| Interacting proteins: Q9UKV5 and P55072 |
Pubmed |
SVM Score :0.64231856 |
| We now report that gp 78 physically interacts with p97 / VCP and enhances p97 / VCP polyubiquitin association . 0.64231856^^^ |
|
| Interacting proteins: Q9UKV5 and P55072 |
Pubmed |
SVM Score :0.0 |
| In addition , gp 78 couples regulated ubiquitination to degradation of reductase by binding to VCP , an ATPase that plays a key role in recognition and degradation of ERAD substrates . ^^^ The current results identify gp 78 as the E 3 that initiates sterol accelerated degradation of reductase , and Insig 1 as a bridge between gp78 / VCP and the reductase substrate . . ^^^ |
|
| Interacting proteins: Q9UKV5 and P55072 |
Pubmed |
SVM Score :0.0 |
| We show here that p97 / VCP and gp 78 form complexes with CFTR during translocation from the ER for degradation by the cytosolic proteasome . ^^^ |
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