| Interacting proteins: P54252 and P55072 |
Pubmed |
SVM Score :0.66177197 |
| Here , we demonstrate that such a motif consisting of four basic amino acids in the polyglutamine protein ataxin 3 ( Atx 3 ) serves as a recognition site for the interaction with the molecular chaperone VCP . 0.66177197^^^ |
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| Interacting proteins: P54252 and P55072 |
Pubmed |
SVM Score :0.0 |
| Ataxin 3 interactions with rad 23 and valosin containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin mediated proteolysis . ^^^ Additionally , ataxin 3 associates with the ubiquitin and proteasome binding factors Rad 23 and valosin containing protein ( VCP / p97 ) , findings that support the hypothesis that ataxin 3 is a proteasome associated factor that mediates the degradation of ubiquitinated proteins . . ^^^ |
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| Interacting proteins: P54252 and P55072 |
Pubmed |
SVM Score :0.0 |
| Ataxin 3 binds VCP / p97 and regulates retrotranslocation of ERAD substrates . ^^^ AT 3 binds VCP / p97 , a key protein responsible for extracting ERAD substrates from the ER ; binding is modulated by the size of the polyglutamine tract , and mutating a sequence adjacent to the polyglutamine tract inhibits the AT 3 VCP interaction and AT 3 dependent accumulation of CD3delta . ^^^ AT 3 and Ufd 1 bind VCP in a mutually exclusive manner ; AT 3 decreases the interaction of VCP with Ufd 1 as well as with ubiquitylated proteins . ^^^ These data suggest that a normal function of AT 3 is to regulate flow through the ERAD pathway by modulating VCP dependent extraction of proteins from the ER . . ^^^ |
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| Interacting proteins: P54252 and P55072 |
Pubmed |
SVM Score :0.0 |
| We previously identified p97 / valosin containing protein ( VCP ) , an AAA ATPase with two conserved ATPase domains ( D 1 and D 2 ) , as an interacting partner of the Machado Joseph disease ( MJD ) protein with expanded polyglutamines that causes Machado Joseph disease . ^^^ |
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| Interacting proteins: P54252 and P55072 |
Pubmed |
SVM Score :0.0 |
| An AAA family ATPase VCP was isolated from the active fraction , and found to binds to MJD 1 . ^^^ Furthermore , UFD2a , a mammalian ubiquitin chain assembly factor ( E 4 ) , associated with VCP and induced polyubiquitylation of MJD 1 . ^^^ |
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| Interacting proteins: P54252 and P55072 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54252 and P55072 |
Pubmed |
SVM Score :0.0 |
| NA |
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