Bid cleavage , loss of DeltaPsim , cytochrome c release to the cytosol and activation of caspase 9 and 3 in RA synovial fibroblasts . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
To probe the relationship between teratogen induced activation of caspase 9 / caspase 3 and the activation of caspase 6 / caspase 7 , we used a mitochondrial free embryo lysate with or without the addition of cytochrome c , recombinant active caspase 3 , or recombinant active caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Induction of apoptosis was confirmed in HL 60 cells by DNA fragmentation and the appearance of a sub G 1 DNA peak , which were preceded by dissipation of mitochondrial membrane potential , cytochrome c release , and subsequent induction of pro caspase 9 and 3 processing . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The subsequent confirmation of the altered gene expression by northern analysis demonstrated that overexpression of the Expi gene induced expression of several genes , which included B cell activating factor ( BAFF ) , Bax , cytochrome c , caspase 9 , caspase 3 , caspase 6 , and CIDE A . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In contrast , paclitaxel induced apoptosis MM depolarization , cytochrome C release and activation of caspase 9 were all blocked by Bcl 2 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytotoxic cytokines such as tumor necrosis factor ( TNF ) alpha or Fas ligand ( FasL ) bind to their receptors to activate caspase 8 , while damaging agents can cause mitochondrial release of cytochrome c , which can initiate activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
When ectopically expressed , ASC interacted directly with Bax , colocalized with Bax to the mitochondria , induced cytochrome c release with a significant reduction of mitochondrial membrane potential and resulted in the activation of caspase 9 , 2 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptosis assays showed that rNEP promoted anticancer drug induced apoptosis in PC 3 cells specifically through PKCdelta activity that mediated anticancer drug induced mitochondrial change such as cytochrome c release and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The underlying mechanism of action of SAH mediated inhibition of BCL XL ( and / or BCL 2 ) cell survival appears to be due to loss of mitochondrial integrity as reflected in enhanced cytochrome c release leading to the activation of caspase 9 and finally caspase 3 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In HeLa cells overexpressing CD 95 , infection with Chlamydia trachomatis inhibited the appearance of apoptotic morphology , effector caspase activity , the activation of caspase 9 and 3 , and the release of cytochrome c from mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
However , paracetamol induced apoptosis is a caspase dependent process that involves activation of caspase 9 and caspase 3 in the absence of cytosolic cytochrome c or Smac / DIABLO . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The relocation of Bax is accompanied by sequestration of ultracondensed mitochondria into paranuclear areas of apoptotic germ cells , cytosolic translocation of mitochondrial cytochrome c and DIABLO , and is associated with activation of the initiator caspase 9 and the executioner caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In contrast , the lack of mitochondrial transmembrane potential transition , release of cytochrome c and absence of caspase 9 and PARP cleavage showed a strong correlation with Bcl xL expression . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
A time dependent release of cytochrome c from mitochondria was observed , which was accompanied by activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The addition of IETD CHO , a caspase 8 specific inhibitor , completely prevents beta Carotene induced apoptosis , whereas only a partial prevention was observed in the presence of LEHD CHO , a caspase 9 specific inhibitor . beta Carotene activates caspase 9 via cytochrome c release from mitochondria and loss of mitochondrial membrane potential ( Dym ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Subsequent studies revealed that 2 , 3 DCPE could cause cleavage of caspase 8 , caspase 3 , caspase 9 , and poly ( ADP ribose ) polymerase and release of cytochrome c in cancer cells but not in normal human fibroblasts . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In thymocytes , dexamethasone initiates cytochrome c dependent processing of caspase 9 and the activation of caspase 3 to trigger apoptotic damage . ^^^ This approach implicated the VDAC in dexamethasone mediated cytochrome c release , processing of caspase 9 and caspase 3 , the loss of mitochondrial transmembrane potential ( Deltapsim ) , nuclear damage and cell lysis . ^^^ The first event is an increase in permeability of the mitochondrial outer membrane leading to VDAC regulated efflux of cytochrome c and initial processing of caspase 9 followed by ANT dependent caspase 3 processing and apoptotic damage to cells . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Avian encephalomyelitis virus nonstructural protein 2C induces apoptosis by activating cytochrome c / caspase 9 pathway . ^^^ Altogether , the results demonstrate that the protein 2C localized to the mitochondria of the transfected cells triggered the efflux of cytochrome c into the cytosol in turn activating the upstream caspase 9 and then the downstream caspase 3 , thus leading to apoptosis in the cells . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Redistribution of cytochrome c , the upstream trigger of caspase 9 , was measured in the cytosol fraction of T HCEC following irradiation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
After ox LDL treatment , there was a significant release of activators of caspase 9 , including cytochrome c and Smac from mitochondria to cytoplasmic compartment , and their release was not affected by treatment of cells with inhibitors of either caspase 8 or caspase 9 . ^^^ Ox LDL also decreased expression of antiapoptotic proteins Bcl 2 and c IAP ( inhibitory apoptotic protein ) 1 , which are involved in the release of cytochrome c and Smac and activation of caspase 9 , in a concentration and time dependent manner . ^^^ This is followed by activation of apoptotic signaling pathway , involving release of cytochrome c and Smac and activation of caspase 9 and then caspase 3 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The results showed the following : 1 ) PMA can prevent MG induced apoptosis ; 2 ) triggering of this antiapoptotic signal depends on the mitogen activated protein kinase kinase / extracellular signal regulated kinase ( ERK ) pathway ; 3 ) PMA inhibits MG induced activation of caspase 3 and caspase 9 , release of cytochrome c , and decline of mitochondrial membrane potential , but it does not affect MG induced JNK activation ; 4 ) the ERK pathway modulates outer mitochondrial membrane permeability and regulates the mitochondrial death machinery ; and 5 ) activated ERK prevents JNK induced leakage of cytochrome c from isolated mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Heyneanol A also induced cytochrome c release from mitochondria into the cytosol and subsequent caspase activation involving caspase 9 and 3 to cleave PARP . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Assembly of the apoptosome in response to mitochondrial permeabilization , the hallmark of the intrinsic apoptotic pathway , involves binding of cytochrome c to Apaf 1 , recruitment and auto processing of the apical / signaling pro caspase 9 , and coupled activation of downstream / executioner caspases like caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Released cytochrome c then activates the initiator caspase , caspase 9 , which can be blocked by the anti apototic ( IAP ) family of molecules . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
As expected by the cytochrome c release into the cytosol , caspase 9 is processed to active forms ( p 37 and p 35 ) , along with a yet unidentified p 28 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The apoptotic response is initiated by G protein signaling and involves activation of phosphoinositide 3 kinase , mitogen activated protein kinases , and c Src resulting in cytochrome c release from mitochondria and ultimately caspase 9 and caspase 3 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c and dATP dependent formation of Apaf 1 / caspase 9 complex initiates an apoptotic protease cascade . ^^^ Caspase 9 and Apaf 1 bind to each other via their respective NH 2 terminal CED 3 homologous domains in the presence of cytochrome c and dATP , an event that leads to caspase 9 activation . ^^^ Mutation of the active site of caspase 9 attenuated the activation of caspase 3 and cellular apoptotic response in vivo , indicating that caspase 9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cell death was preceded by cytochrome c release and cleavage of caspase 9 and 3 , but not of caspase 8 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
When overexpressed , HGTD P was localized to mitochondria and facilitated apoptotic cell death via typical mitochondrial apoptotic cascades , including permeability transition , cytochrome c release , and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Type 2 involves changes in mitochondrial integrity initiated by various effectors like Ca ( 2+ ) , reactive oxygen species ( ROS ) , Bax , or ceramide , leading to the release of cytochrome c and activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Moreover , in HuH 6 cells , butyrate induced loss of mitochondrial membrane potential , release of cytochrome c from mitochondria , activation of caspase 9 and caspase 3 , and degradation of poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
When stably expressed in human embryonic kidney ( HEK 293 ) cells , M11L effectively protects these cells from Fas ligand induced apoptosis , thereby blocking release of cytochrome c , activation of caspase 9 , and cleavage of poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Taurine treatment had no effect on mitochondrial membrane potential and cytochrome c release ; however , it inhibited ischemia induced cleavage of caspase 9 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Exogenous APIP inhibits cytochrome c induced activation of caspase 3 and caspase 9 , and suppresses cell death triggered by mitochondrial apoptotic stimuli through inhibiting the downstream activity of cytochrome c released from mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Mitochondrial permeability transition , cytochrome c release and subsequent processing of caspase 9 preceded the onset of apoptosis , and were enhanced by TNFalpha pretreatment . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
While this activation of caspase 3 was paralleled by an elevated caspase 9 expression at 9 h post irradiation , there was no major induction in Apaf 1 or cytochrome c release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , we showed that release of mitochondrial cytochrome c , cleavage of caspase 9 and PARP during apoptosis in T . vaginalis treated RAW264 . 7 cells were considerably diminished by transfection with overexpressed Bcl 10 ( L ) , and overexpressed Bcl 10 ( L ) could inhibit T . vaginalis induced apoptosis in RAW264 . 7 cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Importantly , cells overexpressing both GCL subunits exhibit increased resistance to TNF induced apoptosis as judged by a loss of redox potential ; mitochondrial membrane potential ; translocation of cytochrome c to the cytoplasm ; and activation of caspase 3 , caspase 8 , and caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Treatment of cells with NOCF caused dose dependent upregulation of cytosolic factors , such as Bax and Bid , and release of cytochrome c , which were accompanied by activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
When grown in coculture with endothelial cells and exposed to LPS in coculture but harvested independently , pericytes showed decreased levels of p 11 and p 17 and increased levels of Bcl xL , an antiapoptotic protein that protects the integrity of mitochondria , and prevents cytochrome c release and subsequent caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Induction of apoptosis in LAA treated AML cells involved a dose dependent increase of Bax protein , release of cytochrome C from mitochondria to cytosol , activation of caspase 9 and caspase 3 , and cleavage of poly [ ADP ribose ] polymerase . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
It enhanced caspase 3 and caspase 9 activation and favored cytochrome c release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Western blotting was used for caspase 3 and PARP , caspase 7 , caspase 9 , cytochrome c , Bcl 2 , Bax , Mcl 1 , cyclinA , cyclin B 1 , cyclin D 1 , cyclin E , CDK 2 , CDK 4 , CDK 6 , P 21 , P 27 , GADD 45 , GADD 153 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c induces cell death by activation of caspase 9 and 3 , while AIF leads to detrimental DNA damage by an capase independent pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , release of cytochrome c from mitochondria , down expression of Bcl 2 and Bcl 10 ( L ) , up regulation of Bax , and caspase 9 activities were observed in SM treated A 549 cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Azelnidipine administration ameliorated cellular and mitochondrial Ca ( 2+ ) accumulation , mitochondrial permeability transition , cytochrome c release , caspase 9 activation , and resultant apoptosis ( 15 . 8 + / 0 . 8 % versus 8 . 9 + / 0 . 7 % ; P < 0 . 01 ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The activation of the intrinsic death pathway involves the release of cytochrome c from the mitochondria and formation of the apoptosome , a catalytic multiprotein platform that activates caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cocaine induced time dependent , concurrent increases in cytochrome c release and activities of caspase 9 and caspase 3 , which preceded apoptosis . ^^^ Consistent with its inhibition of apoptosis , SB 203580 inhibited cocaine induced cytochrome c release and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
METHODS : With methylene chloride fraction of Herba Scutellariae barbatae ( MCSB ) , apoptosis related experiments were carried out on human U 937 leukemia cells by ( a ) 2 , 3 bis [ 2 4 nitro 5 sulphophenyl ] 2H tetrazolium 5 carboxanilide ( XTT ) assay for cytotoxicity ; ( b ) terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) assay for morphological changes ; ( c ) cell cycle analysis ; ( d ) Western blot analysis of poly ( ADP ribose ) polymerase ( PARP ) , caspase 8 , caspase 9 , caspase 3 and Bax , Bcl 2 and cytochrome c expressions for apoptosis signaling pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Knockdown of Bcl xL and administration of TRAIL significantly synergized in dissipation of mitochondrial membrane potential , release of cytochrome c , activation of caspase 9 and 3 and , consequently , apoptotic cell death . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We find that secondary brain injury is preceded by impairment of mitochondrial respiration , signs of membrane permeability transition , intramitochondrial accumulation of calcium , changes in the Bcl 2 family proteins , release of proapoptotic proteins ( cytochrome C , apoptosis inducing factor ) and downstream activation of caspase 9 and caspase 3 after hypoxia ischemia . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The mechanism ( s ) by which bilirubin induces apoptosis was investigated by Western blotting for cytochrome c release , assaying for caspase 8 and caspase 9 activation and for mitochondrial depolarization by JC 1 staining . ^^^ Bilirubin treatment evokes specific activation of caspase 9 , enhances cytochrome c release into the cytoplasm and triggers the mitochondrial permeability transition in colon cancer monolayers . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Ectopic expression of hsp 70 in HL 60 cells ( HL 60 / hsp70 ) inhibited Ara C and etoposide induced Bax conformation change and translocation to the mitochondria ; attenuated the accumulation of cytochrome c , Smac , and Omi / HtrA2 in the cytosol ; and inhibited the processing and activity of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
A treatment of cadmium caused the caspase 8 dependent Bid cleavage , the release of cytochrome c ( Cyt c ) , activation of caspase 9 and 3 , and PARP cleavage . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These results suggest the sequential mechanism of diclofenac induced apoptosis of HL 60 cells : ROS generation suppresses Akt activity , thereby activating caspase 8 , which stimulates Bid cleavage and induces cytochrome c release and the activation of caspase 9 and 3 in a CsA insensitive mechanism . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
However , despite the release of cytochrome c from the mitochondria in taxol treated cells , caspase 9 was not activated . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Induce apoptosis was confirmed in COLO 205 cells by DNA fragmentation and the appearance of a sub G 1 DNA peak , which were preceded by loss of mitochondrial membrane potential , reactive oxygen species ( ROS ) generation , cytochrome c release , and subsequent induction of pro caspase 9 and 3 processing . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
CPS induced apoptosis involved intracellular free calcium ( Ca2+ ) influx , phosphatidylserine exposure , mitochondrial permeability transmembrane pore ( PTP ) opening and mitochondrial transmembrane potential ( Delta Psi m ) dissipation leading to cytochrome c release , activation of caspase 9 and 3 and oligonucleosomal DNA fragmentation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , EspF was associated with the release of cytochrome c from mitochondria into the cytoplasm and with caspase 9 and caspase 3 cleavage . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This apoptotic cell death was accompanied by caspase 9 and caspase 3 activation , as indicated by the cleavage of caspase substrates , which was preceded by mitochondrial cytochrome c release . ^^^ These results suggest that the release of mitochondrial cytochrome c , and the sequential caspase 9 and caspase 3 activations are important events in the signal transduction pathway of abrin induced apoptotic cell death in the HeLa cell line . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the latter , mitochondrial damage results in cytochrome c release and formation of the apoptosome , a multimeric protein complex containing Apaf 1 , cytochrome c , and caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Anti beta 1 integrin fails to activate caspase 8 , Bid , caspase 9 and to induce the release of cytochrome c in c FLIP ( L ) overexpressing keratinocytes . ^^^ However , the release of cytochrome c and the later activation of caspase 9 seem to suggest that the intrinsic mitochondrial pathway may intervene as a positive feedback loop of caspase activation . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In Bcl 2 overexpressing cells , apoptosis and cytochrome c release were blocked whereas processing of caspase 9 , 3 and 8 was partially inhibited . ^^^ Moreover , cytochrome c release and processing of caspase 9 and 3 occurred to an equal extent in wild type FADD / and caspase 8 / Jurkat cells . ^^^ Thus , we conclude that apoptosis induced by nucleoside analogues is independent from death receptor signaling as well as from a proposed direct effect on APAF 1 , but rather follows the mitochondrial signaling pathway of cytochrome c release and subsequent processing of caspase 9 and 3 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The main mechanism for these apoptosis appeared to be mitochondria mediated pathway accompanied with loss of the mitochondrial transmembrane potential ( Delta Psi m ) followed by cytochrome c release from the mitochondria into the cytosol , resulting in the activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In this regard , caspase 8 mediated activation of Bid induces the release of cytochrome c from the mitochondria , which , in turn , triggers the formation of the apoptosome protein complex , resulting in the activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , considering that the expression of both cytochrome c and caspase 9 were not changed in this model , its mechanism might be independent of mitochondria related apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
EGCG raised the activities of caspase 9 , enhanced the releasing of cytochrome c from the mitochondria , and suppressed the protein expression of Bcl 2 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 9 and Apaf 1 were expressed and cytochrome c released from mitochondria upon serum withdrawal . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These data suggest that Apaf 1 recruitment of caspase 9 is faulty in the presence of Bcr Abl and that cytochrome c / dATP induced exposure of the Apaf 1 CARD is likely defective . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In turn , activated Bid , acting with pX induced Bax and Noxa , mediates the mitochondrial release of cytochrome c , resulting in the activation of caspase 9 and apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
ASA and indomethacin triggered apoptosis in cells of all three lines through release of cytosolic cytochrome c , activation of caspase 9 and 3 , and cleavage of poly ( ADP ribose ) polymerase ( PARP ) , but NS 398 induced minimal apoptosis only in Ishikawa cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Protein and transcriptome expression analysis showed that combined 5 FU and DENSPM treatment activated caspase 9 , but not caspase 3 , and significantly suppressed NADH dehydrogenases and cytochrome c oxidases , consistent with the observed increase in hydrogen peroxide , loss of mitochondrial membrane potential , and release of cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In the mitochondrial mediated pathway , there were no significant treatment effects observed in cytosolic cytochrome c and cleaved ( active ) caspase 9 in either sex . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
PURPOSE : To determine whether the FAS mediated apoptosis pathway becomes activated in the retina after retinal detachment and to investigate the temporal relationship between the activation of the FAS pathway and the intrinsic apoptosis pathway involving caspase 9 and cytochrome c . ^^^ A caspase 9 activity assay and immunoprecipitation of the caspase 9 / cytochrome c complex were performed at these same time points . ^^^ RESULTS : Retinal detachment resulted in the time dependent formation of the FAS receptor / FAS ligand complex that preceded the peak of caspase 9 activity and caspase 9 / cytochrome c complex formation . ^^^ Retinal detachment resulted in the transcriptional upregulation of the FAS receptor , FAS ligand , caspase 8 and BID , but not caspase 9 and cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The time course analysis revealed that molecules activated in apoptosis were in the following order : caspase 8 ( 1 . 5 h ) , t Bid ( 2 . 5 h ) , Bax ( 3 h ) , cytochrome c release ( 6 h ) , caspase 9 ( 7 h ) , and caspase 3 ( 8 h ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We showed that aspirin activated caspase 8 , caspase 9 and capase 3 , cleaved and translocated Bid , induced a conformational change in and translocation of Bax and cytochrome c release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Our experiments showed that 5 FU engaged the mitochondrial apoptotic pathway involving cytosolic cytochrome c release and subsequent activation of caspase 9 and caspase 3 as well as the membrane death receptor ( DR ) mediated apoptotic pathway involving activation of caspase 8 with an Apo 1 / CD95 ( Fas ) dependent fashion . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Inactivation of Akt was associated with dephosphorylation of BAD , increased cytochrome c release , and activation of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Our data showed that NCTD caused accumulation of cytosolic cytochrome c and activation of caspase 9 , suggesting that apoptosis occurred via the mitochondria mediated pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In this study , gammaT or its combination with delta tocopherol induced apoptosis in androgen sensitive prostate LNCaP , but not in androgen resistant PC 3 cells , by the induction of cytochrome c release , activation of caspase 9 and caspase 3 , cleavage of poly ADP ribose polymerase ( PARP ) , and involvement of caspase independent pathways . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
High glucose stimulated mitochondrial release of cytochrome c , cleavage of procaspase 9 , and caspase 9 enzyme activity , suggesting an intrinsic pathway of proapoptotic signaling . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Asiatic acid treatment triggered the mitochondrial apoptotic pathway indicated by changing Bax / Bcl 2 ratios , cytochrome c release , and caspase 9 activation , but it did not act on Fas / Fas ligand pathways and the activation of caspase 8 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
However , the apoptotic process requires Smac / DIABLO , but not cytochrome c mediated caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In this pathway , release of mitochondrial cytochrome c into the cytoplasm induces formation of the apoptosome , which leads to the activation of caspase 9 and subsequently other caspases . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
When deprived of this stimulus , CGNs die via an intrinsic apoptotic cascade involving Bim induction , Bax translocation , cytochrome c release , and caspase 9 and 3 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This apoptosis is associated with up regulation and nuclear localization of the tumor suppressor p 53 and activation of mitochondrial apoptosis , which includes up regulation of Bax , Bak , and Pidd , translocation of Bax and caspase 2 onto mitochondria , release of cytochrome c and apoptosis inducing factor , and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Palmitate stimulated an intrinsic pathway of pro apoptotic signaling as evidenced by increased mitochondrial release of cytochrome c and activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In hypothermic conditions , Fas mediated cytochrome c release from mitochondria of hepatocytes and the proximate downstream activation of caspase 9 were suppressed under mild hypothermic conditions . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptotic protease activating factor 1 ( Apaf 1 ) is a cell death effector that acts with cytochrome c and caspase 9 to mediate apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
However , unlike CA induced , caspase 9 / 3 dependent apoptosis , there was no increased activity in caspase 9 , caspase 3 or poly ( ADP ribose ) polymerase ( PARP ) cleavage in RO induced cytotoxicity , in spite of time dependent release of cytochrome c and apoptosis inducing factor ( AIF ) following mitochondrial membrane depolarization and a significant increase in reactive oxygen species generation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Under hyperoxia , there was neither a significant change of cytosolic cytochrome C or of caspase 9 activity , nor an increase in apoptosis of TIIcells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We found that overexpression of wild type ApoL 6 induced mitochondria mediated apoptosis in DLD 1 cells characterized by release of cytochrome c and Smac / DIABLO from mitochondria and activation of caspase 9 , whereas ApoL 6 BH3 domain deletion allele did not . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
There are two pathways of caspase 3 and caspase 7 mediated apoptosis : ( 1 ) the `` extrinsic ' ' pathway involving the death receptor Fas , Fas ligand ( FasL ) , and caspase 8 and ( 2 ) the `` mitochondrial ' ' or `` intrinsic ' ' pathway involving Bcl 2 proteins , caspase 2 , cytochrome c release , and caspase 9 . ^^^ CONCLUSION : In Cy / Cy kidneys with ADPKD , there was an increase of the proform of caspase 9 , an increase in cytochrome c release into the cytosol , and an increase in caspase 2 protein and activity demonstrating involvement of the intrinsic pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Protein kinase A regulates caspase 9 activation by Apaf 1 downstream of cytochrome c . ^^^ A critical component of the intrinsic apoptotic pathway is caspase 9 , which is activated by Apaf 1 in the apoptosome , a large complex assembled in response to release of cytochrome c from mitochondria . ^^^ We show that protein kinase A inhibits activation of caspase 9 and caspase 3 downstream of cytochrome c in Xenopus egg extracts and in a human cell free system . ^^^ Importantly , protein kinase A inhibits cytochrome c dependent recruitment of procaspase 9 to Apaf 1 but not activation of caspase 9 by a constitutively activated form of Apaf 1 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The activation of caspase 3 seems to be independent of cytochrome c release and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In strong support of a role for JNK in promoting the mitochondrial apoptosis signaling pathway , JNK inhibition prevented ischemia induced mitochondrial translocation of Bax and Bim , release of cytochrome c and Smac , and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The antiapoptotic proteins , Bcl 2 and Bcl xl , were downregulated by GSP , whereas the expression of the pro apoptotic protein , Bax , and the levels of cytochrome c release , Apaf 1 , caspase 9 , and cleaved caspase 3 ( p 19 and p 17 ) were markedly increased in JB 6 C141 cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , apoptosis was inhibited in cells expressing the R 1 subunit of herpes simplex virus type 2 ribonucleotide reductase ( HSV 2 R1 ) or hsp 70 , two proteins which are known to inhibit apoptosis associated with caspase 8 activation and cytochrome c release dependent caspase 9 activation , respectively . ^^^ Given that HSV 2 R1 , a specific inhibitor of the caspase 8 activation pathway , efficiently suppressed apoptosis and also prevented caspase 9 activation , the overall results indicate that the BVDV NS3 / NS3Delta50 induces apoptosis initiated by caspase 8 activation and subsequent cytochrome c release dependent caspase 9 activation . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Attenuating erbB signals in cultured neonatal rat cardiomyocytes by the erbB 2 antagonist tyrphostin AG 825 , by the erbB1 / 4 antagonist AG 1478 or by antisense induced lowering of erbB 2 receptors resulted in an augmented Bcl xS / Bcl xL ratio , mitochondrial release of cytochrome c , activation of caspase 9 and caspase 3 , and nucleosome sized DNA fragmentation . ^^^ A similar DNA fragmentation and caspase 3 activation was induced by TNF alpha , but without Bcl xS / Bcl xL increase , cytochrome c release or caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The combination of manumycin and methoxyamine resulted in enhanced apoptosis by six criteria increased annexin 5 binding , release of mitochondrial cytochrome c into the cytosol , activation of caspase 9 , activation of caspase 3 , specific cleavage of poly adenosyl ribose polymerase , and increase in the sub G 1 cell cycle fraction . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
AT 514 preferentially activated the intrinsic apoptotic pathway , as evidenced by loss of mitochondrial membrane potential , release of cytochrome c and activation of caspase 9 and 3 , but not of caspase 8 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Consequently , gamma tocopherol treatment caused cytochrome c release and caspase 9 , 3 and 7 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This conclusion is based on the following observations : ( a ) sulforaphane treatment caused a dose and time dependent increase in the protein levels of both Bax and Bak and conformational change and mitochondrial translocation of Bax in SV 40 transformed mouse embryonic fibroblasts ( MEF ) derived from wild type mice to trigger cytosolic release of apoptogenic molecules ( cytochrome c and Smac / DIABLO ) , activation of caspase 9 and caspase 3 , and ultimately cell death ; ( b ) MEFs derived from Bax or Bak knockout mice resisted cell death by sulforaphane , and ( c ) MEFs derived from Bax and Bak double knockout mice exhibited even greater protection against sulforaphane induced cytochrome c release , caspase activation , and apoptosis compared with wild type or single knockout cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Investigation of the mechanism of CTXIII induced apoptosis revealed that the treatment of K 562 cells with CTX 3 resulted in the activation of caspase 9 , caspase 3 and subsequent cleavage of its substrate PARP and that CTXIII was also associated with an early release of cytochrome c from the mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptosis has also been caused by the efflux of cytochrome c from mitochondria , and subsequently by cleavage of caspase 9 in all cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In marked contrast , in HQ treated Jurkat cells , ZVAD significantly abrogated PS exposure , loss of MTP , and caspase 9 processing but not release of cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , reducing the wild type VSMC [ Ca2+ ] 1 by Verapamil or BAPTA AM significantly increased cellular cAMP concentration ( mainly by phosphodiesterase [ PDE ] inhibition ) , the rate of VSMC proliferation ( determined by direct cell counting , 3H incorporation , FACS analysis of cells entering S phase , and quantitative Western PCNA and ERK1 / 2 analyses ) , and the rate of apoptosis ( by Hoechst staining , FACS analysis of the Annexin 5 positive cells , and quantitative Western Bax , cytochrome c , and activated caspase 9 and 3 analyses ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , EAC also initiated mitochondrial apoptotic pathway through regulation of Bcl 2 family proteins expression , release of cytochrome c , and activation of caspase 9 both in Hep G 2 and PLC / PRF / 5 cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , AdvBcl 2 pretreatment led to diminished cytochrome c release into cytosolic extracts and reduced intragraft IL 1beta production and inhibited intragraft caspase 3 and caspase 9 activity . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
To characterize the mechanisms of apoptosis induction by proteasome inhibitors , we examined levels of Bcl 2 protein family members ( Bik / NBK , Bax , Bak , Bcl 2 , and Bcl XL ) , release of cytochrome c , and activation of caspase 9 and 3 in human colon cancer cell lines DLD 1 , LOVO , SW 620 , and HCT 116 ; human lung cancer cell line H 1299 ; and human ovarian cancer cell line SKOV 3 after they were treated with bortezomib . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Since caspase 9 is related to the mitochondrial apoptotic pathway , we analyzed some mitochondrial events such as changes in the mitochondrial transmembrane potential ( Deltapsim ) and mitochondrial release of apoptogenic proteins such as cytochrome c and the apoptosis inducing factor ( AIF ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Resveratrol induces cytochrome c release from mitochondria to the cytoplasm and activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
During apoptosis , Apaf 1 binds to cytochrome c and in the presence of ATP / dATP forms an apoptosome , leading to the recruitment and activation of the initiator caspase , caspase 9 ( ref . 2 ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Although inhibition of PI3 ' kinase induced cleavage of BID in all cell lines , cytochrome c was released from the mitochondria and caspase 9 and caspase 3 were activated in LY 294002 induced apoptotic BC 1 but not in resistant BCP 1 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Acrolein induced apoptosis through a decrease in mitochondrial membrane potential , the liberation of cytochrome c , the activation of initiator caspase 9 , and the activation of the effector caspase 7 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
During apoptosis , a key event is the release of Smac / DIABLO ( an inhibitor of XIAP ) and cytochrome c ( Cyt c , an activator of caspase 9 ) from mitochondria to cytosol . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Taken together , we suggest that iron deprivation induces apoptosis via mitochondrial changes concerning proapoptotic Bax translocation to mitochondria , collapse of the mitochondrial membrane potential , release of cytochrome c from mitochondria , and activation of caspase 9 and caspase 3 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The cleavage of C 3 via calcium dependent proteolysis is independent of caspase 9 ; lysate exposure to calcium prevents further cleavage and activation by the cytochrome c and dATP pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Intracellular AA also prevents loss of mitochondrial membrane potential and the release of cytochrome C and activation of caspase 9 and caspase 3 during H R . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Our results clearly show that beta elemene induced caspase 3 , 7 and 9 activities , decreased Bcl 2 expression , caused cytochrome c release and increased the levels of cleaved caspase 9 and poly ( ADP ribose ) polymerase in NSCLC cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c was shown to leak from the mitochondria , followed by caspase 9 cleavage within 8 h of treatment . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Despite the high caspase 3 activity in RBL / PR3 , no apoptosis was detected as demonstrated by an absence of 1 ) phosphatidylserine externalization , 2 ) mitochondria cytochrome c release , 3 ) upstream caspase 8 or caspase 9 activation , or 4 ) DNA fragmentation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Both caused apoptosis by increasing the protein expression of Bax and Bcl xs while decreasing Bcl 2 and Bcl 10 ( L ) , releasing apoptogenic cytochrome c , and augmenting the activity of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Inhibition of hepatitis C virus core protein expression in immortalized human hepatocytes induces cytochrome c independent increase in Apaf 1 and caspase 9 activation for cell death . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This was possibly induced through the mitochondrial metabolism , as evidenced by the release of cytochrome c and a significant increase in the active forms of caspase 9 and 3 , but not caspase 8 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , treatment with TSA induced caspase 9 activation and resulted in the release of cytochrome c and Smac / DIABLO from mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Our data reveal that pramanicin induced the release of cytochrome c and caspase 9 and caspase 3 activation , as evidenced by detection of active caspase fragments and fluorometric caspase assays . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Changes in Bax ( proapoptotic Bcl 2 associated 10 protein ) , cytochrome c , and caspase 9 cleavage in the cytosolic and mitochondrial fractions of neural retinal tissues were measured by Western blot analysis . ^^^ This translocation was accompanied by cytosolic accumulation of cytochrome c and cleavage of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Another complex is the cytosolic apoptosome , assembled in response to the release of mitochondrial cytochrome c , which recruits caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The apoptosis inducing activities were determined by nuclear condensation , sub G 1 appearance , DNA fragmentation , loss of mitochondrial membrane potential ( Deltapsim ) , release of mitochondrial cytochrome c into cytoplasm and proteolytic activation of caspase 9 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
METHODS : We examined thirty two samples of herniated lumbar disc tissue with use of immunohistochemical staining and Western blot analysis to determine the presence of several proteins , including caspase 8 ( associated with the Type 1 pathway ) ; BID ( BH 3 interacting domain death agonist ) , cytochrome c , and caspase 9 ( associated with the Type 2 pathway ) ; and caspase 3 ( an executioner of apoptosis ) . ^^^ RESULTS : The proteins associated with the Type 2 pathway ( BID , cytochrome c , and caspase 9 ) stained positively in all samples . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We have demonstrated involvement of the intrinsic apoptotic pathway ; IFN gamma treatment resulted in mitochondrial membrane depolarisation , cytochrome c release into the cytosol and activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Studies on intracellular signaling revealed that the degree of cytochrome c release , dissipation of mitochondrial membrane potentials , and caspase 9 activity were all more prominent in dnHIF 1alpha clones than in control IRPTC , pointing to the accelerated signaling of mitochondrial pathways . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Recent studies have shown that mitochondrially formed oxidants are mediators of molecular signaling and have implicated mitochondria dependent apoptosis involving pro and antiapoptotic protein binding , the release of cytochrome c and Smac , the activation of downstream caspase 9 and 3 , and the fragmentation of DNA . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The granulosa cells go through the mitochondria dependent apoptosis pathway ; the indicated pro apoptosis protein Bax was expressed and induced cytochrome c release from mitochondria , which then activated caspase 9 and caspase 3 until cell death occurred . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , upon exposure to toxic stimuli , increased mitochondrial release of cytochrome C and activation of caspase 9 and caspase 3 are found in HD cells and tissue . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
DAB treatment decreases the viability of HL 60 cells , increases the dATP concentration and induces apoptogenic cytochrome c release from mitochondria with concomitant elevation of caspase 9 activity . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Activation of the intrinsic pathway proceeded by release of mitochondrial factors Smac / DIABLO and cytochrome c , and caspase 9 cleavage . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These results indicate that polyamines regulate PP2A activity , and inhibition of PP2A in response to polyamine depletion increases steady state levels of Bad and Bcl 2 proteins and their phosphorylation and thereby prevents cytochrome c release , caspase 9 , and caspase 3 activation . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In contrast , caspase 9 inhibition prevents mitochondrial uncoupling and ROS production and allows for continued electron transport despite the release of cytochrome c . ^^^ Taken together , these data suggest that activated caspase 9 prevents the accessibility of cytochrome c to complex 3 , resulting in the production of reactive oxygen species , and that effector caspases may depolarize mitochondria to terminate ROS production and preserve an apoptotic phenotype . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Activated caspase expression and apoptosis increase in keloids : cytochrome c release and caspase 9 activation during the apoptosis of keloid fibroblast lines . ^^^ These results strongly suggest that keloid fibroblasts are predisposed to apoptosis and cytochrome c release and that caspase 9 activation may underlie regulation of apoptosis in keloid fibroblasts in vivo . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We evaluated the levels of Bax , Bcl xL , Bcl 2 and cytochrome c expression by Western blot analysis , and caspase 9 and 3 activities were determined in a colorimetric assay . ^^^ Following Bax gene transfer , release of cytochrome c to the cytosol was detected , the activities of caspase 9 and 3 increased , and TUNEL positive cells ( 37 . 5 % ) were detected . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Hair cell nuclei showed both apoptotic and necrotic like appearances but markers for classic apoptotic pathways ( cytochrome c , caspase 9 , caspase 3 , JNK , TUNEL ) were absent . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Investigation of the mechanism of CTX 3 induced apoptosis revealed that treatment of K 562 cells with CTX 3 resulted in the loss of mitochondrial membrane potential , cytochrome c release from mitochondria into the cytosol and activation of caspase 9 and caspase 3 and the subsequent cleavage of the caspase 3 substrate PARP ; however , CTX 3 did not generate reactive oxygen species ( ROS ) . 4 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Ellipticine increased the expression of Bax , but decreased the level of Bcl 2 , Bcl XL and 10 linked inhibitor of apoptosis protein ( XIAP ) , and subsequently triggered the mitochondrial apoptotic pathway ( release of cytochrome c , and activation of caspase 9 and 3 ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We thereafter observed ( a ) a loss of mitochondrial membrane potential ( as from 10 h , based on spectrophotometric and confocal microscopy using JC 1 probe ) and ( b ) the release of cytochrome c from granules to cytosol , and the activation of caspase 9 ( as from 12 h ; evidenced by Western blot analysis ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Overexpression of HIF 1alpha inhibited the generation of reactive oxygen species ( ROS ) , elevation of intracellular Ca ( 2+ ) concentration , reduction of mitochondrial membrane potential , and cytosolic accumulation of cytochrome c , which resulted in the inactivation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
More pronounced increases of Bax / Bcl 2 ratio , cytosolic cytochrome c , and caspase 9 , which are involved in mitochondria mediated apoptosis , were found in aged rats than in young rats , and were associated with a more pronounced decrease in superoxide dismutase activity and increase of malondialdehyde content . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In this study , we report that in murine macrophages GBS induces unique changes in the regulation and localization of the apoptotic regulators Bad , 14 3 3 , and Omi / high temperature requirement A 2 and leads to the release of cytochrome c and the activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The decrease of Bcl 2 and Bcl XL along with this oxidative stress caused release of mitochondrial cytochrome c into the cytosol and subsequent induction of pro caspase 9 processing . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptosis by I3C involves downregulation antiapoptotic gene products , including Bcl 2 , Bcl xL , survivin , inhibitor of apoptosis protein ( IAP ) , 10 chromosome linked IAP ( XIAP ) , and Fas associated death domain protein like interleukin 1 beta converting enzyme inhibitory protein ( FLIP ) ; upregulation of proapoptotic protein Bax ; release of micochondrial cytochrome C ; and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The death rate , degree of the apoptotic damage , reduction of mitochondrial membrane potential , translocation of Bax , release of cytochrome C and activation of caspase 9 and 3 were determined at each time point . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
LPS also induced nitric oxide ( NO ) and superoxide ( O ( 2 ) ( ) ) production , depressed mitochondrial Complex 1 and 4 activity , promoted the release of cytochrome c from mitochondria to cytosol , upregulated the cytosolic expression of activated caspase 9 and 3 , or increased caspase 3 enzyme activity in the RVLM . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Release of cytochrome c from mitochondria and activation of caspase 9 were detectable after 5 and 10 min , respectively , whereas remarkable activation of Bid was not detected . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Both ToxB and dominant negative N17Rac1 elicited CGN apoptosis , characterized by cytochrome c release and activation of caspase 9 and 3 , whereas dominant negative N19RhoA or N17Cdc42 did not cause significant cell death . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
APAF 1 couples cytochrome c release from the mitochondria to caspase 9 activation and has been considered a central adaptor in the intrinsic pathway of programmed cell death . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
To ascertain the mechanism of epithelial apoptosis , we determined that PAR 1AP , thrombin , and leukocyte elastase dissipated mitochondrial membrane potential , induced translocation of cytochrome c to the cytosol , enhanced cleavage of caspase 9 and caspase 3 , and led to JNK activation and Akt inhibition . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NaBt treatment results in a marked down regulation of Bcl xL expression , mitochondrial membrane depolarization , cytochrome c release from mitochondria , activation of caspase 9 and 3 and apoptosis induction . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Here we report that treatment with BAY 43 9006 results in marked cytochrome c and AIF release into the cytosol , caspase 9 , 8 , 7 , and 3 activation , and apoptosis in human leukemia cells ( U 937 , Jurkat , and K 562 ) . ^^^ Finally , ectopic expression of Mcl 1 in leukemic cells markedly inhibited BAY 43 9006 mediated cytochrome c cytosolic release , caspase 9 , 7 , and 3 activation , as well as cell death , indicating that Mcl 1 operates upstream of cytochrome c release and caspase activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
RESULTS : ( ) Epigallocatechin 3 gallate rapidly induced apoptotic cell death in various malignant B cell lines in a dose and time dependent manner . ( ) Epigallocatechin 3 gallate induced apoptosis was in association with the loss of mitochondrial transmembrane potentials ( Deltapsim ) ; the release of cytochrome c , Smac / DIABLO , and AIF from mitochondria into the cytosol ; and the activation of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
METHODS : Tissue specimens of 12 tooth germs , 41 benign ameloblastomas , and five malignant ameloblastomas were examined by reverse transcriptase polymerase chain reaction ( RT PCR ) and immunohistochemistry to determine the expression of cytochrome c , apoptotic protease activating factor 1 ( APAF 1 ) , caspase 9 , and apoptosis inducing factor ( AIF ) . ^^^ Immunohistochemical reactivity for cytochrome c , APAF 1 , caspase 9 , and AIF was detected in both normal and neoplastic odontogenic tissues . ^^^ Expression of cytochrome c and AIF was evident in odontogenic epithelial cells neighboring the basement membrane , and APAF 1 and caspase 9 were detected in most odontogenic epithelial cells . ^^^ CONCLUSION : Expression of cytochrome c , APAF 1 , caspase 9 , and AIF in tooth germs and ameloblastomas suggests that the mitochondria mediated apoptotic pathway has a role in apoptotic cell death of normal and neoplastic odontogenic epithelium . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptosis required caspase 9 and caspase 3 activity , and cytochrome c accumulated in the cytosol of CKI treated cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Administration of 0 . 1 microM MG 132 led to activation of a mitochondria dependent apoptotic signaling cascade involving cytochrome c , caspase 9 , caspase 3 and degradation of tau protein ; such activation was markedly reduced with 10 microM MG 132 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In this report , we demonstrate that MGd triggers the mitochondrial apoptotic pathway in the HF 1 lymphoma cell line as determined by loss of mitochondrial membrane potential , release of cytochrome c from mitochondria , activation of caspase 9 prior to caspase 8 , cleavage of PARP and annexin 5 binding . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We found that the intrinsic pathway is activated early on during anesthesia exposure ( within two hours ) , as measured by the down regulation of bcl 10 ( L ) , up regulation of cytochrome c and the activation of caspase 9 in 7 day old rats ( the peak of synaptogenesis ) , but remains inactivated in 14 day old rats ( the end of synaptogenesis ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The increase in apoptosis was partly due to cytochrome c release and subsequently caspase 9 activation by Bcl 2 ASO . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , release of cytochrome c from mitochondria was increased and caspase 9 and 3 were activated following irradiation in Saos 2 mIkappaB cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The number of apoptotic cells in lung sections was determined by a TUNEL method . mRNAs for Fas , FasL and caspase 8 , and for Bad , Bax , Bcl w , Bcl xL and caspase 9 , for the FasL and the mitochondrial cytochrome c pathways of apoptosis , respectively , and mRNA for the effector caspase 3 were quantified in lung tissues by RT PCR . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This redox shift was kinetically linked to decreased BcL 2 , increased Bax , and release of mitochondrial cytochrome c which preceded caspase 9 and 3 activation and poly ADP ribose polymerase ( PARP ) cleavage ( 1 2 h ) , consistent with mitochondrial apoptotic signaling . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The catalytic activity of caspase 3 and caspase 9 was significantly increased and was accompanied by cytosolic release of cytochrome c and MPT in response to mitomycin C . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Dose dependently elevated mRNA and protein levels of Fas , and promoted apoptotic initiator caspase 8 ( active form ) , a molecule of a death receptor dependent pathway , coupled with unaltered or decreased levels of cytosolic cytochrome c and the apoptotic initiator caspase 9 ( active form ) , molecules of mitochondria dependent pathways , may be indicative of cardiac apoptosis , which is Fas death receptor apoptotic signaling dependent , but not mitochondria pathway dependent in rats exposed to second hand smoke ( SHS ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Pharmacologic modulation of GSK 3beta markedly impaired p 53 dependent transactivation of targets including p 21 and Puma but promoted p 53 dependent conformational activation of Bax , resulting in cytochrome c release , loss of mitochondrial membrane potential , and caspase 9 processing . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Radiation induced apoptosis is independent of caspase 8 but dependent on cytochrome c and the caspase 9 cascade in human leukemia HL 60 cells . ^^^ These results suggest that , unlike the caspase cascade of H ( 2 ) O ( 2 ) induced apoptosis , cytochrome c and caspase 9 are important for the intrinsic pathway of radiation induced apoptosis , independent of caspase 8 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , melatonin treatment diminished cytochrome c release from mitochondria and reduced caspase 3 and caspase 9 activation induced by hyperhomocysteinemia . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These sensitive cells showed an increased Bax and PUMA transcription , altered mitochondrial membrane potential , followed by the release of cytochrome c , and cleaved caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Coadministration of sulindac sulfide and the small molecule Bcl 2 inhibitor HA 14 1 increased apoptosis induction and enhanced caspase 8 and caspase 9 cleavage , Bax redistribution , and cytochrome c and second mitochondria derived activator of caspase release . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Inducing expression of A53T alpha synuclein in differentiated PC 12 cells decreased proteasome activity , increased the intracellular ROS level and caused up to approximately 40 % cell death , which was accompanied by mitochondrial cytochrome C release and elevation of caspase 9 and 3 activities . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Activation of the route from cell surface requires the cellular components that include membrane receptors , adaptor proteins such as TRADD and FADD , and caspase 8 , while activation of the other from mitochondria requires Apaf 1 , caspase 9 , and cytosolic cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
It also decreased activity of both caspase 8 and caspase 9 , prevented caspase 8 dependent cleavage of the proapoptotic factor Bid , and suppressed release of cytochrome c from mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
RESULTS : H 4 cells treated with R ( + ) MA showed typical signs of mitochondrial apoptosis , i . e . , release of mitochondrial cytochrome c into the cytosol and activation of initiator caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
CCN 1 induces fibroblast apoptosis through its adhesion receptors , integrin alpha6beta1 and the heparan sulfate proteoglycan ( HSPG ) syndecan 4 , triggering the transcription independent p 53 activation of Bax to render cytochrome c release and activation of caspase 9 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Caspase 9 is a critical component of the mitochondrial or intrinsic apoptotic pathway and is activated by Apaf 1 following release of cytochrome c from mitochondria in response to a variety of stimuli . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Smac enhanced activation of caspase 2 , caspase 3 , caspase 8 , and caspase 9 , loss of mitochondrial membrane potential , and cytochrome c release on gamma irradiation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
With U 937 , MCF 7 ( caspase 3 deficient ) , MCF 7 / c3 cells ( stably transfected with caspase 3 ) , we demonstrate that caspase 3 is essential for caspase 9 , 7 , 8 activation , for Bid degradation mediating mitochondrial cytochrome c release , for cleavage of poly ( ADP ribose ) polymerase and inhibitor of the caspase activated deoxyribonuclease , and , at least in part , for internucleosomal DNA fragmentation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Upon treatment of the Jurkat cells with p 29 at a lower concentration , translocation of phosphatidylserine to the external cell surface , release of cytochrome c and Smac / DIABLO from the mitochondria , and activation of caspase 9 were induced . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Cell cycle characteristics , DNA fragmentation , p 53 and p 21 ( WAF1 / CIP1 ) expression , caspase 3 and caspase 9 activity , cytochrome c release from mitochondria during cell death induction by the taxanes paclitaxel and docetaxel in highly sensitive MDA MB 435 and highly resistant NCI ADR RES human breast cancer cells were compared . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cerebral I / R induced internucleosomal DNA fragmentation , caspase 8 , caspase 9 , and caspase 3 activation , and cytochrome c release were reduced by TMP treatment . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Overexpression of SLK enhanced anoxia / recovery induced apoptosis , release of cytochrome c , and activities of caspase 8 and 9 , and apoptosis was reduced significantly with p 38 and caspase 9 inhibitors . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We were also able to demonstrate HNE induced release of cytochrome c from mitochondria , caspase 9 , and caspase 3 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Although the mitochondrial transmembrane potential collapsed , neither cytosolic translocation of mitochondrial cytochrome c nor activation of caspase 9 , caspase 8 , caspase 3 , and poly ( ADP ribose ) polymerase were found . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We found that the apoptotic effect of NE was associated with increased processing of ER resident pro caspase 12 , cleavage of caspase 9 and 3 , and mitochondrial release of cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Ad COX 1 / PGIS transfection was found to reduce the adriamycin stimulated activities of caspase 3 and caspase 9 , inhibit adriamycin induced release of cytochrome c , elevate the expression of Bcl 10 ( L ) , and suppress the activation and translocation of nuclear factor kappaB ( NF kappaB ) in adriamycin treated renal tubular cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c in turn activated caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Treatment with the p 38 MAPK inhibitor , SB 203580 , or the overexpression of kinase inactive p 38 MAPK , induced an attenuation of T . vaginalis induced apoptosis but not cytochrome c release , the activation of caspase 9 and caspase 3 , or PARP cleavage . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
RESULTS : Hsp 70 overexpression reduced cytosolic translocation of cytochrome c without affecting the levels of Apaf 1 and pro caspase 9 24 hours after H / I . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
SNAP , an NO donor , induces apoptosis in these cells because it 1 ) increases the p 53 and 2 ) induces cytochrome c release and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
However , we did not detect the changes in cytochrome c expression and the participation of caspase 9 in this process , suggesting that there might exist an unknown signal pathway ( s ) from the mitochondria to the downstream protein PARP , which is cleaved in a caspase independent manner . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
We found that FK 228 activated caspase 9 and a subsequent caspase cascade by perturbing the mitochondrial membrane to release cytochrome c , which was almost completely blocked by overexpression of Bcl 2 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Both PUNI and EA provoked the same effects on Caco 2 cells : down regulation of cyclins A and B 1 and upregulation of cyclin E , cell cycle arrest in S phase , induction of apoptosis via intrinsic pathway ( FAS independent , caspase 8 independent ) through bcl XL down regulation with mitochondrial release of cytochrome c into the cytosol , activation of initiator caspase 9 and effector caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Release of cytochrome c from mitochondria triggered the activation of caspase 9 and the subsequent activation of the executioner caspase , caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This report shows that the induction of apoptosis by trimidox occurs through a cytochrome c dependent pathway , which sequentially activates caspase 3 and caspase 9 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The evidence clearly points to T . gondii targeting multiple steps in the transmission [ inhibition of c Jun N terminal kinase ( JNK ) activation in response to UV ] , triggering ( inhibition of cytochrome c release by affecting the balance of pro and anti apoptotic BCL 2 family members ) and execution ( inhibition of caspase 9 and caspase 3 ) phases of the apoptotic cascade . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Similar to what was previously observed by others for keratinocytes and fibroblasts , we show here that anoikis of intestinal epithelial cells does not involve caspase 9 , a target of a mitochondrial protein cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
LNCaP cells treated with selenite also showed p 53 translocation to mitochondria , cytochrome c release into the cytosol , and activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This result coincided with increased activation of the type 2 or intrinsic , mitochondrial path to cell death , manifested by increased caspase 9 activation and increased cytochrome c release after Jo 2 exposure . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The apoptosis inducing activities were determined by nuclear condensation , DNA fragmentation , sub G 1 appearance , loss of mitochondrial membrane potential ( delta psi ( m ) ) , release of mitochondrial cytochrome c into cytoplasm and proteolytic activation of caspase 9 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Using primary rat hippocampal cultures , staurosporine ( STS , 100 nM ) induced a time dependent apoptosis , accompanied by a marked production of reactive oxygen species ( ROS ) , release of cytochrome c and activation of caspase 9 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Additionally , we studied changes in nuclear morphology , as well as in genomic DNA degradation , cytochrome c release , and caspase 9 and 3 presence and processing induced by toxic concentrations of digitalis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Consequently , a loss of mitochondrial membrane potential and the release of cytochrome c lead to the activation of caspase 9 and , subsequently , caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c release contributes to caspase activation , such as caspase 9 , caspase 6 , and caspase 3 , which results in the degradation of numerous nuclear proteins including poly ( ADP ribose ) polymerase ( PARP ) , which subsequently leads to the internucleosomal cleavage of DNA , resulting cell death . ^^^ The results showed that Hcy mediated ROS production preceded the loss of MP , the release of cytochrome c , and the activation of caspase 9 and 3 . ^^^ Our data suggested that Hcy mediated ROS production promotes endothelial cell death in part by disturbing MP , which results in subsequent release of cytochrome c and activation of caspase 9 and 3 , leading to cell death . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The present results indicate that ISL inhibits prostate cancer cell growth by the induction of apoptosis , which is mediated through mitochondrial events , which are associated with an evident disruption of the mitochondrial membrane potential , and the release of cytochrome c and Smac / Diablo , and the activation of caspase 9 . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The released cytochrome c then activates the initiator active caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptosome ( a multi protein complex consisting of cytochrome c , Apaf 1 , caspase 9 , and ATP ) formation was confirmed by immunoprecipitation using cytochrome c antibody . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
When Jurkat T cells were treated with HaBC 18 ( 0 . 5 2microg / ml ) , apoptosis along with several biochemical events such as mitochondrial cytochrome c release , activation of caspase 9 and 3 , degradation of PARP , and DNA fragmentation was induced in a dose dependent manner . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The protein expressions of Cbfa 1 , Bax , Bcl 2 , caspase 3 , and caspase 9 , cytochrome C and TNF alpha were determined by Western immunoblot . ^^^ RESULTS : After the transient transfection with the two isforms of Cbfa 1 , MBA 1 , the cells apoptotic rates increased , and the ratio of Bax / Bcl 2 , the expressions of cytochrome C , caspase 3 , caspase 9 , and TNF alpha were significantly increased . ^^^ Bax / Bcl 2 , cytochrome C , caspase 9 , caspase 3 , and TNF alpha are also involved in the apoptosis pathway . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Furthermore , the loss of mitochondrial membrane potential coincident with the release of cytochrome c from the mitochondria into the cytosol led to a rapid activation of caspase 9 and caspase 3 ( an executioner ) , indicating that the selective damage to the mitochondria by HAL PDT can induce a cytochrome c mediated apoptotic response in the 320DM cells . . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
ATRA mediated apoptosis in CHP 134 and NB 39 nu cells was associated with a significant activation of caspase 9 and caspase 3 as well as cytoplasmic release of cytochrome c from mitochondria in a p 53 independent manner . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , we found that mitochondria are involved in TEF induced apoptosis , characterized by the dissipation of the mitochondrial transmembrane potential , the release of cytochrome c into the cytosolic compartment and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
After I / R , expressions of cytochrome c and cleaved caspase 9 were significantly increased . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Enhanced induction of apoptosis of the cells by the combined treatment was mediated by loss of mitochondrial membrane potential , which resulted in the activation of caspase 8 , caspase 9 , and caspase 3 accompanied by cytochrome c release and Bid cleavage . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c content increased in the cytosol and decreased in the mitochondrial fraction of testis from EAO rats compared with C , concomitant with increased caspase 9 activity . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Mitochondrial regulation of apoptosis further downstream of Bax was investigated , showing change in the mitochondrial membrane potential , cytochrome c release into the cytosol , and enhanced caspase 9 and caspase 3 activities . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Western blot data demonstrated that cytochrome c ( Cyt c ) , Smac ( the second mitochondria derived activator of caspase ) , calpain 1 , caspase 9 , 3 and 8 were involved in the apoptotic process , while the pan caspase inhibitor zVAD fmk almost completely inhibited Dc induced apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Western blot analyses showed an increase in activities of calpain and caspase 12 , upregulation of Bax : Bcl 2 ratio , release of cytochrome c from mitochondria , and increase in caspase 9 and caspase 3 activities during apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
EAC also initiated the mitochondrial apoptotic pathway through regulation of Bcl 2 family proteins expression , release of cytochrome c , and activation of caspase 9 in Hep 3B cells . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Similarly , although cytochrome c was released from mitochondria following heat shock , functional Apaf 1 . caspase 9 apoptosome complexes were not formed , and caspase 9 was not essential for the activation of caspase 3 or the induction of apoptosis . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Cytochrome c finally triggered apoptosis by activating caspase 9 and caspase 3 in apoptotic cascade . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Bax activation , release of cytochrome c , and activation of caspase 9 and caspase 3 all correlated with the observed cell death responses of wild type or capn 4 ( / ) MEFs to the various challenges , suggesting that calpain might play distinct roles in transducing different death signals to the mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Plumbagin treatment triggered the mitochondrial apoptotic pathway indicated by a change in Bax / Bcl 2 ratios , resulting in mitochondrial membrane potential loss , cytochrome c release , and caspase 9 activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , Hcy increased cytochrome c release into the cytosol , and activated caspase 9 and caspase 3 , but not caspase 8 , indicating that Hcy induces apoptosis via the mitochondria pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Treatment of RAW264 . 7 cells with OxLDL induces a series of time dependent events , including the release of cytochrome c , Smac and Omi from the mitochondria to the cytosol , activation of caspase 9 , 6 , 2 , and 3 , which are blocked by A 20 expression . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
These changes were associated with elevation of oxidative stress , decreases of mitochondrial Bcl 2 and cytochrome c proteins , increases of cytosolic Bax and cytochrome c proteins , caspase 9 and caspase 3 activities and myocyte apoptosis , and downregulation of beta adrenergic receptor sensitivity and SR Ca2+ ATPase . ^^^ Combined treatment with vitamins C and E diminished oxidative stress , increased mitochondrial Bcl 2 protein , decreased cytosolic Bax , prevented cytochrome c release from mitochondria to cytosol , reduced caspase 9 and caspase 3 activities and myocyte apoptosis , blocked beta adrenergic receptor desensitization and SR Ca2+ ATPase downregulation , and attenuated LV dilation and dysfunction in HF after MI . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Many proapoptotic stimuli trigger cytochrome c release from mitochondria , promoting the formation of a complex between Apaf 1 and caspase 9 in a caspase activating structure known as the apoptosome . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Nucling is a novel type of apoptosis associated molecule , essential for cytochrome c , apoptosis protease activating factor 1 ( Apaf 1 ) , pro caspase 9 apoptosome induction and caspase 9 activation following pro apoptotic stress . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
They showed early mitochondrial swelling , loss of mitochondrial membrane potential and cytoplasmic release of cytochrome c , followed by activation of caspase 9 , and by caspase 9 dependent activation of caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Apoptosis inhibition correlated with blockade of mitochondrial cytochrome c release , abolition of caspase 3 activity along with inhibition of caspase 9 and PARP cleavage . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
GSE induced anoikis and apoptosis were accompanied by a strong decrease in focal adhesion kinase levels , but an increase in caspase 3 , caspase 9 , and poly ( ADP ribose ) polymerase cleavage ; however , GSE caused both caspase dependent and caspase independent apoptosis as evidenced by cytochrome c and apoptosis inducing factor release into cytosol . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Andro triggered a caspase 8 dependent Bid cleavage , followed by a series of sequential events including Bax conformational change and mitochondrial translocation , cytochrome c release from mitochondria , and activation of caspase 9 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
LBH 589 favored apoptosome formation by inducing cytochrome c release , Apaf 1 up regulation , and caspase 9 cleavage . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The apoptotic AM were characterized by decreased mitochondrial trans membrane potential , increased mitochondrial release of cytochrome c , activated caspase 9 ( but not caspase 8 ) and caspase 3 activities , and PARP degradation , comparing to cells from the saline control . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Bortezomib induces apoptosis by releasing cytochrome C from mitochondria and by activating caspase 9 and Jun kinases ( JNK ) and the Fas caspase 8 dependent apoptotic pathway . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
With the increased Bax : Bcl 2 ratio , cytochrome c was released from mitochondria to cytosol for sequential activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The damaged and surviving neurons in hippocampus were observed by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) and cresyl violet staining , the expression of caspase 8 , Bid , XIAP , caspase 9 , cytochrome c and Smac / DIABLO were detected with immunofluorescence and Western blot . ^^^ The cleavage of caspase 8 and Bid increased at 0 h , cytosolic fraction of cytochrome c and Smac / DIABLO increased by 2 h , cleavage of caspase 9 was detected by 4 h , TUNEL positive neurons appeared at 8 h and reached a maximum at 24 h following administration of diazepam in the ipsilateral CA 3 subfield of hippocampus . ^^^ Inhibition of caspase 8 significantly decreased neuronal cell death , accompanied by reduction of t Bid , cleaved caspase 9 and cytosol cytochrome c . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Mouse Apop 1 expression induces apoptotic death by releasing cytochrome c from mitochondria into the cytosolic space followed by activation of caspase 9 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
TNF alpha secretion , caspase 8 and 3 activation ) , but also the mitochondrial pathway ( i . e . 8 hydroxy 2 ' desoxyguanosine formation , cytochrome c release from mitochondria , caspase 9 and 3 activation ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
After cytochrome c is released into the cytosol from the mitochondria , it binds to Apaf 1 and ATP , which then activate caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The early caspase 3 activation occurs within 1 min of stimulation and is independent on caspase 9 or mitochondrial cytochrome c release suggesting that is a non apoptotic event . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
VA 13 cells incubated with ethanol appears to be mediated by release of mitochondrial cytochrome c via activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
CCL 5 induced cell death involves the cytosolic release of cytochrome c , the activation of caspase 9 and caspase 3 , and poly ( ADP ribose ) polymerase cleavage . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Our results show that LCL 30 is highly cytotoxic to SW 403 cells ( and other cancer cell lines ) and preferentially accumulates in mitochondria , resulting in a decrease of the mitochondrial membrane potential , release of mitochondrial cytochrome c , and activation of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Low MOI reduced mitochondrial membrane depolarization , caspase 3 and caspase 9 activation , and cytochrome c release and increased Bcl 2 levels . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
They induce cytochrome c release , caspase 9 , 3 and 8 activities , poly ( ADP ) ribose polymerase 1 ( PARP ) cleavage , and internucleosomal DNA fragmentation by a mechanism which involves caspase 2 activation but not Fas signaling . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addition , we found that overexpression of Hsp105alpha or Hsp105beta suppressed the activation of caspase 3 and caspase 9 by preventing the release of cytochrome c from mitochondria . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The expression of cytosolic cytochrome c and activated caspase 9 and caspase 3 was significantly increased whereas the expression of mitochondrial cytochrome c significantly decreased in I / R with GdCl 3 in comparison to the control . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
At the cellular level , ischemia hypoxia produced proinflammatory cytokines and simultaneously activated both prosurvival ( eg , synthesis of heat shock 70 protein , phosphorylation of ERK and AKT ) and proapoptosis signaling pathways ( eg , release of cytochrome c and AIF from mitochondria , cleavage of caspase 9 and 8 ) . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
The release of mitochondrial cytochrome c ( Cyt c ) was also detected within 9 h in HL 60 cells treated with 7 and 10 , consistent with the fact that Cyt c is the apoptotic trigger that activates caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In cell free systems supplemented with ATP caspase 9 activation is induced by addition of cytochrome c and we show that in this process PP1alpha is indispensable for triggering caspase 9 as well as caspase 3 cleavage and activation . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Selenite and TRAIL combined treatment led to synergistic increases of Bax abundance and translocation into mitochondria , loss of mitochondrial membrane potential , cytochrome c release , and cleavage activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
In addiction , release of cytochrome c and caspase 9 and caspase 8 activation were detected . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Treatment of TMK 1 cells with adriamycin ( ADR ) caused apoptosis and apoptosis related reactions such as the release of cytochrome c from mitochondria and the activation of caspase 9 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
Similar to animal cell apoptosis , cytochrome c was released into the cytosol and caspase 9 and caspase 3 like proteolytic activities were strongly induced . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
This was followed by the release of cytochrome c into the cytoplasm and a substantial increase in the activities of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
CTX 3 treatment caused loss of the mitochondrial membrane potential ( DeltaPsim ) , release of mitochondrial cytochrome c to the cytosol , and activation of both caspase 9 and 3 . ^^^
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P99999	Pubmed	SVM Score :0.0
NA