| Interacting proteins: P55042 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P55042 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55042 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55042 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55042 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55042 and P62158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55042 and P62158 |
Pubmed |
SVM Score :0.92680854 |
| Here we show that Rad and Gem bind to calmodulin ( CaM ) Sepharose in vitro in a calcium dependent manner and that Rad can be co immunoprecipitated with CaM in C2C12 cells . 0.92680854^^^ The interaction is influenced by the guanine nucleotide binding state of Rad with the GDP bound form exhibiting 5 fold better binding to CaM than the GTP bound protein . 0.66857451^^^ |
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| Interacting proteins: P55042 and P62158 |
Pubmed |
SVM Score :0.0 |
| We also demonstrate with a newly developed [ 32P ] CaM overlay technique that full length Kir / Gem and Rad proteins bind CaM in a Ca2+ dependent fashion . ^^^ |
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| Interacting proteins: P55042 and P62158 |
Pubmed |
SVM Score :0.0 |
| We have recently shown that Rad and Gem bind calmodulin in a Ca2+ dependent manner via this C terminal extension , involving residues 278 297 in human Rad . ^^^ This domain also contains several consensus sites for serine phosphorylation , and Rad is complexed with calmodulin dependent protein kinase 2 ( CaMKII ) in C2C12 cells . ^^^ However , phosphorylation of Rad by PKC and CKII abolishes the interaction of Rad with calmodulin . ^^^ These findings suggest that the binding of Rad to calmodulin , as well as its ability to bind GTP , might be regulated by the activation of several serine kinases . . ^^^ |
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| Interacting proteins: P55042 and P62158 |
Pubmed |
SVM Score :0.0 |
| Roles of 14 3 3 and calmodulin binding in subcellular localization and function of the small G protein Rem 2 . kir / Gem , Rad , Rem and Rem 2 comprise the RGK ( Rad / Gem / kir ) family of Ras related small G proteins . ^^^ |
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| Interacting proteins: P55042 and P62158 |
Pubmed |
SVM Score :0.0 |
| Nuclear sequestration of beta subunits by Rad and Rem is controlled by 14 3 3 and calmodulin and reveals a novel mechanism for Ca2+ channel regulation . ^^^ This function is regulated by calmodulin and 14 3 3 binding only for Rad and not for Rem . ^^^ We show that , similar to Kir / Gem and Rem 2 , 14 3 3 and CaM binding regulate the subcellular distribution of Rad and Rem , which both inhibit Ca2+ channel activity by preventing its expression on the cell surface . ^^^ |
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