Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.53255744
We demonstrate that Dex induced apoptosis in MM . 1S cells is mediated by downstream activation of caspase 9 , with resultant caspase 3 cleavage ; and conversely , that IL 6 triggers activation of PI 3 K and its association with SHP 2 , inactivates caspase 9 , and protects against Dex induced apoptosis . 0.53255744^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.65092954
Fluorometric studies demonstrated that LPS in vivo significantly increased caspase 8 and caspase 3 activity and by use of specific inhibitors , the activation of caspase 3 was shown to be initiated by caspase 8 with no contribution from caspase 9 . 0.65092954^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.73082559
Fluorometric studies demonstrated that TNF alpha in vivo predominantly increased caspase 8 and 3 activity and by use of specific inhibitors , the activation of caspase 3 was shown to be initiated by caspase 8 with only a minor contribution from caspase 9 . 0.73082559^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We report here the purification of the third protein factor , Apaf 3 , that participates in caspase 3 activation in vitro . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Casp 9 deletion prevents activation of Casp 3 in embryonic brains in vivo , and Casp 9 deficient thymocytes show resistance to a subset of apoptotic stimuli , including absence of Casp 3 like cleavage and delayed DNA fragmentation . ^^^ Moreover , the cytochrome c mediated cleavage of Casp 3 is absent in the cytosolic extracts of Casp 9 deficient cells but is restored after addition of in vitro translated Casp 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Comparison of the requirement for Casp 9 and Casp 3 in different apoptotic settings indicates the existence of at least four different apoptotic pathways in mammalian cells . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The cytosolic protein APAF 1 , human homolog of C . elegans CED 4 , participates in the CASPASE 9 ( CASP 9 ) dependent activation of CASP 3 in the general apoptotic pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In contrast , disturbance of the caspase cascade by targeted disruption of either casp 9 or casp 3 leads to decreased PCD causing expansion and exencephaly of the forebrain as well as supernumerary neurons in the cerebral cortex . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In all three lines tested , the use of a specific inhibitor of Casp 9 almost completely blocked cisplatin induced apoptosis , while the use of Casp 3 and 8 inhibitors resulted in a partial blockade of cisplatin induced apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Consistently , caspase 8 deficient ( Casp 8 ( / ) ) cells were sensitive to ASK 1 induced caspase 3 activation and apoptosis , suggesting that caspase 8 is dispensable for ASK 1 induced apoptosis , whereas ASK 1 failed to activate caspase 3 in caspase 9 dificient ( Casp 9 ( / ) ) cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Bindings studies with the PACAP recombinant protein demonstrated specific binding to casp 2 and casp 9 but not to casp 3 , 4 , 7 , or 8 in cell extracts . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , detailed analyses of the programmed cell death of developing motoneurons in mice following the genetic deletion of two key caspases , casp 3 and casp 9 , and in the chick embryo following treatment with caspase inhibitors , indicate that normal amounts of cell loss occur although the death process is delayed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Likewise , pro apoptotic genes such as the caspases ( CASP 9 , CASP 3 , CASP 2 ) and apoptotic protease activating factor ( APAF ) were induced during the same period . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , BID , BCL 2 , APAF 1 , CASP 2 , CASP 3 and CASP 9 were found to be preferentially expressed in tumours with favourable biology , whereas CDKN1A ( p 21 ) , IL2RA , and MCL 1 , were found to be preferentially expressed in NB tumours with unfavourable biology . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
RESULTS : Reverse transcription PCR revealed the detection of apoptosis related m RNAs as follows ( group A compared to group B ) : Apaf 1 0 % / 0 % ; Bcl 2 0 % / 35 % ; Bim 0 % / 9 % ; Bag 1 0 % / 9 % ; p 53 0 % / 4 % ; casp 3 11 % / 52 % ; casp 5 59 % / 48 % ; casp 8 44 % / 22 % ; casp 9 4 % / 9 % ; Bax 81 % / 52 % ; Bad 96 % / 56 % , and c myc 89 % / 96 % . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cleaved caspase 3 ( CASP 3 ) , caspase 9 ( CASP 9 ) ( P < 0 . 05 ) and poly ADP ribose polymerase ( PARP 1 ) ( P < 0 . 01 ) expression was increased and BCL 2 ( P < 0 . 01 ) expression was decreased in rats treated with 4 microg PTHLH ( 7 34 ) compared to that in control . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In contrast , caspase 3 and caspase 7 zymogens are proteolytically processed by active caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Once activated , caspase 9 can initiate a caspase cascade involving the downstream executioners caspase 3 , 6 , and 7 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Recent studies have demonstrated that Apaf 1 is the adaptor molecule which in the presence of cytosolic cytochrome c ( cyt c ) and dATP interacts with procaspase 9 , resulting in the sequential cleavage and activity of caspase 9 and caspase 3 , followed by apoptosis . ^^^ It was , however , clearly associated with caspase 9 cleavage , as well as the poly ( ADP ribose ) polymerase and DFF 45 cleavage activity of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 is required for the activation of four other caspases ( 2 , 6 , 8 , and 10 ) in this pathway and also participates in a feedback amplification loop involving caspase 9 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NO donor glycerol trinitrate ( at the concentration , which induces apoptotic cell death ) caused ( 1 ) a significant decrease in the concentration of cardiolipin , a major mitochondrial lipid ; ( 2 ) a downregulation in respiratory chain complex activities ; ( 3 ) a release of the mitochondrial protein cytochrome c into the cytosol ; and ( 4 ) an activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In the cytosol , cytochrome c combines with APAF 1 in the presence of ATP to activate caspase 9 that , in turn , activates effectors caspases such as caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Pathways to caspase 3 activation have been identified that are either dependent on or independent of mitochondrial cytochrome c release and caspase 9 function . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Once activated , caspase 9 disassociates from the complex and becomes available to cleave and activate downstream caspases such as caspase 3 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The involvement of caspases is demonstrated because ( a ) a peptide caspase inhibitor almost completely prevented ML 1 induced cell death and ( b ) proteolytic activation of caspase 8 , caspase 9 , and caspase 3 was observed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These results suggested that the ATP dependent step ( s ) of Fas mediated apoptotic signal transduction in type 1 cells are only located downstream of caspase 3 activation , whereas the activation of caspase 9 by released cytochrome c is the most upstream ATP dependent step in type 2 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The smaller microaposome complex ( M ( r ) = approximately 200 , 000 300 , 000 ) contained active caspase 3 and 7 but little if any Apaf 1 or active caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , both caspase 9 and caspase 3 were processed to their active forms in serum / glucose deprived myocytes . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Human platelets contained caspase 9 , caspase 3 , and the caspase activators APAF 1 and cytochrome c as shown by sodium dodecyl sulfate polyacrylamide gel electrophoresis and Western blotting . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The phosphatase inhibitors orthovanadate and okadaic acid prevented catalytic processing and activation of caspase 3 and digestion of Akt and partially inhibited cleavage of caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We also show by Western blot that Bcl xL , caspase 9 , caspase 8 , and Bid are processed by caspase 3 in injected wild type mice but that this processing does not occur in caspase 3 / mice . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 is one caspase upstream of caspase 3 and its activation is stimulated by Apaf 1 / cytochrome c and inhibited by Akt signals . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
On the other hand , activation of caspase 8 was clearly observed at 36 hours after TGF beta 1 treatment , followed by activation of caspase 9 , and caspase 3 was activated at 48 hours after treatment at which time apoptosis of HuH 7 cells was observed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Consistent with the appearance of activated caspase 3 positive cells , BMP 4 and RA together induced processing of caspase 9 , Ac DEVD MCA cleavage activity and DNA fragmentation . ^^^ In the RA / BMP 4 treatment induced apoptosis , caspase 9 was upstream of caspase 3 in the enzyme cascade , and the caspase 9 to 3 step was key in the apoptotic pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both caspase 9 and caspase 3 inhibitors ( Z LEHD FMK and Ac DEVD CHO , respectively ) blocked cocaine induced apoptosis . ^^^ Furthermore , the release of cytochrome c from the mitochondria and its subsequent activation of caspase 9 and caspase 3 play a key role in cocaine induced apoptosis . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
At a verteporfin concentration that produced the death of a high proportion of cells after light irradiation , evidence of caspase 3 and caspase 9 processing and of poly ( ADP ribose ) polymerase cleavage was present within whole cell lysates . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activated caspase 9 will then cleave and activate downstream caspases such as caspase 3 , 6 , and 7 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Together , these data support the notion that these three teratogens induce changes in embryonic mitochondria resulting in the release of cytochrome c and the subsequent activation of caspase 9 , the upstream activator of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Western blot analysis showed that HNE treatment induced time and dose dependent activation of caspase 8 , caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
When K 562 cells ( derived from a patient with blast crisis CML ) were treated with AG 957 , dose and time dependent p210bc / abl down regulation was followed by mitochondrial release of cytochrome c , activation of caspase 9 and caspase 3 , and apoptotic morphological changes . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 and caspase 9 are essential for apoptosis during brain development . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cleavage of caspase 9 by calpain generates truncated caspase 9 that is unable to activate caspase 3 in cell lysates . ^^^ Furthermore , direct cleavage of caspase 9 by calpain blocks dATP and cytochrome c induced caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase 9 and caspase 3 in leukaemia HL 60 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Further biochemical data suggest that SfIAP and CpIAP are specific inhibitors of mammalian caspase 9 , the pinnacle caspase in the mitochondria / cytochrome c pathway for apoptosis , but are not inhibitors of downstream caspase 3 and caspase 7 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activated Caspase 9 cleaves downstream caspases such as Caspase 3 , 6 and 7 initiating the caspase cascade . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Western analysis showed cleavage of caspase 9 , an initiator caspase , of caspase 3 , an executioner caspase , and of a caspase substrate , poly ( ADP ribose ) polymerase ( PARP ) in staurosporine treated cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Staurosporine treatment caused time and concentration dependent increases in the activities of caspase 3 and caspase 9 but not caspase 1 , increased proteolysis of poly ( ADP ribose ) polymerase , and induced morphological changes consistent with apoptosis . ^^^ Overexpression of glycogen synthase kinase 3beta to levels 3 . 5 times that in control cells did not alter basal indices of apoptosis but potentiated staurosporine induced activation of caspase 3 , caspase 9 , proteolysis of poly ( ADP ribose ) polymerase , and morphological changes indicative of apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Notably , genes involved in cell death , even thymocyte death , such as Fas , Fas ligand , p 53 , caspase 1 , caspase 3 , and caspase 9 , and Bcl 2 have been found to not be required for normal thymic negative selection . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , some subtle differences have been observed between caspase 9 and caspase 3 in the subsite contacts with the covalently linked inhibitor Ac DVAD fmk . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These results indicate that Apaf 1 overexpression lowers the apoptotic threshold by activating caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We also demonstrated immunohistochemically the activation of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Subsequently caspase 9 and caspase 3 were sequentially activated . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both caspase 9 ( Z LEHD FMK ) and caspase 3 ( Ac DEVD CHO ) inhibitors blocked cocaine induced apoptosis . ^^^ The release of cytochrome c from the mitochondria and its subsequent activation of caspase 9 and caspase 3 may play a key role in cocaine induced apoptosis . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We assessed a non selective caspase inhibitor ( Z VAD . fmk , 0 . 1 microM ) , a caspase 8 inhibitor ( Z IETD . fmk , 0 . 07 microM ) , a caspase 9 inhibitor ( Z LEHD . fmk , 0 . 07 microM ) and a caspase 3 inhibitor ( Ac DEVD . cmk , 0 . 07 microM ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In the tumors resected for biochemical studies , apoptosis was visualized by activation of caspase 9 and caspase 3 and a gradual increase in the cleavage of the nuclear enzyme poly ( ADP ribose ) polymerase ( PARP ) to a maximum of approximately 60 % of the total PARP present at approximately 26 h . ^^^ Our results suggest that : ( a ) Pc 4 PDT is effective in the treatment of SW 480 human colon cancer xenografts independent of p 53 status ; ( b ) PARP cleavage may be mediated by caspase 9 and caspase 3 activation in the Pc 4 PDT treated tumors ; and ( c ) p 38 phosphorylation may be a trigger of apoptosis in response to PDT in vivo in this tumor model . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The cleavage of caspase 9 is , however , minimal and a much later event than the processing / activation of caspase 3 , suggesting that it is not the apical caspase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Whereas A 1 is able to inhibit mitochondrial depolarization , loss of cytochrome c , cleavage of caspase 9 , BID , and poly ( ADP ribose ) polymerase , it does not block caspase 8 or caspase 3 cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
RESULTS : By 24 h , zinc treatment resulted in the translocation of cytochrome c from the mitochondria to the cytosol , the activation of caspase 9 and caspase 3 , and eventually , the cleavage of nuclear poly ( ADP ) ribose polymerase ( PARP ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
HA 14 1 effectively induced apoptosis of human acute myeloid leukemia ( HL 60 ) cells overexpressing Bcl 2 protein that was associated with the decrease in mitochondrial membrane potential and activation of caspase 9 followed by caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 activity was effectively restored by addition of recombinant caspase 9 and APAF 1 proteins , and to a lesser extent by caspase 9 alone , but not by APAF 1 alone . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Purified active caspase 3 is sufficient to cleave nuclear caspase 9 zymogen . ^^^ These results suggest that , in addition to the mitochondrial localization , caspase 9 proform is found within the nucleus and its processing can be regulated by caspase 3 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The death of cRGDfV treated ( 20 microg / ml ) glioma cells was blocked by pretreatment ( 10 microM ) of cells with DEVD FMK and LEHD FMK , inhibitors of caspase 3 and caspase 9 , respectively . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , 5 lipoxygenase inhibitors 5 , 8 , 11 , 14 eicosatetraynoic acid and MK 886 , cyclooxygenase inhibitor indomethacin , caspase 3 and caspase 9 inhibitors Z DEVD FMK and Z LEHD FMK , but not nitric oxide synthase inhibitor Nomega nitro l arginine methyl ester , significantly reduced the cell death inducing effect of AEA . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Specific inhibitors of caspase 3 and caspase 6 showed a similar ability to BAF in preventing EDBA mediated ganglion cell loss , whereas inhibitors of caspase 8 and caspase 9 were not able to rescue EDBA treated ganglion cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Neither caspase 9 nor caspase 3 activation was detected in ebselen treated cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These results suggest that XIAP inhibits caspase 3 and caspase 9 in a different manner . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
E1B 19K expression interrupted caspase 3 processing , permitting cleavage to remove the p 12 subunit but not the prodomain consistent with caspase 8 and not caspase 9 enzymatic activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 8 and caspase 3 were activated in MMC treated cells whereas caspase 1 was not activated , and cytochrome c was released from mitochondrial membrane to cytosol suggesting that caspase 9 was activated during the MMC induced apoptotic process . ^^^ Taken together , these findings indicate that MMC induced apoptosis in SNU 16 cells was mediated by caspase 8 , caspase 9 , and caspase 3 activation independently of FasL / Fas interactions . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Although resistant cells displayed partial inhibition of UV induced apoptosis through the caspase 3 pathway , there was no consistent difference in the activation of this and related caspase 9 caspases compared to parental HeLa cells . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both caspase 3 inhibitor Z Asp ( OCH 3 ) Glu ( OCH 3 ) Val Asp ( OCH 3 ) CH2F and caspase 9 inhibitor Z Leu Glu ( OCH 3 ) His Asp ( OCH 3 ) CH2F prevented the chondrocyte death . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We found that MT 21 activated caspase 3 via caspase 9 , but not via caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
When cytosolic extract from cells expressing P 35 was added , caspase 9 mediated maturation of caspase 3 proceeded normally but caspase 3 mediated further events were prevented , such as complete processing of caspase 3 , processing of caspase 7 and the appearance of DEVD cleaving activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In contrast to caspase 9 that was cleaved in these cells , anticancer drugs induced caspase 8 activation only in caspase 3 transfected MCF 7 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Acetyl IETD fluoromethylketone , a caspase 8 inhibitor , potently suppressed TRAIL induced cell death compared to acetyl DEVD fluoromethylketone and acetyl LEHD fluoromethylketone , inhibitors of caspase 3 and caspase 9 , respectively . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Etoposide induced increased formation of ceramide from sphingomyelin and release of mitochondrial cytochrome c followed by activation of caspase 9 and caspase 3 , but not caspase 1 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These results suggest that cytochrome c and caspase 9 initiate the activation of executor caspase 3 in H2O2 treated PC 12 cells , and that Bcl 2 inhibits H2O2 induced release of cytochrome c from mitochondria and then proteolytic processing of procaspase 9 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
It was preceded by decrease in Bcl 2 protein level and accompanied by activation of caspase 9 and caspase 3 . ^^^ Also , inhibition of caspase 8 was ineffective in modifying the apoptotic response , whereas inhibition of caspase 3 and caspase 9 blocked apoptosis . ^^^ Overall , the data indicate that O6MeG induces apoptosis via secondary lesions that trigger Bcl 2 decline , cytochrome c release , and caspase 9 and caspase 3 activation independently of Fas / Fas ligand and p 53 , for which the cells are mutated . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Deficiency in caspase 9 or caspase 3 induces compensatory caspase activation . ^^^ Hepatocyte apoptosis and mouse death induced by the Fas agonistic antibody Jo 2 required proapoptotic Bcl 2 family member Bid and used a Bid mediated mitochondrial pathway of caspase activation ; deficiency in caspases essential for this pathway , caspase 9 or caspase 3 , unexpectedly resulted in rapid activation of alternate caspases after injection of Jo 2 , and therefore failed to protect mice against Jo 2 toxicity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Examination of initiator caspases revealed the cleavage of caspase 9 but not caspase 8 or the effector caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Enzymatic cleavages of DEVD AFC , VDVAD AFC , and LEHD AFC ( specific substrates for caspase 3 like protease ( caspase 3 and 7 ) , caspase 2 , and caspase 9 , respectively ) were observed by treatment with NO . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Correspondingly , cocaine induced activation of caspase 9 preceded that of caspase 3 . ^^^ Collectively , these data indicate that the release of cytochrome c from the mitochondria and the subsequent activation of caspase 9 and caspase 3 play a key role in cocaine induced apoptosis in these cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We found that caspase 9 , which is activated earlier than caspase 3 , directly or indirectly inactivates nuclear transport and increases the diffusion limit of the nuclear pores . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apo 2L induced apoptosis was associated with the processing of caspase 8 , Bid , and the cytosolic accumulation of cytochrome c as well as the processing of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
DNA damage induced neural precursor cell apoptosis requires p 53 and caspase 9 but neither Bax nor caspase 3 . ^^^ We found that DNA damage induced neural precursor cell apoptosis , both in vitro and in vivo , was critically dependent on p 53 and caspase 9 , but neither Bax nor caspase 3 expression . ^^^ The apoptotic pathway regulating DNA damage induced neural precursor cell death is different from that required for normal brain morphogenesis , which involves both caspase 9 and caspase 3 but not p 53 , indicating that additional apoptotic stimuli regulate neural precursor cell numbers during telencephalic development . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both caspase 9 and caspase 3 activities were increased in RIN Arg 972 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The pathway is characterized by cytochrome c release into the cytoplasm , and activation of caspase 9 and caspase 3 , 4 6h after treatment ; cleavage products of caspase 8 and caspase 2 were not detectable in the cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Western blotting was used to measure pro caspase 9 , caspase 3 , DFF 45 , the activated nuclease CPAN and poly ( ADP ribose ) polymerase , a DNA repair enzyme inactivated by caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The elevated level of reactive oxygen species ( ROS ) , caspase 9 and caspase 3 activation , and poly ( ADP ribose ) polymerase ( PARP ) cleavage in silica treated AMs were also determined . ^^^ The results showed that there was a temporal pattern of apoptotic events in silica treated AMs , starting with ROS formation and followed by caspase 9 and caspase 3 activation , PARP cleavage , and DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The obtained lysosomal and mitochondrial factors activated caspase 3 in different manners ; caspase 3 activation by lysosomal and mitochondrial factors was specifically suppressed by E 64 , a cysteine protease inhibitor , and caspase 9 inhibitor , respectively . ^^^ Thus , the activation of caspase 3 by lysosomal factors was found to be distinct from the activation by mitochondrial Cyt . c dependent formation of the Apaf 1 / caspase 9 complex . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , immunoblots revealed a strongly reduced expression of the adaptor molecule APAF 1 , which is required for cytochrome c dependent activation of caspase 9 and subsequently caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Immunoblot analyses showed that bone marrow precursors express appreciable levels of caspase 3 and caspase 9 but no or very low levels of c fms ( M CSF receptor ) and the apoptosis regulators 10 linked inhibitor of apoptosis protein ( XIAP ) , c IAP 1 , Bcl 2 and Bax . ^^^ However , the levels of caspase 3 and caspase 9 stayed essentially unchanged even after prolonged incubation ( more than 10 days ) with M CSF . ^^^ Unlike bone marrow precursor cells , mature BMDM ( day 7 10 ) were resistant to apoptosis induced by M CSF depletion , which includes the activation of caspase 3 and caspase 9 and the degradation of XIAP , Bcl 2 and Bax proteins in the process . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Full activation of caspase 9 and caspase 3 appeared to be correlated with the appearance of superoxide anions in the mitochondria , and followed the drop in NADPH . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In the present study , we report that caspase 9 , known to be an important activator of caspase 3 , becomes activated in the axotomized adult rat retina as revealed by immunoblot analysis and protease activity assays . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
To examine Bcl 2 and Caspase family dependent apoptotic pathways in telencephalic neurons , we compared the effects of cytosine arabinoside ( AraC ) , a known neuronal apoptosis inducer , on wild type , Bcl 10 ( L ) , Bax , Caspase 9 , Caspase 3 , and p 53 deficient telencephalic neurons in vitro . ^^^ AraC caused extensive apoptosis of wild type and Bcl 10 ( L ) deficient neurons . p 53 and Bax deficient neurons showed marked protection from AraC induced death , whereas Caspase 9 and Caspase 3 deficient neurons showed minimal or no protection , respectively . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The CD 437 and TRAIL combination enhanced activation of caspase 3 , caspase 7 , caspase 8 , and caspase 9 and the subsequent cleavage of poly ( ADP ribose ) polymerase and DNA fragmentation factor 45 . ^^^ These results suggest that the mechanism of enhanced apoptosis by this combination involves p 53 dependent increase of death receptors by CD 437 , activation of these receptors by TRAIL , enhanced Bid cleavage , release of cytochrome c , and activation of caspase 3 , caspase 7 , caspase 8 , and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Here , we show that after UV radiation , MIHA prevented apoptosis by inhibiting caspase 9 and caspase 3 activation . ^^^ Unlike Bcl 2 , MIHA functioned after release of cytochrome c and DIABLO from the mitochondria and was able to bind to both processed caspase 9 and processed caspase 3 to prevent feedback activation of their zymogen forms . ^^^ Once released into the cytosol , DIABLO bound to MIHA and disrupted its association with processed caspase 9 , thereby allowing caspase 9 to activate caspase 3 , resulting in apoptosis . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
After 6 days of 9CRA treatment , RARbeta transfectants overexpressed Waf 1 / Cip 1 / Sdi 1 / p 21 , Kip 1 / p 27 , chk 1 , p 300 / CBP , BAX , Bak , Apaf 1 , caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In these transfectants , caspase 3 activity and the expression of activated caspase 9 after radiation treatment were suppressed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Western blotting showed that treatment of cells with RGD tachyplesin could activate caspase 9 , caspase 8 , and caspase 3 and increase the expression of the Fas ligand , Fas associated death domain , caspase 7 , and caspase 6 , suggesting that apoptotic molecules related to both mitochondrial and Fas dependent pathways are involved in the induction of apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Induction of apoptosis by the oolong tea polyphenol theasinensin A through cytochrome c release and activation of caspase 9 and caspase 3 in human U 937 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Immunoblot analysis and fluorometric assays revealed that the extents of IR induced activation of caspase 3 and caspase 9 were markedly greater in AT4BIVA and AT5BIVA cells than in AT3BIVA and control cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
When protein synthesis is blocked , both infection with Mtb and addition of TNF alpha are required to induce caspase 9 activation , caspase 3 activation and apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Consistent with these results , BMP 2 increases caspase 9 and caspase 3 , 6 , and 7 activity , and an anti caspase 9 agent suppresses BMP 2 induced apoptosis . ^^^ The results show that BMP 2 uses a Smad independent , PKC dependent pathway to promote apoptosis via a Bax / Bcl 2 and cytochrome c caspase 9 caspase 3 , 6 , 7 cascade in human osteoblasts . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Introduction of these mutations into full length XIAP reduced caspase 3 inhibitory activity up to 500 fold , but did not affect its ability to inhibit caspase 9 or interact with the IAP antagonist DIABLO . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The apoptosome recruits and activates caspase 9 , which in turn activates caspase 3 and 7 , which then kill the cell by proteolysis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In response to oncogene activation , p 53 mediates apoptosis through a linear pathway involving bax transactivation , Bax translocation from the cytosol to membranes , cytochrome c release from mitochondria , and caspase 9 activation , followed by the activation of caspase 3 , 6 , and 7 . p 53 mediated apoptosis can be blocked at multiple death checkpoints , by inhibiting p 53 activity directly , by Bcl 2 family members regulating mitochondrial function , by E1B 19K blocking caspase 9 activation , and by caspase inhibitors . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Active caspase 3 , 8 and caspase 9 were detected by Western blot analysis and immunofluorescence . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Here we show that DA induces apoptosis in SH SY5Y neuroblastoma cells demonstrated by activation of caspase 9 and caspase 3 , cleavage of poly ( ADP ribose ) polymerase as well as nuclear condensation . ^^^ We also show that p 38 mitogen activated protein kinase is activated within 10 min of DA treatment , which precedes the onset of apoptosis because the potent p 38 kinase inhibitor SB 203580 protects against DA induced cell death as well as against caspase 9 and caspase 3 activation . ^^^ In addition , the antioxidant N acetyl L cysteine ( NAC ) effectively blocks DA induced p 38 kinase activation , caspase 9 and caspase 3 cleavage and subsequent apoptosis , indicating that DA triggers apoptosis via a signaling pathway that is initiated by the generation of reactive oxygen species ( ROS ) . ^^^ These observations indicate that DA induces apoptosis primarily by generating ROS , p 38 kinase activation , cytochrome c release followed by caspase 9 and caspase 3 activation . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We have reconstituted the Apaf 1 activated apoptosis mechanism in Sacchromyces cerevisiae such that the presence of a constitutively active form of Apaf 1 together with both Caspase 9 and Caspase 3 results in yeast death . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Biochemical analysis of TNF treated cell lines expressing mouse DAPK beta suggests that the cytoprotective effect of DAPK is mediated through both intrinsic and extrinsic apoptotic signaling pathways and results in the inhibition of cytochrome c release from the mitochondria as well as inhibition of caspase 3 and caspase 9 activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Heat shock and staurosporine treatments increased nuclear GSK 3 beta prior to activation of caspase 9 and caspase 3 , and this nuclear accumulation of GSK 3 beta was unaltered by pretreatment with a general caspase inhibitor . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , the release of cytochrome c from mitochondria and the activation of caspase 3 and caspase 9 were also observed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 , but not caspase 9 , was activated following treatment of primary human microvascular endothelial cells of lung origin with either Tat or anti Fas agonist Ab ( anti Fas ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Decreased psi ( m ) was associated with a cyclosporin A sensitive loss of cytochrome c but not with activation of caspase 3 or caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This study demonstrates that the activation of caspase 3 , caspase 9 and caspase 8 is an important determinant of apoptotic death induced by emodin . 6 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
By 6 hours this was accompanied by activation of caspase 9 , followed by activation of caspase 3 , cleavage of caspase substrates , and chromatin fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 , an initiator caspase , and caspase 3 , an effector caspase , have been suggested to mediate the terminal stages of neuronal apoptosis , but little is known about their activation in vivo . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 processing by caspase 3 via a feedback amplification loop in vivo . ^^^ In contrast to the autoprocessing of caspase 9 , little is known about the biological significance of caspase 9 processing by caspase 3 via a feedback loop in vivo . ^^^ Using these antisera and caspase 9 and caspase 3 deficient mouse embryonic fibroblasts , we demonstrated that mouse caspase 9 is initially autoprocessed at D ( 353 ) and D ( 368 ) at low levels during staurosporine induced apoptosis , whereupon the D ( 368 ) and D ( 168 ) sites are preferentially processed over D ( 353 ) by activated caspase 3 as part of a feedback amplification loop . ^^^ Ac DEVD MCA ( caspase 3 like ) and Ac LEHD MCA ( caspase 9 like ) cleavage activities clearly showed that caspase 9 autoprocessing was necessary for the activation of caspase 3 , whereas full activation of caspase 3 and caspase 9 was achieved only through the feedback amplification loop . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis induced by combined treatment of TRAIL and radiation in TRAIL resistant cells was associated with cleavage of caspase 8 and the proapoptotic Bid protein , resulting in the activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Stimulation of HAECs with gly ox HDL elicited a marked increase in caspase 3 activity and the expressions of active caspase 3 and caspase 9 , whereas concomitant treatment with a caspase 3 inhibitor significantly blocked gly ox HDL induced apoptosis of HAECs . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Investigations of apoptosis revealed that cytosolic cytochrome c is associated with a complex of apoptotic protease activating factor 1 ( Apaf 1 ) , an adapter molecule , and caspase 9 to activate caspase 3 . ^^^ Ac LEHD CHO , a caspase 9 inhibitor or Ac IETD CHO , a caspase 8 inhibitor , inhibited cisplatin induced caspase 3 activation and apoptosis similarly in both cell lines . ^^^ In addition , cisplatin induced the activation of caspase 9 , the upstream activator of caspase 3 , in a dose dependent manner , and the activation of caspase 9 was less induced in resistant cells . ^^^ Increasing the cellular concentration of Apaf 1 through the transient expression of the gene increased the induction of apoptosis in resistant cells , associated with enhanced activation of caspase 9 , caspase 3 and DNA fragmentation factor . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Injury induced cytochrome c specific cleavage of caspase 9 followed by activation of caspase 3 in mature brain correlated with marked increases in Apaf 1 and caspase 3 mRNA and protein expression . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Levels of procaspase 9 ( 8 . 02+ / 0 . 91 versus 6 . 16+ / 0 . 43 oligodeoxynucleotide [ OD ] units ; P < 0 . 01 ) , cleaved caspase 9 ( 10 . 02+ / 1 . 0 versus 7 . 34+ / 0 . 40 OD units ; P < 0 . 05 ) , intact and spliced DFF 45 ( 4 . 58+ / 0 . 75 versus 2 . 84+ / 0 . 23 OD units ; P < 0 . 05 ) were raised in LVAD patients , but caspase 3 and human nuclease CPAN were not . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
RESULTS : The cells did not show any decrease of MMP level up to 2 . 5 h after 1 mM adenosine exposure , whereas cytochrome c release , caspase 9 and caspase 3 activity , and DNA fragmentation were already activated , suggesting that mitochondrial depolarization is not a prerequisite of other apoptosis related mitochondrial events . ^^^ Moreover , we found that most of the apoptotic parameters in adenosine induced cellular changes , such as translocation of Bax , the release of cytochrome c , and the consequent activation of caspase 9 and caspase 3 , were attenuated by thymidine supplement , thus indicating that the sensing of a nucleoside or nucleotide balance might be an upstream event of cytochrome c release . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis induction by T 2 toxin : activation of caspase 9 , caspase 3 , and DFF 40 / CAD through cytosolic release of cytochrome c in HL 60 cells . ^^^ These data indicate that T 2 induced apoptosis involves activation of caspase 3 and DFF 40 / CAD through cytosolic accumulation of cytochrome c along with caspase 9 activation . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Here , we show cells deficient for the downstream effectors Apaf 1 , Caspase 9 , or Caspase 3 display only transient protection from `` BH 3 domain only ' ' molecules and die a caspase independent death by mitochondrial dysfunction . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 and caspase 3 deficient neurons were not protected from chloroquine cytotoxicity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
CONCLUSION : Cytochrome c release and caspase 9 activation are required for the activation of executor caspase 3 in TNF alpha induced hepatocyte apoptosis , but caspases 8 and 2 play , if any , a minimal role . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We also demonstrate that caspase 8 , caspase 9 and caspase 3 are activated and PARP is cleaved in response to unrepaired UV C induced DNA damage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This is evidenced by activation of at least two caspases ( caspase 3 and caspase 9 ) as detected by cleavage of poly ( ADP ribose ) polymerase and partial blocking of apoptosis by a selective inhibitor of caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , the levels of Cyto C and caspase 3 were increased in the cytosol while the level of the caspase 9 precursor was decreased . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Upon treatment with staurosporine , generation of effector caspase activity , processing of caspase 3 and caspase 9 and cytochrome c redistribution were all profoundly inhibited in cells infected with C . pneumoniae . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In the absence of extracellular glucose , hypoxia caused cytochrome c release , caspase 3 and poly ( ADP ribose ) polymerase cleavage , and DNA fragmentation ; this apoptotic response was blocked by the caspase 9 inhibitor z LEHD FMK . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cytochrome c release is upstream to activation of caspase 9 , caspase 8 , and caspase 3 in the enhanced apoptosis of anaplastic thyroid cancer cells induced by manumycin and paclitaxel . ^^^ In ARO and KAT 4 cells , manumycin plus paclitaxel induced DNA fragmentation was blocked by the inhibitors of caspase 9 , caspase 8 , and caspase 3 . ^^^ The drug combination enhanced the activation of caspase 9 , caspase 8 , and caspase 3 and cytochrome c release into the cytosol . ^^^ Cytochrome c release was not affected by the inhibitors of caspase 9 , caspase 8 and caspase 3 . ^^^ In both cases , the DNA fragmentation was blocked by the inhibitors of caspase 9 , caspase 8 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Chaperones inhibit caspase 3 and caspase 9 activation mediated by mutant huntingtin , and this inhibition is independent of huntingtin aggregation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Immunoblotting revealed that caspase 9 , and 3 , which were proteolytically cleaved in paclitaxel treated MCF 7 / caspase 3 cells , were sequestered in a salt resistant sedimentable fraction rather than released to the cytosol . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cleavage of caspase 3 and caspase 9 after treatment with pro apoptotic stimuli was considerably diminished by T . gondii . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Taken together , the results suggest that apicidin might induce apoptosis through selective induction of Fas / Fas ligand , resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase 9 and caspase 3 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Wortmannin or LY 294002 , two structurally dissimilar inhibitors of phosphatidylinositol 3 ' kinase ( PI 3 kinase ) , abolished both cisplatin induced Akt phosphorylation and Bad phosphorylation , and promoted cisplatin induced early and accelerated activation of caspase 3 and caspase 9 , but not of caspase 8 and caspase 1 , indicating that inhibition of the Akt / PKB phosphorylation pathway enhances the mitochondrial dependent activation of caspases . ^^^ CONCLUSIONS : These studies demonstrate differential activation and role of caspases in cisplatin injury , and provide the first evidence of cisplatin induced induction of the Akt / PKB phosphorylation pathway , inhibition of which enhances activation of caspase 3 and caspase 9 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cartilage explants were cultured in different inhibitors : Z DEVD FMK ( caspase 3 inhibitor ) , Z LEHD FMK ( caspase 9 inhibitor ) , PD 98059 ( MEK 1 / 2 inhibitor ) . ^^^ RESULTS : The significant level of chondrocyte death in OA cartilage was markedly decreased by caspase 3 and caspase 9 inhibitors . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Comparison of cell lines genetically matched at the bax , cytochrome c , apaf , caspase 9 and caspase 3 loci indicated that except for bax , all of these genes were essential for hypoxia induced apoptosis both in cell culture and in transplanted tumours . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Functional inhibitor studies suggested that caspase 9 is crucial for both caspase 3 and 8 activation , at least in neutrophils . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Results demonstrated that the activation of caspase 3 , caspase 8 , and caspase 9 is an important determinant of apoptotic death induced by aloe emodin . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , apoptosis could be completely blocked by Z VAD FMK ( a general caspase inhibitor ) or by IETD CHO ( a caspase 8 inhibitor ) , but was only partially blocked by Ac DEVD CMK ( a caspase 3 inhibitor ) , by N acetyl L cysteine ( NAC ) ( an antioxidant ) , by N acetyl leucyl leucyl norleucinal ( ALLN ) ( a calpain inhibitor 1 ) , or by Z LEHD FMK ( a caspase 9 inhibitor ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Finally , examination of other factors , such as bcl 2 , bcl xl , caspase 3 , and caspase 9 , demonstrated significant changes that were correlated with oxLDL treatment and ILK overexpression . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
MPTP was found to elicit not only the activation of the effector caspase 3 but also the initiators caspase 8 and caspase 9 , mitochondrial cytochrome c release , and Bid cleavage in the SN of wild type mice . ^^^ MPTP associated toxicity in culture was found temporally to involve cytochrome c release , activation of caspase 9 , caspase 3 , and caspase 8 , and Bid cleavage . ^^^ Caspase 9 inhibition prevented the activation of both caspase 3 and caspase 8 and also inhibited Bid cleavage , but not cytochrome c release . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Here , BAPR induced apoptosis was accompanied by activation of caspase 3 and caspase 9 . ^^^ Besides that , activation of caspase 3 and caspase 9 was found to be rather late event in apoptotic process . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Our investigation of apoptosis in Hep G 2 cells showed a sequence of associated intracellular events that included ( a ) increased cytosolic free Ca ( 2+ ) ; ( b ) increased translocation of cytochrome c ( Cyto c ) from mitochondria to cytosol ; ( c ) activation of caspase 3 , caspase 8 , and caspase 9 ; and ( d ) downregulation of bcl 2 protein . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 is an initiator caspase that is a potent activator of downstream effector caspases such as caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The protein levels of pro caspase 8 and pro caspase 3 were not affected by ADR , whereas pro caspase 9 and Apaf 1 were up regulated . ^^^ Combination treatment with Apo2L / TRAIL and ADR resulted in significant mitochondrial membrane depolarization and activation of caspase 9 and caspase 3 and apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In the present study , we found that mature erythrocytes contain considerable amounts of caspase 3 and 8 , whereas essential components of the mitochondrial apoptotic cascade such as caspase 9 , Apaf 1 and cytochrome c were missing . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Targeted gene disruptions of members of the bcl 2 and caspase gene families have demonstrated particularly significant roles for bcl 10 , bax , caspase 9 and caspase 3 in mammalian brain development . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Diminished Akt signaling promoted the cleavage of caspase 3 , and both caspase 3 cleavage and FasL induction were inhibited by transduction of dominant negative caspase 9 or the caspase 8 inhibitor CrmA . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
A non selective [ 0 . 1 or 0 . 5 microM acetyl Tyr Val Ala Asp chloromethylketone ( YVAD cmk ) ] or selective caspase inhibitors [ 0 . 07 or 0 . 2 microM acetyl Asp Glu Val Asp cmk ( Ac DEVD cmk , caspase 3 inhibitor ) ; 0 . 07 or 0 . 2 microM benzoxycarbonyl Leu Glu OMe His Asp ( OMe ) fluoromethylketone ( z LEHD fmk , caspase 9 inhibitor ) ] were added to the perfusate at the start of reperfusion . ^^^ In hearts perfused with specific caspase inhibitors ( caspase 3 and caspase 9 ) there was no significant reduction in the infarct size , no improvement in post ischaemic cardiac function and no reduction of apoptotic cell death . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Irradiation of PKC eta deficient glioblastoma cells resulted in the activation of caspase 9 and caspase 3 , cleavage of poly ( ADP ribose ) polymerase ( PARP ) , and a substantial increase in subdiploid DNA content that did not occur in PKC eta expressing tumor cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The apoptotic processes , therefore , follow two signaling pathways , namely the mitochondrial independent activation of caspase 3 , and mitochondrial dependent apoptosis due to cleavage of BID by caspase 8 , the formation of apoptosomes , and activation of caspase 9 and the downstream caspases . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
To test this hypothesis , we exposed NPCs from wild type and targeted gene disrupted mouse embryos ( p 53 , caspase 9 , caspase 3 , and bax mutants ) to ethyl nitrosourea ( ENU ) , a known DNA mutagen and neural carcinogen , and measured NPC viability . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Inhibition of caspase 9 activity has no effect on TRAIL induced caspase 3 activation and cell death , whereas expression of the active form of Smac / DIABLO in the cytosol is sufficient to reconstitute TRAIL sensitivity in Bax deficient cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of caspase 8 in 3 deazaadenosine induced apoptosis of U 937 cells occurs downstream of caspase 3 and caspase 9 without Fas receptor ligand interaction . 3 Deazaadenosine ( DZA ) , a cellular methylation blocker was reported to induce the caspase 3 like activities dependent apoptosis in U 937 cells . ^^^ In the U 937 cells treated with DZA , cytochrome c release from mitochondria and subsequent activation of caspase 9 , 8 and 3 were observed before the induction of apoptosis . zDEVD Fmk , a specific inhibitor of caspase 3 , and zLEHD Fmk , a specific inhibitor of caspase 9 , prevented the activation of caspase 8 but neither caspase 3 nor caspase 9 , indicating that caspase 8 is downstream of both caspase 3 and caspase 9 , which are activated by independent pathways . zVAD Fmk , a universal inhibitor of caspases , kept the caspase 3 from being activated but not caspase 9 . ^^^ Taken together , these results suggest that in the DZA induced apoptosis , caspase 8 may serve as an executioner caspase and be activated downstream of both caspase 3 and caspase 9 , independently of Fas receptor ligand interaction . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Because other cytokines and bacterial cell wall products also induce monocyte survival , we hypothesized that these factors may also suppress caspase 3 and caspase 9 activation and activate Akt in human monocytes . ^^^ To test this hypothesis , we found that interleukin ( IL ) 1beta , tumor necrosis factor ( TNF ) alpha , lipopolysaccharide ( LPS ) , granulocyte macrophage colony stimulating factor ( GM CSF ) , and IL 18 appeared to suppress DNA fragmentation , caspase 9 , and caspase 3 activation in human monocytes . ^^^ These results suggest that monocyte survival factors may suppress DNA fragmentation , caspase 9 , and caspase 3 activation in a PI 3 kinase dependent manner , perhaps through the activation of Akt . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Infection of tumor cells with pAd T34A resulted in cytochrome c release from mitochondria , cleavage of approximately 46 kDa upstream caspase 9 , processing of caspase 3 to the active subunits of approximately 17 and 19 kDa , and increased caspase 3 catalytic activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This report describes that a proportion of patients with CLL receiving rituximab treatment have in vivo activation of caspase 9 , caspase 3 , and poly ( ADP ribose ) polymerase ( PARP ) cleavage in blood leukemia cells immediately following infusion of rituximab . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The reduction in the amount of caspase 9 in the apoptosome in the SKOV 3 cell line was associated with diminished caspase 3 activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The reduction in mitochondrial membrane potential ( Deltapsim ) and the generation of ROS occurred simultaneously with IDA induced activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 and caspase 9 activities were significantly elevated 24 h after seeding . ^^^ At 48 h after seeding , caspase 3 and caspase 9 activities were further elevated and at this time point a significant activation of caspase 8 was also found . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In MT 450 mammary carcinoma cells hyperforin increased the activity of caspase 9 and caspase 3 , and hyperforin mediated apoptosis was blocked by the broad range caspase inhibitor zVAD . fmk . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Induction of apoptosis was prevented by bongkrekic acid , Z Asp Glu Val Asp fluoromethylketone , and Z Leu Glu His Asp fluoromethylketone , inhibitors of the mitochondrial permeability transition and of caspase 3 and 9 , respectively , but not by Ac Tyr Val Ala Asp CHO , a specific caspase 1 inhibitor , suggesting the involvement of the permeability transition pore , caspase 3 , and caspase 9 in the WK 175 induced apoptotic cascade . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Evidence of caspase 8 , caspase 9 and caspase 3 activation and of cleavage of PARP and Bid was obtained in NOS 4 cells but not in SKOV 3 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The inhibitory effect of IFN gamma in Bcl 2 expression was enhanced by coadministration of TNF alpha and , interestingly , apoptosis of HSG cells , as assessed by DNA fragmentation and the activation of caspase 9 and caspase 3 , and disruption of mitochondrial transmembrane potential was also synergistically augmented by TNF alpha and IFN gamma . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , cytochrome c translocation to the cytosol and activation of caspase 9 and caspase 3 were markedly reduced in Hsp 70 overexpressing cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In pheochromocytoma cells , MMT exposure resulted in rapid increase in generation of reactive oxygen species ( ROS ) within 5 15 min , followed by release of mitochondrial cytochrome C into cytoplasm and subsequent activation of cysteine proteases , caspase 9 ( twofold to threefold ) and caspase 3 ( 15 to 25 fold ) , but not caspase 8 , in a time and dose dependent manner . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis was a late response not detectable before 24 h after methylation and was preceded by DSBs formation , extensive chromosomal breakage , and decline in Bcl 2 level and caspase 9 and caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In the apoptosome , cytochrome c and Apaf 1 activate caspase 9 which subsequently leads to the activation of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , other proteins analyzed [ namely , Apaf 1 , Bax , Bid , caspase 3 , caspase 8 , caspase 9 , 10 linked inhibitor of apoptosis protein ( XIAP ) , cellular inhibitor of apoptosis protein ( cIAP ) 1 , cIAP 2 , cytochrome c , Fas , Fas ligand , FLIP , p 53 , and poly ( ADP ribose ) polymerase ] were not affected by either rituximab or cisplatin . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The activities of caspase 3 and caspase 6 ( effector caspases ) were higher than those of caspase 8 and caspase 9 ( initiator caspases ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
UV radiation triggered activation of caspase 3 , caspase 9 , and caspase 8 with similar kinetics , although the rank order of activation was caspase 3 > caspase 9 > caspase 8 . ^^^ The dominant negative caspase 9 blocked UV induced activation of caspase 3 , caspase 9 , and caspase 8 , and also protected cells from the loss of mitochondrial membrane potential . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Compared with 3SB and Jurkat cells , these carcinoma cell lines exhibited reduced activation of caspase 9 like proteolytic activity by UV radiation , and levels of caspase 3 like activity in HeLa cells were extremely low , similar to those in caspase 3 deficient MCF 7 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cytochrome c is released from mitochondria , while caspase 9 and caspase 3 , but not caspase 8 , are activated upon inhibition of the TRX 2 transgene . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The anti apoptotic activity of XIAP is retained upon mutation of both the caspase 3 and caspase 9 interacting sites . ^^^ These partners include caspase 3 , caspase 9 , DIABLO / Smac , HtrA2 / Omi , TAB 1 , the bone morphogenetic protein receptor , and a presumptive E 2 ubiquitin conjugating enzyme . ^^^ Triple point mutants , unable to bind caspase 9 , caspase 3 , and DIABLO / HtrA2 / Omi , were completely ineffectual in inhibiting apoptosis . ^^^ However , point mutants that had lost the ability to inhibit caspase 9 and caspase 3 but retained the ability to inhibit DIABLO were still able to inhibit apoptosis , demonstrating that IAP antagonism is required for apoptosis to proceed following UV irradiation . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Likewise , infiltrating lymphocytes were negative for caspase 3 , caspase 9 and cleaved PARP . ^^^ CONCLUSION : This study shows that caspase 3 is important in the salivary dysfunction of SS , while caspase 9 appears not to be involved . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The latter was accompanied by a marked increase of caspase 2 activity ( +343 % ) and moderate activation of caspase 9 ( +150 % ) and caspase 3 ( +145 % ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 was activated in primary hepatocytes by STS treatment , but caspase 9 and 12 were not activated , and caspase 3 activation is not dependent on caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cloning and characterization of rat caspase 9 : implications for a role in mediating caspase 3 activation and hippocampal cell death after transient cerebral ischemia . ^^^ Caspase 3 may be activated by the membrane receptor initiated caspase 8 dependent extrinsic pathway and the mitochondria initiated caspase 9 dependent intrinsic pathway ; however , the precise role of these deduced apoptosis signaling pathways in activating caspase 3 in ischemic neurons remains elusive . ^^^ The temporal profile of caspase 9 activation coincided with that of cytochrome c release and caspase 3 activation , but preceded CA 1 neuronal death . ^^^ Furthermore , intracerebral ventricular infusion of the relatively specific caspase 9 inhibitor N benzyloxycarbonyl Leu Glu His Asp fluoro methylketone before ischemia attenuated caspase 3 like activity and significantly enhanced neuronal survival in the CA 1 sector . ^^^ These results suggest that the caspase 9 dependent intrinsic pathway may be the primary mechanism responsible for the activation of caspase 3 in ischemic hippocampal neurons . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
SN 50 induced apoptosis in MM cell lines and patient cells ; down regulated expression of Bcl 2 , A 1 , 10 chromosome linked inhibitor of apoptosis protein ( XIAP ) , cellular inhibitor of apoptosis protein 1 ( cIAP 1 ) , cIAP 2 , and survivin ; up regulated Bax ; increased mitochondrial cytochrome c release into the cytoplasm ; and activated caspase 9 and caspase 3 , but not caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , these results indicate that release of mitochondrial cytochrome c into the cytoplasm within 2 3 h post PDT is a secondary event following the activation of initiator caspase 8 preceding Apaf 1 , caspase 9 and caspase 3 activation , cleavage of PARP and DNA fragmentation . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis of the cells by combined treatment of As2O3 and radiation was associated with reactive oxygen species generation and loss of mitochondrial membrane potential , resulting in the activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Taxol induced apoptosis in human SKOV 3 ovarian and MCF 7 breast carcinoma cells is caspase 3 and caspase 9 independent . ^^^ Using MCF 7 breast carcinoma cells transfected with caspase 3 gene , we showed that taxol induced apoptosis occurred in the absence of caspase 3 and caspase 9 activation . ^^^ We conclude that a unique caspase 3 and caspase 9 independent pathway is elicited by taxol to induce apoptosis in human ovarian and breast cancinoma cells . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase inhibition assays indicated that recombinant Tn IAP1v could specifically inhibit human caspase 9 in vitro instead of caspase 3 , 7 , and 8 , which was further confirmed by the observation that recombinant Tn IAP1v can directly bind caspase 9 in the protein pull down assay . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Down regulation of monocyte apoptosis by phagocytosis of platelets : involvement of a caspase 9 , caspase 3 , and heat shock protein 70 dependent pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
As further indicators of apoptosis , protein was extracted to determine caspase 9 and caspase 3 activation and cleavage of poly ( ADP ribose ) polymerase . ^^^ Either wortmannin or LY 294002 , combined with NaBT , enhanced activation of caspase 9 and caspase 3 and the subsequent cleavage of poly ( ADP ribose ) polymerase . ^^^ CONCLUSIONS : Our results are the first to show that inhibition of PI3k enhances NaBT mediated colon cancer cell apoptosis through the activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
One consequence of caspase 9 activation is nuclear cytoplasmic barrier disassembly , which is required for nuclear caspase 3 translocation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These data demonstrate that at least 50 % of cisplatin induced apoptosis in RPTC is mediated by p 53 and that p 53 activates caspase 3 independently of either caspase 9 or 8 or mitochondrial dysfunction . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , E 6 ( AS ) induced loss of mitochondrial transmembrane potential , release of mitochondrial cytochrome c into the cytoplasm , and subsequent activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activated caspase 9 and caspase 3 activities were present only at endstage disease . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of the caspase 9 pathway resulted in caspase 3 activation and apoptosis in human primary cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
To probe the molecular mechanisms of cellular resistance to apoptosis , melanoma cell lines were analyzed for expression of apoptosis regulators ( apoptotic protease associated factor 1 , FLIP , caspase 8 , caspase 9 , caspase 3 , cellular inhibitor of apoptosis , Bcl 2 , or Bax ) ; no correlation was observed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Mouse mutants that have helped to define the mammalian apoptosis execution machinery , including animals lacking Apaf 1 , caspase 3 and caspase 9 , are also described . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In the mitochondria dependent death pathway , caspase 9 and caspase 3 were also overexpressed in tumors . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , NCTD treatment caused activation of caspase 9 and caspase 3 , preceding DNA fragmentation and morphologic features of apoptosis . ^^^ Furthermore , the increase of p 21 ( Cip1 / Waf1 ) , phosphorylation of Bcl 2 and Bcl 10 ( L ) , activation of caspase 9 and caspase 3 may be the molecular mechanism through which NCTD induces apoptosis . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Further investigations revealed that while caspase 8 activity is detected concomitant to caspase 3 , caspase 9 activation , following mitochondrial cytochrome c release , is detectable later on . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Treatment of NCI H 82 cells with etoposide induces a series of time dependent events , including the release of cytochrome c from the mitochondria to the cytosol , activation of caspase 9 and caspase 3 , and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis was analyzed using propidium iodide staining , DNA fragmentation , TUNEL assay , caspase 9 colorimetric assay , and immunoblotting for caspase 3 , poly ( ADP ribose ) polymerase ( PARP ) , and caspase 8 cleavage products . ^^^ Furthermore , beta lapachone induced typical PARP cleavage , increased caspase 9 proteolytic activity , and activation of caspase 3 , without activation of caspase 8 in U 266 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis was associated with depolarization of mitochondrial membrane , release of cytochrome c and apoptosis inducing factor ( AIF ) from the mitochondria , and activation of caspase 9 and caspase 3 , but not of caspase 8 . ^^^ Finally , exogenous glutathione protected T cells from thimerosal induced apoptosis by upregulation of XIAP and cIAP 1 and by inhibiting activation of both caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These results showed that exogenous GDNF gene transfer successfully reduced the infarct size in a time dependant manner by suppressing active caspase 3 but not active caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Released cytochrome c interacts with apoptotic protease activating factor 1 and caspase 9 , both of which play important roles in the cytochrome c dependent mitochondrial pathway of apoptosis by activating caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The pan caspase inhibitor z VAD . fmk as well as more specific inhibitors of caspase 3 and caspase 9 blocked proplatelet formation , whereas an inhibitor of calpeptin had no effect . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
TMC specifically blocked tyrosine phosphorylation of intracellular signal mediators downstream of Src tyrosine kinases in a T cell specific manner , leading to apoptosis due to cleavage of Bcl 2 , caspase 9 , caspase 3 , and poly ( ADP ribose ) polymerase , but not caspase 1 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both caspase 3 and caspase 9 deficient mice exhibit a variably severe neurodevelopmental phenotype that may include marked ventricular zone expansion , exencephaly , and ectopic neuronal structures . ^^^ Our previous studies of caspase 3 and caspase 9 deficient mice were performed using mice on mixed genetic backgrounds , raising the possibility that strain specific generic factors influence the effects of caspase deficiency on nervous system development . ^^^ Since caspase 9 and Apaf 1 deficient mice also display variably severe developmental neuropathology , this strain dependent modifier ( s ) may be involved in the activation of a caspase independent death pathway ; alternatively , strain dependent compensatory caspase activation and / or its inhibition may influence the severity of the caspase 3 deficient neuronal phenotype . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Molecular mechanism of satratoxin induced apoptosis in HL 60 cells : activation of caspase 8 and caspase 9 is involved in activation of caspase 3 . ^^^ Here we report that satratoxin G treated human leukemia HL 60 cells underwent apoptosis through the action of caspase 3 which was activated by both caspase 8 and caspase 9 . ^^^ These findings indicate that satratoxin G induced apoptosis involves activation of caspase 3 and DFF 40 / CAD through both activation of caspase 8 and cytosolic accumulation of cytochrome c along with activation of caspase 9 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Hepatocyte apoptosis induced by glycodeoxycholate ( GCDC ) was associated with mitochondrial depolarization , activation of caspases , the release of cytochrome c from the mitochondria , and translocation of BAX from the cytosol to the mitochondria . cAMP inhibited GCDC induced apoptosis , caspase 3 and caspase 9 activation , and cytochrome c release in a PI3K dependent manner . cAMP activated PI3K in p 85 immunoprecipitates and resulted in PI3K dependent activation of the survival kinase Akt . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Indeed , we provide the first direct evidence that XIAP can simultaneously bind active caspases 9 and 3 within the same complex and that inhibition of caspase 3 by the Linker BIR 2 domain prevents disruption of BIR 3 caspase 9 interactions . ^^^ However , we clearly demonstrate that inhibition of caspase 3 is required to inhibit CD 95 ( Fas / Apo 1 ) mediated apoptosis , whereas inhibition of either caspase 9 or caspase 3 prevents Bax induced cell death . ^^^ Thus , XIAP ' s capacity to maintain inhibition of caspase 9 within the Apaf 1 apoptosome is influenced by its ability to simultaneously inhibit active caspase 3 , and depending upon the apoptotic stimulus , inhibition of caspase 9 or 3 is essential for XIAP ' s anti apoptotic activity . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , cell apoptosis was attenuated by inhibition of caspase 9 , but not caspase 8 , and blockade of mitochondrial ROS generation and permeability transition pore attenuated caspase 3 activation and cell apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both CsA and a combination of azide , oligomycin and dinitrophenol cause mitochondrial depolarization and caspase 9 activation , but only CsA induced caspase 3 and apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Abeta 17 42 activated caspase 8 and caspase 3 , induced poly ( ADP ribose ) polymerase cleavage , but did not activate caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Further studies showed that the cytochrome c / caspase 9 pathway was responsible for imperatorin induced apoptosis ; i . e . , mitochondrial membrane was depolarized , Bcl 2 was down regulated , cytochrome c was released from mitochondria , caspase 9 and caspase 3 were activated , and poly ( ADP ribose ) polymerase was cleaved . ^^^ Furthermore , imperatorin induced apoptosis was significantly blocked by Z VAD FMK ( a broad spectrum caspase inhibitor ) , Z LEHD FMK ( a caspase 9 inhibitor ) and Ac DMQD CHO ( a caspase 3 inhibitor ) , but not by Z IEDT FMK ( a caspase 8 inhibitor ) . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These inhibitors also induced cytochrome c release , caspase 9 activation , as well as downstream caspase 3 , caspase 7 activation , and PARP cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
COX 2 transfectants showed reduced DR 5 mRNA and protein expression as well as reduced caspase 8 , caspase 3 , and caspase 9 activation relative to parental cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Processing of caspase 3 and caspase 9 but not caspase 8 was seen suggesting that the mitochondrial branch of the apoptotic pathway was activated . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Peak activation of caspase 9 and caspase 3 is detectable post treatment at 4 and 8 h respectively . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Active MKK 4 , JNK , caspase 3 , and caspase 9 were detected in the detached cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Results of experiments utilizing this cell line suggest that the alteration responsible for resistance of CA CD437R cells to CD 437 induced event maps after the activation of p 38 and TR 3 expression , prior to mitochondrial depolarization , subsequent release of cytochrome c and activation of caspase 9 and caspase 3 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The apoptosis was blocked completely by caspase 8 or caspase 3 inhibitor , but inhibited partly by caspase 9 inhibitor . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis after COX 2 inhibition with SC 58635 ( 50 micromol / L ) was independent of BCL 2 , BAX , and the phosphorylation status of AKT / PKB and BAD , but correlated with activation of caspase 9 , caspase 3 , and caspase 6 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Our data indicate that both upstream caspase 8 and upstream caspase 9 , as well as downstream caspase 3 are activated in hair cells exposed to neomycin . ^^^ In addition , caspase 9 inhibition prevented the activation of downstream caspase 3 , whereas the inhibition of caspase 8 did not . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Further evidence of dopamine stimulated apoptosis included PARP cleavage , activation of mitochondrial derived caspase 9 , and the terminal effector caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The release of Smac antagonizes several IAPs and assists the initiator caspase 9 and effector caspases ( caspase 3 , caspase 6 , and caspase 7 ) in becoming active , ultimately leading to death of the cell . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
METHODS : Cultured synovial fibroblasts from human OA synovium were incubated with NO donor sodium nitroprusside ( SNP ) in the absence or presence of specific inhibitors of different protein kinases , cyclooxygenase 2 ( COX 2 ) , caspase 3 and caspase 9 , inducible NO synthase , and in the absence or presence of prostaglandin E 2 ( PGE 2 ) . ^^^ Experiments revealed that SNP treated cells expressed increased levels of active caspase 3 and caspase 9 , while Bcl 2 was downregulated . ^^^ Incubation of these treated cells with inhibitors of caspase 3 ( Z DEVD FMK ) or caspase 9 ( Z LEHD FMK ) protected viability of SNP treated OA synovial fibroblasts , indicating that NO mediated cell death was mainly related to apoptosis . ^^^ In turn , this cell death protection was associated with a marked inhibition of caspase 3 and caspase 9 activities , as well as COX 2 / PGE2 production . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In the developing kidney , apoptotic cells showed expression of caspase 3 , and inhibition of either caspase 3 or caspase 9 attenuated growth of metanephroi , indicating that the mitochondrial pathway of apoptosis plays major roles in kidney development . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Stable expression of caspase 9b , a dominant negative form of caspase 9 , blocks reovirus induced caspase 9 activation but fails to significantly reduce activation of the key effector caspase , caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 inhibition does not counter cytochrome c release , caspase 8 and caspase 3 activation , and apoptosis . ^^^ Caspase 8 inhibition counters cytochrome c release , caspase 9 and caspase 3 activation , and apoptosis , thus suggesting that caspase 8 inhibitor can directly inhibit caspase 9 and / or that DEX induced caspase 8 activation is upstream to mitochondria and can regulate caspase 3 directly or through cytochrome c release and the consequent caspase 9 / caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 is a key executioner of apoptosis , whose activation is mediated by the initiator caspases , caspase 8 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Consistent with these results , peptide caspase inhibitors show a hierarchy of efficacy in inhibiting reovirus induced apoptosis , with inhibitors of caspase 3 > caspase 8 > > > caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
To investigate the regulation of cell cycle modulators during drug treatment , we analyzed release of the apoptosis initiator cytochrome c and activation of the downstream effectors caspase 9 , caspase 3 and poly ( ADP ribose ) polymerase 16 hr after GCV sensitization , followed by transient escalation of tumor suppressor p 53 and cell cycle modulators cyclin A and B ( 1 ) before committing to programmed cell death . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In contrast to the MOLT 4 wild type cells , Ara G resistant cells displayed no increase in caspase 3 or caspase 9 activity , DNA fragmentation , cytochrome c release or a drop in the mitochondrial membrane potential ( DeltaPsi ( mito ) ) upon Ara G treatment . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The activated PKG is required to protect cells from lipid peroxidation and apoptosis , to inhibit caspase 9 and caspase 3 activation , and to elevate the levels of Trx peroxidase 1 and Trx , which subsequently induces the expression of Bcl 2 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Mechanism of CAR syndrome : anti recoverin antibodies are the inducers of retinal cell apoptotic death via the caspase 9 and caspase 3 dependent pathway . ^^^ This correlated with the sequential activation of caspase 9 and caspase 3 , as well as the degradation of the caspase substrate PARP and the fragmentation of DNA . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
IGF 1 blocked activation of the executioner caspase 3 and the intrinsic initiator caspase 9 in primary cerebellar granule neurons deprived of serum and depolarizing potassium . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In other systems , the activation of initiator caspases , such as caspase 8 and caspase 9 , can lead to the activation of the effector caspase 3 . ^^^ Treatment with gentamicin for 6 or 12 h promoted the expression of active caspase 3 and active caspase 9 in many hair cells along the BP as shown by immunohistochemistry . ^^^ At these time points , specific fluorescent labeled peptide substrates detected more active caspase 3 , caspase 8 , and caspase 9 in gentamicin treated hair cells relative to controls . ^^^ Specifically , the upstream caspases , caspase 8 and caspase 9 , and the downstream caspase 3 are activated in aminoglycoside damaged hair cells . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , GSE caused caspase 3 mediated apoptosis also involves other pathway ( s ) including caspase 9 activation . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptotic cell death , as assessed by activation of caspase 9 and 3 and cleavage of poly ( ADP ribose ) polymerase ( a substrate of caspase 3 ) , was only observed in oligodendrocyte progenitors . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , an increase in reactive oxygen species production was detected , and cells were committed to apoptosis along the mitochondrial pathway , evidenced by Bcl 2 down regulation , cytochome c release from mitochondria , caspase 9 cleavage , and caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , cytochrome c release and activation of caspase 9 was also observed in apoptotic cells and a specific inhibitor of caspase 9 ( zLEHD Fmk ) prevented both DNA fragmentation and activation of caspase 3 , but not relative cell survival , implying the upstream mitochondrial event of caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
With the caspase 9 inhibitor Z LEHD FMK we proved that caspase 9 was activated prior to caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 activation was shown to be a prerequisite for ATRA induced apoptosis , which was inhibited by the pan caspase inhibitor Z VAD FMK and the caspase 9 inhibitor Z LEHD FMK . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Ceramide induces neuronal apoptosis through the caspase 9 / caspase 3 pathway . ^^^ Co administration of the selective caspase 3 inhibitor z DEVD fmk or caspase 9 inhibitor z LEHD fmk significantly reduced C ( 2 ) ceramide induced cell death , while co application of the caspase 8 , inhibitor z IETD fmk , was without effect . ^^^ Immunoblot analysis of protein extracts from C ( 2 ) ceramide treated cortical neuronal cultures revealed upregulation of active caspase 9 and caspase 3 protein levels , whereas presence of active caspase 8 immunoreactivity was undetectable in this system . ^^^ Taken together , these data suggest that neuronal death induced by ceramide may be linked to the caspase 9 / caspase 3 regulated intrinsic pathway of cellular apoptosis . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The caspase cascade is activated by the release of cytochrome c , which is initiated by the formation of apoptosomes consisting of procaspase 9 , Apaf 1 and cytochrome c in the presence of dATP , and results in the activation of caspase 9 and caspase 3 , thereby leading to apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , the apoptosis inducing activity of ITM2B ( S ) correlates with caspase 9 and caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
It was demonstrated using specific pairs of caspase substrates and inhibitors that , during in vitro infection of SCPC by MVV , the two major pathways of caspase activation ( i . e . intrinsic and extrinsic pathways ) were stimulated : significant caspase 9 and 8 activities , as well as caspase 3 activity , were detected . ^^^ First , these results showed that both z DEVD FMK ( a potent inhibitor of caspase 3 like activities ) and z VAD FMK ( a broad spectrum caspase inhibitor ) inhibit caspase 9 , 8 and 3 activities . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Subsequent to this , activation of caspase 9 occurs that in turn activates caspase 3 leading to the cleavage of poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both caspase 9 and caspase 3 were shown to be essential for the development of such hallmarks of virus induced apoptosis as chromatin condensation , DNA degradation , and nuclear fragmentation . ^^^ Poliovirus infection activates the apoptotic pathway , involving mitochondrial damage , cytochrome c efflux , and consecutive activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In sensitive PC cell lines , VD 3 activates downstream effector protease , caspase 3 , and upstream initiator protease caspase 9 , the apical protease in the mitochondrial ( `` intrinsic ' ' ) pathway for apoptosis , but not caspase 8 , an initiator caspase linked to an alternative ( `` extrinsic ' ' ) apoptosis pathway triggered by cytokine receptors . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptotic process of A 498 cells was associated with the changes of Bcl ( XL ) , caspase 9 , caspase 3 , and caspase 7 proteins as well as mitochondria transmembrane potential ( Deltapsi ( m ) ) loss . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 , caspase 7 , and caspase 3 but not caspase 8 were activated after treatment , concomitant with cleavage of the capase 3 substrate poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Although PCA inhibited the enzymatic activities of active recombinant caspase 3 , caspase 8 , and caspase 9 at similar concentrations , PCA exerted weak inhibitory effects on activation of caspase 9 and caspase 3 in staurosporine treated cells but strongly inhibited caspase 8 activation in FasL treated cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Despite the complete loss of caspase 3 , the expression levels of other caspases , such as caspase 8 and caspase 9 , were normal in all of the tumor samples studied . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
RESULTS : Incubation of gastric epithelial cells with H . pylori caused a time and concentration dependent induction of DNA fragmentation ( 3 fold increase ) , cleavage of BID , release of cytochrome c and a concomittant sequential activation of caspase 9 ( 4 fold ) , caspase 8 ( 2 fold ) , caspase 6 ( 2 fold ) , and caspase 3 ( 6 fold ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Neovastat markedly induced caspase 3 , caspase 8 , and caspase 9 activities , at similar levels to those measured in cells treated with tumor necrosis factor alpha . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Bufalin or cinobufagin increased [ Ca ( 2+ ) ] ( 1 ) and apoptosis in cancer cells after a 24 hr culture as well as caspase 3 activities in DU 145 and PC 3 cells and caspase 9 activities in LNCaP cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis is induced through the mitochondrial pathway resulting in caspase 9 activation and downstream caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , active caspase 9 was colocalized with active caspase 8 and the accumulation of caspase 3 cleavage products of fodrin . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The initiator caspases ( caspase 8 and caspase 9 ) as well as the effector caspase ( caspase 3 ) were activated by the treatment of L 929 cells with malathion . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Regulation of the Apaf 1 / caspase 9 apoptosome by caspase 3 and XIAP . ^^^ The apoptosome is a multiprotein complex comprising Apaf 1 , cytochrome c , and caspase 9 that functions to activate caspase 3 downstream of mitochondria in response to apoptotic signals . ^^^ In addition to the PEPD site , caspase 9 contains a caspase 3 cleavage site ( DQLD ( 330 ) ) , which when cleaved , produces a smaller p 10 subunit in which the NH ( 2 ) terminal 15 amino acids of p 12 , including the XIAP BIR 3 binding motif , are removed . ^^^ In addition , we characterized the effect of caspase 3 feedback cleavage of caspase 9 on the rate of caspase 3 activation , and the potential ramifications of Asp ( 330 ) cleavage on XIAP mediated inhibition of the apoptosome . ^^^ Thus , whereas feedback cleavage of caspase 9 by caspase 3 significantly increases the activity of the apoptosome , it does little to attenuate its sensitivity to inhibition by XIAP . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
As well as inhibiting the Akt NFkappaB pathway , InsP ( 6 ) itself caused mitochondrial permeabilization , followed by cytochrome c release , which later caused activation of the apoptotic machinery , caspase 9 , caspase 3 and poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
K BA and AK BA increased caspase 8 , caspase 9 and caspase 3 activities accompanied by cleavage of PARP . ^^^ The apoptosis induced by AK BA was inhibited completely by caspase 3 or caspase 8 inhibitor and partially by caspase 9 inhibitor . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In accordance with the changes in ARC expression observed , calorie restriction attenuated the increases in cytosolic cytochrome c and caspase 2 activity with age and suppressed the age associated rise in cleaved caspase 9 and cleaved caspase 3 . ^^^ However , neither age nor calorie restriction had any effect on caspase 3 and caspase 9 activities . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In these cell lines , apoptosis was accompanied by activation of caspase 9 and caspase 3 and by release of cytochrome c to the cytosol . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 protected CH 27 cells against magnolol triggered apoptosis . 4 Magnolol treatment resulted in accumulation of cytosolic cytochrome c and activation of caspase 9 and downstream caspases ( caspase 3 and 6 ) . ^^^ The responsiveness of JNK and ERK to magnolol suggests the involvement of these kinases in the initiation of the apoptosis process . 6 These results indicate that regulation of the Bcl 2 family , accumulation of cytosolic cytochrome c , and activation of caspase 9 and caspase 3 may be the effector mechanisms of magnolol induced apoptosis . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , the time between the initiation of caspase 9 activation and the morphological changes was quite similar to that seen for caspase 3 , indicating the activation of both caspases occurred essentially simultaneously during the initiation of apoptosis . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We demonstrated selective activation of caspases in the thymus during heat shock , i . e . primary activation of initiator caspase 9 ( but not caspase 8 ) and effector caspase 3 ( but not caspase 6 ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This study shows that 2ME2 uses the extrinsic pathway for induction of apoptosis . 2ME2 treatment results in up regulation of death receptor 5 ( DR 5 ) protein expression in vitro and in vivo and renders cells more sensitive to the cytotoxic activities of the DR 5 ligand tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) . 2ME2 induced apoptosis requires caspase activation and kinetic studies show the sequential activation of caspase 8 , caspase 9 , and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Using two cisplatin sensitive ( 2102EP and H12 . 1 ) and one cisplatin resistant human testicular germ cell cancer cell line ( 1411HP ) , we investigated molecular mechanisms in the induction of apoptosis after cisplatin treatment focusing on the cleavage and activation of caspase 2 , caspase 3 , caspase 7 , caspase 8 , and caspase 9 . ^^^ Furthermore , in caspase 9 blocked cells , initiation of apoptosis occurred in a caspase 9 independent manner accompanied by activation of caspase 2 and caspase 3 , which are intrinsic characteristics of resistant 1411HP cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The PUFA induced apoptosis was correlated with increased activity of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Instead , we observed that caspase 9 , Apaf 1 and caspase 3 were all partially truncated by calpain under these conditions . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
ECH inhibited the enzymatic activity of recombinant active caspase 8 at slightly lower concentrations than it did for active caspase 3 and active caspase 9 in vitro . ^^^ Moreover , compared with pro caspase 3 and pro caspase 9 , pro caspase 8 was predominantly depleted by biotinylated ECH with avidin beads in the cell lysates , suggesting that ECH preferentially affects pro caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
After 4 days incubation , all CLA treated cells displayed an increase in caspase 3 ( 27 34 % ) and caspase 9 activities ( 37 47 % ) , cleavage of pro caspase 3 ( 32 kDa ) to 17 and 12 kDa subunits , increased membrane annexin 5 levels and reduced expression of bcl 2 compared with untreated controls . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
To characterize in more detail this apoptotic program , we used human cell lines containing alterations in important elements of apoptotic response such as : p 53 , Bcl 2 , caspase 9 , and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We demonstrate that NaSal mediates ROS production followed by a decrease in mitochondrial membrane potential ( deltapsi ( m ) ) , release of cytochrome c , and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Presentation of nitric oxide regulates monocyte survival through effects on caspase 9 and caspase 3 activation . ^^^ Using human monocytes as a model , we observed that nitrosothiol donors S nitrosoglutathione and S nitroso N acetylpenicillamine suppressed caspase 9 and caspase 3 activity and DNA fragmentation . ^^^ The caspase 3 selective inhibitor DEVD fluoromethyl ketone reversed DNA fragmentation events , and the caspase 9 inhibitor LEHD fluoromethyl ketone reversed caspase 3 activity in monocytes treated with PAPA or DEA NONOate in the presence of macrophage colony stimulating factor . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In this study we demonstrate that anti CD 95 induced apoptosis in T cells is associated with both depolarization of mitochondrial membrane potential ( Delta ( psi ) m ) and increase in mitochondrial mass and activation of caspase 8 and caspase 3 but without caspase 9 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Upon ER stress , P 19 embryonal carcinoma ( EC ) cells showed activation of various caspases , including caspase 3 , caspase 8 , caspase 9 , and caspase 12 , and extensive DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In vivo incubation experiments with Ac DEVD CHO ( a caspase 3 inhibitor ) showed a reduction of apoptotic DNA fragmentation , whereas Ac LEHD CHO ( an inhibitor of caspase 9 ) caused no effect . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Inhibitors blocking primary effector caspases ( including caspase 3 ) , the FAS ( death receptor ) mediated initiator caspases ( including caspase 8 ) , and stress induced caspases ( including caspase 9 ) , were tested for their protective effects . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Immunopositivity was observed for caspase 3 in 57 ( 95 % ) , caspase 8 in 56 ( 93 % ) , caspase 9 in 54 ( 90 % ) , and caspase 10 in 58 ( 97 % ) of the 60 cancers . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , the exclusion from the platelet progeny of caspase 9 present in the progenitor accounts for failure of mitochondrial release of cytochrome c to activate caspase 3 during platelet death . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
KRN 5500 induced cellular injury via caspase dependent apoptosis involving the intrinsic mitochondrial ( caspase 9 ) initiating caspase and caspase 3 effector caspase ; however , expression of the antiapoptotic mitochondrial membrane protein Bcl 2 was unaffected . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Western blot analysis revealed expression ofcleaved caspase 3 and caspase 9 increased with time with hypoxia and hyperoxia promoting the greatest elevation indicating that longer duration of exposure to a change inoxygen tension causes increased apoptosis via a mitochondrial mediated pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Mitochondrially localized active caspase 9 and caspase 3 result mostly from translocation from the cytosol and partly from caspase mediated activation in the organelle . ^^^ Active caspase 9 and caspase 3 have been observed in the mitochondria , but their origins are unclear . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Further , the activation of caspase 9 and caspase 3 , downstream molecules leading to mitochondria mediated apoptosis , were detected after treatment with CDDP . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Also , 17 AAG induced the mitochondrial release and cytosolic accumulation of cytochrome c ( cyt c ) and second mitochondria derived activator of caspases ( Smac ) / DIABLO , resulting in the activation of caspase 9 and caspase 3 and apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These apoptotic events involve the mitochondria because we found cytochrome c depletion and caspase 9 and caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptotic process of Caki 2 cells was associated with the changes of Bcl 2 , Bcl XL , caspase 9 , caspase 3 , caspase 7 proteins as well as mitochondria transmembrane potential ( DeltaPsim ) loss . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Inhibition of the initiator caspase 9 , execution caspase 3 and Ca ( 2+ ) dependent protease m calpain , did not prevent DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Screening potential mediators of DN IkappaB and TNF induced apoptosis shows that caspase 3 , caspase 9 , poly ( ADP ribose ) polymerase , and Bax are activated , whereas levels of Bcl XL , cIAP 1 , and TRAF 6 were reduced . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We also determined the caspase 3 , caspase 8 , and caspase 9 activities in rat testes after chronic cocaine exposure . ^^^ Caspase 3 , caspase 8 , and caspase 9 activities were determined by fluorometric assay . ^^^ The caspase activity study showed caspase 3 and caspase 9 activities increased in cocaine treated testes at each point of the study compared with the corresponding controls . ^^^ CONCLUSIONS : Our results suggest that the release of cytochrome c from mitochondria and its subsequent activation of caspase 9 and caspase 3 in testes play a key role in cocaine induced germ cell apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both FL and MT Smac transfectants increased the sensitivity of leukaemic cells to UV light induced apoptosis and the activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Addition of caspase 3 or caspase 9 inhibitors markedly increased patient cell viablity , but blocking anti Fas antibody did not . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This review focuses on novel strategies to induce apoptosis in glioma cells by transduction with adenoviral vectors carrying a variety of apoptosis related genes , including Fas ligand , Fas , FADD , caspase 8 , p 53 , p33ING1 , p73alpha , Bax , Apaf 1 , caspase 9 , IkappaBdN , caspase 3 , Bcl 2 , and Bcl 10 ( L ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
It bears sequence homology to initiators ( caspase 9 and CED 3 ) , but its cleavage specificity is closer to the effectors ( caspase 3 and 7 ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The caspase 3 and caspase 9 inhibitors Z Asp ( OCH ( 3 ) ) Glu ( OCH ( 3 ) ) Val Asp ( OCH ( 3 ) ) fluoromethylketone ( FMK ) and Z Leu Glu ( OCH ( 3 ) ) His Asp ( OCH ( 3 ) ) FMK reduced apoptotic bodies to 25 30 % of the control cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Administration of a caspase 9 inhibitor ( Ac IETD CHO ) effectively prevented both ureteric bud branching and nephrogenesis , the same as a caspase 3 inhibitor ( Ac DEVD CHO ) . ^^^ Apaf 1 , which executes programmed cell death in the caspase 9 related pathway , was detected in the cells exhibiting caspase 9 activity , and our results suggest that Apaaf 1 / caspase 9 activates caspase 3 in kidney organogenesis . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In particular , we observed a time and dose dependent increase in the activities of the upstream caspase 9 and caspase 8 and of the downstream caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The loss of mitochondrial membrane potential after 18 h , an increase in caspase 9 and caspase 3 activity after 24 h , and the subsequent appearance of TdT mediated dUTP nick end labeling positive nuclei were detected in FPASMC after treatment with 50 microM EUK 134 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Further investigation demonstrated that leptin activated caspase 3 and caspase 9 , but not caspase 8 , and increased the cleavage of poly ( ADP ribose ) polymerase and cytochrome c release into cytosol . ^^^ These data indicated that leptin induced hBMSC apoptosis via ERK / cPLA2 / cytochrome c pathway with activation of caspase 9 and caspase 3 , and cleavage of poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Active caspase 9 cleaves and activates caspase 8 and caspase 3 , leading to apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Pretreatment of IEC 6 cells with LPA inhibited campothecin induced caspase 9 and caspase 3 activation and DNA fragmentation . ^^^ These data indicate that LPA protects IEC 6 cells from camptothecin induced apoptosis through G ( 1 ) coupled inhibition of caspase 3 activation mediated by the attenuation of caspase 9 activation due to diminished cytochrome c release , involving upregulation of Bcl 2 protein expression and prevention of Bax translocation . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptotic process of ACHN cells was associated with the changes of Bcl 2 , caspase 9 , caspase 3 , caspase 7 proteins as well as mitochondria transmembrane potential ( deltapsim ) loss . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Exogenous ROS and caspase 3 induced deltapsi ( m ) drop and cytochrome c release from mitochondria , which could be prevented by molecular ( dominant negative caspase 9 ) and pharmacologic ( zVAD fmk ) caspase inhibitors and overexpression of Bcl 2 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We found that both retinoids induced caspase 3 and caspase 9 enzyme activity . ^^^ Furthermore , using caspase specific inhibitors we determined that caspase 3 and caspase 9 activity was essential for the induction of apoptosis by these synthetic retinoids since these inhibitors completely blocked CD 437 and 4 HPR induced apoptosis . ^^^ Interestingly , we found that treatment with bongkriekic acid ( BA ) , a mitochondrial membrane depolarization inhibitor , blocked apoptosis , caspase 9 activation and caspase 3 activation induced by both retinoids . ^^^ Our results suggest that CD 437 and 4 HPR initially activate separate pathways to induce mitochondrial depolarization but both utilize mitochondrial depolarization , caspase 9 activation , and caspase 3 activation in the later stages of apoptosis induction . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Inhibition of caspase 9 delayed the full activation of caspase 3 but did not affect the dynamics of caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Emodin generated reactive oxygen species ( ROS ) in these cells which brought about a reduction of the intracellular mitochondrial transmembrane potential ( DeltaPsim ) , followed by the activation of caspase 9 and caspase 3 , leading to DNA fragmentation and apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 and caspase 9 activities and cytochrome c release were significantly inhibited in Tg mice compared with those in WT mice . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both caspase 8 and caspase 9 activate caspase 3 , among other caspases , which in turn cleave several crucial substrates , including the DNA repairing enzyme poly ( ADP ribose ) polymerase ( PARP ) , into fragments of 89 and 28 kDa . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Vpr ' s attack on the mitochondria results in release of cytochrome c resulting in activation of the caspase 9 pathway culminating in the activation of caspase 3 and the downstream events of apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The activation of caspase 3 but not that of caspase 9 was detected after rhodostomin treatment . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
To define molecular requirements for ErPC induced apoptosis , activation of caspases 8 , 9 and 3 and cleavage of the caspase 3 substrates PARP and ICAD were tested in normal Jurkat T cells , Jurkat cells resistant to death receptor ( CD 95 or TNFalpha related apoptosis inducing ligand ( TRAIL ) induced apoptosis , Jurkat cells lacking caspase 8 or Fas associated death domain ( FADD ) Jurkat cells expressing a dominant negative caspase 9 or overexpressing Bcl 2 as well as BJAB B lymphoma cells expressing a dominant negative FADD ( FADD DN ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cisplatin ( 15 microM ) activated caspase 3 but not caspase 8 or caspase 9 and produced phosphatidylserine externalization , chromatin condensation , and nuclear fragmentation in wild type [ p 21 ( + / + ) ] MPTC . ^^^ In contrast to p 21 ( + / + ) MPTC , cisplatin activated caspase 9 but not caspase 8 in p 21 ( / ) MPTC before caspase 3 activation . ^^^ We conclude that 1 ) in the presence of p 21 , cisplatin activates caspase 3 through a mechanism independent of caspase 8 or caspase 9 ; 2 ) in the absence of p 21 , caspase 9 activation precedes caspase 3 activation ; 3 ) the lack of p 21 accelerates caspase 3 activation and cisplatin induced MPTC apoptosis ; and 4 ) MPTC apoptosis is caspase independent in the presence of p 21 but partially dependent on caspases in the absence of p21 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Following JNK phosphorylation , cytochrome c is released into the cytosol , leading to the activation of caspase 9 and eventually caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , the caspase inhibitor N benzyloxycarbonyl Val Ala dl Asp fluoromethylketone ( fmk ) suppressed both caspase 3 activation and apoptosis induction . `` Initiator ' ' caspase 9 and caspase 8 were only marginally activated at later times in the apoptotic process . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
LIGHT treatment also resulted in activation of caspase 3 , caspase 6 , caspase 7 , caspase 8 , caspase 9 , DFF 45 , and PARP . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Analysis of PKR induced activation of caspases 3 and 9 revealed that LANA 2 abrogated activation of caspase 3 but not of caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
TUDCA significantly inhibited the release of cytochrome C from mitochondria into cytosol , and the activity of caspase 9 , 3 ( t > or = 13 . 00 , P < 0 . 01 ) , especially at 12 h , caspase 3 activity decreased by 54 . 9 % ( t = 16 . 88 , P < 0 . 01 ) and 52 . 5 % , however it had no obvious effect on the activity of caspase 8 ( t = 1 . 94 , P > 0 . 05 ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Although caspase 9 , caspase 3 / 7 , and caspase 6 activities were increased in BEL 7402 cells , and caspase 7 activity was increased in MCF 7 cells after treatment with 1 microM LDM , this occurred much later , indicating that chromatin condensation reached the maximal level rapidly while caspase activities still remained low . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Many pro apoptotic signals activate caspase 9 , an initiator protease that activates caspase 3 and downstream caspases to initiate cellular destruction . ^^^ Phosphorylation at Thr 125 is sufficient to block caspase 9 processing and subsequent caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Elevated caspase 3 activity in cerebellum than cortex correlating with cytochrome c , caspase 9 , active caspase 3 ( p 17 ) , poly ( ADP ribose ) polymerase 1 and PKC delta data , suggests a mechanism by which ethanol might be exerting pro apoptotic events in brain and how selective brain regions such as cerebellum are vulnerable to ethanol neurotoxicity in terms of cell death . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The proapoptotic effect was correlated to cleavage / activation of caspase 9 and poly ( ADP ) ribose polymerase , but not of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In order to investigate pathways of apoptosis in mouse uterine epithelium and decidua during early pregnancy ( day 4 . 5 7 . 0 post coitum ) , we have investigated different proteins such as TNFalpha , TNF receptor 1 , Fas ligand , Fas receptor 1 , Bax and Bcl 2 as well as caspase 9 and caspase 3 using immunohistochemistry . ^^^ Strong immunolabelling for the initiator caspase 9 was restricted to the decidual compartment , whereas caspase 3 expression characterized the apoptotic uterine epithelium . ^^^ Taken together , the apoptotic degeneration of the uterine epithelium seems to be mediated by TNF receptor 1 followed by caspase 3 , whereas the very moderate regression of the decidua did not show the investigated death receptor , but Bax and Blc 2 instead and in addition caspase 9 , which indicates a different regulation for epithelial versus decidual apoptosis . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Therefore , it became clear for the first time that caspase 9 by itself can activate caspase 7 in the absence of the caspase 3 dependent pathway in TNF alpha induced apoptosis by the use of specific ribozymes . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both antiapoptotic genes such as FLIP and members of the Bcl 2 and IAP family as well as proapoptotic elements of the death receptor and mitochondrial apoptosis pathways were down regulated in carcinomas resulting in a decreased activity of caspase 8 , caspase 9 , and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Diethylmaleate ( DEM ) induced apoptotic damage in Jurkat cells was blocked by the anti apoptotic protein Bcl 2 , whereas , a peptide inhibitor of caspase 3 but not caspase 9 blocked DEM induced mitochondrial damage . ^^^ Caspase 3 activation preceded that of caspase 9 and initial processing of caspase 3 was regulated independent of caspase 9 and Bcl 2 . ^^^ However , inhibitors of caspase 9 or caspase 6 regulated caspase 3 later in the pathway . ^^^ Thus , we describe a pathway where caspase 3 functions to initiate apoptotic damage and caspase 9 and caspase 6 amplify the apoptotic cascade . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , in the presence of CVB 3 infection , the intensity of the phosphorylation of Akt was further enhanced and associated with a delayed activation of caspase 9 and caspase 3 . ^^^ Moreover , IGTP expression inhibited viral replication and delayed CVB 3 induced cleavage of eukaryotic translation initiation factor 4G , indicating that IGTP mediated cell survival relies on not only the activation of PI 3 K / Akt , inactivation of GSK 3 and suppression of caspase 9 and caspase 3 but also the inhibition of viral replication . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We also found that caspase 9 was only activated under K 25 deprivation meanwhile caspase 3 was involved in both protocols . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The caspase activity assay in GALTs clearly showed intense activity of caspase 3 , caspase 9 , and caspace 8 that was high in order . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Exposure of PC 12 cells to dieldrin ( 100 300 microM ) results in the rapid release of cytochrome C , followed by the activation of caspase 9 and caspase 3 in a time and dose dependent manner . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Immunoblot and biochemical analysis also confirmed that activation of both caspase 9 and caspase 3 was induced by 6 OHDA , but not by MPP+ . ^^^ Interestingly , a reconstitution assay indicated that the addition of ATP to the cytosolic fraction obtained from MPP+ treated cells was sufficient to activate both caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In leukemia U 937 cells , HP increased the activity of caspase 9 and caspase 3 and in K 562 cells caspase 8 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The expressions of apoptosis inductive genes , such as DFF 40 , Caspase 3 , Caspase 8 , Caspase 9 , Caspase 10 and CRADD , were increased by 10 ray irradiation in SAS cells with wtp 53 , but not in SAS cells expressing mp 53 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 and 8 inhibitors , but not caspase 9 inhibitor , reduced Fas mediated apoptosis enhanced by the anticancer drugs . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Blocking Hsp 27 by an antisense ( AS ) strategy restores the apoptotic response to Dex in Dex resistant MM cells by triggering the release of mitochondrial protein Smac , followed by activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Dose dependent loss of mitochondrial trans membrane potential in SNB 19 cells occurred with treatment , along with release of cytochrome c , processing of caspase 9 , and 3 and specific cleavage of poly ADP ribose polymerase ( PARP ) , a substrate of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Securioside B plus L cell conditioned medium induced the activation of caspase 3 and caspase 9 , but not caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Treatment with 0 . 2 mM hydrogen peroxide ( H ( 2 ) O ( 2 ) ) or with 0 . 5 mM cisplatin caused caspase 9 and caspase 3 activation and death by apoptosis in U 937 human promonocytic cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both factors stimulated caspase 3 activity , which could be inhibited by caspase 8 or caspase 9 inhibitors . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Treatment of HL 60 cells with lactacystin , a selective inhibitor of the proteasome , exponentially increased caspase 3 like hydrolytic activity and induced apoptosis but had little or no effect on the activity of upstream caspase 8 , caspase 9 , or granzyme B . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , activation of caspase 9 and the executioner caspase 3 was also observed in the LVS infected J774A . 1 macrophages . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 and caspase 3 activity were measured enzymatically 24 h after injury . ^^^ TPCK reduced caspase 9 activity from 72 + / 30 to 43 + / 5 fluorescence units / h / mg ( p < 0 . 05 vs . vehicle ) , and caspase 3 activity from 66 + / 10 to 39 + / 3 . 7 fluorescence units / h / mg ( p < 0 . 05 vs . vehicle ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The results show the caspase 3 , caspase 7 , and caspase 9 are all activated by arsenic trioxide , together with cleavage of the downstream caspase 3 target poly ADP ribose polymerase ( PARP ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Our investigations have focused on cell populations that expressed apoptotic effectors in the enzymatic death pathway including cytochrome c , caspase 9 and caspase 3 . ^^^ In addition , immunodetection demonstrated that cytochrome c and activated caspase 9 and caspase 3 were expressed not only in the neurones , the primarily affected cells , but also within the astrocytes , which constituted a dense network delineating the infarct . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cytochrome c release , caspase 9 , and caspase 3 activation were not implicated , excluding a direct involvement of the intrinsic mitochondrial pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activities of caspase 3 , caspase 8 and caspase 9 were determined by colorimetric assays using the specific substrate and total tumor protein . ^^^ In the absence of tumorigenesis , the activities of caspase 3 , caspase 8 and caspase 9 were increased up to approximately 3 . 6 fold in the mammary gland of rats treated with I3C at 5 or 25 mg / kg of body weight for 4 or 10 days . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Fluorometric assay showed that codeinone time dependently activated caspase 3 and caspase 9 , but not caspase 8 , suggesting the activation of intrinsic apoptotic signaling pathway via mitochondria . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Magnolol increased caspase 3 and caspase 9 activities significantly and reduced the mitochondrial potential ( Deltapsi ( m ) ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activated caspase 9 levels were significantly higher in CR ( 14 . 7 % ) compared with IsCM ( 6 . 9 % ; P < 0 . 01 ) and NL ( 0 % ) groups , whereas activated caspase 3 levels were similarly elevated in both CR and IsCM ( 7 . 8 and 6 . 5 % vs . 0 % in NL ; P < 0 . 01 and P < 0 . 05 ) groups . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We additionally identified a reduction in protein levels of caspase 3 , caspase 7 , and caspase 9 in human colon cancer specimens known to harbor APC mutations . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This was accompanied by increase in ( a ) protein expression of cytochrome c and apoptotic protease activating factor 1 and ( b ) activity and protein expression of caspase 3 , caspase 7 , caspase 8 , and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 , caspase 8 , and caspase 9 activities increased fivefold . ^^^ PTHrP ( 140 173 ) also reduced caspase activities after Fas ligation by activating antibody , but neither peptide had effects on caspase 3 or caspase 9 activity after 1 microM staurosporine . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Results showed that 3NP induced death of striatal neurons was preceded by cytochrome c redistribution , transient caspase 9 processing , and activation of calpain , whereas levels of the active / processed form of caspase 3 remained low and were even reduced as compared with control animals . ^^^ Our results showed that calpain can down regulate the caspase 9 / caspase 3 cell death pathway during neurodegeneration due to chronic mitochondrial defects in vivo and that this effect may involve , at least in part , direct cleavage of the caspase 3 p 20 subunit . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Immunoblot analysis demonstrated proteolytic processing of caspase 3 , 7 , and 8 , but not caspase 9 , suggesting the involvement of the ' extrinsic ' pathway , linked to apoptosis induction by TNF family death receptors . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
A caspase 9 specific inhibitor was more effective in delaying the progression of apoptosis in the FL5 . 12 Bcl 10 ( L ) cells than was an inhibitor specific to caspase 3 . ^^^ Consistent with this , proteolytic processing of caspase 9 was observed prior to processing by caspase 3 , suggesting that caspase 3 was not responsible for early caspase 9 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Sensitization was accompanied by caspase 3 and caspase 8 activation , whereas no cleavage of caspase 9 was observed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Inhibition of UV induced activation of Akt increased release of mitochondrial cytochrome c 3 . 5 fold , and caused appearance of active forms of caspase 9 , caspase 8 , and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Using MCF 7 cells overexpressing caspase 3 we have shown that resistance of caspase 9 to cleavage was not altered by the expression of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , the degree of HOCl oxLDL induced caspase 3 and 8 activation , and apoptosis was significantly reduced in U937 / Bcl 2 cells , with no activation of caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The apoptosis induced by Sim is probably initiated by the mitochondrial caspase 9 , which indirectly leads to activation of caspase 3 and 8 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Consistent with the induction of apoptosis , 15 deoxy PGJ 2 increased the expression of proapoptotic proteins caspase 3 , caspase 9 , and Bax but down regulated antiapoptotic protein Bcl 2 . 15 Deoxy PGJ 2 also activated extracellular signal regulated kinase ( ERK ) 2 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Reactive oxygen species was positively correlated with cytochrome c ( r= . 43 ; P < . 03 ) , caspase 9 ( r= . 56 ; P < . 001 ) , and caspase 3 ( r= . 65 ; P < . 01 ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , expression of myristoylated Akt 1 not only prevented cell injury through the prevention of membrane phosphatidylserine exposure and genomic DNA fragmentation but also inhibited microglial activation and proliferation that required the inhibition of caspase 9 , caspase 3 , and caspase 1 like activities linked to cytochrome c release . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
MPP+ exposure in rat dopaminergic neuronal cells resulted in time dependent increases in reactive oxygen species generation , cytochrome c release , and caspase 9 and caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of upstream caspase 9 , but not caspase 8 , suggested that apoptosis proceeds via a mitochondrial pathway , followed by caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In particular , CD26 / DPPIV presence is associated with increased susceptibility to the mitochondrial pathway of apoptosis , documented by enhanced cleavage of poly ( ADP ribose ) polymerase ( PARP ) , caspase 3 and caspase 9 , Bcl xl , and Apaf 1 , as well as increased expression of death receptor 5 ( DR 5 ) . ^^^ We also show that the caspase 9 specific inhibitor z LEHD fmk inhibits drug mediated apoptosis , leading to decreased PARP and caspase 3 cleavage , and reduced DR 5 expression . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Treatment of SH SY5Y cells with DADS resulted in arrest of cell cycle in G ( 2 ) / M phase and commitment to apoptosis through the activation of the mitochondrial pathway ( Bcl 2 down regulation , cytochrome c release into the cytosol , and activation of caspase 9 and caspase 3 ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Smac 3 disrupts processed caspase 9 binding to XIAP , promotes caspase 3 activation , and potentiates apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Time course studies of caspase activation revealed that caspase 9 and caspase 3 were activated before caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The noise exposure also caused the activation of caspase 8 and caspase 9 , each of which is associated with a distinct signaling pathway that leads to activation of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , the mitochondrial pathway is implicated as mitochondrial depolarization and caspase 9 and caspase 3 activation were observed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of caspase 3 , caspase 8 , and caspase 9 was determined by flow cytometry . ^^^ Increased cell death was correlated with increased depolarization of mitochondrial membrane potential and increased activation of caspase 3 , caspase 8 , and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The effect of SFRP 1 on apoptosis was linked to the regulation of several apoptosis related genes , including p 53 , caspase 3 , caspase 9 , and BCL 2 interacting killer ( BIK ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis is accompanied by the activation of caspase 9 and caspase 3 and processing of poly ( ADP ribose ) polymerase and is inhibited by Z VAD a general caspase inhibitor . ^^^ Based on these observations , we propose that the lack of activation of a caspase 9 > caspase 3 > poly ( ADP ribose ) polymerase pathway is important and protects T . parva transformed cells from spontaneous apoptosis . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
PDNF also strongly suppresses the overproduction of MPTP induced reactive oxygen species ( ROS ) , and the activation of both initiator caspase 9 and effector caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We have shown previously that the apoptotic response of NPCs to genotoxic agents is dependent on p 53 and caspase 9 , but not Bax or caspase 3 expression . ^^^ Conversely , DNA damage induced reactive oxygen species generation was inhibited significantly by gene disruption of p 53 , Apaf 1 , or caspase 9 , and combined deficiency of Bax and Bak , but not by caspase 3 or caspase 6 deficiency . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Since there is evidence that low K ( + ) induced apoptosis in CGNs is associated with a drop in intracellular Ca ( 2+ ) concentration ( [ Ca ( 2+ ) ] ( 1 ) ) , activation of the cell death effector proteases caspase 3 and caspase 9 , and of the transcription factor nuclear factor kappa B ( NF kappaB ) , the interference of CAPE with these purported mediators of apoptosis was also evaluated . ^^^ It was found that CAPE did not interfere with the marked decrease in [ Ca ( 2+ ) ] ( 1 ) induced by low K ( + ) , whereas it completely blocked caspase 3 , caspase 9 , and NF kappaB activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
When the extract was activated by cytochrome c , caspase 3 recruitment to the apoptosome was not observed , although apoptotic protease activating factor 1 ( Apaf 1 ) , caspase 9 , and 10 linked inhibitor of apoptosis protein ( XIAP ) existed in the apoptosome . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of caspase 9 was also immunohistochemically detected in the ventral forebrain at E8 . 5 9 , suggesting that activation of caspase 3 and caspase 9 occurs in the PCD of this region . ^^^ Thus , it is likely that decreased cell death in the ventral forebrain of caspase 3 and caspase 9 deficient 129 / Sv mice increases the number of neuroprogenitor cells in the MGE , leading to hyperplasia of the forebrain . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We further investigated the IAA / HRP mediated apoptotic pathways , and found that IAA / HRP activates caspase 8 and caspase 9 , leading to caspase 3 activation and poly ( ADP ribose ) polymerase ( PARP ) cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis inducing concentrations of beta sitosterol induced caspase 3 and caspase 9 activation accompanied by proteolytic cleavage of poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both drugs activated caspase 9 and caspase 3 but not caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The combination treatment resulted in the formation of truncated Bid , cytosolic accumulation of cytochrome c and second mitochondria derived activator of caspase / direct inhibitor of apoptosis binding protein with low PI , activation of caspase 9 , caspase 7 , caspase 3 , and cleavage of poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Here we demonstrate in a mouse macrophage cell line ( MH S cells ) that alpha quartz silica exposure ( 12 . 5 mug / cm2 to 50 mug / cm2 ) elicited activation of both caspase 3 and caspase 9 , whereas anatase titanium dioxide ( TiO 2 ) , a non fibrogenic particle , did not . ^^^ Silica induced apoptosis and caspase 3 activation were , in part , caspase 9 dependent , as determined by their sensitivity to either a general caspase inhibitor ( Z VAD FMK ) or a specific caspase 9 inhibitor ( Z LEHD FMK ) . ^^^ Cyclosporin A , an inhibitor of the mitochondrial permeability pore , partially decreased mitochondrial depolarization , caspase 3 activation , and caspase 9 activation , suggesting a role for mitochondrial dysfunction in these events . ^^^ Pepstatin A , an inhibitor of cathepsin D , also decreased mitochondrial depolarization , caspase 3 activation , and caspase 9 activation , whereas leupeptin , an inhibitor of cathepsin B , had no effect . ^^^ These data suggest that short term silica exposure in vitro induces both caspase 3 and caspase 9 activity , which appears to participate in apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
AFP was unable to regulate activity of caspase 3 in cell extracts depleted of cytochrome c or caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The apoptotic index was increased 4 7 fold , Bcl 2 protein expression decreased , Bax increased , and caspase 9 , caspase 6 , and caspase 7 were activated but not caspase 3 and caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The cytoplasmic and nuclear events of bufadienolide induced apoptosis were strongly inhibited in the presence of caspase 8 , caspase 9 , or caspase 3 inhibitors , as well as in the presence of the broad spectrum caspase inhibitor Z VAD FMK . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
When Jurkat T cells were treated with thialysine ( 0 . 32 2 . 5 mM ) , apoptotic cell death along with several biochemical events such as mitochondrial cytochrome c release , caspase 9 activation , caspase 3 activation , degradation of poly ( ADP ribose ) polymerase , and DNA fragmentation was induced in a dose and time dependent manner . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 2 , caspase 3 , and caspase 9 were activated , and specific caspase inhibitor prevented apoptosis and increased long term survival . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The present study was initiated to determine whether AMPA receptor induced DCD in PNs is associated with Bax translocation to the mitochondria , cytochrome C release from the mitochondria , changes in mitochondrial potential , and activation of representative initiator and executor caspases that include caspase 9 , caspase 3 , and caspase 7 . ^^^ Immunohistochemical analyses revealed the active form of caspases 3 and 9 were markedly and significantly increased in PNs following 30 microM AMPA , and caspase 9 activation preceded caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
A fraction of PSR knockout mice manifested a hyperplasic brain phenotype resembling that of mice deficient in the cell death associated genes encoding Apaf 1 , caspase 3 , and caspase 9 , which suggests that phagocytes may also be involved in promoting apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These cells were resistant to both receptor mediated apoptosis ( induced by anti Fas IgM and tumor necrosis factor related apoptosis inducing ligand ) and chemical induced apoptosis ( induced by pyrrolidine dithiocarbamate , etoposide , and staurosporine ) , as evidenced by the presence of hypodiploid DNA positive cells , activation of caspase 3 and caspase 9 , disruption of mitochondrial transmembrane potential ( DeltaPsim ) and inhibition of cytochrome c release in tax positive JPX 9 cells compared with tax negative JPX 9 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Of the four nonclear cell RCC that could be included , both oncocytomas gave no response to cytochrome c ( in one case , no Apaf 1 was detected ) , one chromophobe RCC lacked caspase 9 and failed to activate caspase 3 in response to cytochrome c , and one papillary RCC showed good caspase activation despite the lack of caspase 7 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Bax deficiency also affected the activation of caspase 3 and 8 and abolished caspase 9 activation during UV induced apoptosis , suggesting that the absence of caspase 9 activation may affect caspase 2 , 3 and 8 activation in Bax deficient cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The inhibition of the H ( 2 ) O ( 2 ) induced activation of caspase 3 , but not that of caspase 9 , by nicorandil in the presence of 5 HD or by SNAP was reversed by the addition of dithiothreitol to the enzyme assay . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
It induced cleavage of eukaryotic translation initiation factor 4G , leading to cell death through a mechanism involving activation of caspase 9 , caspase 3 and poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Silibinin also induced the cytochrome c release , activation of caspase 3 and caspase 9 and cleavage of PARP . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
To elucidate the role of caspase 9 in ALS , we examined the effects of an inhibitor of 10 chromosome linked inhibitor of apoptosis ( XIAP ) , a mammalian inhibitor of caspase 3 , 7 and 9 , and p 35 , a baculoviral broad caspase inhibitor that does not inhibit caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The activities of caspase 9 and the subsequent caspase 3 like cysteine proteases were increased during NO induced cell death . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
LLL CHO , etoposide , and C 2 ceramide also caused DeltaPsim , the increment of both hypodiploid DNA ( + ) cells and TUNEL ( + ) cells , and the activation of both Leu Glu His Asp ase ( LEHDase ; caspase 9 like activity ) and Asp Glu Val Asp ase ( DEVDase ; caspase 3 like activity ) in synovial cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Key to the activation of this pathway is the activation of a caspase cascade involving the cleavage induced activation of an initiator procaspase , caspase 9 , and the downstream effector procaspase , caspase 3 . ^^^ To probe the relationship between teratogen induced activation of caspase 9 / caspase 3 and the activation of caspase 6 / caspase 7 , we used a mitochondrial free embryo lysate with or without the addition of cytochrome c , recombinant active caspase 3 , or recombinant active caspase 9 . ^^^ In addition , caspase 6 could be activated by the addition of either recombinant caspase 3 or caspase 9 to a lysate prepared from untreated embryos . ^^^ In contrast , caspase 7 could be activated by addition of recombinant caspase 3 but only minimally by recombinant caspase 9 . ^^^ Like caspase 9 / caspase 3 , caspase 6 and caspase 7 were not activated in hearts isolated from embryos exposed to these three teratogens . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both caspase 3 and 8 were indispensable in RosA induced apoptosis and work downstream of mitochondria and caspase 9 in the order of caspase 9 / caspase 3 / caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Evidence supporting the involvement of K+ efflux , the apoptosome ( caspase 9 , apoptosis activating factor 1 , APAF 1 , and Bcl xL ) , caspase 3 , c jun kinase , and p 53 in the p75NTR cell death pathway is discussed and regulatory roles for the p75NTR ectodomain and death domain are proposed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Subsequently , the Apaf 1 / caspase 9 holoenzyme complex recruits the effector caspase 3 via an interaction between the active site cysteine in caspase 9 and the critical aspartate , which is the cleavage site for generating the large and small subunits of caspase 3 that constitute the activated form of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This altered expression of Bcl 2 family members triggered the activation of initiator caspase 9 followed by activation of effector caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In our study we tested the utility of antibodies that specifically recognize the cleaved large ( active ) subunits of caspase 3 and caspase 9 for immunohistochemical detection of apoptotic hepatocytes in rat liver sections using archival material from cyproterone acetate ( CPA ) treated and control rats . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
GCDC time dependently induced caspase 3 ( 3 . 4 fold ) and caspase 9 ( 1 . 4 fold ) mediated apoptosis of cholangiocytes , but this was inhibited by lecithins and TUDC . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The subsequent confirmation of the altered gene expression by northern analysis demonstrated that overexpression of the Expi gene induced expression of several genes , which included B cell activating factor ( BAFF ) , Bax , cytochrome c , caspase 9 , caspase 3 , caspase 6 , and CIDE A . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Unexpectedly , the inhibition afforded by ac DEVD CHO on several components , that is , caspase 3 / 7 and caspase 9 activities , and Apaf 1 proteolytic degradation , did not abrogate the apoptotic morphology and cell detachment , nor the proteolytic degradation of crucial targets , such as poly ( ADP ribose ) polymerase ( PARP ) and lamin B . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The extent of apoptosis was determined using TdT dUTP nick end labeling ( TUNEL ) and immunohistochemistry of apoptosis regulators caspase 3 , caspase 9 , Bax , and Bcl 2 . ^^^ Active caspase 9 and caspase 3 deposits were present in the same areas , suggesting an involvement of the mitochondrial pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The underlying mechanism of action of SAH mediated inhibition of BCL XL ( and / or BCL 2 ) cell survival appears to be due to loss of mitochondrial integrity as reflected in enhanced cytochrome c release leading to the activation of caspase 9 and finally caspase 3 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cytokeratin filaments may thus provide a scaffold whereby active subunits of caspase 9 can activate caspase 3 which , in turn , can activate more caspase 9 so forming an amplification loop to facilitate cleavage of cytokeratin 18 , disruption of the cytoskeleton and the ensuing formation of cytoplasmic inclusions . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Anti apoptotic Bcl 2 and Bcl XL , pro apoptotic Bax , caspase 3 and caspase 9 expression and activation were analysed using Western immunoblots and densitometry . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , paracetamol induced apoptosis is a caspase dependent process that involves activation of caspase 9 and caspase 3 in the absence of cytosolic cytochrome c or Smac / DIABLO . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The relocation of Bax is accompanied by sequestration of ultracondensed mitochondria into paranuclear areas of apoptotic germ cells , cytosolic translocation of mitochondrial cytochrome c and DIABLO , and is associated with activation of the initiator caspase 9 and the executioner caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 , and to a lesser extent caspase 3 , but not caspase 8 , were transiently cleaved ( activated ) by treatment with the c Src inhibitors . c Src inhibition stabilized p 38 mitogen activated protein kinase ( MAPK ) , whereas the c Jun N terminal kinase ( JNK ) pathway did not appear to be modulated by our compounds . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Additionally , aspirin effectively prevents caspase 3 and caspase 9 ( cysteinyl aspartate specific proteases ) activation by H2O2 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We show that caspase 3 processing into its p 20 occurs rapidly after Fas cross linking , in the absence of mitochondrial depolarization and caspase 9 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Effector caspases 3 and 6 , but not 7 , were cleaved with the initial time of caspase 3 activation occurring before caspase 9 cleavage ; this suggests possible earlier cleavage of caspase 3 by caspase 12 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Subsequent studies revealed that 2 , 3 DCPE could cause cleavage of caspase 8 , caspase 3 , caspase 9 , and poly ( ADP ribose ) polymerase and release of cytochrome c in cancer cells but not in normal human fibroblasts . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In thymocytes , dexamethasone initiates cytochrome c dependent processing of caspase 9 and the activation of caspase 3 to trigger apoptotic damage . ^^^ This approach implicated the VDAC in dexamethasone mediated cytochrome c release , processing of caspase 9 and caspase 3 , the loss of mitochondrial transmembrane potential ( Deltapsim ) , nuclear damage and cell lysis . ^^^ The first event is an increase in permeability of the mitochondrial outer membrane leading to VDAC regulated efflux of cytochrome c and initial processing of caspase 9 followed by ANT dependent caspase 3 processing and apoptotic damage to cells . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , the protein 2C induced apoptosis in the transfected CEB and Cos 7 cells through activation of caspase 9 rather than caspase 8 followed by activation of caspase 3 pathway . ^^^ Analysis of the Western blots of caspase 3 and caspase 9 showed the characteristics of active caspase 3 and 9 in the 2C transfected CEB and Cos 7 cells as seen in the AEV infected CEB cells while they were in the form of procaspase 3 and procaspase 9 in the 2C mutant transfected cells . ^^^ Altogether , the results demonstrate that the protein 2C localized to the mitochondria of the transfected cells triggered the efflux of cytochrome c into the cytosol in turn activating the upstream caspase 9 and then the downstream caspase 3 , thus leading to apoptosis in the cells . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Ox LDL also activated caspase 9 and caspase 3 , but not caspase 8 . ^^^ In other experiments , pretreatment of HCAECs with the caspase 9 inhibitor z LEHD fmk , but not the caspase 8 inhibitor z IETD fmk , blocked ox LDL induced activation of caspase 3 and apoptosis . ^^^ This is followed by activation of apoptotic signaling pathway , involving release of cytochrome c and Smac and activation of caspase 9 and then caspase 3 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These effects were found to correlate with an activation of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The results showed the following : 1 ) PMA can prevent MG induced apoptosis ; 2 ) triggering of this antiapoptotic signal depends on the mitogen activated protein kinase kinase / extracellular signal regulated kinase ( ERK ) pathway ; 3 ) PMA inhibits MG induced activation of caspase 3 and caspase 9 , release of cytochrome c , and decline of mitochondrial membrane potential , but it does not affect MG induced JNK activation ; 4 ) the ERK pathway modulates outer mitochondrial membrane permeability and regulates the mitochondrial death machinery ; and 5 ) activated ERK prevents JNK induced leakage of cytochrome c from isolated mitochondria . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In three adjacent sections , apoptotic neurons were identified by TUNEL staining and immunostaining for active caspase 9 and caspase 3 . ^^^ The number of apoptotic ( TUNEL , caspase 3 , and caspase 9 positive ) cells 1 day after ischemia was significantly more in the awake versus isoflurane group . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The latency related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
RGDS activated both caspase 8 and caspase 9 after 4 hours of treatment and caspase 3 after 24 hours of treatment , and markedly enhanced HUVEC apoptosis by transferase mediated deoxyuridine triphosphate nick end labeling ( TUNEL ) / Hoechst staining and fluorescence activated cell sorting ( FACS ) analysis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In aged coronary arteries there was an increased expression of TNFalpha , TNFbeta , and caspase 9 ( microarray , real time PCR ) , as well as increased caspase 9 and caspase 3 activity , whereas expression of TNFR 1 , TNFalpha converting enzyme ( TACE ) , Bcl 2 , Bcl 10 ( L ) , Bid , Bax , caspase 8 , and caspase 3 were unchanged . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Assembly of the apoptosome in response to mitochondrial permeabilization , the hallmark of the intrinsic apoptotic pathway , involves binding of cytochrome c to Apaf 1 , recruitment and auto processing of the apical / signaling pro caspase 9 , and coupled activation of downstream / executioner caspases like caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Our data also indicate that the inhibition afforded by ac DEVD CHO on several components ( i . e . , caspase 3 / 7 and caspase 9 activities ) , and Apaf 1 proteolytic degradation , does not significantly abrogate either the apoptotic morphology or the cleavage of canonical targets , such as poly ( ADP ribose ) polymerase ( PARP ) and lamin B . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , apoptosis induced by both AP 1 inhibitors was accompanied by the activation of a downstream apoptotic cascade such as caspase 9 , caspase 3 , and poly [ ADP ribose ] polymerase ( PARP ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The apoptotic response is initiated by G protein signaling and involves activation of phosphoinositide 3 kinase , mitogen activated protein kinases , and c Src resulting in cytochrome c release from mitochondria and ultimately caspase 9 and caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We demonstrated that cells aggregated on cellulose substrates for up to 48 h underwent programmed cell death that was associated with phosphatidylserine flipping and caspase 9 and caspase 3 activation , suggesting a mitochondria dependent apoptotic process . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Correspondingly , remarkable activation of caspase 3 , caspase 9 and cleavage of PARP were seen in HERG expressing cells , which were otherwise minimal in non transfected cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , in HuH 6 cells , butyrate induced loss of mitochondrial membrane potential , release of cytochrome c from mitochondria , activation of caspase 9 and caspase 3 , and degradation of poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Consistent with initiation of apoptosis , cellular caspase 8 , caspase 9 and caspase 3 activities were elevated in lovastatin treated cells . ^^^ However , lovastatin induced cell death was significantly reduced by the broad spectrum caspase inhibitor z VAD fmk , as well as the caspase 9 inhibitor z LEHD fmk and the caspase 3 inhibitor z DEVD fmk , but not by the specific caspase 8 inhibitor z IETD fmk . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Concomitant alterations in caspase 9 , caspase 3 , Bcl xl , and Bak indicated that the resistance to apoptosis in this model involved the mitochondrial pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase inhibition by overexpression of XIAP prevented caspase 9 and caspase 3 activation but not cell death , presumably because of increased caspase independent cell death . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Exogenous APIP inhibits cytochrome c induced activation of caspase 3 and caspase 9 , and suppresses cell death triggered by mitochondrial apoptotic stimuli through inhibiting the downstream activity of cytochrome c released from mitochondria . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
While this activation of caspase 3 was paralleled by an elevated caspase 9 expression at 9 h post irradiation , there was no major induction in Apaf 1 or cytochrome c release . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The additions of inhibitors of caspase 3 , caspase 8 , and caspase 9 significantly reduced DMAs ( 5 ) induced apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Importantly , cells overexpressing both GCL subunits exhibit increased resistance to TNF induced apoptosis as judged by a loss of redox potential ; mitochondrial membrane potential ; translocation of cytochrome c to the cytoplasm ; and activation of caspase 3 , caspase 8 , and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Inhibition of p 38 MAPK activity through the use of a specific inhibitor , SB 202190 , in combination with UVA treatment induced a rapid cleavage of caspase 9 , caspase 8 , and caspase 3 , whereas UVA irradiation alone had no effect . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase inhibition markedly reduced the amount of apoptosis , and the role of these proteases was confirmed by the increased activity of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cell cycle distribution and cell cycle regulator proteins p 27 ( Kip 1 ) and cyclin D 1 , together with the PI 3 K / Akt pathway , mitogen activated protein kinases and cleaved caspase 3 and caspase 9 , were evaluated . ^^^ FTY 720 selectively induced cell apoptosis in hepatoma cell lines with overexpression of cleaved caspase 3 and caspase 9 , but the same phenomena were not found in MIHA cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase family inhibitor ( z VAD fmk ) , caspase 9 inhibitor ( Ac AAVALPAVLLALLAPLEHD CHO ) , and caspase 3 inhibitor ( z DEVD fmk ) partially prevented diosgenin induced apoptosis , but not caspase 8 inhibitor ( z IETD fmk ) and caspase 10 inhibitor ( z AEVD fmk ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Hypoxia induces caspase 9 and caspase 3 activation without neuronal death in gerbil brains . ^^^ To investigate the in vivo apoptotic machinery in oxygen deprived brain , we examined the expression of caspase 9 and caspase 3 in the hippocampus of Mongolian gerbils subjected to either transient hypoxia ( 4 % O 2 for 6 min ) or forebrain ischemia ( 10 min bilateral carotid artery occlusion ) followed by 8 h to 7 days of reoxygenation or blood recirculation . ^^^ The results showed that both hypoxic and ischemic gerbil brains exhibited an increase in caspase 9 and caspase 3 gene expression . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
High levels of gene induction were observed with BID , caspase 3 , and 8 , while caspase 9 mRNA had the lowest level of induction . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The inhibitory effect of NCTD on human melanoma , A 375 S2 cells , was partially reversed by the inhibitors of pan caspase , caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
METHODS : The parameters reflecting cell proliferation and cell death were studied together with oxidative response , mitochondrial membrane potential ( MMP ) and changes of selected regulatory molecules associated with cell cycle ( p 27 ( Kip 1 ) and p 21 ( Cip1 / WAF1 ) ) and apoptosis ( caspase 3 , caspase 9 , poly ( ADP ribose ) polymerase PARP , Bcl 2 , Bax , Bak , Mcl 1 ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apart from caspase 12 , caspase 9 , and caspase 3 were activated in the transgenic ALS mice . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Induction of apoptosis in LAA treated AML cells involved a dose dependent increase of Bax protein , release of cytochrome C from mitochondria to cytosol , activation of caspase 9 and caspase 3 , and cleavage of poly [ ADP ribose ] polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The antiapoptotic effect of estrogen did not depend on cell cycle phase , and in both normal and cancer cervical cells , it involved attenuation of activation of caspase 9 and the terminal caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
High glucose also induces loss of the initiator caspase 9 and increases caspase 3 cleavage , effects blocked by IGF 1 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Inhibition of caspase 9 after combination treatment blunted neither JNK1 / 2 / 3 activation nor the enhanced expression of BAD and BAX , but did block caspase 3 cleavage , reduced expression of BCL XL and inhibition of ERK1 / 2 activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Challenge of Fah ( / ) mice on NTBC with HGA led to massive death of renal proximal tubular cells , with positive terminal deoxynucleotidyl transferase mediated deoxyuridine diphosphate ( dUDP ) nick end labeling ( TUNEL ) and DNA fragmentation assays , but hardly any cleavage of caspase 9 and caspase 3 . ^^^ Fah ( / ) mice off NTBC acquired resistance to HGA induced renal cell death and the kidneys exhibited relatively few features of apoptosis upon challenge with HGA , with a small increase in expression of cleaved caspase 9 and caspase 3 . ^^^ CONCLUSION : Kidneys of adult Fah ( / ) mice , withdrawn from NTBC for 15 days , reveal limited characteristics of apoptosis , and have acquired resistance to a caspase 9 and caspase 3 independent form of cell death provoked by HGA . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , poliovirus infection facilitated nuclear protein efflux also in cells deficient in caspase 3 and caspase 9 , suggesting that the efflux may occur without the involvement of these enzymes . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
It enhanced caspase 3 and caspase 9 activation and favored cytochrome c release . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Western blotting was used for caspase 3 and PARP , caspase 7 , caspase 9 , cytochrome c , Bcl 2 , Bax , Mcl 1 , cyclinA , cyclin B 1 , cyclin D 1 , cyclin E , CDK 2 , CDK 4 , CDK 6 , P 21 , P 27 , GADD 45 , GADD 153 . ^^^ RESULTS : The caspase 3 , caspase 7 , and caspase 9 activities were significantly increased as well as the cleavage of caspase 3 , downstream substrate poly ADP ribose polymerase ( PARP ) was induced . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Among the compounds examined , a lignocresol derivative from bamboo ( lig 8 ) exhibited the most potent neuroprotective activity against hydrogen peroxide ( H ( 2 ) O ( 2 ) ) induced apoptosis in human neuroblastoma cell line SH SY5Y by preventing the caspase 3 activation via either caspase 8 or caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Active phenylurea based compounds dissociated effector protease caspase 3 but not initiator protease caspase 9 from XIAP in vitro and restored caspase 3 but not caspase 9 enzymatic activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 8 and caspase 3 inhibitors , but not a caspase 9 inhibitor , were also capable of restoring cell viability . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Two hours after transplantation , production of inflammatory cytokines and adhesion molecules , cardiomyocyte apoptosis , and caspase 3 and caspase 9 ( but not caspase 8 ) activities were significantly reduced in the PKC regulator treated group . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cardiomyocyte apoptosis and caspase 3 and caspase 9 activities were significantly decreased in these recipients ; caspase 8 activity was unchanged . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cocaine induced time dependent , concurrent increases in cytochrome c release and activities of caspase 9 and caspase 3 , which preceded apoptosis . ^^^ In accordance , cyclosporin A and the inhibitors of caspase 9 and caspase 3 inhibited cocaine induced caspase activation and apoptosis . ^^^ Consistent with its inhibition of apoptosis , SB 203580 inhibited cocaine induced cytochrome c release and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
METHODS : With methylene chloride fraction of Herba Scutellariae barbatae ( MCSB ) , apoptosis related experiments were carried out on human U 937 leukemia cells by ( a ) 2 , 3 bis [ 2 4 nitro 5 sulphophenyl ] 2H tetrazolium 5 carboxanilide ( XTT ) assay for cytotoxicity ; ( b ) terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) assay for morphological changes ; ( c ) cell cycle analysis ; ( d ) Western blot analysis of poly ( ADP ribose ) polymerase ( PARP ) , caspase 8 , caspase 9 , caspase 3 and Bax , Bcl 2 and cytochrome c expressions for apoptosis signaling pathway . ^^^ Caspase 9 and caspase 3 were activated while caspase 8 was intact by MCSB . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Also , increased expression of the pro apoptotic Bcl 2 members Bax , Bad and activation of caspase 3 and caspase 9 , but not the activation of caspase 8 or Fas were detected in the NS 1 transfected cells . p 53 induced Bax expression and subsequent activation of caspase 9 is probably the apoptotic pathway in NS 1 transfected cells since activation of the caspase 9 was suppressed by the p 53 inhibitor and apoptosis was significantly inhibited by the caspase 9 inhibitor . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The maximal translocation of cytochromec from mitochondria into the cytosol was observed at 1 d postexposure , whereas the activation of caspase 9 and caspase 3 and caspase 3 dependent cleavage of PARP was found to reach a peak level at 3 d postexposure . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
SJG 136 induced apoptosis was associated with the activation of caspase 3 that could be partially abrogated by the caspase 9 inhibitor Z LEHD FMK . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , caspase 3 , caspase 8 or caspase 9 inhibitors , or blockade of protein synthesis by cycloheximide did not alter anandamide related cell death . ^^^ Moreover , AEA caused cell death in caspase 3 deficient MCF 7 cell line and showed similar cytotoxic effects in caspase 9 dominant negative , caspase 8 dominant negative or mock transfected SH SY5Y neuroblastoma cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We find that secondary brain injury is preceded by impairment of mitochondrial respiration , signs of membrane permeability transition , intramitochondrial accumulation of calcium , changes in the Bcl 2 family proteins , release of proapoptotic proteins ( cytochrome C , apoptosis inducing factor ) and downstream activation of caspase 9 and caspase 3 after hypoxia ischemia . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Ectopic expression of hsp 70 in HL 60 cells ( HL 60 / hsp70 ) inhibited Ara C and etoposide induced Bax conformation change and translocation to the mitochondria ; attenuated the accumulation of cytochrome c , Smac , and Omi / HtrA2 in the cytosol ; and inhibited the processing and activity of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The apoptosis related genes fas mRNA expression levels increased 0 . 44 and 1 . 39 fold , bax mRNA 0 . 74 and 2 . 56 fold , caspase 3 mRNA 0 . 60 and 1 . 29 fold , and caspase 9 mRNA 2 . 50 and 4 . 08 fold , respectively , in the 12 mg and 50 mg G+H treated groups vs . the control group . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Treatment of HUVECs with LLL CHO , etoposide , or C 2 ceramide induced DeltaPsim , activation of caspase 3 , caspase 8 , and caspase 9 and the appearance of hypodiploid DNA positive cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The caspase activity was measured using 50 mmol / L of fluorogenic substrate , AC DEVD AMC ( caspase 3 ) , AC VEID AMC ( caspase 8 ) or AC LEHD AFC ( caspase 9 ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Our data indicate that the 1 157 region of p 21 inhibits apoptosis caused by gamma irradiation by reducing the activity of caspase 9 and caspase 3 , and the 148 157 region is critical for its inhibiting activity . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
AB also restores caspase 3 which can be attributed to the activation of the upstream activator of caspase 3 , caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , despite these proapoptotic alterations , cell death and activation of the initiator caspase 9 were not induced in MCF 7 cells but were interestingly only observed after reexpression of caspase 3 . ^^^ The second event is the loss of caspase 3 that surprisingly seems essential for a fully functional caspase 9 pathway , even despite the previous release of mitochondrial proapoptotic proteins . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , EspF was associated with the release of cytochrome c from mitochondria into the cytoplasm and with caspase 9 and caspase 3 cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This apoptotic cell death was accompanied by caspase 9 and caspase 3 activation , as indicated by the cleavage of caspase substrates , which was preceded by mitochondrial cytochrome c release . ^^^ These results suggest that the release of mitochondrial cytochrome c , and the sequential caspase 9 and caspase 3 activations are important events in the signal transduction pathway of abrin induced apoptotic cell death in the HeLa cell line . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The results showed that in experimental conditions resembling a physiological stimulation , there was a statistically significant increase in the enzymatic activity of caspase 3 , caspase 8 , and caspase 9 in PBMCs from a small , but well characterized , cohort of sporadic AD patients compared to those from a comparable control group of aged adults ( AA ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This led to increased activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The activities of caspase 3 and caspase 8 were determined by colorimetric protease assay and that of caspase 9 was determined by fluorescent intensity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Incubation of cytosol with recombinant caspases 9 and 3 in the absence or presence of inhibitors showed that activation of caspase 9 , leading to the activation of caspase 3 was necessary for the truncation of Bid . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caseamembrin C also induced the up regulation of Fas ligand ( FasL ) expression , cleavage and activation of caspase 8 and caspase 9 , Bid cleavage and activation of executor caspase 3 . ^^^ Taken together , it is suggested that caseamembrin C induced apoptosis is predominantly through the activation of intrinsic apoptosis pathways by causing the down regulation of Bcl 2 and Bcl xL expression , up regulation of Mcl 1S protein and activation of caspase 9 and caspase 3 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Derivatives induced apoptosis was mediated by the cleavage and activation of caspase 9 and caspase 3 , but not caspase 8 , implicating the mitochondrial pathway for apoptosis induction . ^^^ Inhibitors of caspase 3 and caspase 9 and cyclosporin A , a mitochondrial membrane potential stabilizer , attenuated derivative induced apoptosis . ^^^ Inhibition of caspase 3 prevented the activation of caspase 8 , while the inhibition of caspase 9 inhibitor blocked activation of both caspase 3 and 8 by the derivatives . ^^^ These results indicate that the second generation celecoxib derivatives induce apoptosis in human oral cancer lines by the disruption of mitochondrial membrane potential activating caspase 9 and downstream caspase 3 and 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Through these associations , BRUCE promotes the degradation of Smac and inhibits the activity of caspase 9 but not the effector caspase , caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspases 8 and 10 are the first caspases to be activated whereas caspase 8 inhibitor zIETD fmk delays the activation of Bid , caspase 9 and caspase 3 . ^^^ However , the caspase 9 inhibitor zLEDH fmk does not block the activation of caspase 8 , Bid , caspase 10 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of procaspase 9 is mediated by means of a conformational change . ( 8 ) The activated caspase 9 cleaves downstream effector caspases ( caspase 3 ) . ( 9 ) Finally , apoptosis is induced . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Since caspase 3 may be activated by initiator caspase 9 and 8 , it is significant to show that such caspase activation cascade is induced by 4 microM DAU and TT bisquinones at 6 h in HL 60 S cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Exposure of cerebellar granule cells to Abeta 25 35 markedly enhanced caspase 3 but not caspase 9 activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The main mechanism for these apoptosis appeared to be mitochondria mediated pathway accompanied with loss of the mitochondrial transmembrane potential ( Delta Psi m ) followed by cytochrome c release from the mitochondria into the cytosol , resulting in the activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The observations identified cytoplasmic expression of caspase 3 and caspase 6 in more than 50 per cent of tumor cells , caspase 8 and caspase 9 in more than 10 per cent of tumor cells in high grade anaplastic ASTR and glioblastoma . ^^^ The immunocytochemical expression pattern in about 10 per cent of the tumor cells for caspase 3 and caspase 6 and about 1 to 5 per cent of the tumor cells for caspase 8 and caspase 9 demonstrated a translocation tendency from the cytoplasm to the cell nuclei in the apoptotic cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Transient transfection of Nodal and ALK 7 ca significantly decreased 10 linked inhibitor of apoptosis protein ( Xiap ) expression , activated both caspase 3 and caspase 9 , and increased apoptosis as determined by Hoechst nuclear staining and flow cytometry . ^^^ These findings demonstrate that Nodal induces apoptosis and inhibits proliferation via ALK 7 and Smad2 / 3 and that the effect of Nodal ALK 7 on apoptosis may be mediated in part by the down regulation of Xiap and activation of caspase 9 and caspase 3 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
At 100 nM , both caspase 3 and caspase 9 were transiently upregulated after 1 h , but returned to normal levels after 6 h of exposure . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Terminal deoxynucleotidyltransferase mediated uridine triphosphate end labeling assays demonstrated that HDACIs induced apoptosis , which occurred in concert with alterations in the expression of genes related to apoptosis , cell growth , and malignant phenotype , including the activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The ORF displays two putative caspase 9 cleavage sites LLVETDGPS , VKLEHDGSK , and a caspase 3 cleavage site EEDEVDGVP . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In rat 423 cells , caspase 8 and caspase 3 were apparently sufficient to initiate and proceed apoptosis without involving the intrinsic amplification loop via caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
FR 901228 activated caspase 9 and caspase 3 but not caspase 8 , and the caspase 3 inhibitor Z DEVD fmk blocked the cytotoxicity of FR 901228 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Protein and transcriptome expression analysis showed that combined 5 FU and DENSPM treatment activated caspase 9 , but not caspase 3 , and significantly suppressed NADH dehydrogenases and cytochrome c oxidases , consistent with the observed increase in hydrogen peroxide , loss of mitochondrial membrane potential , and release of cytochrome c . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis inducing concentrations of dideoxypetrosynol A induced caspase 3 and caspase 9 activation accompanied by proteolytic degradation of poly ( ADP ribose ) polymerase and selective down regulation of cIAP 1 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In contrast , 7beta OHchol did not activate caspase 3 and activation of caspase 9 and DNA fragmentation were delayed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The time course analysis revealed that molecules activated in apoptosis were in the following order : caspase 8 ( 1 . 5 h ) , t Bid ( 2 . 5 h ) , Bax ( 3 h ) , cytochrome c release ( 6 h ) , caspase 9 ( 7 h ) , and caspase 3 ( 8 h ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In cerebellar granule neurons , vincristine and to a lesser extent topotecan induced caspase 3 and caspase 9 cleavage , and enhanced caspase activity and Akt dependent expression of phosphorylated BAD . zVAD fmk , a caspase inhibitor and brain derived neurotrophic factor ( BDNF ) , but not MK 801 , a non competitive NMDA receptor antagonist , significantly reduced vincristine or topotecan induced cell death . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The results also demonstrate that NM 3 enhances dexamethasone induced activation of the intrinsic caspase 9 > caspase 3 apoptotic pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
BCL 2 , BAX , FAS , caspase 9 , caspase 3 and BCL2L12 were amplified by PCR . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Here , we report that tPA potentiates apoptosis in ischemic human brain endothelium and in mouse cortical neurons treated with N methyl D aspartate ( NMDA ) by shifting the apoptotic pathways from caspase 9 to caspase 8 , which directly activates caspase 3 without amplification through the Bid mediated mitochondrial pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Our experiments showed that 5 FU engaged the mitochondrial apoptotic pathway involving cytosolic cytochrome c release and subsequent activation of caspase 9 and caspase 3 as well as the membrane death receptor ( DR ) mediated apoptotic pathway involving activation of caspase 8 with an Apo 1 / CD95 ( Fas ) dependent fashion . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of proapoptotic caspase 9 and caspase 3 pathways , by binding with tumor suppressor p 53 , HIF 1alpha could lead to harmful actions such as apoptosis . ^^^ The expressions of p 53 , caspase 9 , and caspase 3 were all increased in a similar time course . ^^^ HBO treatment reduced expressions of HIF 1alpha , p 53 , caspase 9 , and caspase 3 and decreased cell death . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
AGE induced apoptosis was largely dependent on the effector caspase , caspase 3 , which was activated through both cytoplasmic ( caspase 8 dependent ) and mitochondrial ( caspase 9 ) pathways . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 and caspase 3 were rapidly activated , and extensive cleavage occurred in focal adhesion and cytoskeletal molecules in the hsp70 . 1 / MEFs . ^^^ In contrast , hsp70 . 1+ / + MEFs exhibited no caspase 9 or caspase 3 activation and finally recovered intact cell morphology when cells were shifted back to an isosmotic state . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Inactivation of Akt was associated with dephosphorylation of BAD , increased cytochrome c release , and activation of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
An increase in postmitochondrial caspase 9 and caspase 3 activity was observed in hypoxic myocytes . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In this study , gammaT or its combination with delta tocopherol induced apoptosis in androgen sensitive prostate LNCaP , but not in androgen resistant PC 3 cells , by the induction of cytochrome c release , activation of caspase 9 and caspase 3 , cleavage of poly ADP ribose polymerase ( PARP ) , and involvement of caspase independent pathways . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of caspase 9 and caspase 3 , but not caspase 8 , was detected after treatment with CDDP , and the cleavage of fodrin by activated caspase 3 was observed within damaged hair cells . ^^^ Intracochlear perfusions with caspase 3 inhibitor ( z DEVD fmk ) and caspase 9 inhibitor ( z LEHD fmk ) prevent hearing loss and loss of sensory cells , but caspase 8 inhibitor ( z IETD fmk ) and cathepsin B inhibitor ( z FA fmk ) do not . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , upregulated active caspase 3 in CD 44 deficient colon was accompanied by concomitant molecular alterations in caspase 9 and not caspase 8 , and this indicated the involvement of the mitochondrial pathway in apoptosis execution . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
A cell permeable , caspase 9 selective inhibitor blocked caspase 3 activation and prevented chromatin condensation and nuclear segmentation in cells treated with high glucose . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , treatment with ucf 101 before reperfusion attenuated 10 linked inhibitor of apoptosis protein degradation and inhibited caspase 9 and caspase 3 activities . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , NO significantly suppressed activities of caspase 3 , caspase 8 and caspase 9 that had been upregulated by UVB radiation . ^^^ These findings suggested that NO might suppress UVB induced keratinocyte apoptosis by regulating apoptotic signaling cascades in p 53 , Bcl 2 , caspase 3 , caspase 8 and caspase 9 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 and caspase 9 activities were increased 18 to 51 fold and 6 to 11 fold , respectively , after 24 h of culture . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
HLJDT inhibited the proliferation of myeloma cell lines and the survival of primary myeloma cells , especially MPC 1 immature myeloma cells , and induced apoptosis in myeloma cell lines via a mitochondria mediated pathway by reducing mitochondrial membrane potential and activating caspase 9 and caspase 3 . ^^^ Baicalein inhibited the phosphorylation of IkB alpha , which was followed by decreased expression of the IL 6 and XIAP genes and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Growth factor deprivation in turn induces PP1alpha phosphatase activation , responsible for cytoplasmic Bad dephosphorylation as well as caspase 9 and caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This apoptosis is associated with up regulation and nuclear localization of the tumor suppressor p 53 and activation of mitochondrial apoptosis , which includes up regulation of Bax , Bak , and Pidd , translocation of Bax and caspase 2 onto mitochondria , release of cytochrome c and apoptosis inducing factor , and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
A caspase 9 selective inhibitor blocked caspase 3 activation but incompletely blocked apoptosis in response to palmitate , suggesting an additional caspase 9 independent pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
CONCLUSIONS : The hypothesis to explain AMA induced HL 60 apoptosis was clearly inadequate because : ( a ) caspase 9 inhibition did not prevent DNA fragmentation or cell death , ( b ) apoptosis proceeded in the absence of caspase 3 activation , ( c ) the main pathway leading to activation of the executioner caspases was by caspase 8 activation , but caspase 8 inhibition only delayed apoptosis , and ( d ) activation of caspases 8 and 9 may be necessary for caspase 3 activation . ^^^ Thus , in this cell model , apoptosis triggered from within the mitochondria does not necessarily proceed by caspase 9 , and caspase 3 is not critical to apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , inhibition of c Abl with STI 571 blocked DNA damage induced autoprocessing of caspase 9 to the p 35 subunit and activation of caspase 3 . ^^^ Caspase 9 ( Y153F ) also attenuated DNA damage induced processing of caspase 9 to p 35 , activation of caspase 3 , and apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , unlike CA induced , caspase 9 / 3 dependent apoptosis , there was no increased activity in caspase 9 , caspase 3 or poly ( ADP ribose ) polymerase ( PARP ) cleavage in RO induced cytotoxicity , in spite of time dependent release of cytochrome c and apoptosis inducing factor ( AIF ) following mitochondrial membrane depolarization and a significant increase in reactive oxygen species generation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 and caspase 9 , however , were not activated , thus indicating the existence of alternate or compensatory cell death pathway ( s ) in dopaminergic neuronal cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 inhibitor ( Ac Asp Glu Val Asp CHO ) and caspase 9 inhibitor ( Ac Leu Glu His Asp CHO ) completely inhibited this DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Interestingly , the expression of the pro apoptotic genes caspase 3 and caspase 9 was also significantly decreased at 3 , 6 ( caspase 9 only ) , and 12 months after TBI , suggesting that long term neuronal loss after TBI is not mediated by increased expression of pro apoptotic genes . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The purified AMVIAP protein also inhibits the enzymatic activities of human caspase 9 and caspase 3 in vitro . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Enzymatic assays were performed to measure the activities of 2 cysteine proteases , i . e . , caspase 9 and caspase 3 , in tempo treated cells . ^^^ Tempo treatment of LNCaP cells resulted in enhanced activities of caspase 9 ( tempo , 5 mM , 15 hours : approximately 2 fold ) and caspase 3 ( tempo , 2 . 5 mM , 24 hours : approximately 12 fold ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
There are two pathways of caspase 3 and caspase 7 mediated apoptosis : ( 1 ) the `` extrinsic ' ' pathway involving the death receptor Fas , Fas ligand ( FasL ) , and caspase 8 and ( 2 ) the `` mitochondrial ' ' or `` intrinsic ' ' pathway involving Bcl 2 proteins , caspase 2 , cytochrome c release , and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
That is , hybrid liposomes fused and accumulated in tumor cell membranes , and the apoptosis signal first passed through mitochondria , caspase 9 and caspase 3 , second through Fas , caspase 8 , caspase 3 and then reached the nucleus . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 cleaves and activates effector caspases , predominantly caspase 3 , resulting in the demise of the cell . ^^^ We show that protein kinase A inhibits activation of caspase 9 and caspase 3 downstream of cytochrome c in Xenopus egg extracts and in a human cell free system . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We therefore generated a stable transfected beta cell line ( INS 1 ) overexpressing human TXNIP and found that TXNIP overexpression induced apoptosis as assessed by Bax , Bcl 2 , caspase 3 , and cleaved caspase 9 as well as Hoechst staining . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Decursin caused cell death was associated with an increase in apoptosis ( P < 0 . 05 0 . 001 ) and cleaved caspase 9 , caspase 3 , and poly ( ADP ribose ) polymerase ; however , pretreatment with all caspases inhibitor ( z VAD fmk ) only partially reversed decursin induced apoptosis , suggesting the involvement of both caspase dependent and caspase independent pathways . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The rats were killed at intervals up to 8 weeks and serial sections through the graft sites were processed for immunofluorescence using primary antibodies against human nuclear and mitochondrial antigens , microtubule associated protein 2 , TUJ 1 , CD 5 , natural killer cells , and activated microglia macrophages , caspase 3 and caspase 9 . ^^^ Cells died by apoptosis via the cytochrome c / caspase 9 / caspase 3 pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This is the first in vivo demonstration that the `` effector ' ' caspase 3 plays an `` initiator ' ' role in the regulation of caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Src inhibition enhances paclitaxel cytotoxicity in ovarian cancer cells by caspase 9 independent activation of caspase 3 . ^^^ The activation of caspase 3 seems to be independent of cytochrome c release and caspase 9 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Sulindac increased expression of ectopic MDA 7 protein in tumor cells , thereby increasing the expression of downstream effectors RNA dependent protein kinase , p38MAPK , caspase 9 , and caspase 3 and enhancing apoptosis of non small cell lung cancer cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cell death was preceded by ultrastructural disintegration at the endoplasmic reticulum , PERK phosphorylation , degradation of caspase 12 like protein and cleavage of caspase 9 , resulting in apoptosis through the activation of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We showed early activation of death receptor dependent apoptosis ( caspase 8 activation 2 days after ischaemia ) and a biphasic activation of caspase 3 and caspase 9 after ischaemia . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This effect of PKCdelta is specific to caspase 3 , as evidenced by the absence of similar effects on caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In strong support of a role for JNK in promoting the mitochondrial apoptosis signaling pathway , JNK inhibition prevented ischemia induced mitochondrial translocation of Bax and Bim , release of cytochrome c and Smac , and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The antiapoptotic proteins , Bcl 2 and Bcl xl , were downregulated by GSP , whereas the expression of the pro apoptotic protein , Bax , and the levels of cytochrome c release , Apaf 1 , caspase 9 , and cleaved caspase 3 ( p 19 and p 17 ) were markedly increased in JB 6 C141 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Enzymatic activity measurements of caspases revealed that caspase 3 and caspase 9 are activated in phytosphingosine induced apoptosis , but there is little activation of caspase 8 suggesting that phytosphingosine influences mitochondrial functions . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
RESULTS : Gemcitabine treatment , as well as stimulation of CD 95 , resulted in cleavage of effector caspase 3 as well as its substrate PARP and caspase 9 , followed by DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Forced expression of alpha 5 integrin rescued cell attachment and corrected both the Bax / Bcl 2 ratio and caspase 3 and caspase 9 activities in FGFR 2 mutant osteoblasts . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Attenuating erbB signals in cultured neonatal rat cardiomyocytes by the erbB 2 antagonist tyrphostin AG 825 , by the erbB1 / 4 antagonist AG 1478 or by antisense induced lowering of erbB 2 receptors resulted in an augmented Bcl xS / Bcl xL ratio , mitochondrial release of cytochrome c , activation of caspase 9 and caspase 3 , and nucleosome sized DNA fragmentation . ^^^ A similar DNA fragmentation and caspase 3 activation was induced by TNF alpha , but without Bcl xS / Bcl xL increase , cytochrome c release or caspase 9 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
DHL 4 cells express low levels of caspase 3 and caspase 8 ; furthermore , no cleavage in caspase 8 , caspase 9 , caspase 3 , poly ADP ribose polymerase ( PARP ) , or DNA fragmentation factor 45 was triggered by PS 341 treatment . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In this study , we compared the potency of alpha TS and alpha TOB using a panel of bioassays : cell growth , TUNEL labelling for apoptosis , PARP cleavage , caspase 3 and caspase 9 activation , as well as Akt and JNK phosphorylation . ^^^ Nonetheless , these two compounds shared the same mechanism of targeting the Akt and JNK signaling pathways , and activating the intrinsic cell death mediators of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The combination of manumycin and methoxyamine resulted in enhanced apoptosis by six criteria increased annexin 5 binding , release of mitochondrial cytochrome c into the cytosol , activation of caspase 9 , activation of caspase 3 , specific cleavage of poly adenosyl ribose polymerase , and increase in the sub G 1 cell cycle fraction . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This conclusion is based on the following observations : ( a ) sulforaphane treatment caused a dose and time dependent increase in the protein levels of both Bax and Bak and conformational change and mitochondrial translocation of Bax in SV 40 transformed mouse embryonic fibroblasts ( MEF ) derived from wild type mice to trigger cytosolic release of apoptogenic molecules ( cytochrome c and Smac / DIABLO ) , activation of caspase 9 and caspase 3 , and ultimately cell death ; ( b ) MEFs derived from Bax or Bak knockout mice resisted cell death by sulforaphane , and ( c ) MEFs derived from Bax and Bak double knockout mice exhibited even greater protection against sulforaphane induced cytochrome c release , caspase activation , and apoptosis compared with wild type or single knockout cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This increase in apoptosis was associated with a decrease in Bcl 2 and expression , an increase of Bax , and an activation of caspase 3 and caspase 9 . beta lapachone treatment markedly inhibited the activity of telomerase in a dose dependent fashion . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Investigation of the mechanism of CTXIII induced apoptosis revealed that the treatment of K 562 cells with CTX 3 resulted in the activation of caspase 9 , caspase 3 and subsequent cleavage of its substrate PARP and that CTXIII was also associated with an early release of cytochrome c from the mitochondria . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In WEHI 231 cells , the natural PPARgamma agonist 15 deoxy Delta ( 12 , 14 ) PGJ ( 2 ) and the synthetic PPARgamma agonist ciglitazone induced activation of caspase 3 and caspase 9 , a decrease in mitochondrial membrane potential , and caused cleavage of the caspase substrate poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
DDE 46 enhanced the activity of the pro apoptotic enzymes Caspase 3 , Caspase 6 , Caspase 8 , and Caspase 9 leading to the apoptotic death of the leukemic cell line Jurkat . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The caspase 8 inhibitor zIETDfmk completely abolished apoptosis and caspase 9 and caspase 3 cleavage , whereas the caspase 9 inhibitor zLEHDfmk significantly decreased caspase 3 cleavage and apoptosis but had no effect on caspase 8 cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Western blot analysis showed that the hypoxia augmented TRAIL induced PARP cleavage as well as the activation of caspase 8 and caspase 3 , but not caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspases are activated in cells at a relatively long time after detachment , and caspase 3 activation may require caspase 8 or caspase 9 activation , as determined by using HCT 116 isogenic clones impaired in apoptosis mechanisms that involve these two caspases . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We showed that in primary cultures of cortical neurons , NT 3 reduces Abeta induced apoptosis by limiting caspase 8 , caspase 9 , and caspase 3 cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The appearance of two cleaved forms of caspase 3 occurred subsequent to increases in caspase 9 activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
METHODS : The cell viability was determined by Trypan blue staining and the state of cell proliferation was analyzed ; DNA ladder pattern and AO / EB staining were applied to identify the cell apoptosis ; the apoptotic signal proteins including caspase 9 , caspase 3 , and PARP and the proteins of JNK signal pathway such as MEK 4 , JNK , P JNK , and P C Jun , were detected by Western blotting . ^^^ RESULTS : Indomethacin at 200 to approximately 400 micromol significantly inhibited the proliferation of HL 60 cells and induced the cell apoptosis in a time or concentration dependent manner ; caspase 9 , caspase 3 , and PARP were cleaved and activated in undergoing apoptotic cells ; and the expressions of MEK 4 , P JNK , and P C Jun were upregulated with the increase of indomethacin concentration . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
RESULTS : ( 1 ) H2O2 ( 0 . 5 mmol / L ) resulted in a marked release of Smac from mitochondria to cytoplasm at 2 h after the treatment , the activation of caspase 9 and caspase 3 at 4 h after the treatment and specific morphological changes of apoptosis at 24 h after the treatment . ( 2 ) Heat shock pretreatment ( 42 degrees C , 1 h ) could increase the expression of hsp 90 , hsp 70 and betaB crystallin , and inhibit the H2O2 induced release of Smac from mitochondria , the activity of caspase 9 , caspase 3 and apoptosis of cardiomyocytes . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The treatment of K 562 cells with nucleosides only was accompanied by the activation of caspase 3 and caspase 9 , rather than caspase 6 , increased fluorescence of ethidium bromide and DAPI upon binding to DNA , and apoptosis . ^^^ Intracellular activation of caspase 6 , inhibition of caspase 9 , a markedly decreased activity of caspase 3 and of fluorescence of DNA binding dyes , and inhibition of apoptosis were observed when the cells were treated with phorbol 12 myeristet 13 acetate combined with nucleosides . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , MZR increased the catalytic activity of caspase family cysteine proteases , including caspase 3 , caspase 8 , and caspase 9 , in human Jurkat T cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : Apoptotic terminal deoxynucleotidyl transferase mediated dUTP nick end labeling method , immunohistochemistry for caspase 2 , caspase 3 , caspase 8 , caspase 9 , and other apoptosis markers were done on 12 normal cervical samples and 103 low and high grade cervical lesions , containing human papillomavirus ( es ) from 35 HIV negative and 33 HIV positive women before tritherapy advent . ^^^ This was associated with a greater expression of caspase 8 , active caspase 9 , and active caspase 3 in those samples . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
After 2 hr of reperfusion , peak inspiratory pressures ( PIP ) and donor pulmonary vein PaO ( 2 ) was measured in all grafts ; grafts were then excised and protein extracts were analyzed by enzyme linked immunosorbent assay ( ELISA ) and activated caspase 3 and caspase 9 assays . ^^^ In addition , AdvBcl 2 pretreatment led to diminished cytochrome c release into cytosolic extracts and reduced intragraft IL 1beta production and inhibited intragraft caspase 3 and caspase 9 activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Treatment of Jurkat T leukemia cells with LfcinB resulted in the production of reactive oxygen species followed by caspase 2 induced dissipation of mitochondrial transmembrane potential and subsequent activation of caspase 9 and caspase 3 . ^^^ Selective inhibitors of caspase 2 ( Z VDVAD FMK ) , caspase 9 ( Z LEHD FMK ) , and caspase 3 ( Z DEVD FMK ) protected both leukemia and carcinoma cells from LfcinB induced apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , binding to these receptors triggers the phosphatidyloinositol 3 kinase ( PI3K ) / Akt signal transduction system and , in consequence , leads to the inhibition of PCD by activating antiapoptotic proteins through the transcription factor NFkappaB and inhibiting proapoptotic signaling by Bad , caspase 9 , caspase 3 , and other effectors . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
To further investigate the cellular mechanism of this effect , we found that E1A enhances TRAIL induced activation of caspase 8 , caspase 9 , and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These events coincided with high molecular weight DNA fragmentation , activation of caspase 9 and caspase 3 and poly ( ADP ribose ) polymerase cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Although inhibition of PI3 ' kinase induced cleavage of BID in all cell lines , cytochrome c was released from the mitochondria and caspase 9 and caspase 3 were activated in LY 294002 induced apoptotic BC 1 but not in resistant BCP 1 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis was inhibited by an inhibitor of caspase 9 , but not by an inhibitor of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Addition of specific inhibitors for caspase 9 and caspase 3 also blocked zinc induced apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We detected the activation of caspase 3 as well as the activation of caspase 9 in sensitive cells but not in resistant cells under iron deprivation . ^^^ Taken together , we suggest that iron deprivation induces apoptosis via mitochondrial changes concerning proapoptotic Bax translocation to mitochondria , collapse of the mitochondrial membrane potential , release of cytochrome c from mitochondria , and activation of caspase 9 and caspase 3 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Atiprimod also induced apoptosis and activated both caspase 9 and caspase 3 in T 84 colon carcinoma cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 activation was detected during Salmonella infection of THP 1 cells , but caspase 8 and caspase 9 activities were not found . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
HGS ETR 1 reduced the viability of multiple types of tumour cells in vitro , and induced activation of caspase 8 , Bid , caspase 9 , caspase 3 , and cleavage of PARP , indicating activation of TRAIL R 1 alone was sufficient to induce both extrinsic and intrinsic apoptotic pathways . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Bax , caspase 3 and caspase 9 , and poly ADP ribose polymerase ( PARP ) activation were measured by Western blotting . ^^^ However , TUNEL positive nuclei , Bax , caspase 3 and caspase 9 activation , and PARP cleavage were all increased in dopa and FK+D groups , but not in CSA+D . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Intracellular AA also prevents loss of mitochondrial membrane potential and the release of cytochrome C and activation of caspase 9 and caspase 3 during H R . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Analysis of the Fas apoptotic pathway showed that anti Fas treatment induced caspase 8 activation and concomitantly Bid cleavage , caspase 9 and caspase 3 activation , PARP cleavage and apoptosis in HeLa and CaSki . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The caspase 8 inhibitor z IETD fmk was not as effective an inhibitor of PLSCR 1 augmented UV induced apoptosis compared to treatment with caspase 3 , caspase 9 , or pan caspase inhibitors . ^^^ The inability of the caspase 8 inhibitor to decrease UV induced apoptosis was dependent on PLSCR 1 , as UV induced apoptosis was decreased by a similar amount in the control cells in the presence of inhibitors of caspase 8 , caspase 9 , caspase 3 , or the pan caspase inhibitor . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We observed that codonoposide 1c caused activation of caspase 8 , caspase 9 , and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Our results clearly show that beta elemene induced caspase 3 , 7 and 9 activities , decreased Bcl 2 expression , caused cytochrome c release and increased the levels of cleaved caspase 9 and poly ( ADP ribose ) polymerase in NSCLC cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activities of caspase 3 and caspase 9 were assayed with Western blotting . ^^^ RESULTS : H2O2 ( 0 . 5 mmol / L ) activated caspase 3 , caspase 9 8 h after the treatment and specific morphological changes of apoptosis 12 h after the treatment , and overexpression of Smac significantly promoted H2O2 induced activation of caspase 3 , caspase 9 and apoptosis in C2C12 myogenic cells . ^^^ HSP 70 overexpression significantly inhibited H2O2 induced and Smac promoted apoptosis , as shown by no specific DNA ladder pattern in agarose gel electrophoresis , decrease of percentage of apoptotic nuclei , and marked inactivation of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of apoptotic proteins including the caspase 3 , caspase 9 , PARP , D 4 GDI proteins was identified in H ( 2 ) O ( 2 ) treated cells by Western blotting and enzyme activity assay , and that was significantly blocked by an addition of QE , but not RUT and QI . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Resistance to apoptosis was not due to presence of the multidrug resistance pump or to impaired expression of caspase 8 , caspase 9 , or `` executioner ' ' caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Despite the high caspase 3 activity in RBL / PR3 , no apoptosis was detected as demonstrated by an absence of 1 ) phosphatidylserine externalization , 2 ) mitochondria cytochrome c release , 3 ) upstream caspase 8 or caspase 9 activation , or 4 ) DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both caused apoptosis by increasing the protein expression of Bax and Bcl xs while decreasing Bcl 2 and Bcl 10 ( L ) , releasing apoptogenic cytochrome c , and augmenting the activity of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Although analysis of variance demonstrated no overall difference in expression of mRNA levels for heat shock protein 70 , bcl 2 , caspase 3 , caspase 9 and interleukin 1beta in uninjured CA 3 neurons at all injury levels , post hoc analysis suggested that TBI induces increases in neuroprotective gene expression that offset concomitant increases in deleterious gene expression . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Preincubation of the LLC PK 1 cells with the caspase 9 inhibitor did not attenuate caspase 3 activation and provided no significant protection . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Combining the Bcl 10 ( L ) siRNA with TRAIL protein treatment resulted in an increase in the percentage of apoptotic cells and increased cleavage of caspase 8 , caspase 9 , caspase 3 and PARP . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Our data reveal that pramanicin induced the release of cytochrome c and caspase 9 and caspase 3 activation , as evidenced by detection of active caspase fragments and fluorometric caspase assays . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Aloe emodin treatment of t HSC / Cl 6 cells caused activation of caspase 3 and caspase 9 , detected with a caspase activity assay , although no change was observed in caspase 8 activity . ^^^ Western blotting showed caspase 3 and caspase 9 active forms and the subsequent proteolytic cleavage of poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , not only caspase 3 / 7 activities , but also caspase 9 activity was increased in Beclin 1 gene transfectants treated with CDDP , and caspase 9 inhibitor completely abolished augmentation of CDDP induced apoptosis by Beclin 1 as did a caspase 3 inhibitor . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Among their downstream initiator ( caspase 8 , 9 , and 10 ) and executioner ( caspase 3 ) caspases tested , caspase 9 and 3 were expressed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
METHODS : We examined thirty two samples of herniated lumbar disc tissue with use of immunohistochemical staining and Western blot analysis to determine the presence of several proteins , including caspase 8 ( associated with the Type 1 pathway ) ; BID ( BH 3 interacting domain death agonist ) , cytochrome c , and caspase 9 ( associated with the Type 2 pathway ) ; and caspase 3 ( an executioner of apoptosis ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Antiapoptotic property of human alpha synuclein in neuronal cell lines is associated with the inhibition of caspase 3 but not caspase 9 activity . ^^^ Analyses of capase 3 and caspase 9 activation reveal that the antiapoptotic property of Hualpha Syn in neuronal cell lines is associated with the attenuation of caspase 3 activity without affecting the caspase 9 activity or the levels of cleaved , active caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In parallel experiments , the expression of genes related to apoptosis , BCL 2 , BCLXL , BAX , P 53 , APAF 1 , Caspase 3 , and Caspase 9 , was determined by RT PCR . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cleaved caspase 9 and caspase 3 proteins were time dependently increased after MI . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Combined treatment with MEM and caspase 3 , 8 and 9 inhibitors , the caspase 3 and 8 inhibitors were accounting for 63 and 47 % inhibition in MEM induced apoptosis , respectively ; however , caspase 9 inhibitor exhibited no obvious inhibition effect on the apoptosis percentage ( p > 0 . 05 ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Although colchicine evoked an increase in caspase 3 , caspase 6 and caspase 9 activation , selective caspase inhibitors did not attenuate apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Mutant ataxin 7 Q 75 induced the formation of active caspase 3 and caspase 9 without activating caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Western blotting showed the expressions of caspase 9 and caspase 3 in patients ' granulosa cells . ^^^ The granulosa cells go through the mitochondria dependent apoptosis pathway ; the indicated pro apoptosis protein Bax was expressed and induced cytochrome c release from mitochondria , which then activated caspase 9 and caspase 3 until cell death occurred . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Increased exposure to 15 HPETE induced apoptosis , as determined by internucleosomal DNA fragmentation , chromatin condensation , caspase 3 activation , and caspase 9 activation , which suggests mitochondrial dysfunction . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , upon exposure to toxic stimuli , increased mitochondrial release of cytochrome C and activation of caspase 9 and caspase 3 are found in HD cells and tissue . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Olfactory receptor neurons ( ORNs ) undergo caspase mediated retrograde apoptosis after target removal ( bulbectomy ) , in which axonal caspase 9 and caspase 3 activation leads to terminal apoptosis in ORN soma of the olfactory epithelium . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These results indicate that polyamines regulate PP2A activity , and inhibition of PP2A in response to polyamine depletion increases steady state levels of Bad and Bcl 2 proteins and their phosphorylation and thereby prevents cytochrome c release , caspase 9 , and caspase 3 activation . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of caspase 3 and caspase 9 , and induction of bax gene expression , were involved in tumor cell apoptosis induced by ZD 55 IL 24 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The activation of caspase 3 , which is activated by caspase 9 , degraded DNA approximately 180 bp in size , which resulted in the appearance of a characteristic DNA ladder . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
TSA treatment induced the proteolytic activation of caspase 3 and caspase 9 , and a concomitant degradation of poly ( ADP ribose ) polymerase protein . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Chan Su treatment induced the proteolytic activation of caspase 3 and caspase 9 , and a concomitant degradation of poly ( ADP ribose ) polymerase and beta catenin protein . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Hair cell nuclei showed both apoptotic and necrotic like appearances but markers for classic apoptotic pathways ( cytochrome c , caspase 9 , caspase 3 , JNK , TUNEL ) were absent . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
ZD 1839 inhibited the phosphorylation of Akt , and enhanced TRAIL induced apoptosis via activation of caspase 3 and caspase 9 , and inactivation of Bcl xL . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Investigation of the mechanism of CTX 3 induced apoptosis revealed that treatment of K 562 cells with CTX 3 resulted in the loss of mitochondrial membrane potential , cytochrome c release from mitochondria into the cytosol and activation of caspase 9 and caspase 3 and the subsequent cleavage of the caspase 3 substrate PARP ; however , CTX 3 did not generate reactive oxygen species ( ROS ) . 4 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The induction of apoptosis was further confirmed by showing that CMT 3 induces activation of caspase 3 and caspase 9 in HMC 1 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Lastly , we show that NF kappaB inhibits c Myc induced activation of caspase 9 and caspase 3 through up regulation of the antiapoptotic target genes Bcl 10 ( L ) and 10 linked inhibitor of apoptosis ( XIAP ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 and caspase 9 activities in the mutant brains were significantly elevated , whereas bax expression was unchanged from controls . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Overexpression of HIF 1alpha inhibited the generation of reactive oxygen species ( ROS ) , elevation of intracellular Ca ( 2+ ) concentration , reduction of mitochondrial membrane potential , and cytosolic accumulation of cytochrome c , which resulted in the inactivation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Overexpression of wild type PINK 1 also reduced the levels of cleaved caspase 9 , caspase 3 , caspase 7 , and activated poly ( ADP ribose ) polymerase under both basal and staurosporine induced conditions . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In this study , we report that in murine macrophages GBS induces unique changes in the regulation and localization of the apoptotic regulators Bad , 14 3 3 , and Omi / high temperature requirement A 2 and leads to the release of cytochrome c and the activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis by I3C involves downregulation antiapoptotic gene products , including Bcl 2 , Bcl xL , survivin , inhibitor of apoptosis protein ( IAP ) , 10 chromosome linked IAP ( XIAP ) , and Fas associated death domain protein like interleukin 1 beta converting enzyme inhibitory protein ( FLIP ) ; upregulation of proapoptotic protein Bax ; release of micochondrial cytochrome C ; and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Similarly , immunoreactivity for the apoptotic signals Fas , Fas ligand , Bax , Bcl 10 , caspase 8 , caspase 9 and caspase 3 was absent from the NBM of AD and control brains . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
LPS also induced nitric oxide ( NO ) and superoxide ( O ( 2 ) ( ) ) production , depressed mitochondrial Complex 1 and 4 activity , promoted the release of cytochrome c from mitochondria to cytosol , upregulated the cytosolic expression of activated caspase 9 and 3 , or increased caspase 3 enzyme activity in the RVLM . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activities of caspase 3 and caspase 9 were assayed by colorimetry and Western blotting . ^^^ These data demonstrate that H ( 2 ) O ( 2 ) could result in apoptosis of C2C12 myogenic cells , and that release of Smac / DIABLO from mitochondria to cytoplasm and the subsequent activation of caspase 9 and caspase 3 played important roles in H ( 2 ) O ( 2 ) induced apoptosis in C2C12 myogenic cells . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Data suggest that in the presence of mitochondrial derived ROS , TRAIL induced mitochondrial release of Smac / DIABLO and inactivation of 10 linked inhibitor of apoptosis through caspase 9 independent activation of caspase 3 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
To ascertain the mechanism of epithelial apoptosis , we determined that PAR 1AP , thrombin , and leukocyte elastase dissipated mitochondrial membrane potential , induced translocation of cytochrome c to the cytosol , enhanced cleavage of caspase 9 and caspase 3 , and led to JNK activation and Akt inhibition . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Ataxin 3 Q 79 activated caspase 3 and caspase 9 without inducing the formation of active caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Incubation of BL 3 cells with a low concentration of LKT results in the activation of caspase 3 and caspase 9 but not caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
UVB at levels comparable to physiologic solar exposure induces apoptosis of corneal epithelial cells in culture , demonstrated by activation of caspase 9 and caspase 3 , and DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Western blot comparing the effect of hyperthermia in BZR T 33 cells to BEAS 2 B cells revealed : TRAIL and FAS L displayed significant increases ( threefold and twofold , respectively ) ; caspase 3 showed a decrease in uncleaved form and an increase in cleaved form , and a 50 fold increase in activity effectively blocked with the caspase 3 inhibitor DEVD fmk ; caspase 9 showed near depletion of uncleaved ; poly ( ADP ribose ) polymerase ( PARP ) degradation was clearly visible during heating . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
RESULTS : ( ) Epigallocatechin 3 gallate rapidly induced apoptotic cell death in various malignant B cell lines in a dose and time dependent manner . ( ) Epigallocatechin 3 gallate induced apoptosis was in association with the loss of mitochondrial transmembrane potentials ( Deltapsim ) ; the release of cytochrome c , Smac / DIABLO , and AIF from mitochondria into the cytosol ; and the activation of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Finally , we demonstrated that HMGB 1 overexpression suppressed caspase 9 and caspase 3 activity , suggesting that HMGB 1 interferes with the apoptotic machinery at the level of apoptosomal caspase 9 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
At 24 h , 15 . 9 % and 17 . 7 % of DRG neurons exhibited immunoreactivity for caspase 9 and caspase 3 , respectively . ^^^ Double label immunohistochemistry revealed co expression of caspase 9 and DNA fragmentation or caspase 3 and DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The obvious DNA ladder and the significantly increased both hepatic caspase 9 and caspase 3 activity indicated that fluoride induced caspase dependent apoptosis in vivo . ^^^ The results suggest that fluoride induces apoptosis by elevating the oxidative stress induced lipid peroxidation , causing mitochondrial dysfunction and further activating caspase 9 and caspase 3 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
For all Abetas , the executor was caspase 3 , while the initiator was caspase 9 for Abeta 42 and caspase 8 for Abeta 40 and Abeta 17 42 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Regarding the caspases , there were increases in the levels of pro caspases 12 and 7 and cleaved caspase 9 , although the levels of pro and cleaved caspase 3 as well as cleaved caspase 12 remained unchanged . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both the ( Bu ( 2 ) Sn ) ( 2 ) TPPS and the ( Bu ( 3 ) Sn ) ( 4 ) TPPS compounds activate caspase 8 and caspase 9 leading to caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis required caspase 9 and caspase 3 activity , and cytochrome c accumulated in the cytosol of CKI treated cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Administration of 0 . 1 microM MG 132 led to activation of a mitochondria dependent apoptotic signaling cascade involving cytochrome c , caspase 9 , caspase 3 and degradation of tau protein ; such activation was markedly reduced with 10 microM MG 132 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Here we demonstrated for the first time the feasibility to express a short functional peptide in mammalian cells that abrogates the apoptosis cascade through interference with the proteolytic activity of the initiator caspase 9 and the executing caspase 3 enzymes . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Siglec 8 crosslinking induced rapid cleavage of caspase 3 , caspase 8 , and caspase 9 in eosinophils . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
BPA activated caspase 9 and caspase 3 , suggesting induction of apoptosis via caspase activation by the caspase recruitment domain . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of the apoptosis by TRAIL and radiation was shown by activation of caspase 9 , caspase 8 , caspase 3 , and poly ( ADP ribose ) polymerase and increased DNA sub G ( 1 ) accumulation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Similarly , the extent of caspase 9 and caspase 3 activation in paclitaxel NU 6140 treated cells was approximately 4 fold higher than after the paclitaxel purvalanol A combination . ^^^ A synergistic effect of the paclitaxel NU 6140 combination , as a consequence of survivin inhibition and increased activation of caspase 9 and caspase 3 , was also observed in OAW42 / e ovarian cancer line but not in the derived OAW42 / Surv subline ectopically expressing survivin . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Analysis of the caspase cascade demonstrated that activation of caspase 9 preceded activation of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The number of apoptotic cells in lung sections was determined by a TUNEL method . mRNAs for Fas , FasL and caspase 8 , and for Bad , Bax , Bcl w , Bcl xL and caspase 9 , for the FasL and the mitochondrial cytochrome c pathways of apoptosis , respectively , and mRNA for the effector caspase 3 were quantified in lung tissues by RT PCR . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Stretch induced apoptosis was modulated by inhibition of caspase 3 and to a lesser extent by caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The aim of this study was to determine whether heat shock pretreatment exerts a protective effect against hydrogen peroxide ( H2O2 ) induced apoptotic cell death in neonatal rat cardiomyocytes and C2C12 myogenic cells and whether such protection is associated with decreased release of second mitochondria derived activator of caspase direct IAP binding protein with low pl ( where IAP is inhibitor of apoptosis protein ) ( Smac / DIABLO ) from mitochondria and the activation of caspase 9 and caspase 3 . ^^^ Caspase 9 and caspase 3 activities were assayed by caspase colorimetric assay kit and Western analysis . ^^^ The release of Smac / DIABLO from mitochondria to cytoplasm was observed by Western blot and indirect immunofluorescence analysis . ( 1 ) H2O2 ( 0 . 5 mmol / L ) exposure induced apoptosis in neonatal rat cardiomyocytes and C2C12 myogenic cells , with a marked release of Smac / DIABLO from mitochondria into cytoplasm and activation of caspase 9 and caspase 3 , ( 2 ) heat shock pretreatment induced expression of Hsp 70 , Hsp 90 , and alphaB crystallin and inhibited H2O2 mediated Smac / DIABLO release from mitochondria , the activation of caspase 9 , caspase 3 , and subsequent apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Enzymatic digestion of florigenic biosubstrate assessed the catalytic activity of caspase proteases , including caspase 3 , caspase 8 , and caspase 9 . ^^^ The catalytic activity of caspase 3 and caspase 9 was significantly increased and was accompanied by cytosolic release of cytochrome c and MPT in response to mitomycin C . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 activation was observed in MCF 7 and MDA MB 468 human breast cancer cell lines on treatment with Ado / EHNA or dAdo / EHNA , but , as expected , caspase 3 activation was only observed in MDA MB 468 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 and caspase 3 were activated in caspase 1alpha overexpressing A 2780 cells , suggesting involvement of an intrinsic apoptotic pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Specific inhibitors of caspase 3 and caspase 9 prevented the apoptotic process induced by skullcapflavone 1 . ^^^ From these results , skullcapflavone 1 from S . baicalensis selectively induced apoptosis in T HSC / Cl 6 cells via caspase 3 and caspase 9 activation . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This apoptosis was prevented with pancaspase or caspase 3 or caspase 9 inhibitors . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The caspase 3 or 8 inhibitor reduced the pro apoptotic effect of the PI 3 K inhibitors for Fas mediated apoptosis in HL 60 cells , but the caspase 9 inhibitor did not . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , melatonin treatment diminished cytochrome c release from mitochondria and reduced caspase 3 and caspase 9 activation induced by hyperhomocysteinemia . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These sensitive cells showed an increased Bax and PUMA transcription , altered mitochondrial membrane potential , followed by the release of cytochrome c , and cleaved caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Human immunodeficiency virus type 1 viral protein R ( Vpr ) is required for viral pathogenesis and has been implicated in T cell apoptosis through its activation of caspase 3 and caspase 9 and perturbation of mitochondrial membrane potential . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
That protection results in a significant reduction of caspase 3 activity induced by staurosporine which by its turn seems to result from a protection observed in the membrane receptor pathway ( caspase 8 ) together with a protection observed in the mitochondrial pathway ( caspase 9 ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cadmium chloride stimulated three major mitogen activated protein kinases ( MAPKs ) : extracellular signal regulated kinase ( ERK ) , c Jun N terminal kinase ( JNK ) , and p 38 , and led apoptotic pathway via caspase 9 and caspase 3 activations . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The aortas were placed in gluteraldehyde for subsequent transmission electron microscopy , Bouin ' s solution for TUNEL , or paraformaldehyde for immunohistochemical staining for caspase 9 , caspase 3 , and Bid . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Finally , caspase 9 and caspase 3 were activated in the absence of caspase 8 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The up regulation of death receptors and inhibition of cFLIP by HDAC inhibitors will increase the ability of TRAIL to induce apoptosis , due to enhance activation of caspase 8 , cleavage of Bid , and release of mitochondrial proteins to the cytosol , and subsequent activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Guggulsterone treatment resulted in cleavage ( activation ) of caspase 9 , caspase 8 , and caspase 3 , and guggulsterone induced cell death was significantly attenuated in the presence of general caspase inhibitor as well as specific inhibitors of caspase 9 and caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
PVL induced apoptosis was associated with a rapid disruption of mitochondrial homeostasis and activation of caspase 9 and caspase 3 , suggesting that PVL induced apoptosis is preferentially mediated by the mitochondrial pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
RECENT FINDINGS : Studies have shown that caspase 9 and caspase 3 are key mediators of hair cell death induced by noise , aminoglycosides , and cisplatin . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 9 cleaves and activates effector caspases , mainly caspase 3 , leading to the demise of the cell . ^^^ Prevention of Ser 144 phosphorylation by inhibition of PKCzeta or mutation of caspase 9 promotes caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Smac enhanced activation of caspase 2 , caspase 3 , caspase 8 , and caspase 9 , loss of mitochondrial membrane potential , and cytochrome c release on gamma irradiation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Treatment of apigenin significantly induced caspase 3 , 7 , 10 and caspase 9 activity ( 160 209 % and 203 270 % ) in a dose dependent manner . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In the present study , we investigated the molecular mechanisms of atRA induced apoptosis and its putative action pathway . atRA induced apoptosis is associated with activation of the initiator caspase 9 and the effector caspase 3 , but not of the effector caspase 8 . ^^^ A broad caspase inhibitor ( z VAD fmk ) , caspase 9 inhibitor z LEHD fmk and caspase 3 inhibitor ( z DEVD fmk ) blocked atRA induced DNA fragmentation and sub G 1 fraction , but not caspase 8 inhibitor z IETD fmk . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
With U 937 , MCF 7 ( caspase 3 deficient ) , MCF 7 / c3 cells ( stably transfected with caspase 3 ) , we demonstrate that caspase 3 is essential for caspase 9 , 7 , 8 activation , for Bid degradation mediating mitochondrial cytochrome c release , for cleavage of poly ( ADP ribose ) polymerase and inhibitor of the caspase activated deoxyribonuclease , and , at least in part , for internucleosomal DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Our data also demonstrated that activation of caspase 3 was accompanied with activation of caspase 9 and mitochondrial dysfunction , which was also apparently suppressed by pretreatment with p 38 kinase inhibitors . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Celecoxib caused a significant increase of apoptosis and activation of caspase 3 and caspase 9 in both cells . ^^^ CONCLUSION : The present study showed that celecoxib causes COX 2 dependent and COX 2 independent growth inhibition of hepatocellular carcinoma cells and xenografts by ( a ) decreased retinoblastoma phosphorylation and DP1 / E2F1 complex ; ( b ) increased activation of caspase 3 and caspase 9 ; and ( c ) increased expression of proliferator activated receptor gamma . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Platelets express , among others , initiator caspase 9 and effector caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Experiments with caspase inhibitors confirmed the participation of caspase 3 and caspase 9 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Cell cycle characteristics , DNA fragmentation , p 53 and p 21 ( WAF1 / CIP1 ) expression , caspase 3 and caspase 9 activity , cytochrome c release from mitochondria during cell death induction by the taxanes paclitaxel and docetaxel in highly sensitive MDA MB 435 and highly resistant NCI ADR RES human breast cancer cells were compared . ^^^ The activity of the executioner caspase 3 increased significantly ( 2 to 2 . 5 fold ) and , similarly , the activity of caspase 9 increased significantly ( 2 to 3 . 5 fold ) in both cell types . ^^^ CONCLUSION : The death induced by the taxanes in the studied breast cancer cells can be characterized as an apoptosis like death , including caspase 3 and caspase 9 activation but not oligonucleosomal DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cerebral I / R induced internucleosomal DNA fragmentation , caspase 8 , caspase 9 , and caspase 3 activation , and cytochrome c release were reduced by TMP treatment . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We were also able to demonstrate HNE induced release of cytochrome c from mitochondria , caspase 9 , and caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Although the mitochondrial transmembrane potential collapsed , neither cytosolic translocation of mitochondrial cytochrome c nor activation of caspase 9 , caspase 8 , caspase 3 , and poly ( ADP ribose ) polymerase were found . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Baicalein also inhibited caspase 9 and caspase 3 activation , which can be triggered by mitochondrial malfunctions . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 and caspase 9 activity was lower in Klotho treated HUVEC than in control cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , erythropoietin diminished markers of apoptosis in MN9D cells , including caspase 9 and caspase 3 activation and internucleosomal DNA fragmentation , suggesting that erythropoietin interferes with the apoptosis execution process . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Besides , ellipticine also initiated mitochondrial apoptotic pathway through regulation of Bcl 2 family proteins expression , alteration of mitochondrial membrane potential ( DeltaPsim ) , and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Ad COX 1 / PGIS transfection was found to reduce the adriamycin stimulated activities of caspase 3 and caspase 9 , inhibit adriamycin induced release of cytochrome c , elevate the expression of Bcl 10 ( L ) , and suppress the activation and translocation of nuclear factor kappaB ( NF kappaB ) in adriamycin treated renal tubular cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
It is assumed that the Apaf 1 caspase 9 apoptosome processes caspase 7 in an analogous manner to that described for caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cytochrome c in turn activated caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , The caspase 9 specific inhibitor ( Z LEHD FMK ) could not counteract the synergistic effect of TRAIL induced apoptosis in combination with E1A , and caspase 3 activation and cleavage were not inhibited by Z LEHD FMK . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Treatment with the p 38 MAPK inhibitor , SB 203580 , or the overexpression of kinase inactive p 38 MAPK , induced an attenuation of T . vaginalis induced apoptosis but not cytochrome c release , the activation of caspase 9 and caspase 3 , or PARP cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
To clarify the controversy concerning whether the cell death of motor neurons in ALS is apoptosis , we investigated the expression of Apaf 1 and caspase 9 mRNA in spinal cord tissue obained at autopsy from patients with ALS and controls using RT PCR ; the presence of in situ nuclear DNA fragmentation in motor neurons by the TdT mediated dUTP biotin nick end labeling ( TUNEL ) method ; and immunocytochemical localization of Apaf 1 and caspase 3 , which are known as promotors of apoptotic processes . ^^^ Although Apaf 1 and caspase 9 mRNAs levels were increased in ALS , Apaf 1 immunoreactivity ( IR ) showed no significant difference between ALS and the control , and caspase 3 IR was not observed in ALS motoneurons , casting doubt on the notion that motor neurons in ALS undergo death by the classic apoptotic pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This was shown in comparison to cells containing the wild type MT 3 sequence and blank vector controls as regards the % of DAPI stained fragmented nuclei , DNA laddering , LDH release , caspase 9 , and caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
SNAP , an NO donor , induces apoptosis in these cells because it 1 ) increases the p 53 and 2 ) induces cytochrome c release and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Alisol B acetate induced Bax up regulation and nuclear translocation ; it also induced the activation of initiator caspase 8 and caspase 9 , and executor caspase 3 , suggesting the involvement of both extrinsic and intrinsic apoptosis pathways . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
RRR gamma tocopherol treatment resulted in cleavage of PARP , caspase 3 , 7 , and 8 , but not caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The phosphorylated Akt and activated fragments of caspase 9 , caspase 3 were examined by Western blotting analysis . ^^^ Western blotting analysis showed remarkable activation of caspase 9 , caspase 3 and dephosphorylation of Akt ( Thr ( 308 ) ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , unlike Z VAD fmk , Ac LEHD CHO did not inhibit caspase 3 activation in alphaFas treated mice , although this inhibitor attenuated caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The FLJ 21908 protein induces apoptosis through activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
According to our model , activation of caspase 3 by caspase 9 in thymocytes occurs both directly as well as indirectly via a lysosomal amplification loop . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both PUNI and EA provoked the same effects on Caco 2 cells : down regulation of cyclins A and B 1 and upregulation of cyclin E , cell cycle arrest in S phase , induction of apoptosis via intrinsic pathway ( FAS independent , caspase 8 independent ) through bcl XL down regulation with mitochondrial release of cytochrome c into the cytosol , activation of initiator caspase 9 and effector caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Release of cytochrome c from mitochondria triggered the activation of caspase 9 and the subsequent activation of the executioner caspase , caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The increased apoptosis was best observed when UDCA was present after SN 38 stimulation and was independent of caspase 8 but dependent on caspase 9 and caspase 3 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , trimidox induced apoptosis was prevented by a broad spectrum caspase inhibitor , a caspase 3 , and a caspase 9 inhibitor , but not by a caspase 8 inhibitor . ^^^ This report shows that the induction of apoptosis by trimidox occurs through a cytochrome c dependent pathway , which sequentially activates caspase 3 and caspase 9 . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
OxLDL induced Saos 2 cell death with morphological features of apoptosis that was inhibited mainly by caspase 9 and partially by caspase 3 but not by caspase 8 inhibitors . nLDL , like oxLDL , has induced cell death , where 60 % ( P = 0 . 00033 ) and 30 % ( P = 0 . 075 , ns ) of the cell death , respectively , could be inhibited by scyphostatin ( a neutral sphingomyelinase [ nSMase ] inhibitor ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The evidence clearly points to T . gondii targeting multiple steps in the transmission [ inhibition of c Jun N terminal kinase ( JNK ) activation in response to UV ] , triggering ( inhibition of cytochrome c release by affecting the balance of pro and anti apoptotic BCL 2 family members ) and execution ( inhibition of caspase 9 and caspase 3 ) phases of the apoptotic cascade . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Brucine induced HepG 2 cell apoptosis was caspase dependent , with caspase 3 activated by caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We also observed activation of caspase 9 and caspase 3 , DNA ladder formation , proteolytic degradation of poly ( ADP ribose ) polymerase ( PARP ) , and selective down regulation of cIAP 1 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Studies using antioxidants and specific caspase inhibitors indicated that activation of caspase 8 , but not caspase 9 , mediates ROS dependent caspase 3 activation and suggested that ROS from NADPH oxidase activate caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Extracellular adenosine , thus , appears to activate caspase 9 followed by the effector caspase , caspase 3 , at least via two independent pathways linked to A ( 1 ) adenosine receptor mediated adenylate cyclase inhibition and adenosine uptake into cells / conversion to AMP / activation of AMPK , possibly regardless of mitochondrial damage , thereby leading to RCR 1 cell death , dominantly by apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
A specific caspase assay reveals an increase in caspase 9 and caspase 3 activity but no change in caspase 8 activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Mechanistic studies demonstrated a strong caspase 9 , caspase 3 and poly ( ADP ribose ) polymerase ( PARP ) cleavages by GA in DU 145 cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Plasminogen treatment also markedly reduced internucleosomal DNA fragmentation and reduced levels of active caspase 3 , caspase 8 , and caspase 9 induced by TNFalpha or by cycloheximide . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Vpr increased the activity of caspase 3 and caspase 9 , but not of caspase 8 . ^^^ Moreover , Vpr induced apoptosis could be inhibited by inhibitors of caspase 3 and caspase 9 , but not by inhibitor of caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 3 activity increased with the magnitude of the compressive force , and this effect was reduced significantly by a caspase 8 inhibitor , whereas a caspase 9 inhibitor had no such effect . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Moreover , whereas initially only caspase 1 is involved in caspase 3 activation , later on caspase 9 seems also to participate . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Developmental apoptosis in the GCL between P 2 and P 6 was shown to involve caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Berberine also significantly ( P < 0 . 05 0 . 001 ) enhanced apoptosis of DU 145 and LNCaP cells with induction of a higher ratio of Bax / Bcl 2 proteins , disruption of mitochondrial membrane potential , and activation of caspase 9 , caspase 3 , and poly ( ADP ribose ) polymerase . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Consequently , a loss of mitochondrial membrane potential and the release of cytochrome c lead to the activation of caspase 9 and , subsequently , caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cytochrome c release contributes to caspase activation , such as caspase 9 , caspase 6 , and caspase 3 , which results in the degradation of numerous nuclear proteins including poly ( ADP ribose ) polymerase ( PARP ) , which subsequently leads to the internucleosomal cleavage of DNA , resulting cell death . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Treatment of the neurons with taurine , a caspase 9 specific inhibitor , could prevent the amphiphile induced apoptotic cell death , suggesting that formation of apoptosome , followed by caspase 9 and caspase 3 activation , might play a critical role in the neuronal death pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Isoliquiritigenin dose dependently increased the levels of cleaved caspase 9 , caspase 7 , caspase 3 and poly ( ADP ribose ) polymerase ( P < . 05 ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The expression of caspase 9 , caspase 8 , caspase 3 and poly ( ADP ribose ) polymerase ( PARP ) was assessed by Western blot analysis . ^^^ Caffeine at concentrations higher than 100 microM significantly increased cleaved caspase 9 , caspase 3 and PARP expression in HUVECs at 24 h treatment compared with untreated cultures , whereas 30 microM caffeine significantly increased only caspase 3 expression at 24 h . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis was induced by 4 oxo 4 HPR in both 4 HPR sensitive and 4 HPR resistant cells and involved activation of caspase 3 and caspase 9 but not caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Treatment with FME caused induction of caspase 2 , caspase 3 , caspase 6 , caspase 8 , and caspase 9 activity in a time dependent manner , but not affect caspase 1 activity ; it induced the proteolysis of DNA fragmentation factor ( DFF 45 ) and poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The data show that administration of 7 NINA , an nNOS inhibitor , prevented the hypoxia induced increase in caspase 9 activity that leads to increase in caspase 3 activity . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The sensitization of these cells by SAHA was accompanied by activation of caspase 8 , caspase 9 and caspase 3 and was concomitant with Bid and PARP cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Growth arrest and apoptosis via caspase 3 and caspase 9 activities were demonstrated in SARS CoV 3CLpro expressing human promonocyte cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Here we demonstrate that a lack of expression of Oct 3 / 4 in TGCT cells is associated with a higher apoptotic threshold and cisplatin resistance which is accompanied by an impaired caspase 9 activation , reduced caspase 3 activity and altered p 53 accumulation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , the activities of caspase 9 and caspase 3 were also enhanced in a time dependent manner upon treatment with the isoflavonoids 2 , 3 , and 4 . ^^^ Caspase 9 and caspase 3 inhibitors suppressed apoptosis induced by isoflavonoids 2 , 3 , and 4 . ^^^ These results suggest that the isoflavonoids induced apoptosis in HL 60 cells through activation of the caspase 9 / caspase 3 pathway , which is triggered by mitochondrial dysfunction . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The protein expressions of Cbfa 1 , Bax , Bcl 2 , caspase 3 , and caspase 9 , cytochrome C and TNF alpha were determined by Western immunoblot . ^^^ RESULTS : After the transient transfection with the two isforms of Cbfa 1 , MBA 1 , the cells apoptotic rates increased , and the ratio of Bax / Bcl 2 , the expressions of cytochrome C , caspase 3 , caspase 9 , and TNF alpha were significantly increased . ^^^ Bax / Bcl 2 , cytochrome C , caspase 9 , caspase 3 , and TNF alpha are also involved in the apoptosis pathway . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , the loss of mitochondrial membrane potential coincident with the release of cytochrome c from the mitochondria into the cytosol led to a rapid activation of caspase 9 and caspase 3 ( an executioner ) , indicating that the selective damage to the mitochondria by HAL PDT can induce a cytochrome c mediated apoptotic response in the 320DM cells . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
ATRA mediated apoptosis in CHP 134 and NB 39 nu cells was associated with a significant activation of caspase 9 and caspase 3 as well as cytoplasmic release of cytochrome c from mitochondria in a p 53 independent manner . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Using cultured neurospheres from PPT 1 KO and wild type mouse fetuses , we further demonstrate that the levels of ROS , SOD 2 , cleaved caspase 9 , activated caspase 3 and cleaved PARP are elevated . ^^^ We propose that : ( 1 ) ER stress due to PPT 1 deficiency increases ROS and disrupts calcium homeostasis activating caspase 9 and ( 2 ) caspase 9 activation mediates caspase 3 activation and apoptosis contributing to rapid neurodegeneration in INCL . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Although no difference was observed in the phosphorylation of p 53 at serine 15 residue site by etoposide between the GM 3 reconstituted cells and mock transfected cells , the activation of both caspase 3 and caspase 9 was specifically inhibited in the former . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase activity assay showed that our peptide successfully increased the activity of caspase 3 and caspase 9 in etoposide induced apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Enhanced induction of apoptosis of the cells by the combined treatment was mediated by loss of mitochondrial membrane potential , which resulted in the activation of caspase 8 , caspase 9 , and caspase 3 accompanied by cytochrome c release and Bid cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of apoptosis by Ad / TRAIL F / RGD plus radiotherapy was demonstrated by activation of caspase 9 , caspase 8 , and caspase 3 and cleaved poly ( adenosine diphosphate ribose ) polymerase in vitro and TUNEL assay in vivo . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Mitochondrial regulation of apoptosis further downstream of Bax was investigated , showing change in the mitochondrial membrane potential , cytochrome c release into the cytosol , and enhanced caspase 9 and caspase 3 activities . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
H2O2 treated cells showed apoptotic features , such as activation of caspase 9 and caspase 3 , nuclear fragmentation , and DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We further demonstrated that the release of mitochondrial proteins and the activation of calpains occurred upstream of the caspase cascade , in which caspase 9 was activated in response to the release of Cyt c , that caspase 8 activation was caspase and calpain dependent , and that caspase 3 was activated mainly by caspase 8 and 9 . ^^^ Caspase 8 played important roles in the activation of caspase 3 and induction of apoptosis , whereas the role of the caspase 9 was limited . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Western blot analyses showed an increase in activities of calpain and caspase 12 , upregulation of Bax : Bcl 2 ratio , release of cytochrome c from mitochondria , and increase in caspase 9 and caspase 3 activities during apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
We studied SCLC apoptosis and necrosis during ADCC and the activity and cleavage of caspase 3 , caspase 9 , and poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Treatment of T 24 cells with beta lapachone resulted in a down regulation of Bcl 2 expression and up regulation of Bax expression . beta lapachone induced apoptosis was also associated with activation of caspase 3 and caspase 9 , inhibition of IAP expression , and degradation of poly ( ADP ribose ) polymerase , phospholipase C gamma 1 and beta catenin proteins . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In vitro incubation experiments showed that MGO modified Hsp 27 reduced the activity of caspase 9 , and MGO modified pHsp 27 reduced activities of both caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Caspase 2 inhibitors or antisense silencing of caspase 2 prevented cell death induced by resveratrol and partially prevented processing of downstream caspases , including caspase 9 , caspase 3 , and caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Similarly , although cytochrome c was released from mitochondria following heat shock , functional Apaf 1 . caspase 9 apoptosome complexes were not formed , and caspase 9 was not essential for the activation of caspase 3 or the induction of apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cytochrome c finally triggered apoptosis by activating caspase 9 and caspase 3 in apoptotic cascade . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
However , increased caspase 3 activity by estradiol was observed in the presence of caspase 9 inhibitor , indicating the preferential involvement of caspase 8 pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Nevertheless , TNF RI DeltaTRID , though lacking a DISC , still allows for residual activation of caspase 3 followed by cell death , although caspase 9 activation was not detected . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Bax activation , release of cytochrome c , and activation of caspase 9 and caspase 3 all correlated with the observed cell death responses of wild type or capn 4 ( / ) MEFs to the various challenges , suggesting that calpain might play distinct roles in transducing different death signals to the mitochondria . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
HI induced a marked increase in activated caspase 9 , caspase 3 and PARP cleavage at 12 h to 7 days after HI in brain areas displaying TUNEL ( + ) cells . ^^^ FGF 1 attenuated the HI induced increase in activated caspase 3 , caspase 9 and cleaved PARP protein levels and markedly blocked the HI induced decrease in XIAP expression under the conditions at which FGF 1 showed significant neuroprotection . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , both caspase 9 and caspase 3 were also time dependently activated upon treatment with the alkaloids . ^^^ Caspase 9 and caspase 3 inhibitors suppressed apoptosis induced by these alkaloids . ^^^ The results suggest that these three alkaloids induced apoptosis in HL 60 cells through activation of the caspase 9 / caspase 3 pathway , through mitochondrial dysfunction . . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , Hcy increased cytochrome c release into the cytosol , and activated caspase 9 and caspase 3 , but not caspase 8 , indicating that Hcy induces apoptosis via the mitochondria pathway . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Finally , the caspase 9 active fragment was increased significantly in both Hend and IMR 90 cells ; however , only Hend cells showed caspase 8 and caspase 3 activation with DNA fragmentation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , PAF inhibited etoposide induced increases in caspase 3 , caspase 8 , and caspase 9 activities , as well as cell death . p50 / p65 heterodimer increased the mRNA expression of Bcl 2 and Bcl xL and decreased etoposide induced caspase activities and cell death . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Both HA and RES induced cleavage of caspase 9 and caspase 3 and PARP were completely blocked by a pan caspase inhibitor , Z VAD FMK . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These changes were associated with elevation of oxidative stress , decreases of mitochondrial Bcl 2 and cytochrome c proteins , increases of cytosolic Bax and cytochrome c proteins , caspase 9 and caspase 3 activities and myocyte apoptosis , and downregulation of beta adrenergic receptor sensitivity and SR Ca2+ ATPase . ^^^ Combined treatment with vitamins C and E diminished oxidative stress , increased mitochondrial Bcl 2 protein , decreased cytosolic Bax , prevented cytochrome c release from mitochondria to cytosol , reduced caspase 9 and caspase 3 activities and myocyte apoptosis , blocked beta adrenergic receptor desensitization and SR Ca2+ ATPase downregulation , and attenuated LV dilation and dysfunction in HF after MI . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The expression of Bax , Bcl 2 , caspase 3 and caspase 9 was regulated differently with aging between muscle types and in a manner not consistent with mitochondria mediated apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
They showed early mitochondrial swelling , loss of mitochondrial membrane potential and cytoplasmic release of cytochrome c , followed by activation of caspase 9 , and by caspase 9 dependent activation of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis inhibition correlated with blockade of mitochondrial cytochrome c release , abolition of caspase 3 activity along with inhibition of caspase 9 and PARP cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Blockade of NFkappaB with AdIkappaBalpha , an IkappaBalpha dominant negative overexpressing adenovirus , prevented activation of caspase 9 ( more than that caspase 3 ) but did not affect cell death in hyperosmotically stressed cardiomyocytes . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : Apoptosis was determined using TUNEL ( terminal deoxynucleotidyl transferase biotin dUTP nick end labeling ) assay and p 53 , p 27 , Bax , caspase 3 , caspase 8 , caspase 9 , Fas L , Bcl 2 , GATA 4 , Ki 67 , proliferating cell nuclear antigen ( PCNA ) , estrogen receptor , P receptor , and androgen receptor expression by immunohistochemistry . ^^^ DNA fragmentation and expression of Bax , caspase 3 , caspase 8 , caspase 9 , Fas L , Bcl 2 , GATA 4 , Ki 67 , and PCNA were observed in the whole ovary in both groups . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
GSE induced anoikis and apoptosis were accompanied by a strong decrease in focal adhesion kinase levels , but an increase in caspase 3 , caspase 9 , and poly ( ADP ribose ) polymerase cleavage ; however , GSE caused both caspase dependent and caspase independent apoptosis as evidenced by cytochrome c and apoptosis inducing factor release into cytosol . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cells treated with 50 microM H2O2 exhibited caspase 9 and caspase 3 activation , finally leading to apoptotic cell death . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The apoptotic AM were characterized by decreased mitochondrial trans membrane potential , increased mitochondrial release of cytochrome c , activated caspase 9 ( but not caspase 8 ) and caspase 3 activities , and PARP degradation , comparing to cells from the saline control . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
From a mechanistic standpoint , cannabidiol exposure resulted in activation of caspase 8 , caspase 9 , and caspase 3 , cleavage of poly ( ADP ribose ) polymerase , and a decrease in full length Bid , suggesting possible cross talk between the intrinsic and extrinsic apoptotic pathways . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
OBJECTIVE : To analyze the expression and role of three proteins ( HSP 110 , caspase 3 and caspase 9 ) during craniofacial development . ^^^ Slide staining occurred alternatively using anti Hsp 110 , anti caspase 3 and anti caspase 9 immunohistochemistry . ^^^ RESULTS : Expression of HSP 110 , caspase 3 and caspase 9 was found in cells of well known locations of programmed cell death . ^^^ Quantification of positive cells shows that caspase 9 and Hsp 110 were expressed before caspase 3 . ^^^ Caspase 3 positive cells were more numerous than caspase 9 positive cells especially in mesectodermal irradiation induced apoptotic cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
With the increased Bax : Bcl 2 ratio , cytochrome c was released from mitochondria to cytosol for sequential activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Using immunoblot analyses , we further demonstrate that doppel expression activates caspase 10 as well as caspase 3 , but does not activate caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Instead , decrease in the content of Apaf 1 and caspase 3 and some degradation of caspase 9 during brain ageing were observed . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
MK 801 treatment did not modify the activity of caspase 8 at any age , but decreased caspase 9 activity at P 8 and increased the activity of caspase 1 ( 76 % ) at P 8 , caspase 3 ( 160 % ) at P 16 and caspase 9 ( 50 % ) at P 12 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
There was no significant difference in the cleavage of caspase 3 or caspase 9 detected by Western blotting of hippocampal samples from transgenic or wild type mice after TBI . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Higher levels of inactivated caspase 9 in PAI 1 / EC led to lower levels of procaspase 3 and cleaved caspase 3 , thereby promoting survival . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
A number of pro apoptotic stimuli induce the activation of caspase 9 , an initiator protease that activates executioner caspases , such as caspase 3 , leading to the development of programmed cell death . ^^^ The early caspase 3 activation occurs within 1 min of stimulation and is independent on caspase 9 or mitochondrial cytochrome c release suggesting that is a non apoptotic event . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Furthermore , the appearance of the active proteolytic subunits of caspase 3 and caspase 9 were detected in cell lysate from THP 1 cells and also increased in a dose and time dependent manner following pioglitazone treatment . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
VA 13 cells incubated with ethanol appears to be mediated by release of mitochondrial cytochrome c via activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
CCL 5 induced cell death involves the cytosolic release of cytochrome c , the activation of caspase 9 and caspase 3 , and poly ( ADP ribose ) polymerase cleavage . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Our results show that LCL 30 is highly cytotoxic to SW 403 cells ( and other cancer cell lines ) and preferentially accumulates in mitochondria , resulting in a decrease of the mitochondrial membrane potential , release of mitochondrial cytochrome c , and activation of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Low MOI reduced mitochondrial membrane depolarization , caspase 3 and caspase 9 activation , and cytochrome c release and increased Bcl 2 levels . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In contrast to the cells transfected with wild type survivin , or the control NSCLC 3 / neo , those cells transfected with mutant survivin and treated with SN 38 > PS 341 exhibited enhanced caspase 9 activity ( > 2 fold ) , caspase 3 ( > 2 to 3 fold ) activity and cytotoxicity compared to the NSCLC 3 / neo cells . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
RESULTS : Proteasome 20S activity was reduced in PBLs of treated PD patients vs healthy controls ( mean + / SEM : 1 . 0 + / 0 . 1 vs 2 . 3 + / 0 . 2 nmol 7 amino 4 methylcoumarin ( AMC ) / 10 ( 6 ) cells , p < 0 . 001 ) , whereas marked increases in caspase 3 activity ( 1370 + / 153 vs 586 + / 104 pmol AMC / 10 ( 6 ) cells , p < 0 . 001 ) and caspase 9 activity ( 873 + / 86 vs 304 + / 27 U / 10 ( 6 ) cells , p < 0 . 001 ) were found . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , we describe early activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Following DNA damage , resveratrol led to an activation of caspases 2 and 8 / 10 at 6h and consequently of caspase 3 at 12h , but failed to activate caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apigenin induced apoptosis was mediated by the activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In addition , we found that overexpression of Hsp105alpha or Hsp105beta suppressed the activation of caspase 3 and caspase 9 by preventing the release of cytochrome c from mitochondria . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
On addition of either orexin ( 10 ( 6 ) m ) for 48 h , apoptosis was demonstrated by DNA fragmentation , chromatin condensation , annexin 5 binding , and activation of caspase 3 and caspase 9 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The expression of cytosolic cytochrome c and activated caspase 9 and caspase 3 was significantly increased whereas the expression of mitochondrial cytochrome c significantly decreased in I / R with GdCl 3 in comparison to the control . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The apoptosis triggering concentration of NGEN was shown to markedly promote the activation of caspase 3 , and slightly promote that of caspase 9 , but had no effect on caspase 8 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
In cell free systems supplemented with ATP caspase 9 activation is induced by addition of cytochrome c and we show that in this process PP1alpha is indispensable for triggering caspase 9 as well as caspase 3 cleavage and activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Cotreatment with 15d PGJ ( 2 ) and TRAIL enhanced the sequential activation of caspase 8 , caspase 10 , caspase 9 , caspase 3 , and Bid . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Selenite and TRAIL combined treatment led to synergistic increases of Bax abundance and translocation into mitochondria , loss of mitochondrial membrane potential , cytochrome c release , and cleavage activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These events are associated with increased activity of major initiator ( caspase 9 ) and effector ( caspase 3 ) caspases . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Troglitazone inhibited the growth of human cholangiocarcinoma cell lines by inducing apoptosis and by cell cycle regulation ( G 1 arrest ) , and this was associated with caspase 3 and caspase 9 activation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
This was followed by the release of cytochrome c into the cytoplasm and a substantial increase in the activities of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activation of caspase 9 and caspase 3 was detected in generation of 35 kD and 20 kD active fragments , respectively . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Dying cells were only weakly positive for phosphatidyl serine and showed only a transient activation of caspase 9 with no signs of activation of caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Also , IVC loading in the LNZ led to a 276 . 0 + / 36 . 0 % and 85 . 8 + / 25 . 1 % ( P < 0 . 05 ) increase in the cleavage of caspase 3 and caspase 9 , respectively , with no effect on these molecules in the OSXZ . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
ECs undergo apoptosis associated with increased LEHDase ( caspase 9 ) and DEVDase ( caspase 3 ) activity and DNA fragmentation after 24h of serum deprivation . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Apoptosis induced by 3 microm NMDA was caspase 3 but not caspase 9 mediated . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
Activity of caspases 3 , 8 , and 9 ( measured by specific fluorogenic peptide substrates and immunohistochemistry ) increased progressively , particularly with the onset of myocardial dysfunction ( caspase 3 7 . 92 + / 1 . 19 vs . 1 . 00 + / 0 . 15 , caspase 8 1 . 94 + / 0 . 21 vs . 1 . 00 + / 0 . 04 , caspase 9 5 . 87 + / 0 . 97 vs . 1 . 00 + / 0 . 18 relative fluorescent units , p < 0 . 05 ) . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The critical regulatory step in this process is downstream of the mitochondrion and involves reduced cleavage and activation of caspase 9 and caspase 3 . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
The Ced 3 / interleukin 1beta converting enzyme like homolog Mch 6 and the lamin cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP 32 . ^^^ We demonstrate that the pro enzymes of Mch 6 and the lamin cleaving enzyme Mch2alpha are substrates for mature CPP 32 . ^^^ Site directed mutagenesis revealed that CPP 32 processes pro Mch 6 preferentially at Asp 330 to generate two subunits of molecular masses 37 kDa ( p 37 ) and 10 kDa ( p 10 ) . ^^^ Interestingly , granzyme B can also process pro Mch 6 but at a site N terminal to that cleaved by CPP 32 . ^^^ These data suggest that Mch2alpha and Mch 6 are downstream proteases activated in CPP 32 and granzyme B mediated apoptosis . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
These data suggest that Mch 5 is the most upstream protease that receives the activation signal from the Fas receptor to initiate the apoptotic protease cascade that leads to activation of ICE like proteases ( TX , ICE , and ICE relIII ) , Ced 3 like proteases ( CPP 32 , Mch 2 , Mch 3 , Mch 4 , and Mch 6 ) , and the ICH 1 protease . ^^^
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA
Interacting proteins: P55211 and P42574	Pubmed	SVM Score :0.0
NA