| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| Similarly , ephrin A 5 is expressed not only in tectal cells but also in the nasal retina , with a pattern reciprocal to that of its receptor EphA 3 and partially overlapping with that of its other receptor EphA 4 . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| Conversely , ephrin A 2 , ephrin A 3 , and ephrin A 5 bind EphA 7 but not EphA 4 . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| Although several patterns of early gene expression are stable ( e . g . , EphA 3 , EphA 4 , and EphA 6 ) , others change as development proceeds ( e . g . , EphA 5 , EphA 7 , ephrin A 2 , ephrin A 3 , and ephrin A 5 ) , perhaps responding to extrinsic cues . ^^^ Thus , at E 95 , after connections between the cortical plate and thalamus have formed , receptor subtypes EphA 3 , EphA 5 , EphA 6 , and EphA 7 and the ligand ephrin A 5 are expressed in posterior regions , whereas EphA 4 and ephrin A 2 and ephrin A 3 are either uniformly distributed or anteriorly biased . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| Three putative receptors for ephrin A 5 EphA 3 , EphA 4 and EphA 5 showed distinct expression patterns in the developing thalamus . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| EphA 3 , EphA 4 , ephrin A 2 , and ephrin A 5 were also expressed in the connective tissues of limb muscles and EphA 3 and EphA 4 expressing motor neurons innervated EphA 3 and EphA 4 expressing limb muscles , respectively . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| Ephrin A 5 was expressed in a medial > lateral gradient across S 1 , whereas its receptor EphA 4 was in a matching gradient across the thalamic ventrobasal ( VB ) complex , which provides S 1 input . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| Expression of EphA 4 , ephrin A 2 and ephrin A 5 during axon outgrowth to the hindlimb indicates potential roles in pathfinding . ^^^ Here , we examine the spatiotemporal distributions of the EphA 4 receptor tyrosine kinase ( RTK ) and its cognate ligands , ephrin A 2 and ephrin A 5 , on motor neurons , their axons and their pathways to the avian hindlimb to determine whether these molecules may influence axonal projections . ^^^ The expression patterns of EphA 4 , ephrin A 2 and ephrin A 5 mRNAs and proteins are highly complex and appear to exhibit some overlap during motor axon outgrowth and pathfinding to the hindlimb , reminiscent of the co expression of Eph RTKs and ephrins in the retinotectal system . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| Spatiotemporal expression patterns of six members of the Eph gene family ( EphA 4 , EphA 3 , EphB 2 , ephrin B 1 , ephrin A 2 , and ephrin A 5 ) were characterized immunocytochemically at various stages of chick cerebellar development . ^^^ During the early period of cerebellar development ( E 3 E8 ) , complementarity is observed between EphA 4 and ephrin A 5 expression within the cerebellar isthmal region . ^^^ Banded expression of the ephrin A 5 ligand complements EphA 4 expression during the middle period ( E 9 E15 ) . ^^^ Variability in the banding expression is observed for EphA 4 , EphA 3 , ephrin A 5 , and ephrin A 2 across different lobes , and graded complementarity in the expression pattern of EphA 3 and ephrin A 5 is observed in the external granular layer between the posterior and anterior lobes . ^^^ Analysis of Purkinje cell birth date in correlation with Eph ephrin expression during the middle period reveals that early born cells express EphA 4 , whereas late born cells express ephrin A 5 . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| The EphA 4 receptor tyrosine kinase and its ligand , ephrin A 5 , are expressed by muscle precursor cells and forelimb mesoderm in unique spatiotemporal patterns during the period when muscle precursors delaminate from the dermomyotome and migrate into the limb . ^^^ These data suggest that ephrin A 5 normally restricts migrating , EphA 4 positive muscle precursor cells to their appropriate territories in the forelimb , disallowing entry into abnormal embryonic regions . . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| EphA 4 , ephrin A 2 and ephrin A 5 were expressed by primary olfactory axons during the embryonic formation of the olfactory nerve . ^^^ In contrast , loss of EphA 4 from axons during glomerular formation may facilitate the interaction of ephrin A 5 with Eph receptors on target cells in the bulb . ^^^ While EphA 4 , EphA 5 and EphA 7 are not mosaically expressed by bulbar neurons , other Eph receptors may have expression patterns complementary to the ephrin A 5 positive subpopulation of glomeruli . . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| In functional analyses , addition of ephrin A 2 , ephrin A 5 , and EphA 4 Fc disrupted the segmental organization of trunk neural crest migration in explants : neural crest cells entered rostral and caudal halves of somites . ^^^ Surprisingly , neural crest cells avoided ephrin A 2 or ephrin A 5 substrates ; this avoidance was abolished by the addition of EphA 4 . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| Ephrin A 5 exerts positive or inhibitory effects on distinct subsets of EphA 4 positive motor neurons . ^^^ Here , we show that distinct subsets of motor neurons that express EphA 4 respond differently to ephrin A 5 . ^^^ EphA 4 positive LMC ( l ) axons avoid entering ephrin A 5 positive hindlimb mesoderm . ^^^ In contrast , EphA 4 positive MMC ( m ) axons extend through ephrin A 5 positive rostral half sclerotome . ^^^ Blocking EphA 4 activation in MMC ( m ) neurons or expanding the domain of ephrin A 5 expression in the somite results in the aberrant growth of MMC ( m ) axons into the caudal half sclerotome . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| Ephrin A 1 , ephrin A 5 , EphA 2 , EphA 3 , EphA 4 , and EphA 7 were expressed in the tooth germ at the epithelial thickening stage , and later , ephrin A 1 , ephrin A 5 , EphA 2 , EphA 4 , and EphA 7 showed distinct expression patterns in the enamel organ undergoing epithelial folding morphogenesis . ^^^ Prior to birth , ephrin A 1 , ephrin A 5 , EphA 2 , and EphA 4 transcripts were present in the cuspal area of the dental papilla including the preodontoblasts . ^^^ |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P52803 and P54764 |
Pubmed |
SVM Score :0.0 |
| NA |
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