| Interacting proteins: Q92890 and P55072 |
Pubmed |
SVM Score :0.0 |
| Destabilization of the VCP Ufd 1 Npl4 complex is associated with decreased levels of ERAD substrates . p97 / VCP associated with Ufd 1 Npl4 is considered a key player in ER associated degradation ( ERAD ) . ^^^ RNA interference ( RNAi ) of one component of the Ufd 1 Npl4 heterodimer destabilizes the VCP Ufd 1 Npl4 complex inducing proteasome dependent degradation of the other component and releasing free VCP . ^^^ In contrast to RNAi of VCP , RNAi of Ufd 1 or Npl 4 depleting approximately 90 % of the VCP Ufd 1 Npl4 complexes does not induce unfolded protein response , indicating that the Ufd 1 Npl4 dimer is not involved in the regulation of ER function by VCP . ^^^ To explain our findings , we propose a model , where association of emerging ERAD substrates with VCP Ufd 1 Npl4 is not required for their degradation but has a regulatory role . . ^^^ |
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| Interacting proteins: Q92890 and P55072 |
Pubmed |
SVM Score :0.0 |
| AT 3 and Ufd 1 bind VCP in a mutually exclusive manner ; AT 3 decreases the interaction of VCP with Ufd 1 as well as with ubiquitylated proteins . ^^^ |
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| Interacting proteins: Q92890 and P55072 |
Pubmed |
SVM Score :0.0 |
| In response to oxidative stress , VCP strengthened the interaction with Npl 4 and Ufd 1 , both of which are essential in endoplasmic reticulum associated protein degradation . ^^^ |
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