Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Overexpression of Bcl 10 ( L ) prevented the processing of caspase 8 as well as caspase 9 , 6 and Bid in response to drugs , but was less effective in CD 95 induced apoptosis . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Despite its lack of response to caspase inhibitors and Bcl 10 ( L ) , we show that this form of cell death is driven by an alternative caspase 9 activity that is Apaf 1 independent . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Bcl 10 ( L ) caspase 9 interactions in the developing nervous system : evidence for multiple death pathways . ^^^ Targeted disruption of bcl 10 ( L ) , an antiapoptotic bcl 2 gene family member , causes massive death of immature neurons in the developing nervous system whereas disruption of caspase 9 , a proapoptotic caspase gene family member , leads to decreased neuronal apoptosis and neurodevelopmental abnormalities . ^^^ To determine whether Bcl 10 ( L ) and Caspase 9 interact in an obligate pathway of neuronal apoptosis , bcl x / caspase 9 double homozygous mutants were generated . ^^^ The increased apoptosis of immature neurons observed in Bcl 10 ( L ) deficient embryos was completely prevented by concomitant Caspase 9 deficiency . ^^^ In contrast , bcl 10 ( / ) / caspase 9 ( / ) embryonic mice exhibited an expanded ventricular zone and neuronal malformations identical to that observed in mice lacking only Caspase 9 . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Cell death is blocked by a dominant negative form of caspase 9 and Bcl 10 ( L ) consistent with a pathway that involves mitochondria . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Furthermore we observed cleavage of both caspase 9 and caspase 8 after overexpression of p 53 and found that p 53 dependent apoptosis was inhibited by either cellular ( c Flip s , Bcl 10 ( L ) ) or pharmacological inhibitors of caspase 8 or caspase 9 respectively . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Bcl 10 ( L ) prevented oxygen deprivation induced cell death by inhibiting the release of cytochrome c and caspase 9 activation . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
EGCG also caused a decrease in the Bcl 2 and Bcl 10 ( L ) proteins , an increase in the Bax protein , and activation of caspase 9 , suggesting that EGCG induces apoptosis via a mitochondrial pathway . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Targeted gene disruptions of members of the bcl 2 and caspase gene families have demonstrated particularly significant roles for bcl 10 , bax , caspase 9 and caspase 3 in mammalian brain development . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl 10 in A 549 lung adenocarcinoma cells . ^^^ Previous studies have demonstrated that several splice variants are derived from both the caspase 9 and Bcl 10 genes in which the Bcl 10 splice variant , Bcl 10 ( L ) and the caspase 9 splice variant , caspase 9b , inhibit apoptosis in contrast to the pro apoptotic splice variants , Bcl 10 ( s ) and caspase 9 . ^^^ In this study , the regulation of the alternative processing of pre mRNA of both caspase 9 and Bcl 10 ( L ) was examined in response to ceramide . ^^^ Treatment of A 549 lung adenocarcinoma cells with cell permeable ceramide , D e C ( 6 ) ceramide , down regulated the levels of Bcl 10 ( L ) and caspase 9b mRNA and immunoreactive protein with a concomitant increase in the mRNA and immunoreactive protein levels of Bcl 10 ( s ) and caspase 9 in a dose and time dependent manner . ^^^ A role for endogenous ceramide in regulating the alternative splicing of caspase 9 and Bcl 10 was demonstrated using the chemotherapeutic agent , gemcitabine . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Bcl 10 ( L ) protected cells from nitric oxide induced apoptosis during hypoxia by preventing the release of cytochrome c , caspase 9 activation , and by maintaining a mitochondrial membrane potential . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Rat1a cells exposed to hyperoxia underwent apoptosis characterized by the release of cytochrome c , activation of caspase 9 , and nuclear fragmentation that was prevented by the overexpression of Bcl 10 ( L . ) Murine embryonic fibroblasts from bax ( / ) bak ( / ) mice were resistant to hyperoxia induced cell death . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
The antiapoptotic protein Bcl 10 ( L ) prevented the anoxia induced cell death by inhibiting the release of cytochrome c and caspase 9 activation . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Furthermore , the increase of p 21 ( Cip1 / Waf1 ) , phosphorylation of Bcl 2 and Bcl 10 ( L ) , activation of caspase 9 and caspase 3 may be the molecular mechanism through which NCTD induces apoptosis . . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Tumor cells with constitutive activation of CK 2 exhibit a high Bcl 10 ( L ) / tBID ratio and fail to activate caspase 9 or undergo apoptosis in response to Apo2L / TRAIL . ^^^ Conversely , reduction of the Bcl 10 ( L ) / tBID ratio by inhibition of CK 2 renders such cancer cells sensitive to Apo2L / TRAIL induced activation of caspase 9 and apoptosis . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
The apoptosis triggered by H 6 was accompanied by up regulation of Bcl 10 ( S ) , accumulation of cytosolic cytochrome c and activation of caspase cascade ( caspase 9 and 3 ) . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
BCR ligation activated mitochondrial apoptotic pathways including down regulation of Bcl 10 ( L ) , dissipation of mitochondrial transmembrane potential , release of cytochrome c , and activation of caspase 9 . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
We detected a decrease in the expression of bcl 2 and bcl 10 ( L ) , two antiapoptotic proteins that decrease mitochondrial membrane permeability , an increase in cytochrome c immunoreactivity in the cytosolic fraction , and an activation of caspase 9 in brain regions which show apoptotic neurodegeneration following percussion brain trauma in 7 day old rats . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Furthermore , it is believed that the apoptosis of osteoclast precursors may be involved in the activation of caspase 9 and that M CSF may promote their survival through Bcl 10 ( L ) induced inhibition of caspase 9 activation . . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
This review focuses on novel strategies to induce apoptosis in glioma cells by transduction with adenoviral vectors carrying a variety of apoptosis related genes , including Fas ligand , Fas , FADD , caspase 8 , p 53 , p33ING1 , p73alpha , Bax , Apaf 1 , caspase 9 , IkappaBdN , caspase 3 , Bcl 2 , and Bcl 10 ( L ) . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
CONCLUSION : Decreased proapoptotic Bcl 10 ( S ) and increased antiapoptotic Bcl 10 ( L ) , as well as decreased downstream proapoptotic caspase 9 expression , during liver ischemia after treatment with rATG , all favor cell survival . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Bcl 10 ( L ) expression delays , but does not totally block , the release of mitochondrial cytochrome c ( cyt c ) in these cells in response to TNFalpha induced apoptosis and caspase 9 is processed prior to mitochondrial cyt c release under these circumstances . ^^^ A caspase 9 specific inhibitor was more effective in delaying the progression of apoptosis in the FL5 . 12 Bcl 10 ( L ) cells than was an inhibitor specific to caspase 3 . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Reduced beta cell apoptosis resulted from elevated Bcl 2 and Bcl 10 ( L ) activity and diminished caspase 9 activity , indicating a novel role for a mitochondrial dependent pathway of beta cell death . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
In addition , ectopic expression of mitochondrial antiapoptotic Bcl 2 , Bcl 10 ( L ) , or inactive caspase 9 short form suppressed DeltaTau 1 toxicity . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Furthermore , we showed that release of mitochondrial cytochrome c , cleavage of caspase 9 and PARP during apoptosis in T . vaginalis treated RAW264 . 7 cells were considerably diminished by transfection with overexpressed Bcl 10 ( L ) , and overexpressed Bcl 10 ( L ) could inhibit T . vaginalis induced apoptosis in RAW264 . 7 cells . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
In addition , release of cytochrome c from mitochondria , down expression of Bcl 2 and Bcl 10 ( L ) , up regulation of Bax , and caspase 9 activities were observed in SM treated A 549 cells . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Here we used embryonic fibroblasts derived from mice deficient in the multidomain proapoptotic members of the Bcl 2 family ( Bax and Bak ) and the apoptotic components of the apoptosome ( Apaf 1 and caspase 9 ) to unravel the cascade of events by which Bcl 10 ( S ) promotes apoptosis . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Both caused apoptosis by increasing the protein expression of Bax and Bcl xs while decreasing Bcl 2 and Bcl 10 ( L ) , releasing apoptogenic cytochrome c , and augmenting the activity of caspase 9 and caspase 3 . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Combining the Bcl 10 ( L ) siRNA with TRAIL protein treatment resulted in an increase in the percentage of apoptotic cells and increased cleavage of caspase 8 , caspase 9 , caspase 3 and PARP . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
In this study , we show that UPR gene expression is induced in cells treated with ER stress agents in the presence or absence of murine caspase 12 or human caspase 4 expression and in cells that overexpress Bcl 10 ( L ) or a dominant negative caspase 9 . ^^^ We further demonstrate that ER stress induced apoptosis is a caspase dependent process that does not require the expression of caspase 12 or caspase 4 but can be inhibited by overexpression of Bcl 10 ( L ) or a dominant negative caspase 9 . ^^^ Additionally , treatment of human and murine cells with ER stress agents led to the cleavage of the caspase 4 fluorogenic substrate , LEVD 7 amino 4 trifluoromethylcoumarin , in the presence or absence of caspase 12 or caspase 4 expression , whereas Bcl 10 ( L ) or a dominant negative caspase 9 overexpression inhibited LEVD 7 amino 4 trifluoromethylcoumarin cleavage . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Lastly , we show that NF kappaB inhibits c Myc induced activation of caspase 9 and caspase 3 through up regulation of the antiapoptotic target genes Bcl 10 ( L ) and 10 linked inhibitor of apoptosis ( XIAP ) . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Similarly , immunoreactivity for the apoptotic signals Fas , Fas ligand , Bax , Bcl 10 , caspase 8 , caspase 9 and caspase 3 was absent from the NBM of AD and control brains . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
We found that the intrinsic pathway is activated early on during anesthesia exposure ( within two hours ) , as measured by the down regulation of bcl 10 ( L ) , up regulation of cytochrome c and the activation of caspase 9 in 7 day old rats ( the peak of synaptogenesis ) , but remains inactivated in 14 day old rats ( the end of synaptogenesis ) . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
The increased levels of active caspase 9 correlated with Bax / Bcl 2 and Bcl 10 ( L ) expression suggesting that the apoptotic mitochondrion dependent pathway is involved in decidual regression during pregnancy progression . . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Expression of Smad 7 and Bcl 10 ( L ) , but not viral FLIP , was shown to prevent TGF beta induced apoptosis , indicating an exclusive requirement of the activation of Smad signaling pathway and mitochondrial dysfunction followed by activation of caspase 9 . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
In addition , chalcone also triggered the mitochondrial apoptotic signaling by increasing the amount of Bax and Bak and reducing the level of Bcl 2 and Bcl 10 ( L ) , and subsequently activated caspase 9 in MCF 7 and MDA MB 231 cells . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Ad COX 1 / PGIS transfection was found to reduce the adriamycin stimulated activities of caspase 3 and caspase 9 , inhibit adriamycin induced release of cytochrome c , elevate the expression of Bcl 10 ( L ) , and suppress the activation and translocation of nuclear factor kappaB ( NF kappaB ) in adriamycin treated renal tubular cells . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
The down regulation of the cyclin A , Bcl 2 , and Bcl 10 ( L ) expression with the simultaneous up regulation of the p 21 and Bax expression , and caspase 9 activation was observed in ECSC after bufalin treatment . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Examples of prominent CARD proteins are caspase 9 and Apaf 1 , which are involved in the intrinsic death pathway ; BCL 10 and CARD 11 , which mediate antigen receptor induced NF kappaB activation ; and receptor interacting protein ( RIP ) like interacting caspase like apoptosis regulatory protein kinase ( RICK ) and the nucleotide binding oligomerization domain ( NOD ) proteins , which induce NF kappaB activation in response to intracellular bacterial peptidoglycan . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
CIPER formed homodimers via its CARD and interacted with viral E 10 but not with several apoptosis regulators containing CARDs including ARC , RAIDD , RICK , caspase 2 , caspase 9 , or Apaf 1 . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
The C terminus of mE 10 bound to the zymogen form of caspase 9 and promoted its processing to the active dimeric species . ^^^ Taken together , these data suggest a model where autoproteolytic activation of pro caspase 9 is mediated by mE 10 induced oligomerization . . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
Apoptosis was attenuated in both conditions in stable transfected cells expressing antiapoptotic proteins Bclx ( L ) and catalytically inactive caspase 9 , and in both scenarios inactive caspase 9 became complexed with caspase 7 . ^^^
Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
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Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
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Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
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Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
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Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
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Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
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Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
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Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
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Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
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Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
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Interacting proteins: O95999 and P55211 Pubmed SVM Score :0.0
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