| Interacting proteins: P10144 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P55211 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10144 and P55211 |
Pubmed |
SVM Score :0.0 |
| ICE LAP 6 , a novel member of the ICE / Ced 3 gene family , is activated by the cytotoxic T cell protease granzyme B . ^^^ More importantly , ICE LAP 6 is proteolytically processed into an active cysteine protease by granzyme B , an important component of cytotoxic T cell mediated apoptosis . ^^^ |
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| Interacting proteins: P10144 and P55211 |
Pubmed |
SVM Score :0.0 |
| Interestingly , granzyme B can also process pro Mch 6 but at a site N terminal to that cleaved by CPP 32 . ^^^ These data suggest that Mch2alpha and Mch 6 are downstream proteases activated in CPP 32 and granzyme B mediated apoptosis . ^^^ This is the first demonstration of a protease cascade involving granzyme B , CPP 32 , Mch2alpha , and Mch 6 and evidence that the lamin cleaving enzyme Mch 2 is a target of mature CPP32 . . ^^^ |
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| Interacting proteins: P10144 and P55211 |
Pubmed |
SVM Score :0.0 |
| Overexpression of TUCAN in cells by stable or transient transfection inhibits apoptosis and caspase activation induced by Apaf1 / caspase 9 dependent stimuli , including Bax , VP 16 , and staurosporine , but not by Apaf1 / caspase 9 independent stimuli , Fas and granzyme B . ^^^ |
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| Interacting proteins: P10144 and P55211 |
Pubmed |
SVM Score :0.0 |
| Treatment of HL 60 cells with lactacystin , a selective inhibitor of the proteasome , exponentially increased caspase 3 like hydrolytic activity and induced apoptosis but had little or no effect on the activity of upstream caspase 8 , caspase 9 , or granzyme B . ^^^ |
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