| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| The pancaspase inhibitor ( Z VAD FMK ) and the caspase 9 inhibitor ( Z LEHD FMK ) were able to partially abrogate the apoptotic effects of EB 1089 but did not affect the phosphorylation of p 38 MAP kinase or the suppression of ERK . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| The responsiveness of JNK and ERK to magnolol suggests the involvement of these kinases in the initiation of the apoptosis process . 6 These results indicate that regulation of the Bcl 2 family , accumulation of cytosolic cytochrome c , and activation of caspase 9 and caspase 3 may be the effector mechanisms of magnolol induced apoptosis . . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| There were no detectable increases in ERK expression and caspase 9 cleavage . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| These data indicated that leptin induced hBMSC apoptosis via ERK / cPLA2 / cytochrome c pathway with activation of caspase 9 and caspase 3 , and cleavage of poly ( ADP ribose ) polymerase . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| Serotonin prevents cytochrome c release and caspase 9 and 3 activation after serum deprivation via cross talks between phosphatidylinositol 3 kinase / Akt and extracellular signal regulated kinase ( ERK ) 1 / 2 signaling pathways . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| Inhibition of caspase 9 through phosphorylation at Thr 125 by ERK MAPK . ^^^ Here , we show that the ERK MAPK pathway inhibits caspase 9 activity by direct phosphorylation . ^^^ Caspase 9 is phosphorylated at Thr 125 , a conserved MAPK consensus site targeted by ERK 2 in vitro , in a MEK dependent manner in cells stimulated with epidermal growth factor ( EGF ) or 12 O tetradecanoylphorbol 13 acetate ( TPA ) . ^^^ We suggest that phosphorylation and inhibition of caspase 9 by ERK promotes cell survival during development and tissue homeostasis . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| Consistent with the induction of apoptosis , 15 deoxy PGJ 2 increased the expression of proapoptotic proteins caspase 3 , caspase 9 , and Bax but down regulated antiapoptotic protein Bcl 2 . 15 Deoxy PGJ 2 also activated extracellular signal regulated kinase ( ERK ) 2 . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| However , Bax translocation and caspase 9 activation was unaffected , indicating that down regulation of the ERK activity is specifically required for the phytosphingosine induced caspase 8 dependent cell death pathway . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| The results showed the following : 1 ) PMA can prevent MG induced apoptosis ; 2 ) triggering of this antiapoptotic signal depends on the mitogen activated protein kinase kinase / extracellular signal regulated kinase ( ERK ) pathway ; 3 ) PMA inhibits MG induced activation of caspase 3 and caspase 9 , release of cytochrome c , and decline of mitochondrial membrane potential , but it does not affect MG induced JNK activation ; 4 ) the ERK pathway modulates outer mitochondrial membrane permeability and regulates the mitochondrial death machinery ; and 5 ) activated ERK prevents JNK induced leakage of cytochrome c from isolated mitochondria . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| Moreover , U 0126 and ERK siRNA inhibition completely suppressed asiatic acid induced Bcl 2 phosphorylation and Bax up regulation , and caspase 9 activation . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| Cadmium chloride stimulated three major mitogen activated protein kinases ( MAPKs ) : extracellular signal regulated kinase ( ERK ) , c Jun N terminal kinase ( JNK ) , and p 38 , and led apoptotic pathway via caspase 9 and caspase 3 activations . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| Porphyromonas gingivalis related H9c2 cell apoptosis was mainly co activated by p 38 and ERK pathways and may be involved in death receptor dependent ( caspase 8 ) and mitochondria ( caspase 9 ) dependent apoptotic pathways . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| At the cellular level , ischemia hypoxia produced proinflammatory cytokines and simultaneously activated both prosurvival ( eg , synthesis of heat shock 70 protein , phosphorylation of ERK and AKT ) and proapoptosis signaling pathways ( eg , release of cytochrome c and AIF from mitochondria , cleavage of caspase 9 and 8 ) . ^^^ |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55211 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|